Identification of a leukemia-initiating stem cell in human mast cell leukemia. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-05

AUTHORS

Gregor Eisenwort, Irina Sadovnik, Juliana Schwaab, Mohamad Jawhar, Alexandra Keller, Gabriele Stefanzl, Daniela Berger, Katharina Blatt, Gregor Hoermann, Martin Bilban, Michael Willmann, Christiana Winding, Wolfgang R Sperr, Michel Arock, Thomas Rülicke, Andreas Reiter, Peter Valent

ABSTRACT

Mast cell leukemia (MCL) is a highly fatal malignancy characterized by devastating expansion of immature mast cells in various organs. Although considered a stem cell disease, little is known about MCL-propagating neoplastic stem cells. We here describe that leukemic stem cells (LSCs) in MCL reside within a CD34+/CD38- fraction of the clone. Whereas highly purified CD34+/CD38 cells engrafted NSGhSCF mice with fully manifesting MCL, no MCL was produced by CD34+/CD38+ progenitors or the bulk of KIT+/CD34- mast cells. CD34+/CD38- MCL cells invariably expressed CD13 and CD133, and often also IL-1RAP, but did not express CD25, CD26 or CLL-1. CD34+/CD38- MCL cells also displayed several surface targets, including CD33, which was homogenously expressed on MCL LSCs in all cases, and the D816V mutant form of KIT. Although CD34+/CD38- cells were resistant against single drugs, exposure to combinations of CD33-targeting and KIT-targeting drugs resulted in LSC-depletion and markedly reduced engraftment in NSGhSCF mice. Together, MCL LSCs are CD34+/CD38- cells that express distinct profiles of markers and target antigens. Characterization of MCL LSCs should facilitate their purification and should support the development of LSC-eradicating curative treatment approaches in this fatal type of leukemia. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41375-019-0460-6

DOI

http://dx.doi.org/10.1038/s41375-019-0460-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113261649

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30953030


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria.", 
            "Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eisenwort", 
        "givenName": "Gregor", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria.", 
            "Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sadovnik", 
        "givenName": "Irina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwaab", 
        "givenName": "Juliana", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jawhar", 
        "givenName": "Mohamad", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keller", 
        "givenName": "Alexandra", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stefanzl", 
        "givenName": "Gabriele", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Daniela", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria.", 
            "Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blatt", 
        "givenName": "Katharina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoermann", 
        "givenName": "Gregor", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bilban", 
        "givenName": "Martin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Veterinary Medicine Vienna", 
          "id": "https://www.grid.ac/institutes/grid.6583.8", 
          "name": [
            "Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria.", 
            "Department for Companion Animals & Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, 1210, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willmann", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Veterinary Medicine Vienna", 
          "id": "https://www.grid.ac/institutes/grid.6583.8", 
          "name": [
            "Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winding", 
        "givenName": "Christiana", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria.", 
            "Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sperr", 
        "givenName": "Wolfgang R", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "\u00c9cole Normale Sup\u00e9rieure de Cachan", 
          "id": "https://www.grid.ac/institutes/grid.6390.c", 
          "name": [
            "Cellular and Molecular Oncology, LBPA CNRS UMR8113, Ecole Normale Sup\u00e9rieure de Cachan, 94230, Cachan, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arock", 
        "givenName": "Michel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Veterinary Medicine Vienna", 
          "id": "https://www.grid.ac/institutes/grid.6583.8", 
          "name": [
            "Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria.", 
            "Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00fclicke", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reiter", 
        "givenName": "Andreas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria. peter.valent@meduniwien.ac.at.", 
            "Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria. peter.valent@meduniwien.ac.at."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valent", 
        "givenName": "Peter", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0145-2126(02)00168-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005299900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005843169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0609.2011.01598.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006801369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1004408107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007004658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-05-353201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007478381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2016.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009388807", 
          "https://doi.org/10.1038/leu.2016.30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-04-496448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010784391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2013.095133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012965978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11899-009-0010-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014154252", 
          "https://doi.org/10.1007/s11899-009-0010-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11899-009-0010-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014154252", 
          "https://doi.org/10.1007/s11899-009-0010-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/517546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014679601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.iac.2014.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015013154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0025-6196(12)62636-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015504806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-02-206565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015531797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lrr.2013.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016629800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019066509", 
          "https://doi.org/10.1038/nrc3184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0145-2126(01)00041-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019200762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-007-0430-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020085822", 
          "https://doi.org/10.1007/s00277-007-0430-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2007.08.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021681387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0797-730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022333282", 
          "https://doi.org/10.1038/nm0797-730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-10-534685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024191562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2009.10.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025871757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026416679", 
          "https://doi.org/10.1038/sj.leu.2403649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026416679", 
          "https://doi.org/10.1038/sj.leu.2403649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0085362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027008441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/ehm.10.42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027508846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2010.031690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028205753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367645a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028822583", 
          "https://doi.org/10.1038/367645a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-02-205237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030761037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-02-205237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030761037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-03-637728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030884237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molonc.2010.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031281111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.17.5745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034389371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-07-442400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035470637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1513098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037873311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-2811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039693200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-5134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040209706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-10-536078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040832385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3000349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043265204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3000349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043265204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0145-2126(01)00050-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046667454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-10-118331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047320221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047485523", 
          "https://doi.org/10.1038/modpathol.2010.224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000138181.89743.7b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048081998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000138181.89743.7b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048081998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.55.2018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048995098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049957835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-02-335950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051079775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-03-083048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052000460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10428190500272507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058362144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2016-09-731893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064123347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156800911793743655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069191097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082397435", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082578893", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083238806", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-05", 
    "datePublishedReg": "2019-04-05", 
    "description": "Mast cell leukemia (MCL) is a highly fatal malignancy characterized by devastating expansion of immature mast cells in various organs. Although considered a stem cell disease, little is known about MCL-propagating neoplastic stem cells. We here describe that leukemic stem cells (LSCs) in MCL reside within a CD34+/CD38- fraction of the clone. Whereas highly purified CD34+/CD38\u2500 cells engrafted NSGhSCF mice with fully manifesting MCL, no MCL was produced by CD34+/CD38+ progenitors or the bulk of KIT+/CD34- mast cells. CD34+/CD38- MCL cells invariably expressed CD13 and CD133, and often also IL-1RAP, but did not express CD25, CD26 or CLL-1. CD34+/CD38- MCL cells also displayed several surface targets, including CD33, which was homogenously expressed on MCL LSCs in all cases, and the D816V mutant form of KIT. Although CD34+/CD38- cells were resistant against single drugs, exposure to combinations of CD33-targeting and KIT-targeting drugs resulted in LSC-depletion and markedly reduced engraftment in NSGhSCF mice. Together, MCL LSCs are CD34+/CD38- cells that express distinct profiles of markers and target antigens. Characterization of MCL LSCs should facilitate their purification and should support the development of LSC-eradicating curative treatment approaches in this fatal type of leukemia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41375-019-0460-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }
    ], 
    "name": "Identification of a leukemia-initiating stem cell in human mast cell leukemia.", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30953030"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41375-019-0460-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113261649"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41375-019-0460-6", 
      "https://app.dimensions.ai/details/publication/pub.1113261649"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117123_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/s41375-019-0460-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-019-0460-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-019-0460-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-019-0460-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-019-0460-6'


 

This table displays all metadata directly associated to this object as RDF triples.

323 TRIPLES      20 PREDICATES      74 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41375-019-0460-6 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Ncde506e0c7d34db48af2b78bb3ffa219
4 schema:citation sg:pub.10.1007/s00277-007-0430-3
5 sg:pub.10.1007/s11899-009-0010-9
6 sg:pub.10.1038/367645a0
7 sg:pub.10.1038/leu.2016.30
8 sg:pub.10.1038/modpathol.2010.224
9 sg:pub.10.1038/nm0797-730
10 sg:pub.10.1038/nrc3184
11 sg:pub.10.1038/sj.leu.2403649
12 https://app.dimensions.ai/details/publication/pub.1082397435
13 https://app.dimensions.ai/details/publication/pub.1082578893
14 https://app.dimensions.ai/details/publication/pub.1083238806
15 https://doi.org/10.1016/j.exphem.2007.08.016
16 https://doi.org/10.1016/j.iac.2014.01.008
17 https://doi.org/10.1016/j.jaci.2009.10.020
18 https://doi.org/10.1016/j.lrr.2013.11.001
19 https://doi.org/10.1016/j.molonc.2010.04.008
20 https://doi.org/10.1016/s0025-6196(12)62636-6
21 https://doi.org/10.1016/s0145-2126(01)00041-8
22 https://doi.org/10.1016/s0145-2126(01)00050-9
23 https://doi.org/10.1016/s0145-2126(02)00168-6
24 https://doi.org/10.1056/nejmoa040258
25 https://doi.org/10.1056/nejmoa1513098
26 https://doi.org/10.1073/pnas.1004408107
27 https://doi.org/10.1080/10428190500272507
28 https://doi.org/10.1093/annonc/mdu047
29 https://doi.org/10.1097/01.pas.0000138181.89743.7b
30 https://doi.org/10.1111/j.1600-0609.2011.01598.x
31 https://doi.org/10.1126/scitranslmed.3000349
32 https://doi.org/10.1155/2012/517546
33 https://doi.org/10.1158/1078-0432.ccr-07-5134
34 https://doi.org/10.1158/1078-0432.ccr-13-2811
35 https://doi.org/10.1182/blood-2007-03-083048
36 https://doi.org/10.1182/blood-2007-10-118331
37 https://doi.org/10.1182/blood-2009-02-205237
38 https://doi.org/10.1182/blood-2009-02-206565
39 https://doi.org/10.1182/blood-2011-02-335950
40 https://doi.org/10.1182/blood-2011-05-353201
41 https://doi.org/10.1182/blood-2012-07-442400
42 https://doi.org/10.1182/blood-2013-04-496448
43 https://doi.org/10.1182/blood-2013-10-534685
44 https://doi.org/10.1182/blood-2013-10-536078
45 https://doi.org/10.1182/blood-2015-03-637728
46 https://doi.org/10.1182/blood-2016-09-731893
47 https://doi.org/10.1200/jco.2008.17.5745
48 https://doi.org/10.1200/jco.2014.55.2018
49 https://doi.org/10.1371/journal.pone.0085362
50 https://doi.org/10.1586/ehm.10.42
51 https://doi.org/10.2174/156800911793743655
52 https://doi.org/10.3324/haematol.2010.031690
53 https://doi.org/10.3324/haematol.2013.095133
54 schema:datePublished 2019-04-05
55 schema:datePublishedReg 2019-04-05
56 schema:description Mast cell leukemia (MCL) is a highly fatal malignancy characterized by devastating expansion of immature mast cells in various organs. Although considered a stem cell disease, little is known about MCL-propagating neoplastic stem cells. We here describe that leukemic stem cells (LSCs) in MCL reside within a CD34<sup>+</sup>/CD38<sup>-</sup> fraction of the clone. Whereas highly purified CD34<sup>+</sup>/CD38<sup>─</sup> cells engrafted NSG<sub>hSCF</sub> mice with fully manifesting MCL, no MCL was produced by CD34<sup>+</sup>/CD38<sup>+</sup> progenitors or the bulk of KIT<sup>+</sup>/CD34<sup>-</sup> mast cells. CD34<sup>+</sup>/CD38<sup>-</sup> MCL cells invariably expressed CD13 and CD133, and often also IL-1RAP, but did not express CD25, CD26 or CLL-1. CD34<sup>+</sup>/CD38<sup>-</sup> MCL cells also displayed several surface targets, including CD33, which was homogenously expressed on MCL LSCs in all cases, and the D816V mutant form of KIT. Although CD34<sup>+</sup>/CD38<sup>-</sup> cells were resistant against single drugs, exposure to combinations of CD33-targeting and KIT-targeting drugs resulted in LSC-depletion and markedly reduced engraftment in NSG<sub>hSCF</sub> mice. Together, MCL LSCs are CD34<sup>+</sup>/CD38<sup>-</sup> cells that express distinct profiles of markers and target antigens. Characterization of MCL LSCs should facilitate their purification and should support the development of LSC-eradicating curative treatment approaches in this fatal type of leukemia.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf sg:journal.1097065
61 schema:name Identification of a leukemia-initiating stem cell in human mast cell leukemia.
62 schema:productId N1d2d01b25cdc421f985c4ac49ca3371f
63 N77d1cc9141f646978809099f015e78bf
64 N927c9657255040b29a9c6cd687ad510c
65 Nbd33ba60a6984eb291d5e90c2d8c2663
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113261649
67 https://doi.org/10.1038/s41375-019-0460-6
68 schema:sdDatePublished 2019-04-11T14:20
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N93f19eca8e05406b98abe8255018cbf8
71 schema:url http://www.nature.com/articles/s41375-019-0460-6
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N017cfa969e27456b9a2d2a1c187d950d schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
76 schema:familyName Stefanzl
77 schema:givenName Gabriele
78 rdf:type schema:Person
79 N018cb7318b334f0ea4af2533c846d5b8 rdf:first N597f7fdca78c438da29344f229978bf9
80 rdf:rest Nba80750ac0774c23ba34086117f196a0
81 N0c2918ba85ea4065a6b890f173168557 schema:affiliation https://www.grid.ac/institutes/grid.6390.c
82 schema:familyName Arock
83 schema:givenName Michel
84 rdf:type schema:Person
85 N1639cbab64fd4e29af9f5855f0158fb9 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
86 schema:familyName Eisenwort
87 schema:givenName Gregor
88 rdf:type schema:Person
89 N1d2d01b25cdc421f985c4ac49ca3371f schema:name pubmed_id
90 schema:value 30953030
91 rdf:type schema:PropertyValue
92 N2026b797e29b4379bc8bb4b3367ede73 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
93 schema:familyName Sperr
94 schema:givenName Wolfgang R
95 rdf:type schema:Person
96 N32d1ae51d81546a7b0bbb8ce9c8e02c6 rdf:first N2026b797e29b4379bc8bb4b3367ede73
97 rdf:rest N7caa56e3b5de4e95bb7cac91e734f0c2
98 N3e4f2011635e462b9246a3f7371dc00c schema:affiliation https://www.grid.ac/institutes/grid.6583.8
99 schema:familyName Rülicke
100 schema:givenName Thomas
101 rdf:type schema:Person
102 N458b82d8470645df9a152a71d58e4298 rdf:first Nc5ab4d30074f44e59c088478ac333828
103 rdf:rest N32d1ae51d81546a7b0bbb8ce9c8e02c6
104 N4751e14ffcc8447b8fdbdf59ae1af93a schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
105 schema:familyName Valent
106 schema:givenName Peter
107 rdf:type schema:Person
108 N4b300a60c3ab49a9bb04a7b91e1fd1c1 rdf:first Nd87fa1e489c64df59affc5534d694331
109 rdf:rest N5a00ec66e2994043a872994988ce11ec
110 N597f7fdca78c438da29344f229978bf9 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
111 schema:familyName Sadovnik
112 schema:givenName Irina
113 rdf:type schema:Person
114 N5a00ec66e2994043a872994988ce11ec rdf:first N4751e14ffcc8447b8fdbdf59ae1af93a
115 rdf:rest rdf:nil
116 N65471a5fa56e4616ad06fdf3cbcf1037 schema:affiliation https://www.grid.ac/institutes/grid.411778.c
117 schema:familyName Schwaab
118 schema:givenName Juliana
119 rdf:type schema:Person
120 N65fef5d672f14331bfb55df6bc23c5cd rdf:first N69e78865db4b40c4a1020087a268ebc0
121 rdf:rest Naf801724ccce466fbe5cdfef06316c19
122 N69e78865db4b40c4a1020087a268ebc0 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
123 schema:familyName Berger
124 schema:givenName Daniela
125 rdf:type schema:Person
126 N75d7790038044bf9a6ad54b0ac9741b9 rdf:first Nf1ac3c0d00de4221aaca1b45b87d9754
127 rdf:rest N89ea2fb8b6cc48dcb3644949ee1591df
128 N77d1cc9141f646978809099f015e78bf schema:name dimensions_id
129 schema:value pub.1113261649
130 rdf:type schema:PropertyValue
131 N7caa56e3b5de4e95bb7cac91e734f0c2 rdf:first N0c2918ba85ea4065a6b890f173168557
132 rdf:rest Nc7907548456b4682adea9d7ab20b5615
133 N7e061c5bc08043be809a7e723768d06d rdf:first Nfeffa2c78815439397d9d57e9ad79be8
134 rdf:rest Ne7c38d71d9744d3eb95133d82f73daad
135 N89ea2fb8b6cc48dcb3644949ee1591df rdf:first N8def91295f3844b5a4695a2b509efafe
136 rdf:rest N458b82d8470645df9a152a71d58e4298
137 N8def91295f3844b5a4695a2b509efafe schema:affiliation https://www.grid.ac/institutes/grid.6583.8
138 schema:familyName Willmann
139 schema:givenName Michael
140 rdf:type schema:Person
141 N927c9657255040b29a9c6cd687ad510c schema:name nlm_unique_id
142 schema:value 8704895
143 rdf:type schema:PropertyValue
144 N93f19eca8e05406b98abe8255018cbf8 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N9d440cf108264e1cae43b223b111d8b5 rdf:first N017cfa969e27456b9a2d2a1c187d950d
147 rdf:rest N65fef5d672f14331bfb55df6bc23c5cd
148 Na98deccade69482ab100a630dfec2bff schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
149 schema:familyName Blatt
150 schema:givenName Katharina
151 rdf:type schema:Person
152 Naf801724ccce466fbe5cdfef06316c19 rdf:first Na98deccade69482ab100a630dfec2bff
153 rdf:rest Ncf8f627e8acf4d89ad4a99399fee0dcb
154 Nba80750ac0774c23ba34086117f196a0 rdf:first N65471a5fa56e4616ad06fdf3cbcf1037
155 rdf:rest N7e061c5bc08043be809a7e723768d06d
156 Nbd33ba60a6984eb291d5e90c2d8c2663 schema:name doi
157 schema:value 10.1038/s41375-019-0460-6
158 rdf:type schema:PropertyValue
159 Nc5ab4d30074f44e59c088478ac333828 schema:affiliation https://www.grid.ac/institutes/grid.6583.8
160 schema:familyName Winding
161 schema:givenName Christiana
162 rdf:type schema:Person
163 Nc7907548456b4682adea9d7ab20b5615 rdf:first N3e4f2011635e462b9246a3f7371dc00c
164 rdf:rest N4b300a60c3ab49a9bb04a7b91e1fd1c1
165 Ncde506e0c7d34db48af2b78bb3ffa219 rdf:first N1639cbab64fd4e29af9f5855f0158fb9
166 rdf:rest N018cb7318b334f0ea4af2533c846d5b8
167 Ncf8f627e8acf4d89ad4a99399fee0dcb rdf:first Nec651b26f8b749139aa3b71343845eb0
168 rdf:rest N75d7790038044bf9a6ad54b0ac9741b9
169 Nd49a85a22c464bb0aed5074f5471ff44 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
170 schema:familyName Keller
171 schema:givenName Alexandra
172 rdf:type schema:Person
173 Nd87fa1e489c64df59affc5534d694331 schema:affiliation https://www.grid.ac/institutes/grid.411778.c
174 schema:familyName Reiter
175 schema:givenName Andreas
176 rdf:type schema:Person
177 Ne7c38d71d9744d3eb95133d82f73daad rdf:first Nd49a85a22c464bb0aed5074f5471ff44
178 rdf:rest N9d440cf108264e1cae43b223b111d8b5
179 Nec651b26f8b749139aa3b71343845eb0 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
180 schema:familyName Hoermann
181 schema:givenName Gregor
182 rdf:type schema:Person
183 Nf1ac3c0d00de4221aaca1b45b87d9754 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
184 schema:familyName Bilban
185 schema:givenName Martin
186 rdf:type schema:Person
187 Nfeffa2c78815439397d9d57e9ad79be8 schema:affiliation https://www.grid.ac/institutes/grid.411778.c
188 schema:familyName Jawhar
189 schema:givenName Mohamad
190 rdf:type schema:Person
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
195 schema:name Cardiorespiratory Medicine and Haematology
196 rdf:type schema:DefinedTerm
197 sg:journal.1097065 schema:issn 0887-6924
198 1476-5551
199 schema:name Leukemia
200 rdf:type schema:Periodical
201 sg:pub.10.1007/s00277-007-0430-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020085822
202 https://doi.org/10.1007/s00277-007-0430-3
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/s11899-009-0010-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014154252
205 https://doi.org/10.1007/s11899-009-0010-9
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/367645a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028822583
208 https://doi.org/10.1038/367645a0
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/leu.2016.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009388807
211 https://doi.org/10.1038/leu.2016.30
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/modpathol.2010.224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047485523
214 https://doi.org/10.1038/modpathol.2010.224
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nm0797-730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022333282
217 https://doi.org/10.1038/nm0797-730
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/nrc3184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019066509
220 https://doi.org/10.1038/nrc3184
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/sj.leu.2403649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026416679
223 https://doi.org/10.1038/sj.leu.2403649
224 rdf:type schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1082397435 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1082578893 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1083238806 schema:CreativeWork
228 https://doi.org/10.1016/j.exphem.2007.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021681387
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.iac.2014.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015013154
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.jaci.2009.10.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025871757
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.lrr.2013.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016629800
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.molonc.2010.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031281111
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0025-6196(12)62636-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015504806
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0145-2126(01)00041-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019200762
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0145-2126(01)00050-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046667454
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0145-2126(02)00168-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005299900
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmoa040258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049957835
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejmoa1513098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037873311
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1073/pnas.1004408107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007004658
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1080/10428190500272507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058362144
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/annonc/mdu047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005843169
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/01.pas.0000138181.89743.7b schema:sameAs https://app.dimensions.ai/details/publication/pub.1048081998
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1600-0609.2011.01598.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006801369
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1126/scitranslmed.3000349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043265204
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1155/2012/517546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014679601
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1158/1078-0432.ccr-07-5134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040209706
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1158/1078-0432.ccr-13-2811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039693200
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1182/blood-2007-03-083048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052000460
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1182/blood-2007-10-118331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047320221
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1182/blood-2009-02-205237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030761037
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1182/blood-2009-02-206565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015531797
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1182/blood-2011-02-335950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051079775
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1182/blood-2011-05-353201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007478381
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1182/blood-2012-07-442400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035470637
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1182/blood-2013-04-496448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010784391
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1182/blood-2013-10-534685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024191562
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1182/blood-2013-10-536078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040832385
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1182/blood-2015-03-637728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030884237
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1182/blood-2016-09-731893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123347
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1200/jco.2008.17.5745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034389371
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1200/jco.2014.55.2018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048995098
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1371/journal.pone.0085362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027008441
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1586/ehm.10.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027508846
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2174/156800911793743655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069191097
301 rdf:type schema:CreativeWork
302 https://doi.org/10.3324/haematol.2010.031690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028205753
303 rdf:type schema:CreativeWork
304 https://doi.org/10.3324/haematol.2013.095133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012965978
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.22937.3d schema:alternateName Medical University of Vienna
307 schema:name Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria.
308 Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria. peter.valent@meduniwien.ac.at.
309 Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
310 Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria.
311 Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria. peter.valent@meduniwien.ac.at.
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.411778.c schema:alternateName University Medical Centre Mannheim
314 schema:name Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167, Mannheim, Germany.
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.6390.c schema:alternateName École Normale Supérieure de Cachan
317 schema:name Cellular and Molecular Oncology, LBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, 94230, Cachan, France.
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.6583.8 schema:alternateName University of Veterinary Medicine Vienna
320 schema:name Department for Companion Animals & Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
321 Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
322 Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090, Vienna, Austria.
323 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...