Prognostic significance of recurring chromosomal abnormalities in transplanted patients with acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-07

AUTHORS

Jonathan Canaani, Myriam Labopin, Maija Itälä-Remes, Didier Blaise, Gerard Socié, Edouard Forcade, Johan Maertens, Depei Wu, Ram Malladi, Jan J. Cornelissen, Anne Huynh, Jean Henri Bourhis, Jordi Esteve, Mohamad Mohty, Arnon Nagler

ABSTRACT

Baseline cytogenetic studies at diagnosis remain the single most important determinant of outcome in patients with acute myeloid leukemia (AML). However, the prognostic role of the complete gamut of cytogenetic aberrations in AML patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently undefined. In addition, their significance in conjunction with FLT3-ITD status has not been addressed thus far. Using the ALWP/EBMT registry we conducted a retrospective analysis to determine the clinical outcomes of AML patients undergoing allo-HSCT with respect to specific recurring cytogenetic abnormalities complemented with FLT3-ITD status. We analyzed a cohort consisting of 8558 adult AML patients who underwent allo-HSCT from either a matched sibling or a matched unrelated donor. Patients with inv(3)(q21q26)/t(3;3)(q21;q26), del(5q), monosomy 7, chromosome 17p abnormalities, t(10;11)(p11-14;q13-23), t(6;11)(q27;q23), as well as those patients with a monosomal or complex karyotype experienced significantly inferior leukemia-free survival (LFS) compared to patients with a normal karyotype. Trisomy 14, del(9q), and loss of chromosome X were associated with improved LFS rates. A novel prognostic model delineating 5 distinct groups incorporating cytogenetic complexity and FLT3-ITD status was constructed with significant prognostic implications. Our analysis supports the added prognostic significance of FLT3-ITD to baseline cytogenetics in patients undergoing allo-HSCT. More... »

PAGES

1-9

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41375-019-0439-3

    DOI

    http://dx.doi.org/10.1038/s41375-019-0439-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112605423

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30846862


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