Ontology type: schema:ScholarlyArticle
2019-04
AUTHORSG Fraser, P Cramer, F Demirkan, R Santucci Silva, S Grosicki, A Pristupa, A Janssens, J Mayer, N L Bartlett, M-S Dilhuydy, H Pylypenko, J Loscertales, A Avigdor, S Rule, D Villa, O Samoilova, P Panagiotidis, A Goy, M A Pavlovsky, C Karlsson, M Hallek, M Mahler, M Salman, S Sun, C Phelps, S Balasubramanian, A Howes, A Chanan-Khan
ABSTRACTWe report follow-up results from the randomized, placebo-controlled, phase 3 HELIOS trial of ibrutinib+bendamustine and rituximab (BR) for previously treated chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) without deletion 17p. Overall, 578 patients were randomized 1:1 to either ibrutinib (420 mg daily) or placebo, in combination with 6 cycles of BR, followed by ibrutinib or placebo alone. Median follow-up was 34.8 months (range: 0.1-45.8). Investigator-assessed median progression-free survival (PFS) was not reached for ibrutinib+BR, versus 14.3 months for placebo+BR (hazard ratio [HR] [95% CI], 0.206 [0.159-0.265]; P < 0.0001); 36-month PFS rates were 68.0% versus 13.9%, respectively. The results are consistent with the primary analysis findings (HR = 0.203, as assessed by independent review committee, with 17-month median follow-up). Median overall survival was not reached in either arm; HR (95% CI) for ibrutinib+BR versus placebo: 0.652 (0.454-0.935; P = 0.019). Minimal residual disease (MRD)-negative response rates were 26.3% for ibrutinib+BR and 6.2% for placebo+BR (P < 0.0001). Incidence of treatment-emergent adverse events (including grades 3-4) were generally consistent with the initial HELIOS report. These long-term data support improved survival outcomes and deepening responses with ibrutinib+BR compared with BR in relapsed CLL/SLL. More... »
PAGES1-12
http://scigraph.springernature.com/pub.10.1038/s41375-018-0276-9
DOIhttp://dx.doi.org/10.1038/s41375-018-0276-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1107585403
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30315239
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "McMaster University",
"id": "https://www.grid.ac/institutes/grid.25073.33",
"name": [
"Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada. fraserg@HHSC.CA."
],
"type": "Organization"
},
"familyName": "Fraser",
"givenName": "G",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Cologne",
"id": "https://www.grid.ac/institutes/grid.6190.e",
"name": [
"Department of Internal Medicine, Center of Integrated Oncology and German CLL Study Group, University of Cologne, Cologne, Germany."
],
"type": "Organization"
},
"familyName": "Cramer",
"givenName": "P",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Dokuz Eyl\u00fcl University",
"id": "https://www.grid.ac/institutes/grid.21200.31",
"name": [
"Division of Hematology, Dokuz Eylul University, Izmir, Turkey."
],
"type": "Organization"
},
"familyName": "Demirkan",
"givenName": "F",
"id": "sg:person.010650504314.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010650504314.81"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"IEP S\u00e3o Lucas/Hemomed Oncologia e Hematologia, S\u00e3o Paulo, Brazil."
],
"type": "Organization"
},
"familyName": "Silva",
"givenName": "R Santucci",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Medical University of Silesia",
"id": "https://www.grid.ac/institutes/grid.411728.9",
"name": [
"Department of Cancer Prevention, Faculty of Public Health, Silesian Medical University, Katowice, Poland."
],
"type": "Organization"
},
"familyName": "Grosicki",
"givenName": "S",
"id": "sg:person.0743135030.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743135030.35"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Regional Clinical Hospital, Ryazan, Russia."
],
"type": "Organization"
},
"familyName": "Pristupa",
"givenName": "A",
"id": "sg:person.01372611151.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372611151.93"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universitaire Ziekenhuizen Leuven",
"id": "https://www.grid.ac/institutes/grid.410569.f",
"name": [
"Universitaire Ziekenhuizen Leuven, Leuven, Belgium."
],
"type": "Organization"
},
"familyName": "Janssens",
"givenName": "A",
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Internal Medicine, Hematology and Oncology, Masaryk University Hospital Brno, Jihlavska, Brno, Czech Republic."
],
"type": "Organization"
},
"familyName": "Mayer",
"givenName": "J",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Washington University in St. Louis",
"id": "https://www.grid.ac/institutes/grid.4367.6",
"name": [
"Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA."
],
"type": "Organization"
},
"familyName": "Bartlett",
"givenName": "N L",
"id": "sg:person.015757323304.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015757323304.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Bordeaux",
"id": "https://www.grid.ac/institutes/grid.42399.35",
"name": [
"H\u00f4pital Haut-L\u00e9v\u00eaque, Pessac, Bordeaux, France."
],
"type": "Organization"
},
"familyName": "Dilhuydy",
"givenName": "M-S",
"id": "sg:person.01257603526.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257603526.68"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, Cherkassy Regional Oncological Center, Cherkassy, Ukraine."
],
"type": "Organization"
},
"familyName": "Pylypenko",
"givenName": "H",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital Universitario de La Princesa",
"id": "https://www.grid.ac/institutes/grid.411251.2",
"name": [
"Hematology Department, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain."
],
"type": "Organization"
},
"familyName": "Loscertales",
"givenName": "J",
"id": "sg:person.01332204157.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332204157.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tel Aviv University",
"id": "https://www.grid.ac/institutes/grid.12136.37",
"name": [
"Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, University of Tel-Aviv, Tel-Aviv, Israel."
],
"type": "Organization"
},
"familyName": "Avigdor",
"givenName": "A",
"id": "sg:person.0743612004.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743612004.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Plymouth University",
"id": "https://www.grid.ac/institutes/grid.11201.33",
"name": [
"Department of Haematology, Plymouth University Medical School, Plymouth, UK."
],
"type": "Organization"
},
"familyName": "Rule",
"givenName": "S",
"id": "sg:person.01234451652.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234451652.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada."
],
"type": "Organization"
},
"familyName": "Villa",
"givenName": "D",
"type": "Person"
},
{
"affiliation": {
"name": [
"Nizhny Novogorod Regional Clinical Hospital, Nizhny Novogorod, Russia."
],
"type": "Organization"
},
"familyName": "Samoilova",
"givenName": "O",
"type": "Person"
},
{
"affiliation": {
"alternateName": "National and Kapodistrian University of Athens",
"id": "https://www.grid.ac/institutes/grid.5216.0",
"name": [
"1st Department of Propedeutic Medicine, National and Kapodistrian University of Athens, Athens, Greece."
],
"type": "Organization"
},
"familyName": "Panagiotidis",
"givenName": "P",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hackensack University Medical Center",
"id": "https://www.grid.ac/institutes/grid.239835.6",
"name": [
"John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA."
],
"type": "Organization"
},
"familyName": "Goy",
"givenName": "A",
"id": "sg:person.01241267414.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241267414.41"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, Fundaleu, Buenos Aires, Argentina."
],
"type": "Organization"
},
"familyName": "Pavlovsky",
"givenName": "M A",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Karolinska Institute",
"id": "https://www.grid.ac/institutes/grid.4714.6",
"name": [
"Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.",
"Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden."
],
"type": "Organization"
},
"familyName": "Karlsson",
"givenName": "C",
"id": "sg:person.0744251457.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744251457.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Cologne",
"id": "https://www.grid.ac/institutes/grid.6190.e",
"name": [
"Department I of Internal Medicine, University of Cologne, Cologne, Germany."
],
"type": "Organization"
},
"familyName": "Hallek",
"givenName": "M",
"id": "sg:person.01025161256.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025161256.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Janssen (United States)",
"id": "https://www.grid.ac/institutes/grid.497530.c",
"name": [
"Janssen Research & Development, Raritan, NJ, USA."
],
"type": "Organization"
},
"familyName": "Mahler",
"givenName": "M",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Janssen (United States)",
"id": "https://www.grid.ac/institutes/grid.497530.c",
"name": [
"Janssen Research & Development, Raritan, NJ, USA."
],
"type": "Organization"
},
"familyName": "Salman",
"givenName": "M",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Janssen (United States)",
"id": "https://www.grid.ac/institutes/grid.497530.c",
"name": [
"Janssen Research & Development, Raritan, NJ, USA."
],
"type": "Organization"
},
"familyName": "Sun",
"givenName": "S",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Janssen (United States)",
"id": "https://www.grid.ac/institutes/grid.497530.c",
"name": [
"Janssen Research & Development, Raritan, NJ, USA."
],
"type": "Organization"
},
"familyName": "Phelps",
"givenName": "C",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Janssen (United States)",
"id": "https://www.grid.ac/institutes/grid.497530.c",
"name": [
"Janssen Research & Development, Spring House, PA, USA."
],
"type": "Organization"
},
"familyName": "Balasubramanian",
"givenName": "S",
"type": "Person"
},
{
"affiliation": {
"name": [
"Janssen Research & Development, High Wycombe, UK."
],
"type": "Organization"
},
"familyName": "Howes",
"givenName": "A",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Mayo Clinic Cancer Center, Jacksonville, FL, USA."
],
"type": "Organization"
},
"familyName": "Chanan-Khan",
"givenName": "A",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s1470-2045(16)30051-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001917202"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1756-8722-6-59",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002663036",
"https://doi.org/10.1186/1756-8722-6-59"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.33.8061",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002847770"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10428194.2013.777837",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004684564"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1400376",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005487964"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2007-06-093906",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006649234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2015-05-644690",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006803876"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2404584",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009036417",
"https://doi.org/10.1038/sj.leu.2404584"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2014-10-606038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011356913"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1509388",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011419396"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(15)00465-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018604803"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/bjh.14324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019352979"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2014-09-585869",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022071546"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2016.67.1305",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028975158"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.42.7906",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030970812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2015-08-634816",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042124450"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1215637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047519052"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2016-05-712828",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064123091"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.14694/edbook_am.2015.35.164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067344651"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/17474086.2017.1350166",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090390504"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3324/haematol.2017.171041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090917864"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-04",
"datePublishedReg": "2019-04-01",
"description": "We report follow-up results from the randomized, placebo-controlled, phase 3 HELIOS trial of ibrutinib+bendamustine and rituximab (BR) for previously treated chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) without deletion 17p. Overall, 578 patients were randomized 1:1 to either ibrutinib (420\u2009mg daily) or placebo, in combination with 6 cycles of BR, followed by ibrutinib or placebo alone. Median follow-up was 34.8 months (range: 0.1-45.8). Investigator-assessed median progression-free survival (PFS) was not reached for ibrutinib+BR, versus 14.3 months for placebo+BR (hazard ratio [HR] [95% CI], 0.206 [0.159-0.265]; P\u2009<\u20090.0001); 36-month PFS rates were 68.0% versus 13.9%, respectively. The results are consistent with the primary analysis findings (HR\u2009=\u20090.203, as assessed by independent review committee, with 17-month median follow-up). Median overall survival was not reached in either arm; HR (95% CI) for ibrutinib+BR versus placebo: 0.652 (0.454-0.935; P\u2009=\u20090.019). Minimal residual disease (MRD)-negative response rates were 26.3% for ibrutinib+BR and 6.2% for placebo+BR (P\u2009<\u20090.0001). Incidence of treatment-emergent adverse events (including grades 3-4) were generally consistent with the initial HELIOS report. These long-term data support improved survival outcomes and deepening responses with ibrutinib+BR compared with BR in relapsed CLL/SLL.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41375-018-0276-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1097065",
"issn": [
"0887-6924",
"1476-5551"
],
"name": "Leukemia",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "33"
}
],
"name": "Updated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma",
"pagination": "1-12",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"c25b4a20858a8737b953091c2aff687257ce57a801e27d866405ca9b34324adb"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30315239"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8704895"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41375-018-0276-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1107585403"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41375-018-0276-9",
"https://app.dimensions.ai/details/publication/pub.1107585403"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:50",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130794_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41375-018-0276-9"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0276-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0276-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0276-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0276-9'
This table displays all metadata directly associated to this object as RDF triples.
368 TRIPLES
21 PREDICATES
50 URIs
21 LITERALS
9 BLANK NODES