Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Donia M. Moujalled, Giovanna Pomilio, Corina Ghiurau, Adam Ivey, Jessica Salmon, Sewa Rijal, Sarah Macraild, Lan Zhang, Tse-Chieh Teh, Ing-Soo Tiong, Ping Lan, Maia Chanrion, Audrey Claperon, Francesca Rocchetti, Adrien Zichi, Laurence Kraus-Berthier, Youzhen Wang, Ensar Halilovic, Erick Morris, Frédéric Colland, David Segal, David Huang, Andrew W. Roberts, Ana Leticia Maragno, Guillaume Lessene, Olivier Geneste, Andrew H. Wei

ABSTRACT

Improving outcomes in acute myeloid leukemia (AML) remains a major clinical challenge. Overexpression of pro-survival BCL-2 family members rendering transformed cells resistant to cytotoxic drugs is a common theme in cancer. Targeting BCL-2 with the BH3-mimetic venetoclax is active in AML when combined with low-dose chemotherapy or hypomethylating agents. We now report the pre-clinical anti-leukemic efficacy of a novel BCL-2 inhibitor S55746, which demonstrates synergistic pro-apoptotic activity in combination with the MCL1 inhibitor S63845. Activity of the combination was caspase and BAX/BAK dependent, superior to combination with standard cytotoxic AML drugs and active against a broad spectrum of poor risk genotypes, including primary samples from patients with chemoresistant AML. Co-targeting BCL-2 and MCL1 was more effective against leukemic, compared to normal hematopoietic progenitors, suggesting a therapeutic window of activity. Finally, S55746 combined with S63845 prolonged survival in xenograft models of AML and suppressed patient-derived leukemia but not normal hematopoietic cells in bone marrow of engrafted mice. In conclusion, a dual BH3-mimetic approach is feasible, highly synergistic, and active in diverse models of human AML. This approach has strong clinical potential to rapidly suppress leukemia, with reduced toxicity to normal hematopoietic precursors compared to chemotherapy. More... »

PAGES

1-13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41375-018-0261-3

DOI

http://dx.doi.org/10.1038/s41375-018-0261-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106921216

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30214012


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Australian Centre for Blood Diseases, Monash University, Melbourne, Australia", 
            "Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moujalled", 
        "givenName": "Donia M.", 
        "id": "sg:person.0623561531.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623561531.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Australian Centre for Blood Diseases, Monash University, Melbourne, Australia", 
            "Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pomilio", 
        "givenName": "Giovanna", 
        "id": "sg:person.01005715770.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005715770.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghiurau", 
        "givenName": "Corina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Department of Pathology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ivey", 
        "givenName": "Adam", 
        "id": "sg:person.015536330044.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015536330044.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Australian Centre for Blood Diseases, Monash University, Melbourne, Australia", 
            "Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salmon", 
        "givenName": "Jessica", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Australian Centre for Blood Diseases, Monash University, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rijal", 
        "givenName": "Sewa", 
        "id": "sg:person.0721311205.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721311205.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Department of Pathology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macraild", 
        "givenName": "Sarah", 
        "id": "sg:person.011155465044.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011155465044.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Lan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Australian Centre for Blood Diseases, Monash University, Melbourne, Australia", 
            "Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teh", 
        "givenName": "Tse-Chieh", 
        "id": "sg:person.0776213570.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776213570.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiong", 
        "givenName": "Ing-Soo", 
        "id": "sg:person.01020125456.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020125456.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Walter and Eliza Hall Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lan", 
        "givenName": "Ping", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chanrion", 
        "givenName": "Maia", 
        "id": "sg:person.01033517723.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033517723.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Claperon", 
        "givenName": "Audrey", 
        "id": "sg:person.01114547174.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114547174.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rocchetti", 
        "givenName": "Francesca", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zichi", 
        "givenName": "Adrien", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kraus-Berthier", 
        "givenName": "Laurence", 
        "id": "sg:person.01245237020.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245237020.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, 02139, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Youzhen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, 02139, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halilovic", 
        "givenName": "Ensar", 
        "id": "sg:person.01005736512.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005736512.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, 02139, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morris", 
        "givenName": "Erick", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colland", 
        "givenName": "Fr\u00e9d\u00e9ric", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Walter and Eliza Hall Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Segal", 
        "givenName": "David", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia", 
            "Department of Medical Biology, The University of Melbourne, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "David", 
        "id": "sg:person.014333014447.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014333014447.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia", 
            "Department of Medical Biology, The University of Melbourne, Parkville, Australia", 
            "Department of Clinical Haematology, Royal Melbourne Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "Andrew W.", 
        "id": "sg:person.012323237012.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012323237012.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maragno", 
        "givenName": "Ana Leticia", 
        "id": "sg:person.01232654006.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232654006.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia", 
            "Department of Medical Biology, The University of Melbourne, Parkville, Australia", 
            "Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lessene", 
        "givenName": "Guillaume", 
        "id": "sg:person.01227330307.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227330307.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France", 
            "Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geneste", 
        "givenName": "Olivier", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alfred Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1623.6", 
          "name": [
            "Australian Centre for Blood Diseases, Monash University, Melbourne, Australia", 
            "Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia", 
            "Department of Pathology, The Alfred Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Andrew H.", 
        "id": "sg:person.0737672301.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737672301.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1507471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001798183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-02-556340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003059155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003206661", 
          "https://doi.org/10.1038/nature10738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004573428", 
          "https://doi.org/10.1038/nature02067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004573428", 
          "https://doi.org/10.1038/nature02067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005125454", 
          "https://doi.org/10.1038/leu.2010.158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1513257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010434640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4652(199603)166:3<523::aid-jcp7>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015970322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1516192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016166624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2014.561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017816441", 
          "https://doi.org/10.1038/cddis.2014.561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-02-204818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020924987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.182980.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021005774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021225281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep27696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021594796", 
          "https://doi.org/10.1038/srep27696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.08.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022057947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024300308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-02-629543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027295752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2009.201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028672821", 
          "https://doi.org/10.1038/cdd.2009.201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-05-159145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031020287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.215855.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031353118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.215871.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041018606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature19830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043611991", 
          "https://doi.org/10.1038/nature19830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044728825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.01.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046839929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047783808", 
          "https://doi.org/10.1038/nbt.1549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-07-657114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052282040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-03-013771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052479132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4940-07.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052594199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-08-447441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053001480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-16-0313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053070176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1106114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062451294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aaa4642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062688675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2016-08-733196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064123306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sigtrans.2017.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084538011", 
          "https://doi.org/10.1038/sigtrans.2017.12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2017.243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090917892", 
          "https://doi.org/10.1038/leu.2017.243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-08-784066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092304045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.24744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103259279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.24744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103259279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2016.34.15_suppl.7009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106842458"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "Improving outcomes in acute myeloid leukemia (AML) remains a major clinical challenge. Overexpression of pro-survival BCL-2 family members rendering transformed cells resistant to cytotoxic drugs is a common theme in cancer. Targeting BCL-2 with the BH3-mimetic venetoclax is active in AML when combined with low-dose chemotherapy or hypomethylating agents. We now report the pre-clinical anti-leukemic efficacy of a novel BCL-2 inhibitor S55746, which demonstrates synergistic pro-apoptotic activity in combination with the MCL1 inhibitor S63845. Activity of the combination was caspase and BAX/BAK dependent, superior to combination with standard cytotoxic AML drugs and active against a broad spectrum of poor risk genotypes, including primary samples from patients with chemoresistant AML. Co-targeting BCL-2 and MCL1 was more effective against leukemic, compared to normal hematopoietic progenitors, suggesting a therapeutic window of activity. Finally, S55746 combined with S63845 prolonged survival in xenograft models of AML and suppressed patient-derived leukemia but not normal hematopoietic cells in bone marrow of engrafted mice. In conclusion, a dual BH3-mimetic approach is feasible, highly synergistic, and active in diverse models of human AML. This approach has strong clinical potential to rapidly suppress leukemia, with reduced toxicity to normal hematopoietic precursors compared to chemotherapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41375-018-0261-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "name": "Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia", 
    "pagination": "1-13", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "71dda36610fbca9ab6247595acb7cc1fe28792b357894d5f5ee9549770c90195"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30214012"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41375-018-0261-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106921216"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41375-018-0261-3", 
      "https://app.dimensions.ai/details/publication/pub.1106921216"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130820_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41375-018-0261-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0261-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0261-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0261-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0261-3'


 

This table displays all metadata directly associated to this object as RDF triples.

386 TRIPLES      21 PREDICATES      66 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41375-018-0261-3 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nb35506d07c424bf4964724349bc092d6
4 schema:citation sg:pub.10.1038/cdd.2009.201
5 sg:pub.10.1038/cddis.2014.561
6 sg:pub.10.1038/leu.2010.158
7 sg:pub.10.1038/leu.2017.243
8 sg:pub.10.1038/nature02067
9 sg:pub.10.1038/nature10738
10 sg:pub.10.1038/nature19830
11 sg:pub.10.1038/nbt.1549
12 sg:pub.10.1038/sigtrans.2017.12
13 sg:pub.10.1038/srep27696
14 https://doi.org/10.1002/(sici)1097-4652(199603)166:3<523::aid-jcp7>3.0.co;2-r
15 https://doi.org/10.1002/hep.22664
16 https://doi.org/10.1002/hep.23126
17 https://doi.org/10.1016/j.cell.2007.01.037
18 https://doi.org/10.1016/j.cell.2012.08.038
19 https://doi.org/10.1016/j.stem.2009.04.018
20 https://doi.org/10.1056/nejmoa1507471
21 https://doi.org/10.1056/nejmoa1513257
22 https://doi.org/10.1056/nejmoa1516192
23 https://doi.org/10.1101/gad.182980.111
24 https://doi.org/10.1101/gad.215855.113
25 https://doi.org/10.1101/gad.215871.113
26 https://doi.org/10.1126/science.1106114
27 https://doi.org/10.1126/scitranslmed.aaa4642
28 https://doi.org/10.1158/2159-8290.cd-16-0313
29 https://doi.org/10.1182/blood-2006-03-013771
30 https://doi.org/10.1182/blood-2008-05-159145
31 https://doi.org/10.1182/blood-2009-02-204818
32 https://doi.org/10.1182/blood-2012-08-447441
33 https://doi.org/10.1182/blood-2014-02-556340
34 https://doi.org/10.1182/blood-2015-02-629543
35 https://doi.org/10.1182/blood-2015-07-657114
36 https://doi.org/10.1182/blood-2016-08-733196
37 https://doi.org/10.1182/blood-2017-08-784066
38 https://doi.org/10.1200/jco.2016.34.15_suppl.7009
39 https://doi.org/10.1523/jneurosci.4940-07.2008
40 https://doi.org/10.18632/oncotarget.24744
41 schema:datePublished 2019-04
42 schema:datePublishedReg 2019-04-01
43 schema:description Improving outcomes in acute myeloid leukemia (AML) remains a major clinical challenge. Overexpression of pro-survival BCL-2 family members rendering transformed cells resistant to cytotoxic drugs is a common theme in cancer. Targeting BCL-2 with the BH3-mimetic venetoclax is active in AML when combined with low-dose chemotherapy or hypomethylating agents. We now report the pre-clinical anti-leukemic efficacy of a novel BCL-2 inhibitor S55746, which demonstrates synergistic pro-apoptotic activity in combination with the MCL1 inhibitor S63845. Activity of the combination was caspase and BAX/BAK dependent, superior to combination with standard cytotoxic AML drugs and active against a broad spectrum of poor risk genotypes, including primary samples from patients with chemoresistant AML. Co-targeting BCL-2 and MCL1 was more effective against leukemic, compared to normal hematopoietic progenitors, suggesting a therapeutic window of activity. Finally, S55746 combined with S63845 prolonged survival in xenograft models of AML and suppressed patient-derived leukemia but not normal hematopoietic cells in bone marrow of engrafted mice. In conclusion, a dual BH3-mimetic approach is feasible, highly synergistic, and active in diverse models of human AML. This approach has strong clinical potential to rapidly suppress leukemia, with reduced toxicity to normal hematopoietic precursors compared to chemotherapy.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf N5e3febff086c43f1ad451aace393d7d6
48 Nce3c3b2a194f4321aff5d1236fb3501f
49 sg:journal.1097065
50 schema:name Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia
51 schema:pagination 1-13
52 schema:productId N0a4f4f74f1884ca3916d59aff8293b59
53 N4c08170704164efe95d4c25e68f7f626
54 N507975d111f541b4b344a8d6208b6f65
55 N53f77d2bf145444c962c80dbfc9e4489
56 N877bea7102284106ae0b8e27bb9b00d5
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106921216
58 https://doi.org/10.1038/s41375-018-0261-3
59 schema:sdDatePublished 2019-04-11T13:58
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N44672089b15d4f66ba06d0ca56325f07
62 schema:url https://www.nature.com/articles/s41375-018-0261-3
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N05157c273fc04cd1a5ced017246a9408 rdf:first N849babb33c4c47138f4cdc733650a51b
67 rdf:rest N716c5b6d7509457b8a58e008f47badd5
68 N0980fc883f88471db40613e9c0393ade rdf:first N2b1082001e904ecd82bf20439af0bc15
69 rdf:rest N4b469217beac44b3b6a86f87cd7c28d5
70 N09cc118dfaf54db0adb5e238641c643d rdf:first sg:person.01114547174.67
71 rdf:rest N0980fc883f88471db40613e9c0393ade
72 N0a4f4f74f1884ca3916d59aff8293b59 schema:name readcube_id
73 schema:value 71dda36610fbca9ab6247595acb7cc1fe28792b357894d5f5ee9549770c90195
74 rdf:type schema:PropertyValue
75 N0b61e5600a2a4686bc3f4aa417ab3ce4 rdf:first sg:person.0737672301.33
76 rdf:rest rdf:nil
77 N0bf329dd62724bde97be0a1eabaed53b rdf:first sg:person.0721311205.33
78 rdf:rest N5dcda3d82d4447cfa9a43af3c351e867
79 N11b837d0bffd4b22b4cef39bbda3de4f rdf:first sg:person.01005736512.14
80 rdf:rest N9cb57f342fbb42b1a3e17cd72c9f9c45
81 N1383bc29fe2249138bbb420098c3697a rdf:first N940f4c6ba0f245c08cae31bf9f4d13ab
82 rdf:rest N11b837d0bffd4b22b4cef39bbda3de4f
83 N21efc5720c5b496da2833eb1d6b871fd rdf:first N4854b278690640dcba2deca71bc793d5
84 rdf:rest N9ac3f6a9b45149aea553fad5314cdf57
85 N2b1082001e904ecd82bf20439af0bc15 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
86 schema:familyName Rocchetti
87 schema:givenName Francesca
88 rdf:type schema:Person
89 N3431604204e6442b967d095238e1433e rdf:first sg:person.012323237012.22
90 rdf:rest N34b10184fd7a4103b04060ae8eccd8f3
91 N34b10184fd7a4103b04060ae8eccd8f3 rdf:first sg:person.01232654006.56
92 rdf:rest Ndda7a0d4c43f4f8db4b9f781e538ddad
93 N3773f4b8245a4977a622396be02fa73e rdf:first Nd40c993f637140cc889303360108ed5d
94 rdf:rest N21efc5720c5b496da2833eb1d6b871fd
95 N44672089b15d4f66ba06d0ca56325f07 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N4854b278690640dcba2deca71bc793d5 schema:affiliation https://www.grid.ac/institutes/grid.1042.7
98 schema:familyName Segal
99 schema:givenName David
100 rdf:type schema:Person
101 N4b469217beac44b3b6a86f87cd7c28d5 rdf:first Nc622624a70264bb6abe503a217b3ac52
102 rdf:rest N503a9d0fa657402d9f523525bae621ce
103 N4c08170704164efe95d4c25e68f7f626 schema:name pubmed_id
104 schema:value 30214012
105 rdf:type schema:PropertyValue
106 N503a9d0fa657402d9f523525bae621ce rdf:first sg:person.01245237020.47
107 rdf:rest N1383bc29fe2249138bbb420098c3697a
108 N507975d111f541b4b344a8d6208b6f65 schema:name doi
109 schema:value 10.1038/s41375-018-0261-3
110 rdf:type schema:PropertyValue
111 N53f77d2bf145444c962c80dbfc9e4489 schema:name nlm_unique_id
112 schema:value 8704895
113 rdf:type schema:PropertyValue
114 N5dcda3d82d4447cfa9a43af3c351e867 rdf:first sg:person.011155465044.90
115 rdf:rest Nb4b287a20c73456bb31840bf7a4040d0
116 N5e3febff086c43f1ad451aace393d7d6 schema:volumeNumber 33
117 rdf:type schema:PublicationVolume
118 N6eb8a9849e3b4f65ad6cc87121a43811 schema:affiliation https://www.grid.ac/institutes/grid.1042.7
119 schema:familyName Lan
120 schema:givenName Ping
121 rdf:type schema:Person
122 N716c5b6d7509457b8a58e008f47badd5 rdf:first sg:person.015536330044.45
123 rdf:rest N82a8868fcbdc442e847f0caa38aab903
124 N7eaa5f917f5242cabb2efed589ee5182 rdf:first sg:person.01005715770.30
125 rdf:rest N05157c273fc04cd1a5ced017246a9408
126 N82a8868fcbdc442e847f0caa38aab903 rdf:first Nb56947187bf54bfa83f530f3d92a611c
127 rdf:rest N0bf329dd62724bde97be0a1eabaed53b
128 N849babb33c4c47138f4cdc733650a51b schema:affiliation https://www.grid.ac/institutes/grid.419481.1
129 schema:familyName Ghiurau
130 schema:givenName Corina
131 rdf:type schema:Person
132 N877bea7102284106ae0b8e27bb9b00d5 schema:name dimensions_id
133 schema:value pub.1106921216
134 rdf:type schema:PropertyValue
135 N940f4c6ba0f245c08cae31bf9f4d13ab schema:affiliation https://www.grid.ac/institutes/grid.418424.f
136 schema:familyName Wang
137 schema:givenName Youzhen
138 rdf:type schema:Person
139 N9ac3f6a9b45149aea553fad5314cdf57 rdf:first sg:person.014333014447.42
140 rdf:rest N3431604204e6442b967d095238e1433e
141 N9cb57f342fbb42b1a3e17cd72c9f9c45 rdf:first Nf3a1b8569c334ee1bc141b1346ac8ebc
142 rdf:rest N3773f4b8245a4977a622396be02fa73e
143 Na1a4b13956d547c290748ac64d472204 rdf:first sg:person.0776213570.28
144 rdf:rest Nabffa569016e49d6a5567cf4da0e8dfe
145 Na5bb7e9640d84ebe84c1472484717791 rdf:first N6eb8a9849e3b4f65ad6cc87121a43811
146 rdf:rest Nc26fd382110a4ad89ef7a0aec606b01d
147 Naba64ca35a9c49758b54203e8e01ed9c rdf:first Nb14575fc339741de8b0d69f8f35f3779
148 rdf:rest N0b61e5600a2a4686bc3f4aa417ab3ce4
149 Nabffa569016e49d6a5567cf4da0e8dfe rdf:first sg:person.01020125456.22
150 rdf:rest Na5bb7e9640d84ebe84c1472484717791
151 Nb14575fc339741de8b0d69f8f35f3779 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
152 schema:familyName Geneste
153 schema:givenName Olivier
154 rdf:type schema:Person
155 Nb35506d07c424bf4964724349bc092d6 rdf:first sg:person.0623561531.27
156 rdf:rest N7eaa5f917f5242cabb2efed589ee5182
157 Nb4b287a20c73456bb31840bf7a4040d0 rdf:first Nd54a20bf21f9464a95364bb0be7596f1
158 rdf:rest Na1a4b13956d547c290748ac64d472204
159 Nb56947187bf54bfa83f530f3d92a611c schema:affiliation https://www.grid.ac/institutes/grid.1623.6
160 schema:familyName Salmon
161 schema:givenName Jessica
162 rdf:type schema:Person
163 Nc26fd382110a4ad89ef7a0aec606b01d rdf:first sg:person.01033517723.51
164 rdf:rest N09cc118dfaf54db0adb5e238641c643d
165 Nc622624a70264bb6abe503a217b3ac52 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
166 schema:familyName Zichi
167 schema:givenName Adrien
168 rdf:type schema:Person
169 Nce3c3b2a194f4321aff5d1236fb3501f schema:issueNumber 4
170 rdf:type schema:PublicationIssue
171 Nd40c993f637140cc889303360108ed5d schema:affiliation https://www.grid.ac/institutes/grid.419481.1
172 schema:familyName Colland
173 schema:givenName Frédéric
174 rdf:type schema:Person
175 Nd54a20bf21f9464a95364bb0be7596f1 schema:affiliation https://www.grid.ac/institutes/grid.1623.6
176 schema:familyName Zhang
177 schema:givenName Lan
178 rdf:type schema:Person
179 Ndda7a0d4c43f4f8db4b9f781e538ddad rdf:first sg:person.01227330307.11
180 rdf:rest Naba64ca35a9c49758b54203e8e01ed9c
181 Nf3a1b8569c334ee1bc141b1346ac8ebc schema:affiliation https://www.grid.ac/institutes/grid.418424.f
182 schema:familyName Morris
183 schema:givenName Erick
184 rdf:type schema:Person
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
189 schema:name Oncology and Carcinogenesis
190 rdf:type schema:DefinedTerm
191 sg:journal.1097065 schema:issn 0887-6924
192 1476-5551
193 schema:name Leukemia
194 rdf:type schema:Periodical
195 sg:person.01005715770.30 schema:affiliation https://www.grid.ac/institutes/grid.1623.6
196 schema:familyName Pomilio
197 schema:givenName Giovanna
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005715770.30
199 rdf:type schema:Person
200 sg:person.01005736512.14 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
201 schema:familyName Halilovic
202 schema:givenName Ensar
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005736512.14
204 rdf:type schema:Person
205 sg:person.01020125456.22 schema:affiliation https://www.grid.ac/institutes/grid.1623.6
206 schema:familyName Tiong
207 schema:givenName Ing-Soo
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020125456.22
209 rdf:type schema:Person
210 sg:person.01033517723.51 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
211 schema:familyName Chanrion
212 schema:givenName Maia
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033517723.51
214 rdf:type schema:Person
215 sg:person.01114547174.67 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
216 schema:familyName Claperon
217 schema:givenName Audrey
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114547174.67
219 rdf:type schema:Person
220 sg:person.011155465044.90 schema:affiliation https://www.grid.ac/institutes/grid.1623.6
221 schema:familyName Macraild
222 schema:givenName Sarah
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011155465044.90
224 rdf:type schema:Person
225 sg:person.01227330307.11 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
226 schema:familyName Lessene
227 schema:givenName Guillaume
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227330307.11
229 rdf:type schema:Person
230 sg:person.012323237012.22 schema:affiliation https://www.grid.ac/institutes/grid.416153.4
231 schema:familyName Roberts
232 schema:givenName Andrew W.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012323237012.22
234 rdf:type schema:Person
235 sg:person.01232654006.56 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
236 schema:familyName Maragno
237 schema:givenName Ana Leticia
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232654006.56
239 rdf:type schema:Person
240 sg:person.01245237020.47 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
241 schema:familyName Kraus-Berthier
242 schema:givenName Laurence
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245237020.47
244 rdf:type schema:Person
245 sg:person.014333014447.42 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
246 schema:familyName Huang
247 schema:givenName David
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014333014447.42
249 rdf:type schema:Person
250 sg:person.015536330044.45 schema:affiliation https://www.grid.ac/institutes/grid.1623.6
251 schema:familyName Ivey
252 schema:givenName Adam
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015536330044.45
254 rdf:type schema:Person
255 sg:person.0623561531.27 schema:affiliation https://www.grid.ac/institutes/grid.1623.6
256 schema:familyName Moujalled
257 schema:givenName Donia M.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623561531.27
259 rdf:type schema:Person
260 sg:person.0721311205.33 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
261 schema:familyName Rijal
262 schema:givenName Sewa
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721311205.33
264 rdf:type schema:Person
265 sg:person.0737672301.33 schema:affiliation https://www.grid.ac/institutes/grid.1623.6
266 schema:familyName Wei
267 schema:givenName Andrew H.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737672301.33
269 rdf:type schema:Person
270 sg:person.0776213570.28 schema:affiliation https://www.grid.ac/institutes/grid.1623.6
271 schema:familyName Teh
272 schema:givenName Tse-Chieh
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776213570.28
274 rdf:type schema:Person
275 sg:pub.10.1038/cdd.2009.201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028672821
276 https://doi.org/10.1038/cdd.2009.201
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/cddis.2014.561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017816441
279 https://doi.org/10.1038/cddis.2014.561
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/leu.2010.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005125454
282 https://doi.org/10.1038/leu.2010.158
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/leu.2017.243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090917892
285 https://doi.org/10.1038/leu.2017.243
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nature02067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004573428
288 https://doi.org/10.1038/nature02067
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nature10738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003206661
291 https://doi.org/10.1038/nature10738
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nature19830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043611991
294 https://doi.org/10.1038/nature19830
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nbt.1549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047783808
297 https://doi.org/10.1038/nbt.1549
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/sigtrans.2017.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084538011
300 https://doi.org/10.1038/sigtrans.2017.12
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/srep27696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021594796
303 https://doi.org/10.1038/srep27696
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/(sici)1097-4652(199603)166:3<523::aid-jcp7>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1015970322
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/hep.22664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044728825
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/hep.23126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024300308
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.cell.2007.01.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046839929
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.cell.2012.08.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022057947
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.stem.2009.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021225281
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1056/nejmoa1507471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001798183
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1056/nejmoa1513257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010434640
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1056/nejmoa1516192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016166624
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1101/gad.182980.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021005774
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1101/gad.215855.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031353118
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1101/gad.215871.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041018606
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.1106114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062451294
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1126/scitranslmed.aaa4642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062688675
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/2159-8290.cd-16-0313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053070176
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1182/blood-2006-03-013771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052479132
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1182/blood-2008-05-159145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031020287
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1182/blood-2009-02-204818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020924987
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1182/blood-2012-08-447441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053001480
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1182/blood-2014-02-556340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003059155
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1182/blood-2015-02-629543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027295752
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1182/blood-2015-07-657114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052282040
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1182/blood-2016-08-733196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123306
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1182/blood-2017-08-784066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092304045
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1200/jco.2016.34.15_suppl.7009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106842458
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1523/jneurosci.4940-07.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052594199
356 rdf:type schema:CreativeWork
357 https://doi.org/10.18632/oncotarget.24744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103259279
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
360 schema:name Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
361 rdf:type schema:Organization
362 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
363 schema:name Department of Medical Biology, The University of Melbourne, Parkville, Australia
364 Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Australia
365 The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.1042.7 schema:alternateName Walter and Eliza Hall Institute of Medical Research
368 schema:name The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.1623.6 schema:alternateName Alfred Hospital
371 schema:name Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
372 Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia
373 Department of Pathology, The Alfred Hospital, Melbourne, Australia
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.416153.4 schema:alternateName Royal Melbourne Hospital
376 schema:name Department of Clinical Haematology, Royal Melbourne Hospital, Melbourne, Australia
377 Department of Medical Biology, The University of Melbourne, Parkville, Australia
378 The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.418424.f schema:alternateName Novartis (United States)
381 schema:name Oncology Disease Area, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, 02139, Cambridge, MA, USA
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.419481.1 schema:alternateName Novartis (Switzerland)
384 schema:name Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland
385 R&D Unit, Institut de Recherches Servier Oncology, Croissy Sur Seine, France
386 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...