The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Nicolas Duployez, Alice Marceau-Renaut, Céline Villenet, Arnaud Petit, Alexandra Rousseau, Stanley W. K. Ng, Agnès Paquet, Fanny Gonzales, Adeline Barthélémy, Frédéric Leprêtre, Nicolas Pottier, Brigitte Nelken, Gérard Michel, André Baruchel, Yves Bertrand, Guy Leverger, Hélène Lapillonne, Martin Figeac, John E. Dick, Jean C. Y. Wang, Claude Preudhomme, Meyling Cheok

ABSTRACT

Despite constant progress in prognostic risk stratification, children with acute myeloid leukemia (AML) still relapse. Treatment failure and subsequent relapse have been attributed to acute myeloid leukemia-initiating cells (LSC), which harbor stem cell properties and are inherently chemoresistant. Although pediatric and adult AML represent two genetically very distinct diseases, we reasoned that common LSC gene expression programs are shared and consequently, the highly prognostic LSC17 signature score recently developed in adults may also be of clinical interest in childhood AML. Here, we demonstrated prognostic relevance of the LSC17 score in pediatric non-core-binding factor AML using Nanostring technology (ELAM02) and RNA-seq data from the NCI (TARGET-AML). AML were stratified by LSC17 quartile groups (lowest 25%, intermediate 50% and highest 25%) and children with low LSC17 score had significantly better event-free survival (EFS: HR = 3.35 (95%CI = 1.64-6.82), P < 0.001) and overall survival (OS: HR = 3.51 (95%CI = 1.38-8.92), P = 0.008) compared with patients with high LSC17 scores. More importantly, the high LSC17 score was an independent negative EFS and OS prognosticator determined by multivariate Cox model analysis (EFS: HR = 3.42 (95% CI = 1.63-7.16), P = 0.001; OS HR = 3.02 (95%CI = 1.16-7.85), P = 0.026). In conclusion, we have demonstrated the broad applicability of the LSC17 score in the clinical management of AML by extending its prognostic relevance to pediatric AML. More... »

PAGES

348-357

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41375-018-0227-5

DOI

http://dx.doi.org/10.1038/s41375-018-0227-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106053935

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30089916


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional et Universitaire de Lille", 
          "id": "https://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "Laboratory of Hematology, CHU Lille, Lille, France", 
            "UMR-S 1172, JPArc - Jean-Pierre AUBERT Research Center Neurosciences et Cancer, Univ. Lille, Inserm, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duployez", 
        "givenName": "Nicolas", 
        "id": "sg:person.01242241155.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242241155.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional et Universitaire de Lille", 
          "id": "https://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "Laboratory of Hematology, CHU Lille, Lille, France", 
            "UMR-S 1172, JPArc - Jean-Pierre AUBERT Research Center Neurosciences et Cancer, Univ. Lille, Inserm, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marceau-Renaut", 
        "givenName": "Alice", 
        "id": "sg:person.0606204446.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606204446.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Functional Genomics Platform, Univ. Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Villenet", 
        "givenName": "C\u00e9line", 
        "id": "sg:person.01120164565.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120164565.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique -Hopitaux De Paris", 
          "id": "https://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "Department of Pediatric Hematology and Oncology, APHP, Trousseau Hospital, GH HUEP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petit", 
        "givenName": "Arnaud", 
        "id": "sg:person.01045663263.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045663263.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Antoine", 
          "id": "https://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Department of Clinical Pharmacology and Clinical Research Unit of East of Paris, APHP, Saint Antoine Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rousseau", 
        "givenName": "Alexandra", 
        "id": "sg:person.0620475257.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620475257.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Stanley W. K.", 
        "id": "sg:person.0705736323.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705736323.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de Pharmacologie Mol\u00e9culaire et Cellulaire", 
          "id": "https://www.grid.ac/institutes/grid.429194.3", 
          "name": [
            "IPMC, Universit\u00e9 C\u00f4te d\u2019Azur, CNRS, Valbonne, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paquet", 
        "givenName": "Agn\u00e8s", 
        "id": "sg:person.01106467255.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106467255.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional et Universitaire de Lille", 
          "id": "https://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "UMR-S 1172, JPArc - Jean-Pierre AUBERT Research Center Neurosciences et Cancer, Univ. Lille, Inserm, CHU Lille, Lille, France", 
            "Department of Pediatric Hematology-Oncology, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzales", 
        "givenName": "Fanny", 
        "id": "sg:person.07723251035.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07723251035.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional et Universitaire de Lille", 
          "id": "https://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "UMR-S 1172, JPArc - Jean-Pierre AUBERT Research Center Neurosciences et Cancer, Univ. Lille, Inserm, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barth\u00e9l\u00e9my", 
        "givenName": "Adeline", 
        "id": "sg:person.0730045254.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730045254.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Functional Genomics Platform, Univ. Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lepr\u00eatre", 
        "givenName": "Fr\u00e9d\u00e9ric", 
        "id": "sg:person.01052456462.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052456462.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional et Universitaire de Lille", 
          "id": "https://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "Department of Biochemistry, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pottier", 
        "givenName": "Nicolas", 
        "id": "sg:person.0604734252.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604734252.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional et Universitaire de Lille", 
          "id": "https://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "Department of Pediatric Hematology-Oncology, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nelken", 
        "givenName": "Brigitte", 
        "id": "sg:person.01145236614.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145236614.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Timone", 
          "id": "https://www.grid.ac/institutes/grid.411266.6", 
          "name": [
            "Department of Pediatric Hematology, CHU Marseille, La Timone, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michel", 
        "givenName": "G\u00e9rard", 
        "id": "sg:person.013625162602.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013625162602.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Robert Debr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.413235.2", 
          "name": [
            "Department of Pediatric Hematology and Immunology, APHP, Robert Debr\u00e9 University Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baruchel", 
        "givenName": "Andr\u00e9", 
        "id": "sg:person.0763374301.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763374301.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Claude Bernard University Lyon 1", 
          "id": "https://www.grid.ac/institutes/grid.7849.2", 
          "name": [
            "Institute of Hematology and Oncology Pediatrics, Hospices Civils, Claude Bernard University, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bertrand", 
        "givenName": "Yves", 
        "id": "sg:person.01077622701.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077622701.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Functional Genomics Platform, Univ. Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leverger", 
        "givenName": "Guy", 
        "id": "sg:person.0715261101.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715261101.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique -Hopitaux De Paris", 
          "id": "https://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "Laboratory of Hematology, APHP, Trousseau Hospital, GH HUEP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lapillonne", 
        "givenName": "H\u00e9l\u00e8ne", 
        "id": "sg:person.01276270024.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276270024.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Functional Genomics Platform, Univ. Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Figeac", 
        "givenName": "Martin", 
        "id": "sg:person.01225257524.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225257524.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Molecular Genetics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dick", 
        "givenName": "John E.", 
        "id": "sg:person.016114074342.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016114074342.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Molecular Genetics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Jean C. Y.", 
        "id": "sg:person.01011127175.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011127175.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional et Universitaire de Lille", 
          "id": "https://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "Laboratory of Hematology, CHU Lille, Lille, France", 
            "UMR-S 1172, JPArc - Jean-Pierre AUBERT Research Center Neurosciences et Cancer, Univ. Lille, Inserm, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Preudhomme", 
        "givenName": "Claude", 
        "id": "sg:person.0666023003.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666023003.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional et Universitaire de Lille", 
          "id": "https://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "UMR-S 1172, JPArc - Jean-Pierre AUBERT Research Center Neurosciences et Cancer, Univ. Lille, Inserm, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheok", 
        "givenName": "Meyling", 
        "id": "sg:person.01066000201.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066000201.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2014.55.3628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002290526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2008.313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005174024", 
          "https://doi.org/10.1038/leu.2008.313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature20598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009071237", 
          "https://doi.org/10.1038/nature20598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011762576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08880018.2010.528171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015965240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1516192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016166624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.62.8289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016756167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60485-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017304024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017355266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0797-730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022333282", 
          "https://doi.org/10.1038/nm0797-730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2014.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025977869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.16.7981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027470640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.1862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031418278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.1862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031418278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-04-215152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032295211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-04-215152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032295211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-04-084293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033371630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.24.8997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037053034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-03-362608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039542302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2014-15-2-r29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045312009", 
          "https://doi.org/10.1186/gb-2014-15-2-r29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-03-083048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052000460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053038796", 
          "https://doi.org/10.1038/nature10762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-016-2775-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053736574", 
          "https://doi.org/10.1007/s11010-016-2775-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-016-2775-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053736574", 
          "https://doi.org/10.1007/s11010-016-2775-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-12-688705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064122917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-12-689356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064122926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2016-08-733196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064123306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.14991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092404073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099637780", 
          "https://doi.org/10.1038/nm.4439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099637780", 
          "https://doi.org/10.1038/nm.4439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-09-801498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100381779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-09-801498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100381779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-09-801498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100381779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-09-801498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100381779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-09-801498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100381779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hs9.0000000000000031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101151404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hs9.0000000000000031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101151404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hs9.0000000000000031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101151404"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Despite constant progress in prognostic risk stratification, children with acute myeloid leukemia (AML) still relapse. Treatment failure and subsequent relapse have been attributed to acute myeloid leukemia-initiating cells (LSC), which harbor stem cell properties and are inherently chemoresistant. Although pediatric and adult AML represent two genetically very distinct diseases, we reasoned that common LSC gene expression programs are shared and consequently, the highly prognostic LSC17 signature score recently developed in adults may also be of clinical interest in childhood AML. Here, we demonstrated prognostic relevance of the LSC17 score in pediatric non-core-binding factor AML using Nanostring technology (ELAM02) and RNA-seq data from the NCI (TARGET-AML). AML were stratified by LSC17 quartile groups (lowest 25%, intermediate 50% and highest 25%) and children with low LSC17 score had significantly better event-free survival (EFS: HR\u2009=\u20093.35 (95%CI\u2009=\u20091.64-6.82), P\u2009<\u20090.001) and overall survival (OS: HR\u2009=\u20093.51 (95%CI\u2009=\u20091.38-8.92), P\u2009=\u20090.008) compared with patients with high LSC17 scores. More importantly, the high LSC17 score was an independent negative EFS and OS prognosticator determined by multivariate Cox model analysis (EFS: HR\u2009=\u20093.42 (95% CI\u2009=\u20091.63-7.16), P\u2009=\u20090.001; OS HR\u2009=\u20093.02 (95%CI\u2009=\u20091.16-7.85), P\u2009=\u20090.026). In conclusion, we have demonstrated the broad applicability of the LSC17 score in the clinical management of AML by extending its prognostic relevance to pediatric AML.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41375-018-0227-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "name": "The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia", 
    "pagination": "348-357", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "26418de0ab5712ee081e35691918b6a4cce8760a67bce0b3ec775da21a3511ac"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30089916"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41375-018-0227-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106053935"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41375-018-0227-5", 
      "https://app.dimensions.ai/details/publication/pub.1106053935"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29219_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41375-018-0227-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0227-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0227-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0227-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0227-5'


 

This table displays all metadata directly associated to this object as RDF triples.

341 TRIPLES      21 PREDICATES      57 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41375-018-0227-5 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N2d979a666caf47318ff9bfb7e0fb2399
4 schema:citation sg:pub.10.1007/s11010-016-2775-1
5 sg:pub.10.1038/leu.2008.313
6 sg:pub.10.1038/nature10762
7 sg:pub.10.1038/nature20598
8 sg:pub.10.1038/nm.4439
9 sg:pub.10.1038/nm0797-730
10 sg:pub.10.1186/gb-2014-15-2-r29
11 https://doi.org/10.1001/jama.2010.1862
12 https://doi.org/10.1002/cncr.26190
13 https://doi.org/10.1016/j.stem.2014.02.006
14 https://doi.org/10.1016/s0140-6736(12)60485-1
15 https://doi.org/10.1056/nejmoa1516192
16 https://doi.org/10.1097/hs9.0000000000000031
17 https://doi.org/10.1111/bjh.14991
18 https://doi.org/10.1182/blood-2007-03-083048
19 https://doi.org/10.1182/blood-2007-04-084293
20 https://doi.org/10.1182/blood-2009-04-215152
21 https://doi.org/10.1182/blood-2012-03-362608
22 https://doi.org/10.1182/blood-2015-12-688705
23 https://doi.org/10.1182/blood-2015-12-689356
24 https://doi.org/10.1182/blood-2016-08-733196
25 https://doi.org/10.1182/blood-2017-09-801498
26 https://doi.org/10.1200/jco.2008.16.7981
27 https://doi.org/10.1200/jco.2009.24.8997
28 https://doi.org/10.1200/jco.2014.55.3628
29 https://doi.org/10.1200/jco.2015.62.8289
30 https://doi.org/10.3109/08880018.2010.528171
31 https://doi.org/10.3322/caac.21219
32 schema:datePublished 2019-02
33 schema:datePublishedReg 2019-02-01
34 schema:description Despite constant progress in prognostic risk stratification, children with acute myeloid leukemia (AML) still relapse. Treatment failure and subsequent relapse have been attributed to acute myeloid leukemia-initiating cells (LSC), which harbor stem cell properties and are inherently chemoresistant. Although pediatric and adult AML represent two genetically very distinct diseases, we reasoned that common LSC gene expression programs are shared and consequently, the highly prognostic LSC17 signature score recently developed in adults may also be of clinical interest in childhood AML. Here, we demonstrated prognostic relevance of the LSC17 score in pediatric non-core-binding factor AML using Nanostring technology (ELAM02) and RNA-seq data from the NCI (TARGET-AML). AML were stratified by LSC17 quartile groups (lowest 25%, intermediate 50% and highest 25%) and children with low LSC17 score had significantly better event-free survival (EFS: HR = 3.35 (95%CI = 1.64-6.82), P < 0.001) and overall survival (OS: HR = 3.51 (95%CI = 1.38-8.92), P = 0.008) compared with patients with high LSC17 scores. More importantly, the high LSC17 score was an independent negative EFS and OS prognosticator determined by multivariate Cox model analysis (EFS: HR = 3.42 (95% CI = 1.63-7.16), P = 0.001; OS HR = 3.02 (95%CI = 1.16-7.85), P = 0.026). In conclusion, we have demonstrated the broad applicability of the LSC17 score in the clinical management of AML by extending its prognostic relevance to pediatric AML.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf N30134cb0368b4a999f015243fbefffec
39 N42eed07a1c13409f882d6d4aa09057b1
40 sg:journal.1097065
41 schema:name The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia
42 schema:pagination 348-357
43 schema:productId N15f5db6ce3b448ac88db950ffd666437
44 N66837133eb8044f1b4ae373e88ef7618
45 N76fdcabaad884922a554cbfdde23d07b
46 Na4cdf0eabdb741d2a7e3ea8ab3bbdf45
47 Nf5a8876a2ffa48a485deb34769487e28
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106053935
49 https://doi.org/10.1038/s41375-018-0227-5
50 schema:sdDatePublished 2019-04-11T11:57
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher Nf5dd94dec0354d55b31b85b114bf0e28
53 schema:url https://www.nature.com/articles/s41375-018-0227-5
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N05bc278b24424000a3b33f772d78772a rdf:first sg:person.013625162602.73
58 rdf:rest N6fd61033b86d400bacf8ed9445dd5cb8
59 N0c5774098af2456f9e59ae8c8a906eb5 rdf:first sg:person.01106467255.59
60 rdf:rest N72389ccc19fd485d8966f99b6a8c9bb5
61 N11b5c8f7dc1947bb978aa724f0a8fb36 rdf:first sg:person.01120164565.16
62 rdf:rest N8053027859c843c5b218c0767cd94ce9
63 N15f5db6ce3b448ac88db950ffd666437 schema:name dimensions_id
64 schema:value pub.1106053935
65 rdf:type schema:PropertyValue
66 N1fe4c792bd6e405eb773e70a60e1c6d8 rdf:first sg:person.0715261101.35
67 rdf:rest N38327c70e95f47c681a656000024cd92
68 N22ed3d4da4674d828c32e7365406c5a6 rdf:first sg:person.01066000201.31
69 rdf:rest rdf:nil
70 N2350b1c792564b2c8e8fb289b6fd8590 schema:name Functional Genomics Platform, Univ. Lille, Lille, France
71 rdf:type schema:Organization
72 N2d979a666caf47318ff9bfb7e0fb2399 rdf:first sg:person.01242241155.26
73 rdf:rest Ne5dfb6a94fd14b81a860594ba9088cfb
74 N30134cb0368b4a999f015243fbefffec schema:issueNumber 2
75 rdf:type schema:PublicationIssue
76 N38327c70e95f47c681a656000024cd92 rdf:first sg:person.01276270024.87
77 rdf:rest N5437ab118c9a479888ff374b99a945f2
78 N39754c17c5f64d7587b508554db6e6b8 schema:name Functional Genomics Platform, Univ. Lille, Lille, France
79 rdf:type schema:Organization
80 N42eed07a1c13409f882d6d4aa09057b1 schema:volumeNumber 33
81 rdf:type schema:PublicationVolume
82 N5437ab118c9a479888ff374b99a945f2 rdf:first sg:person.01225257524.48
83 rdf:rest N958737fc88134f938b71cc22f7ca2bb7
84 N54eb13933d1d49d6996435107e8b15b5 schema:name Functional Genomics Platform, Univ. Lille, Lille, France
85 rdf:type schema:Organization
86 N66837133eb8044f1b4ae373e88ef7618 schema:name doi
87 schema:value 10.1038/s41375-018-0227-5
88 rdf:type schema:PropertyValue
89 N6fd61033b86d400bacf8ed9445dd5cb8 rdf:first sg:person.0763374301.68
90 rdf:rest N786ddda2f1564a2f988cefc8dcbeca93
91 N72389ccc19fd485d8966f99b6a8c9bb5 rdf:first sg:person.07723251035.21
92 rdf:rest N764fb593bde041bab9513b4282550edc
93 N764fb593bde041bab9513b4282550edc rdf:first sg:person.0730045254.74
94 rdf:rest Ne2670ac877964a35ab0f0efc734e2f0d
95 N76fdcabaad884922a554cbfdde23d07b schema:name readcube_id
96 schema:value 26418de0ab5712ee081e35691918b6a4cce8760a67bce0b3ec775da21a3511ac
97 rdf:type schema:PropertyValue
98 N786ddda2f1564a2f988cefc8dcbeca93 rdf:first sg:person.01077622701.25
99 rdf:rest N1fe4c792bd6e405eb773e70a60e1c6d8
100 N8053027859c843c5b218c0767cd94ce9 rdf:first sg:person.01045663263.39
101 rdf:rest Ndd117996d807486bb2667d8681888e2e
102 N845a948d8530435aa570042b0c64bb2b rdf:first sg:person.0604734252.48
103 rdf:rest N96244278234a4b0d994153e7be1ce1a0
104 N958737fc88134f938b71cc22f7ca2bb7 rdf:first sg:person.016114074342.05
105 rdf:rest Nc1fe3666100a4610b81d07936691e3d7
106 N96244278234a4b0d994153e7be1ce1a0 rdf:first sg:person.01145236614.09
107 rdf:rest N05bc278b24424000a3b33f772d78772a
108 Na4cdf0eabdb741d2a7e3ea8ab3bbdf45 schema:name nlm_unique_id
109 schema:value 8704895
110 rdf:type schema:PropertyValue
111 Nbc6eef2715b343c48d3087ac694fb0c9 rdf:first sg:person.0705736323.18
112 rdf:rest N0c5774098af2456f9e59ae8c8a906eb5
113 Nc1fe3666100a4610b81d07936691e3d7 rdf:first sg:person.01011127175.66
114 rdf:rest Nd20424969390406db191b8945bc8735f
115 Nd20424969390406db191b8945bc8735f rdf:first sg:person.0666023003.82
116 rdf:rest N22ed3d4da4674d828c32e7365406c5a6
117 Nda3744ded84b45aa92ebd41e2d3249e1 schema:name Functional Genomics Platform, Univ. Lille, Lille, France
118 rdf:type schema:Organization
119 Ndd117996d807486bb2667d8681888e2e rdf:first sg:person.0620475257.71
120 rdf:rest Nbc6eef2715b343c48d3087ac694fb0c9
121 Ne2670ac877964a35ab0f0efc734e2f0d rdf:first sg:person.01052456462.91
122 rdf:rest N845a948d8530435aa570042b0c64bb2b
123 Ne5dfb6a94fd14b81a860594ba9088cfb rdf:first sg:person.0606204446.67
124 rdf:rest N11b5c8f7dc1947bb978aa724f0a8fb36
125 Nf5a8876a2ffa48a485deb34769487e28 schema:name pubmed_id
126 schema:value 30089916
127 rdf:type schema:PropertyValue
128 Nf5dd94dec0354d55b31b85b114bf0e28 schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
131 schema:name Medical and Health Sciences
132 rdf:type schema:DefinedTerm
133 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
134 schema:name Oncology and Carcinogenesis
135 rdf:type schema:DefinedTerm
136 sg:journal.1097065 schema:issn 0887-6924
137 1476-5551
138 schema:name Leukemia
139 rdf:type schema:Periodical
140 sg:person.01011127175.66 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
141 schema:familyName Wang
142 schema:givenName Jean C. Y.
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011127175.66
144 rdf:type schema:Person
145 sg:person.01045663263.39 schema:affiliation https://www.grid.ac/institutes/grid.50550.35
146 schema:familyName Petit
147 schema:givenName Arnaud
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045663263.39
149 rdf:type schema:Person
150 sg:person.01052456462.91 schema:affiliation Nda3744ded84b45aa92ebd41e2d3249e1
151 schema:familyName Leprêtre
152 schema:givenName Frédéric
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052456462.91
154 rdf:type schema:Person
155 sg:person.01066000201.31 schema:affiliation https://www.grid.ac/institutes/grid.410463.4
156 schema:familyName Cheok
157 schema:givenName Meyling
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066000201.31
159 rdf:type schema:Person
160 sg:person.01077622701.25 schema:affiliation https://www.grid.ac/institutes/grid.7849.2
161 schema:familyName Bertrand
162 schema:givenName Yves
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077622701.25
164 rdf:type schema:Person
165 sg:person.01106467255.59 schema:affiliation https://www.grid.ac/institutes/grid.429194.3
166 schema:familyName Paquet
167 schema:givenName Agnès
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106467255.59
169 rdf:type schema:Person
170 sg:person.01120164565.16 schema:affiliation N54eb13933d1d49d6996435107e8b15b5
171 schema:familyName Villenet
172 schema:givenName Céline
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120164565.16
174 rdf:type schema:Person
175 sg:person.01145236614.09 schema:affiliation https://www.grid.ac/institutes/grid.410463.4
176 schema:familyName Nelken
177 schema:givenName Brigitte
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145236614.09
179 rdf:type schema:Person
180 sg:person.01225257524.48 schema:affiliation N39754c17c5f64d7587b508554db6e6b8
181 schema:familyName Figeac
182 schema:givenName Martin
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225257524.48
184 rdf:type schema:Person
185 sg:person.01242241155.26 schema:affiliation https://www.grid.ac/institutes/grid.410463.4
186 schema:familyName Duployez
187 schema:givenName Nicolas
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242241155.26
189 rdf:type schema:Person
190 sg:person.01276270024.87 schema:affiliation https://www.grid.ac/institutes/grid.50550.35
191 schema:familyName Lapillonne
192 schema:givenName Hélène
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276270024.87
194 rdf:type schema:Person
195 sg:person.013625162602.73 schema:affiliation https://www.grid.ac/institutes/grid.411266.6
196 schema:familyName Michel
197 schema:givenName Gérard
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013625162602.73
199 rdf:type schema:Person
200 sg:person.016114074342.05 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
201 schema:familyName Dick
202 schema:givenName John E.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016114074342.05
204 rdf:type schema:Person
205 sg:person.0604734252.48 schema:affiliation https://www.grid.ac/institutes/grid.410463.4
206 schema:familyName Pottier
207 schema:givenName Nicolas
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604734252.48
209 rdf:type schema:Person
210 sg:person.0606204446.67 schema:affiliation https://www.grid.ac/institutes/grid.410463.4
211 schema:familyName Marceau-Renaut
212 schema:givenName Alice
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606204446.67
214 rdf:type schema:Person
215 sg:person.0620475257.71 schema:affiliation https://www.grid.ac/institutes/grid.412370.3
216 schema:familyName Rousseau
217 schema:givenName Alexandra
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620475257.71
219 rdf:type schema:Person
220 sg:person.0666023003.82 schema:affiliation https://www.grid.ac/institutes/grid.410463.4
221 schema:familyName Preudhomme
222 schema:givenName Claude
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666023003.82
224 rdf:type schema:Person
225 sg:person.0705736323.18 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
226 schema:familyName Ng
227 schema:givenName Stanley W. K.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705736323.18
229 rdf:type schema:Person
230 sg:person.0715261101.35 schema:affiliation N2350b1c792564b2c8e8fb289b6fd8590
231 schema:familyName Leverger
232 schema:givenName Guy
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715261101.35
234 rdf:type schema:Person
235 sg:person.0730045254.74 schema:affiliation https://www.grid.ac/institutes/grid.410463.4
236 schema:familyName Barthélémy
237 schema:givenName Adeline
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730045254.74
239 rdf:type schema:Person
240 sg:person.0763374301.68 schema:affiliation https://www.grid.ac/institutes/grid.413235.2
241 schema:familyName Baruchel
242 schema:givenName André
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763374301.68
244 rdf:type schema:Person
245 sg:person.07723251035.21 schema:affiliation https://www.grid.ac/institutes/grid.410463.4
246 schema:familyName Gonzales
247 schema:givenName Fanny
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07723251035.21
249 rdf:type schema:Person
250 sg:pub.10.1007/s11010-016-2775-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053736574
251 https://doi.org/10.1007/s11010-016-2775-1
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/leu.2008.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005174024
254 https://doi.org/10.1038/leu.2008.313
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nature10762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053038796
257 https://doi.org/10.1038/nature10762
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nature20598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009071237
260 https://doi.org/10.1038/nature20598
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nm.4439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099637780
263 https://doi.org/10.1038/nm.4439
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nm0797-730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022333282
266 https://doi.org/10.1038/nm0797-730
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/gb-2014-15-2-r29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045312009
269 https://doi.org/10.1186/gb-2014-15-2-r29
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1001/jama.2010.1862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031418278
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/cncr.26190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017355266
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.stem.2014.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025977869
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0140-6736(12)60485-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017304024
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1056/nejmoa1516192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016166624
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1097/hs9.0000000000000031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101151404
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/bjh.14991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092404073
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1182/blood-2007-03-083048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052000460
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1182/blood-2007-04-084293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033371630
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1182/blood-2009-04-215152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032295211
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1182/blood-2012-03-362608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039542302
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1182/blood-2015-12-688705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064122917
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1182/blood-2015-12-689356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064122926
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1182/blood-2016-08-733196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123306
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1182/blood-2017-09-801498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100381779
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1200/jco.2008.16.7981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027470640
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1200/jco.2009.24.8997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037053034
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1200/jco.2014.55.3628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002290526
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1200/jco.2015.62.8289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016756167
308 rdf:type schema:CreativeWork
309 https://doi.org/10.3109/08880018.2010.528171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015965240
310 rdf:type schema:CreativeWork
311 https://doi.org/10.3322/caac.21219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011762576
312 rdf:type schema:CreativeWork
313 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
314 schema:name Department of Molecular Genetics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
315 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada
316 rdf:type schema:Organization
317 https://www.grid.ac/institutes/grid.410463.4 schema:alternateName Centre Hospitalier Regional et Universitaire de Lille
318 schema:name Department of Biochemistry, CHU Lille, Lille, France
319 Department of Pediatric Hematology-Oncology, CHU Lille, Lille, France
320 Laboratory of Hematology, CHU Lille, Lille, France
321 UMR-S 1172, JPArc - Jean-Pierre AUBERT Research Center Neurosciences et Cancer, Univ. Lille, Inserm, CHU Lille, Lille, France
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.411266.6 schema:alternateName Hôpital de la Timone
324 schema:name Department of Pediatric Hematology, CHU Marseille, La Timone, Marseille, France
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.412370.3 schema:alternateName Hôpital Saint-Antoine
327 schema:name Department of Clinical Pharmacology and Clinical Research Unit of East of Paris, APHP, Saint Antoine Hospital, Paris, France
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.413235.2 schema:alternateName Hôpital Robert Debré
330 schema:name Department of Pediatric Hematology and Immunology, APHP, Robert Debré University Hospital, Paris, France
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.429194.3 schema:alternateName Institut de Pharmacologie Moléculaire et Cellulaire
333 schema:name IPMC, Université Côte d’Azur, CNRS, Valbonne, France
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.50550.35 schema:alternateName Assistance Publique -Hopitaux De Paris
336 schema:name Department of Pediatric Hematology and Oncology, APHP, Trousseau Hospital, GH HUEP, Paris, France
337 Laboratory of Hematology, APHP, Trousseau Hospital, GH HUEP, Paris, France
338 rdf:type schema:Organization
339 https://www.grid.ac/institutes/grid.7849.2 schema:alternateName Claude Bernard University Lyon 1
340 schema:name Institute of Hematology and Oncology Pediatrics, Hospices Civils, Claude Bernard University, Lyon, France
341 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...