European experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07-26

AUTHORS

Nicole Engel, Alicia Rovo, Manuela Badoglio, Myriam Labopin, Grzegorz W. Basak, Yves Beguin, Denis Guyotat, Per Ljungman, Arnon Nagler, Anton Schattenberg, Thomas Schroeder, Wilfried Schroyens, Johanna Tischer, Gerard Socie, Hans-Jochem Kolb, Andre Tichelli, Nina Salooja, Rafael F. Duarte, for the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation

ABSTRACT

Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within centres registered with the European Society of Blood and Marrow transplantation (EBMT). We have sought to identify risk factors to shed light on the pathogenesis of DCL as a model for leukaemogenesis. DCL cases were identified by questionnaire and a follow-up questionnaire requested detailed data. Control subjects from the EBMT registry who had not developed DCL were used for a matched pair analysis to identify risk factors. We identified 38 patients with DCL; the estimated prevalence was 80.5/100,000 transplants. Patients were predominantly treated for haematological malignancy. A clone was retrospectively identified in 7/25 (28%) donors for whom data was available. Overall survival was poor with 29/38 patients dead a median of 11 (range 0–91) months after DCL diagnosis. Matched case-pair analysis identified three factors on multivariate analysis as significantly associated with an increased risk for DCL: use of growth factors within the first 100 days after transplantation, in vivo T-cell depletion and multiple allografts. The risk factors identified, support reduced immune surveillance and replicative stress as pathogenic in the development of DCL. More... »

PAGES

508-517

Journal

TITLE

Leukemia

ISSUE

2

VOLUME

33

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41375-018-0218-6

DOI

http://dx.doi.org/10.1038/s41375-018-0218-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105854134

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30050122


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Europe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Factor Analysis, Statistical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelodysplastic Syndromes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Donors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine III, Campus Gro\u00dfhadern, University of Munich, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Internal Medicine III, Campus Gro\u00dfhadern, University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Engel", 
        "givenName": "Nicole", 
        "id": "sg:person.01362332146.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362332146.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, University hospital of Bern, Bern, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.411656.1", 
          "name": [
            "Department of Haematology, University hospital of Bern, Bern, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rovo", 
        "givenName": "Alicia", 
        "id": "sg:person.01210070346.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210070346.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, EBMT Paris study office, Saint Antoine Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Department of Haematology, EBMT Paris study office, Saint Antoine Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Badoglio", 
        "givenName": "Manuela", 
        "id": "sg:person.0623632634.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623632634.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, EBMT Paris study office, Saint Antoine Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Department of Haematology, EBMT Paris study office, Saint Antoine Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Labopin", 
        "givenName": "Myriam", 
        "id": "sg:person.0762572112.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762572112.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland", 
          "id": "http://www.grid.ac/institutes/grid.13339.3b", 
          "name": [
            "Department of Haematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Basak", 
        "givenName": "Grzegorz W.", 
        "id": "sg:person.0710473535.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710473535.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Haematology, Department of Medicine, University of Li\u00e8ge, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Division of Haematology, Department of Medicine, University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beguin", 
        "givenName": "Yves", 
        "id": "sg:person.01351511132.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351511132.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "L\u2019Institut de Canc\u00e9rologie de la Loire, Saint-Priest-en-Jarez, France", 
          "id": "http://www.grid.ac/institutes/grid.488279.8", 
          "name": [
            "L\u2019Institut de Canc\u00e9rologie de la Loire, Saint-Priest-en-Jarez, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guyotat", 
        "givenName": "Denis", 
        "id": "sg:person.0655776276.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655776276.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute, Haematology, Stockholm, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Karolinska Institute, Haematology, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ljungman", 
        "givenName": "Per", 
        "id": "sg:person.01077046511.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077046511.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chair of the ALWP EBMT Paris Office, Hospital Saint Antoine, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "The Chaim Sheba Medical Center, Bone Marrow Transplantation Department, Tel Hashomer, Israel", 
            "Chair of the ALWP EBMT Paris Office, Hospital Saint Antoine, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagler", 
        "givenName": "Arnon", 
        "id": "sg:person.0644252102.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644252102.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Haematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schattenberg", 
        "givenName": "Anton", 
        "id": "sg:person.014214642074.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014214642074.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, Oncology und Clinical Immunology, University of Duesseldorf, Medical Faculty, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Haematology, Oncology und Clinical Immunology, University of Duesseldorf, Medical Faculty, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schroeder", 
        "givenName": "Thomas", 
        "id": "sg:person.01271136615.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271136615.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, University of Antwerp, Antwerpen, The Netherlands", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Haematology, University of Antwerp, Antwerpen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schroyens", 
        "givenName": "Wilfried", 
        "id": "sg:person.0653223122.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653223122.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine III, Campus Gro\u00dfhadern, University of Munich, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Internal Medicine III, Campus Gro\u00dfhadern, University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tischer", 
        "givenName": "Johanna", 
        "id": "sg:person.0726516141.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726516141.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, Immunology, Oncology, APHP Hospital Saint Louis, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Department of Haematology, Immunology, Oncology, APHP Hospital Saint Louis, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Socie", 
        "givenName": "Gerard", 
        "id": "sg:person.015747476457.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015747476457.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit for Haematopoietic Cell Transplantation, Campus Gro\u00dfhadern, University of Munich, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Unit for Haematopoietic Cell Transplantation, Campus Gro\u00dfhadern, University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kolb", 
        "givenName": "Hans-Jochem", 
        "id": "sg:person.01332010455.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332010455.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, University Hospital, Basel, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Department of Haematology, University Hospital, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tichelli", 
        "givenName": "Andre", 
        "id": "sg:person.0674766513.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674766513.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Haematology, Imperial College London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Centre for Haematology, Imperial College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salooja", 
        "givenName": "Nina", 
        "id": "sg:person.0575377452.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575377452.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, Hospital Universitario Puerta de Hierro, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Department of Haematology, Hospital Universitario Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duarte", 
        "givenName": "Rafael F.", 
        "id": "sg:person.01321024667.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321024667.53"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "for the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bmt.1703360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036698319", 
          "https://doi.org/10.1038/sj.bmt.1703360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1704588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021540960", 
          "https://doi.org/10.1038/sj.bmt.1704588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031438922", 
          "https://doi.org/10.1038/sj.bmt.1705750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2017.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084128335", 
          "https://doi.org/10.1038/leu.2017.104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2008.443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018879724", 
          "https://doi.org/10.1038/bmt.2008.443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2014.294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033494998", 
          "https://doi.org/10.1038/bmt.2014.294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2016.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034798043", 
          "https://doi.org/10.1038/leu.2016.310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003023917", 
          "https://doi.org/10.1038/nature08851"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-07-26", 
    "datePublishedReg": "2018-07-26", 
    "description": "Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within centres registered with the European Society of Blood and Marrow transplantation (EBMT). We have sought to identify risk factors to shed light on the pathogenesis of DCL as a model for leukaemogenesis. DCL cases were identified by questionnaire and a follow-up questionnaire requested detailed data. Control subjects from the EBMT registry who had not developed DCL were used for a matched pair analysis to identify risk factors. We identified 38 patients with DCL; the estimated prevalence was 80.5/100,000 transplants. Patients were predominantly treated for haematological malignancy. A clone was retrospectively identified in 7/25 (28%) donors for whom data was available. Overall survival was poor with 29/38 patients dead a median of 11 (range 0\u201391) months after DCL diagnosis. Matched case-pair analysis identified three factors on multivariate analysis as significantly associated with an increased risk for DCL: use of growth factors within the first 100 days after transplantation, in vivo T-cell depletion and multiple allografts. The risk factors identified, support reduced immune surveillance and replicative stress as pathogenic in the development of DCL.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41375-018-0218-6", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "keywords": [
      "donor cell leukemia", 
      "haematopoietic cell transplantation", 
      "risk factors", 
      "cell transplantation", 
      "vivo T-cell depletion", 
      "allogeneic haematopoietic cell transplantation", 
      "T-cell depletion", 
      "risk factor analysis", 
      "matched pair analysis", 
      "follow-up questionnaire", 
      "haematology malignancy", 
      "DCL cases", 
      "multiple allografts", 
      "rare complication", 
      "EBMT registry", 
      "overall survival", 
      "marrow transplantation", 
      "control subjects", 
      "haematological malignancies", 
      "immune surveillance", 
      "cell leukemia", 
      "transplantation", 
      "multivariate analysis", 
      "patients", 
      "growth factor", 
      "European Society", 
      "malignancy", 
      "prevalence", 
      "pair analysis", 
      "questionnaire", 
      "complications", 
      "factors", 
      "allografts", 
      "transplant", 
      "registry", 
      "pathogenesis", 
      "leukemia", 
      "diagnosis", 
      "blood", 
      "months", 
      "median", 
      "leukaemogenesis", 
      "survival", 
      "outcomes", 
      "risk", 
      "surveillance", 
      "subjects", 
      "days", 
      "factor analysis", 
      "MDS", 
      "donors", 
      "replicative stress", 
      "depletion", 
      "detailed data", 
      "data", 
      "analysis", 
      "cases", 
      "center", 
      "clones", 
      "experience", 
      "use", 
      "stress", 
      "European experience", 
      "support", 
      "development", 
      "society", 
      "model", 
      "light"
    ], 
    "name": "European experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation", 
    "pagination": "508-517", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105854134"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41375-018-0218-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30050122"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41375-018-0218-6", 
      "https://app.dimensions.ai/details/publication/pub.1105854134"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_774.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41375-018-0218-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0218-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0218-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0218-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0218-6'


 

This table displays all metadata directly associated to this object as RDF triples.

420 TRIPLES      21 PREDICATES      124 URIs      108 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41375-018-0218-6 schema:about N034b0d1fb9b54fca90d8a66185ec8b6e
2 N04ca2edcd5694c0cadea8e9bd42fe4de
3 N0564b08a33ba4672acf0a228e93c3451
4 N2ad8d0b9bfba419da8ef11febd4fab62
5 N2b1b43b0847646f5a80bda22eeda407e
6 N30f355bb132c4e54878b6f2d5d3dfe1f
7 N329e2d2f754a4b7594e82299b2593dac
8 N4ea2490912734bce852441dd0788849f
9 N4ec8de6ba9a748b18def24216a18f40b
10 N689a268f6e0343e989999e9284b95b3e
11 N8182a37e870a440b991485508627d0e4
12 N839916e79577494c8d9522e084ef513b
13 N91f56485e3264778bac8322fa98ea072
14 Na3195fe252bc4f328159b99293808043
15 Na508cbecc469401690505ead0d5c7657
16 Nac0d3417c5564e429ada645b16ea2997
17 Nc417c9ec1e404e04b06a837e4707beed
18 Nc5f01dd696434450a61396b9689648fb
19 Nccd7479be84040b1a7932b90973345b5
20 Nd0dec94fa22049e29f9ebf4de00dbea6
21 Nd60ec089b4984df7863c7f07b46783f8
22 Ne11ba23541bd48e6a4dca4313b7c103f
23 Ne163c1fe15d743028d0b291064e71a4e
24 anzsrc-for:11
25 anzsrc-for:1102
26 schema:author N9f69cd1b637a4a18a98bdfa98715cc10
27 schema:citation sg:pub.10.1038/bmt.2008.443
28 sg:pub.10.1038/bmt.2014.294
29 sg:pub.10.1038/leu.2016.310
30 sg:pub.10.1038/leu.2017.104
31 sg:pub.10.1038/nature08851
32 sg:pub.10.1038/sj.bmt.1703360
33 sg:pub.10.1038/sj.bmt.1704588
34 sg:pub.10.1038/sj.bmt.1705750
35 schema:datePublished 2018-07-26
36 schema:datePublishedReg 2018-07-26
37 schema:description Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within centres registered with the European Society of Blood and Marrow transplantation (EBMT). We have sought to identify risk factors to shed light on the pathogenesis of DCL as a model for leukaemogenesis. DCL cases were identified by questionnaire and a follow-up questionnaire requested detailed data. Control subjects from the EBMT registry who had not developed DCL were used for a matched pair analysis to identify risk factors. We identified 38 patients with DCL; the estimated prevalence was 80.5/100,000 transplants. Patients were predominantly treated for haematological malignancy. A clone was retrospectively identified in 7/25 (28%) donors for whom data was available. Overall survival was poor with 29/38 patients dead a median of 11 (range 0–91) months after DCL diagnosis. Matched case-pair analysis identified three factors on multivariate analysis as significantly associated with an increased risk for DCL: use of growth factors within the first 100 days after transplantation, in vivo T-cell depletion and multiple allografts. The risk factors identified, support reduced immune surveillance and replicative stress as pathogenic in the development of DCL.
38 schema:genre article
39 schema:isAccessibleForFree true
40 schema:isPartOf N00f4704af9d54dc4bfeaf5f192a2a6ec
41 Na633ce00cb4e48ae81859ba1ed7af246
42 sg:journal.1097065
43 schema:keywords DCL cases
44 EBMT registry
45 European Society
46 European experience
47 MDS
48 T-cell depletion
49 allogeneic haematopoietic cell transplantation
50 allografts
51 analysis
52 blood
53 cases
54 cell leukemia
55 cell transplantation
56 center
57 clones
58 complications
59 control subjects
60 data
61 days
62 depletion
63 detailed data
64 development
65 diagnosis
66 donor cell leukemia
67 donors
68 experience
69 factor analysis
70 factors
71 follow-up questionnaire
72 growth factor
73 haematological malignancies
74 haematology malignancy
75 haematopoietic cell transplantation
76 immune surveillance
77 leukaemogenesis
78 leukemia
79 light
80 malignancy
81 marrow transplantation
82 matched pair analysis
83 median
84 model
85 months
86 multiple allografts
87 multivariate analysis
88 outcomes
89 overall survival
90 pair analysis
91 pathogenesis
92 patients
93 prevalence
94 questionnaire
95 rare complication
96 registry
97 replicative stress
98 risk
99 risk factor analysis
100 risk factors
101 society
102 stress
103 subjects
104 support
105 surveillance
106 survival
107 transplant
108 transplantation
109 use
110 vivo T-cell depletion
111 schema:name European experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation
112 schema:pagination 508-517
113 schema:productId N5262282b8e514e45a85bbc7a11f5b915
114 Nc23430d882be481caf6549a354c3abca
115 Ncc0fc51cb6234d6293c021f503ee27f9
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105854134
117 https://doi.org/10.1038/s41375-018-0218-6
118 schema:sdDatePublished 2022-12-01T06:38
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher Nb3d85c65c842413188e8c972943126ba
121 schema:url https://doi.org/10.1038/s41375-018-0218-6
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N00f4704af9d54dc4bfeaf5f192a2a6ec schema:issueNumber 2
126 rdf:type schema:PublicationIssue
127 N034b0d1fb9b54fca90d8a66185ec8b6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Adult
129 rdf:type schema:DefinedTerm
130 N04ca2edcd5694c0cadea8e9bd42fe4de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N0564b08a33ba4672acf0a228e93c3451 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Transplantation, Homologous
135 rdf:type schema:DefinedTerm
136 N0ef2d438569f4194851152214a326e4c rdf:first sg:person.0674766513.32
137 rdf:rest Nc40a995bdc38416f8ec942c2d38834f1
138 N1ab4f20fb3b4489c81e8adbb2292b1c6 rdf:first sg:person.0644252102.00
139 rdf:rest N84cde8328acc4f0f9a9fa76e7f9e38b6
140 N1b898637c8d5481c9fa114af11c5a9ce rdf:first sg:person.0762572112.39
141 rdf:rest Nffe53f935c36440bbc6edb1b809cb763
142 N1dd7b7bf553941cba3eb49741f19d61b rdf:first sg:person.0653223122.50
143 rdf:rest Ne55e7b46c7974377a73e6057b565ccd9
144 N2ad8d0b9bfba419da8ef11febd4fab62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Transplantation Conditioning
146 rdf:type schema:DefinedTerm
147 N2b1b43b0847646f5a80bda22eeda407e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Myelodysplastic Syndromes
149 rdf:type schema:DefinedTerm
150 N30f355bb132c4e54878b6f2d5d3dfe1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Middle Aged
152 rdf:type schema:DefinedTerm
153 N329e2d2f754a4b7594e82299b2593dac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cohort Studies
155 rdf:type schema:DefinedTerm
156 N4ea2490912734bce852441dd0788849f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Follow-Up Studies
158 rdf:type schema:DefinedTerm
159 N4ec8de6ba9a748b18def24216a18f40b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Europe
161 rdf:type schema:DefinedTerm
162 N5262282b8e514e45a85bbc7a11f5b915 schema:name dimensions_id
163 schema:value pub.1105854134
164 rdf:type schema:PropertyValue
165 N68922d6f567a441ebaf1a5a2037c19cd rdf:first sg:person.01271136615.68
166 rdf:rest N1dd7b7bf553941cba3eb49741f19d61b
167 N689a268f6e0343e989999e9284b95b3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Young Adult
169 rdf:type schema:DefinedTerm
170 N6e05354b5cd04e00b7ecf65300cf7498 rdf:first sg:person.01077046511.37
171 rdf:rest N1ab4f20fb3b4489c81e8adbb2292b1c6
172 N7436fbe1816842eca0b96fc58e0f54b5 rdf:first sg:person.015747476457.00
173 rdf:rest Nac400a1c3d494e86a68834264827941a
174 N7b05cfae92c84665b4fd0be84e91be02 schema:familyName for the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation
175 rdf:type schema:Person
176 N7d2d3d0bb94f4aef8a187f1eedfd47f1 rdf:first sg:person.01321024667.53
177 rdf:rest Na4419557b99a4cbfa95dd98ce43ad8a0
178 N8182a37e870a440b991485508627d0e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Female
180 rdf:type schema:DefinedTerm
181 N839916e79577494c8d9522e084ef513b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Risk Factors
183 rdf:type schema:DefinedTerm
184 N84cde8328acc4f0f9a9fa76e7f9e38b6 rdf:first sg:person.014214642074.18
185 rdf:rest N68922d6f567a441ebaf1a5a2037c19cd
186 N892dc9af78754b3492e9d83e6d3f33b7 rdf:first sg:person.0623632634.46
187 rdf:rest N1b898637c8d5481c9fa114af11c5a9ce
188 N8ed7e403b548402da458474f33664094 rdf:first sg:person.01210070346.32
189 rdf:rest N892dc9af78754b3492e9d83e6d3f33b7
190 N91f56485e3264778bac8322fa98ea072 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Aged
192 rdf:type schema:DefinedTerm
193 N9f69cd1b637a4a18a98bdfa98715cc10 rdf:first sg:person.01362332146.99
194 rdf:rest N8ed7e403b548402da458474f33664094
195 Na3195fe252bc4f328159b99293808043 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Adolescent
197 rdf:type schema:DefinedTerm
198 Na4419557b99a4cbfa95dd98ce43ad8a0 rdf:first N7b05cfae92c84665b4fd0be84e91be02
199 rdf:rest rdf:nil
200 Na508cbecc469401690505ead0d5c7657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Prognosis
202 rdf:type schema:DefinedTerm
203 Na633ce00cb4e48ae81859ba1ed7af246 schema:volumeNumber 33
204 rdf:type schema:PublicationVolume
205 Na69498cc595d4372abae77b3be842afb rdf:first sg:person.0655776276.35
206 rdf:rest N6e05354b5cd04e00b7ecf65300cf7498
207 Nac0d3417c5564e429ada645b16ea2997 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Leukemia
209 rdf:type schema:DefinedTerm
210 Nac400a1c3d494e86a68834264827941a rdf:first sg:person.01332010455.05
211 rdf:rest N0ef2d438569f4194851152214a326e4c
212 Nb0f7a40106064cf18b78356d64549684 rdf:first sg:person.01351511132.15
213 rdf:rest Na69498cc595d4372abae77b3be842afb
214 Nb3d85c65c842413188e8c972943126ba schema:name Springer Nature - SN SciGraph project
215 rdf:type schema:Organization
216 Nc23430d882be481caf6549a354c3abca schema:name doi
217 schema:value 10.1038/s41375-018-0218-6
218 rdf:type schema:PropertyValue
219 Nc40a995bdc38416f8ec942c2d38834f1 rdf:first sg:person.0575377452.83
220 rdf:rest N7d2d3d0bb94f4aef8a187f1eedfd47f1
221 Nc417c9ec1e404e04b06a837e4707beed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Factor Analysis, Statistical
223 rdf:type schema:DefinedTerm
224 Nc5f01dd696434450a61396b9689648fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Case-Control Studies
226 rdf:type schema:DefinedTerm
227 Ncc0fc51cb6234d6293c021f503ee27f9 schema:name pubmed_id
228 schema:value 30050122
229 rdf:type schema:PropertyValue
230 Nccd7479be84040b1a7932b90973345b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Child
232 rdf:type schema:DefinedTerm
233 Nd0dec94fa22049e29f9ebf4de00dbea6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name Male
235 rdf:type schema:DefinedTerm
236 Nd60ec089b4984df7863c7f07b46783f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Child, Preschool
238 rdf:type schema:DefinedTerm
239 Ne11ba23541bd48e6a4dca4313b7c103f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Tissue Donors
241 rdf:type schema:DefinedTerm
242 Ne163c1fe15d743028d0b291064e71a4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
243 schema:name Hematopoietic Stem Cell Transplantation
244 rdf:type schema:DefinedTerm
245 Ne55e7b46c7974377a73e6057b565ccd9 rdf:first sg:person.0726516141.72
246 rdf:rest N7436fbe1816842eca0b96fc58e0f54b5
247 Nffe53f935c36440bbc6edb1b809cb763 rdf:first sg:person.0710473535.27
248 rdf:rest Nb0f7a40106064cf18b78356d64549684
249 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
250 schema:name Medical and Health Sciences
251 rdf:type schema:DefinedTerm
252 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
253 schema:name Cardiorespiratory Medicine and Haematology
254 rdf:type schema:DefinedTerm
255 sg:journal.1097065 schema:issn 0887-6924
256 1476-5551
257 schema:name Leukemia
258 schema:publisher Springer Nature
259 rdf:type schema:Periodical
260 sg:person.01077046511.37 schema:affiliation grid-institutes:grid.4714.6
261 schema:familyName Ljungman
262 schema:givenName Per
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077046511.37
264 rdf:type schema:Person
265 sg:person.01210070346.32 schema:affiliation grid-institutes:grid.411656.1
266 schema:familyName Rovo
267 schema:givenName Alicia
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210070346.32
269 rdf:type schema:Person
270 sg:person.01271136615.68 schema:affiliation grid-institutes:grid.411327.2
271 schema:familyName Schroeder
272 schema:givenName Thomas
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271136615.68
274 rdf:type schema:Person
275 sg:person.01321024667.53 schema:affiliation grid-institutes:grid.73221.35
276 schema:familyName Duarte
277 schema:givenName Rafael F.
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321024667.53
279 rdf:type schema:Person
280 sg:person.01332010455.05 schema:affiliation grid-institutes:grid.5252.0
281 schema:familyName Kolb
282 schema:givenName Hans-Jochem
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332010455.05
284 rdf:type schema:Person
285 sg:person.01351511132.15 schema:affiliation grid-institutes:grid.4861.b
286 schema:familyName Beguin
287 schema:givenName Yves
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351511132.15
289 rdf:type schema:Person
290 sg:person.01362332146.99 schema:affiliation grid-institutes:grid.5252.0
291 schema:familyName Engel
292 schema:givenName Nicole
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362332146.99
294 rdf:type schema:Person
295 sg:person.014214642074.18 schema:affiliation grid-institutes:grid.10417.33
296 schema:familyName Schattenberg
297 schema:givenName Anton
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014214642074.18
299 rdf:type schema:Person
300 sg:person.015747476457.00 schema:affiliation grid-institutes:grid.413328.f
301 schema:familyName Socie
302 schema:givenName Gerard
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015747476457.00
304 rdf:type schema:Person
305 sg:person.0575377452.83 schema:affiliation grid-institutes:grid.7445.2
306 schema:familyName Salooja
307 schema:givenName Nina
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575377452.83
309 rdf:type schema:Person
310 sg:person.0623632634.46 schema:affiliation grid-institutes:grid.412370.3
311 schema:familyName Badoglio
312 schema:givenName Manuela
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623632634.46
314 rdf:type schema:Person
315 sg:person.0644252102.00 schema:affiliation grid-institutes:grid.412370.3
316 schema:familyName Nagler
317 schema:givenName Arnon
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644252102.00
319 rdf:type schema:Person
320 sg:person.0653223122.50 schema:affiliation grid-institutes:None
321 schema:familyName Schroyens
322 schema:givenName Wilfried
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653223122.50
324 rdf:type schema:Person
325 sg:person.0655776276.35 schema:affiliation grid-institutes:grid.488279.8
326 schema:familyName Guyotat
327 schema:givenName Denis
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655776276.35
329 rdf:type schema:Person
330 sg:person.0674766513.32 schema:affiliation grid-institutes:grid.410567.1
331 schema:familyName Tichelli
332 schema:givenName Andre
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674766513.32
334 rdf:type schema:Person
335 sg:person.0710473535.27 schema:affiliation grid-institutes:grid.13339.3b
336 schema:familyName Basak
337 schema:givenName Grzegorz W.
338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710473535.27
339 rdf:type schema:Person
340 sg:person.0726516141.72 schema:affiliation grid-institutes:grid.5252.0
341 schema:familyName Tischer
342 schema:givenName Johanna
343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726516141.72
344 rdf:type schema:Person
345 sg:person.0762572112.39 schema:affiliation grid-institutes:grid.412370.3
346 schema:familyName Labopin
347 schema:givenName Myriam
348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762572112.39
349 rdf:type schema:Person
350 sg:pub.10.1038/bmt.2008.443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018879724
351 https://doi.org/10.1038/bmt.2008.443
352 rdf:type schema:CreativeWork
353 sg:pub.10.1038/bmt.2014.294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033494998
354 https://doi.org/10.1038/bmt.2014.294
355 rdf:type schema:CreativeWork
356 sg:pub.10.1038/leu.2016.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034798043
357 https://doi.org/10.1038/leu.2016.310
358 rdf:type schema:CreativeWork
359 sg:pub.10.1038/leu.2017.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128335
360 https://doi.org/10.1038/leu.2017.104
361 rdf:type schema:CreativeWork
362 sg:pub.10.1038/nature08851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003023917
363 https://doi.org/10.1038/nature08851
364 rdf:type schema:CreativeWork
365 sg:pub.10.1038/sj.bmt.1703360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036698319
366 https://doi.org/10.1038/sj.bmt.1703360
367 rdf:type schema:CreativeWork
368 sg:pub.10.1038/sj.bmt.1704588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021540960
369 https://doi.org/10.1038/sj.bmt.1704588
370 rdf:type schema:CreativeWork
371 sg:pub.10.1038/sj.bmt.1705750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031438922
372 https://doi.org/10.1038/sj.bmt.1705750
373 rdf:type schema:CreativeWork
374 grid-institutes:None schema:alternateName Department of Haematology, University of Antwerp, Antwerpen, The Netherlands
375 schema:name Department of Haematology, University of Antwerp, Antwerpen, The Netherlands
376 rdf:type schema:Organization
377 grid-institutes:grid.10417.33 schema:alternateName Department of Haematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
378 schema:name Department of Haematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
379 rdf:type schema:Organization
380 grid-institutes:grid.13339.3b schema:alternateName Department of Haematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland
381 schema:name Department of Haematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland
382 rdf:type schema:Organization
383 grid-institutes:grid.410567.1 schema:alternateName Department of Haematology, University Hospital, Basel, Switzerland
384 schema:name Department of Haematology, University Hospital, Basel, Switzerland
385 rdf:type schema:Organization
386 grid-institutes:grid.411327.2 schema:alternateName Department of Haematology, Oncology und Clinical Immunology, University of Duesseldorf, Medical Faculty, Duesseldorf, Germany
387 schema:name Department of Haematology, Oncology und Clinical Immunology, University of Duesseldorf, Medical Faculty, Duesseldorf, Germany
388 rdf:type schema:Organization
389 grid-institutes:grid.411656.1 schema:alternateName Department of Haematology, University hospital of Bern, Bern, Switzerland
390 schema:name Department of Haematology, University hospital of Bern, Bern, Switzerland
391 rdf:type schema:Organization
392 grid-institutes:grid.412370.3 schema:alternateName Chair of the ALWP EBMT Paris Office, Hospital Saint Antoine, Paris, France
393 Department of Haematology, EBMT Paris study office, Saint Antoine Hospital, Paris, France
394 schema:name Chair of the ALWP EBMT Paris Office, Hospital Saint Antoine, Paris, France
395 Department of Haematology, EBMT Paris study office, Saint Antoine Hospital, Paris, France
396 The Chaim Sheba Medical Center, Bone Marrow Transplantation Department, Tel Hashomer, Israel
397 rdf:type schema:Organization
398 grid-institutes:grid.413328.f schema:alternateName Department of Haematology, Immunology, Oncology, APHP Hospital Saint Louis, Paris, France
399 schema:name Department of Haematology, Immunology, Oncology, APHP Hospital Saint Louis, Paris, France
400 rdf:type schema:Organization
401 grid-institutes:grid.4714.6 schema:alternateName Karolinska Institute, Haematology, Stockholm, Sweden
402 schema:name Karolinska Institute, Haematology, Stockholm, Sweden
403 rdf:type schema:Organization
404 grid-institutes:grid.4861.b schema:alternateName Division of Haematology, Department of Medicine, University of Liège, Liège, Belgium
405 schema:name Division of Haematology, Department of Medicine, University of Liège, Liège, Belgium
406 rdf:type schema:Organization
407 grid-institutes:grid.488279.8 schema:alternateName L’Institut de Cancérologie de la Loire, Saint-Priest-en-Jarez, France
408 schema:name L’Institut de Cancérologie de la Loire, Saint-Priest-en-Jarez, France
409 rdf:type schema:Organization
410 grid-institutes:grid.5252.0 schema:alternateName Department of Internal Medicine III, Campus Großhadern, University of Munich, Munich, Germany
411 Unit for Haematopoietic Cell Transplantation, Campus Großhadern, University of Munich, Munich, Germany
412 schema:name Department of Internal Medicine III, Campus Großhadern, University of Munich, Munich, Germany
413 Unit for Haematopoietic Cell Transplantation, Campus Großhadern, University of Munich, Munich, Germany
414 rdf:type schema:Organization
415 grid-institutes:grid.73221.35 schema:alternateName Department of Haematology, Hospital Universitario Puerta de Hierro, Madrid, Spain
416 schema:name Department of Haematology, Hospital Universitario Puerta de Hierro, Madrid, Spain
417 rdf:type schema:Organization
418 grid-institutes:grid.7445.2 schema:alternateName Centre for Haematology, Imperial College London, London, UK
419 schema:name Centre for Haematology, Imperial College London, London, UK
420 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...