Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05-23

AUTHORS

Kana Sakamoto, Ryohei Katayama, Reimi Asaka, Seiji Sakata, Satoko Baba, Hideki Nakasone, Sumie Koike, Naoko Tsuyama, Akito Dobashi, Makoto Sasaki, Ryo Ichinohasama, Emi Takakuwa, Rie Yamazaki, Jun Takizawa, Takahiro Maeda, Miwako Narita, Koji Izutsu, Yoshinobu Kanda, Koichi Ohshima, Kengo Takeuchi

ABSTRACT

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare skin-tropic hematological malignancy of uncertain pathogenesis and poor prognosis. We examined 118 BPDCN cases for cytomorphology, MYC locus rearrangement, and MYC expression. Sixty-two (53%) and 41 (35%) cases showed the classic and immunoblastoid cytomorphology, respectively. Forty-one (38%) MYC+BPDCN (positive for rearrangement and expression) and 59 (54%) MYC-BPDCN (both negative) cases were identified. Immunoblastoid cytomorphology was significantly associated with MYC+BPDCN. All examined MYC+BPDCNs were negative for MYB/MYBL1 rearrangement (0/36). Clinically, MYC+BPDCN showed older onset, poorer outcome, and localized skin tumors more commonly than MYC-BPDCN. MYC was demonstrated by expression profiling as one of the clearest discriminators between CAL-1 (MYC+BPDCN) and PMDC05 (MYC-BPDCN) cell lines, and its shRNA knockdown suppressed CAL-1 viability. Inhibitors for bromodomain and extra-terminal protein (BETis), and aurora kinases (AKis) inhibited CAL-1 growth more effectively than PMDC05. We further showed that a BCL2 inhibitor was effective in both CAL-1 and PMDC05, indicating that this inhibitor can be used to treat MYC-BPDCN, to which BETis and AKis are probably less effective. Our data will provide a rationale for the development of new treatment strategies for patients with BPDCN, in accordance with precision medicine. More... »

PAGES

1-14

References to SciGraph publications

  • 2017-05. Plasmacytoid dendritic cell proliferations and neoplasms involving the bone marrow in ANNALS OF HEMATOLOGY
  • 2014-08. Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition in LEUKEMIA
  • 2017-03-13. Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer in NATURE COMMUNICATIONS
  • 2014-03. Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients in BLOOD CANCER JOURNAL
  • 2017-12. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity in SCIENTIFIC REPORTS
  • 2005-02. A Novel Plasmacytoid Dendritic Cell Line, CAL-1, Established from a Patient with Blastic Natural Killer Cell Lymphoma in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2007-08. Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma in LEUKEMIA
  • 2010-04. MYC as a regulator of ribosome biogenesis and protein synthesis in NATURE REVIEWS CANCER
  • 2007-03. Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas in LEUKEMIA
  • 2010-04. Alterations of the Cell-Cycle Inhibitors p27KIP1 and p16INK4a Are Frequent in Blastic Plasmacytoid Dendritic Cell Neoplasms in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2016-07. A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer in NATURE MEDICINE
  • 2016-04. ALK-positive large B-cell lymphoma: identification of EML4-ALK and a review of the literature focusing on the ALK immunohistochemical staining pattern in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2009-04. Recurrent genomic aberrations combined with deletions of various tumour suppressor genes may deregulate the G1/S transition in CD4+CD56+ haematodermic neoplasms and contribute to the aggressiveness of the disease in LEUKEMIA
  • 2013-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2016-06-08. Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells in NATURE
  • 2017-07. Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm in LEUKEMIA
  • 2006-10. Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2 in LEUKEMIA
  • 2015-04. Identification of SUPT3H as a novel 8q24/MYC partner in blastic plasmacytoid dendritic cell neoplasm with t(6;8)(p21;q24) translocation in BLOOD CANCER JOURNAL
  • 2014-04. Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm in LEUKEMIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41375-018-0154-5

    DOI

    http://dx.doi.org/10.1038/s41375-018-0154-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104152322

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29795241


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