Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

Leonhard Busch, Dimitrios Mougiakakos, Maike Büttner-Herold, Miriam J. Müller, Dietrich A. Volmer, Christian Bach, Mario Fabri, Jörg T. Bittenbring, Frank Neumann, Rainer Boxhammer, Jens Nolting, Savita Bisht, Martin Böttcher, Simon Jitschin, Markus H. Hoffmann, Heidi Balzer, Fabian Beier, Deniz Gezer, Diana Dudziak, Kolja Gelse, Friedrich F. Hennig, Christian P. Pallasch, Bernd Spriewald, Andreas Mackensen, Heiko Bruns

ABSTRACT

Macrophages are key mediators of the therapeutic effects exerted by monoclonal antibodies, such as the anti-CD38 antibody MOR202, currently introduced in multiple myeloma (MM) therapy. Therefore, it is important to understand how antibody-mediated effector functions of myeloma-associated macrophages (MAMs) are regulated. Here, we focused on the effects of vitamin D, a known regulator of macrophage effector functions. Consequently, it was the aim of this study to assess whether modulation of the vitamin D pathway alters the tumoricidal activity of MAMs. Here, we demonstrate that MAMs display a defective vitamin D pathway with reduced expression level of CYP27B1 and limited tumoricidal activity which can be restored by the IMiD lenalidomide in vitro. Furthermore, our data indicate that the vitamin D pathway of MAMs from MM patients does recover during an IMiD-containing therapy shown by an improved MOR202-mediated cytotoxic activity of these MAMs against primary MM cells ex vivo. Here, the ex vivo cytotoxic activity could be further enhanced by vitamin D supplementation. These data suggest that vitamin D holds a key role for the effector functions of MAMs and that vitamin D supplementation in IMiD combination trials could further increase the therapeutic efficacy of anti-CD38 antibodies such as MOR202, which remains to be investigated in clinical studies. More... »

PAGES

2445-2458

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41375-018-0114-0

DOI

http://dx.doi.org/10.1038/s41375-018-0114-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101818062

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29654274


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