Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-06

AUTHORS

Reinhard Stauder, Ge Yu, Karin A. Koinig, Tim Bagguley, Pierre Fenaux, Argiris Symeonidis, Guillermo Sanz, Jaroslav Cermak, Moshe Mittelman, Eva Hellström-Lindberg, Saskia Langemeijer, Mette Skov Holm, Krzysztof Mądry, Luca Malcovati, Aurelia Tatic, Ulrich Germing, Aleksandar Savic, Corine van Marrewijk, Agnès Guerci-Bresler, Elisa Luño, Jackie Droste, Fabio Efficace, Alex Smith, David Bowen, Theo de Witte

ABSTRACT

In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p < 0.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p < 0.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p < 0.001); in anxiety/depression in females and in younger people (p < 0.001); and in EQ-VAS in women and in persons older than 75 years (p < 0.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations. More... »

PAGES

1380-1392

Journal

TITLE

Leukemia

ISSUE

6

VOLUME

32

Author Affiliations

  • Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria
  • Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom
  • Service d’Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris, France
  • Department of Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece
  • CIBERONC, Instituto Carlos III, Madrid, Spain
  • Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha, Czech Republic
  • Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel
  • Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden
  • Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
  • Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
  • Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland
  • Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
  • Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania
  • Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany
  • Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia
  • Service d’Hématologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy, France
  • Servicio d’Hematología, Servicio de Salud del Principado de Asturias Oviedo, Oviedo, Spain
  • Fondazione GIMEMA Onlus, Rome, Italy
  • St. James’s Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom
  • Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41375-018-0089-x

    DOI

    http://dx.doi.org/10.1038/s41375-018-0089-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101354095

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29572506


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Age Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Health Status", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myelodysplastic Syndromes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quality of Life", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sex Characteristics", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria", 
              "id": "http://www.grid.ac/institutes/grid.5361.1", 
              "name": [
                "Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stauder", 
            "givenName": "Reinhard", 
            "id": "sg:person.0617564545.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617564545.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom", 
              "id": "http://www.grid.ac/institutes/grid.5685.e", 
              "name": [
                "Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Ge", 
            "id": "sg:person.01214466573.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214466573.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria", 
              "id": "http://www.grid.ac/institutes/grid.5361.1", 
              "name": [
                "Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koinig", 
            "givenName": "Karin A.", 
            "id": "sg:person.01133676453.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133676453.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom", 
              "id": "http://www.grid.ac/institutes/grid.5685.e", 
              "name": [
                "Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bagguley", 
            "givenName": "Tim", 
            "id": "sg:person.014765042600.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014765042600.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) and Universit\u00e9 Paris 7, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Service d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) and Universit\u00e9 Paris 7, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fenaux", 
            "givenName": "Pierre", 
            "id": "sg:person.0766554473.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766554473.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece", 
              "id": "http://www.grid.ac/institutes/grid.11047.33", 
              "name": [
                "Department of Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Symeonidis", 
            "givenName": "Argiris", 
            "id": "sg:person.01306361566.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306361566.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CIBERONC, Instituto Carlos III, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.510933.d", 
              "name": [
                "Department of Hematology, Hospital Universitario y Polit\u00e9cnico La Fe, Valencia, Spain", 
                "CIBERONC, Instituto Carlos III, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sanz", 
            "givenName": "Guillermo", 
            "id": "sg:person.013151467432.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151467432.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cermak", 
            "givenName": "Jaroslav", 
            "id": "sg:person.0726561165.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726561165.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel", 
              "id": "http://www.grid.ac/institutes/grid.12136.37", 
              "name": [
                "Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mittelman", 
            "givenName": "Moshe", 
            "id": "sg:person.0706241721.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706241721.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hellstr\u00f6m-Lindberg", 
            "givenName": "Eva", 
            "id": "sg:person.0730110062.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730110062.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langemeijer", 
            "givenName": "Saskia", 
            "id": "sg:person.0775423370.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775423370.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Aarhus University Hospital, Aarhus, Denmark", 
              "id": "http://www.grid.ac/institutes/grid.154185.c", 
              "name": [
                "Department of Hematology, Aarhus University Hospital, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holm", 
            "givenName": "Mette Skov", 
            "id": "sg:person.01242177302.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242177302.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland", 
              "id": "http://www.grid.ac/institutes/grid.13339.3b", 
              "name": [
                "Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u0105dry", 
            "givenName": "Krzysztof", 
            "id": "sg:person.01067020547.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067020547.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Malcovati", 
            "givenName": "Luca", 
            "id": "sg:person.01015506717.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015506717.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania", 
              "id": "http://www.grid.ac/institutes/grid.415180.9", 
              "name": [
                "Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tatic", 
            "givenName": "Aurelia", 
            "id": "sg:person.01211700172.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211700172.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Universit\u00e4tsklinik D\u00fcsseldorf, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.14778.3d", 
              "name": [
                "Department of Hematology, Oncology and Clinical Immunology, Universit\u00e4tsklinik D\u00fcsseldorf, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Germing", 
            "givenName": "Ulrich", 
            "id": "sg:person.01362464041.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362464041.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia", 
              "id": "http://www.grid.ac/institutes/grid.10822.39", 
              "name": [
                "Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Savic", 
            "givenName": "Aleksandar", 
            "id": "sg:person.0763175413.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763175413.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Marrewijk", 
            "givenName": "Corine", 
            "id": "sg:person.0604661367.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604661367.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service d\u2019H\u00e9matologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service d\u2019H\u00e9matologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guerci-Bresler", 
            "givenName": "Agn\u00e8s", 
            "id": "sg:person.01015422641.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015422641.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Servicio d\u2019Hematolog\u00eda, Servicio de Salud del Principado de Asturias Oviedo, Oviedo, Spain", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Servicio d\u2019Hematolog\u00eda, Servicio de Salud del Principado de Asturias Oviedo, Oviedo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu\u00f1o", 
            "givenName": "Elisa", 
            "id": "sg:person.0624540066.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624540066.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Droste", 
            "givenName": "Jackie", 
            "id": "sg:person.012752673175.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012752673175.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fondazione GIMEMA Onlus, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.428689.9", 
              "name": [
                "Fondazione GIMEMA Onlus, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Efficace", 
            "givenName": "Fabio", 
            "id": "sg:person.01314561674.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314561674.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom", 
              "id": "http://www.grid.ac/institutes/grid.5685.e", 
              "name": [
                "Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "Alex", 
            "id": "sg:person.01070606157.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070606157.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. James\u2019s Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom", 
              "id": "http://www.grid.ac/institutes/grid.443984.6", 
              "name": [
                "St. James\u2019s Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bowen", 
            "givenName": "David", 
            "id": "sg:person.010142003347.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010142003347.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Witte", 
            "givenName": "Theo", 
            "id": "sg:person.015730551677.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015730551677.08"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s40266-015-0312-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034409804", 
              "https://doi.org/10.1007/s40266-015-0312-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00520-016-3344-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013330660", 
              "https://doi.org/10.1007/s00520-016-3344-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10198-003-0182-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047715908", 
              "https://doi.org/10.1007/s10198-003-0182-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11899-016-0343-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000747881", 
              "https://doi.org/10.1007/s11899-016-0343-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-013-2001-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015118319", 
              "https://doi.org/10.1007/s00277-013-2001-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11136-005-8028-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032800504", 
              "https://doi.org/10.1007/s11136-005-8028-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11899-017-0406-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091238232", 
              "https://doi.org/10.1007/s11899-017-0406-x"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-03-06", 
        "datePublishedReg": "2018-03-06", 
        "description": "In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p\u2009<\u20090.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p\u2009<\u20090.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p\u2009<\u20090.001); in anxiety/depression in females and in younger people (p\u2009<\u20090.001); and in EQ-VAS in women and in persons older than 75 years (p\u2009<\u20090.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41375-018-0089-x", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6206476", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3938160", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097065", 
            "issn": [
              "0887-6924", 
              "1476-5551"
            ], 
            "name": "Leukemia", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "32"
          }
        ], 
        "keywords": [
          "anxiety/depression", 
          "health-related quality", 
          "pain/discomfort", 
          "myelodysplastic syndrome", 
          "usual activities", 
          "MDS patients", 
          "EQ-VAS", 
          "red blood cell transfusion needs", 
          "lower-risk myelodysplastic syndromes", 
          "low-risk MDS patients", 
          "relevant patient-reported outcomes", 
          "sex-matched reference population", 
          "higher co-morbidity burden", 
          "dimension pain/discomfort", 
          "European LeukemiaNet study", 
          "co-morbidity burden", 
          "lower hemoglobin levels", 
          "patient-reported outcomes", 
          "EQ-5D questionnaire", 
          "sex-matched peers", 
          "reference population", 
          "initial diagnosis", 
          "hemoglobin levels", 
          "transfusion needs", 
          "MDS patients", 
          "prospective data", 
          "individualized therapy planning", 
          "HRQoL", 
          "dimensions mobility", 
          "patients", 
          "proportion of problems", 
          "older people", 
          "EuroQol Group", 
          "depression", 
          "therapy planning", 
          "age", 
          "significant proportion", 
          "pronounced reduction", 
          "discomfort", 
          "females", 
          "registry", 
          "syndrome", 
          "population", 
          "proportion", 
          "MD experience", 
          "diagnosis", 
          "young people", 
          "impairment", 
          "activity", 
          "women", 
          "outcomes", 
          "burden", 
          "males", 
          "life", 
          "questionnaire", 
          "people", 
          "group", 
          "years", 
          "restriction", 
          "persons", 
          "levels", 
          "quality", 
          "study", 
          "severe problems", 
          "reduction", 
          "experience", 
          "need", 
          "data", 
          "int", 
          "distinct dimensions", 
          "comparison", 
          "limitations", 
          "mobility", 
          "peers", 
          "planning", 
          "problem", 
          "clustering", 
          "dimensions"
        ], 
        "name": "Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study", 
        "pagination": "1380-1392", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1101354095"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41375-018-0089-x"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29572506"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41375-018-0089-x", 
          "https://app.dimensions.ai/details/publication/pub.1101354095"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_773.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41375-018-0089-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0089-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0089-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0089-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-018-0089-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    449 TRIPLES      21 PREDICATES      123 URIs      107 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41375-018-0089-x schema:about N0a25769888d142178382381c180c20d6
    2 N1dbefd23ea5245018d1666440ee14b1e
    3 N6ff2b2c81f1c442a8f110fddac1405e6
    4 N8d4da5b12f6b481cacba8ca589289c2f
    5 N8e90cf326cb94b7db340827998abf478
    6 N90516aefb78842b18a327e0ca134478d
    7 N976b7bab8de04f20927c6574bd80933d
    8 Nbfa1dcd20f3e43dcada2b5be32a439e3
    9 Ncab67e9918664b56bb7cbe9b1dd6c9f7
    10 Nd1615c844886431592e5a3eeed6881f2
    11 Nd9bd58a5906342ce8181bafcdcca6f2d
    12 Ne63c4bae72f84eb5a570d5380a4741f6
    13 Nfc50a17e61e346ae8a769fe50ef7e1c7
    14 anzsrc-for:11
    15 anzsrc-for:1103
    16 anzsrc-for:1117
    17 schema:author N12300203d82d4c81978282d9c75aa6a0
    18 schema:citation sg:pub.10.1007/s00277-013-2001-0
    19 sg:pub.10.1007/s00520-016-3344-6
    20 sg:pub.10.1007/s10198-003-0182-5
    21 sg:pub.10.1007/s11136-005-8028-5
    22 sg:pub.10.1007/s11899-016-0343-0
    23 sg:pub.10.1007/s11899-017-0406-x
    24 sg:pub.10.1007/s40266-015-0312-7
    25 schema:datePublished 2018-03-06
    26 schema:datePublishedReg 2018-03-06
    27 schema:description In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p < 0.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p < 0.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p < 0.001); in anxiety/depression in females and in younger people (p < 0.001); and in EQ-VAS in women and in persons older than 75 years (p < 0.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations.
    28 schema:genre article
    29 schema:isAccessibleForFree true
    30 schema:isPartOf Naa57f4919f7d4f498bcba54c8fcaa1b3
    31 Nc20ead160f0d47f894c871f8e00c4892
    32 sg:journal.1097065
    33 schema:keywords EQ-5D questionnaire
    34 EQ-VAS
    35 EuroQol Group
    36 European LeukemiaNet study
    37 HRQoL
    38 MD experience
    39 MDS patients
    40 activity
    41 age
    42 anxiety/depression
    43 burden
    44 clustering
    45 co-morbidity burden
    46 comparison
    47 data
    48 depression
    49 diagnosis
    50 dimension pain/discomfort
    51 dimensions
    52 dimensions mobility
    53 discomfort
    54 distinct dimensions
    55 experience
    56 females
    57 group
    58 health-related quality
    59 hemoglobin levels
    60 higher co-morbidity burden
    61 impairment
    62 individualized therapy planning
    63 initial diagnosis
    64 int
    65 levels
    66 life
    67 limitations
    68 low-risk MDS patients
    69 lower hemoglobin levels
    70 lower-risk myelodysplastic syndromes
    71 males
    72 mobility
    73 myelodysplastic syndrome
    74 need
    75 older people
    76 outcomes
    77 pain/discomfort
    78 patient-reported outcomes
    79 patients
    80 peers
    81 people
    82 persons
    83 planning
    84 population
    85 problem
    86 pronounced reduction
    87 proportion
    88 proportion of problems
    89 prospective data
    90 quality
    91 questionnaire
    92 red blood cell transfusion needs
    93 reduction
    94 reference population
    95 registry
    96 relevant patient-reported outcomes
    97 restriction
    98 severe problems
    99 sex-matched peers
    100 sex-matched reference population
    101 significant proportion
    102 study
    103 syndrome
    104 therapy planning
    105 transfusion needs
    106 usual activities
    107 women
    108 years
    109 young people
    110 schema:name Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study
    111 schema:pagination 1380-1392
    112 schema:productId N3be546b6a284427f8a1a7d05db7650a6
    113 Na0eee3a430724919a2187dd5c0dcfb01
    114 Nec99ef5785234ddfbe891127e4d33fe9
    115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101354095
    116 https://doi.org/10.1038/s41375-018-0089-x
    117 schema:sdDatePublished 2022-08-04T17:07
    118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    119 schema:sdPublisher N778b47ca5ef44a2bb9449b62f8b6c42d
    120 schema:url https://doi.org/10.1038/s41375-018-0089-x
    121 sgo:license sg:explorer/license/
    122 sgo:sdDataset articles
    123 rdf:type schema:ScholarlyArticle
    124 N0a25769888d142178382381c180c20d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Prospective Studies
    126 rdf:type schema:DefinedTerm
    127 N0e0ad5b129d44d97aa4c7f3df0f1baf9 rdf:first sg:person.0726561165.17
    128 rdf:rest Na5a3c284a31f4ad99bf70e2559de694e
    129 N0ed8b87b9288410696f2807e4fb5d8af rdf:first sg:person.0775423370.22
    130 rdf:rest N3366713c37b9469dbaddf05f39f07d81
    131 N12300203d82d4c81978282d9c75aa6a0 rdf:first sg:person.0617564545.58
    132 rdf:rest N42066606cc0740249bbfe62740e1ca7d
    133 N17d12602aac34225bbaad7b2e4a877dd rdf:first sg:person.0763175413.12
    134 rdf:rest N86ace0cbf67f4548bfdb2bf13cc3df22
    135 N1a66d43753a04686bdc01295c6ad1ed7 rdf:first sg:person.0624540066.48
    136 rdf:rest Na6ea30d4e4df42cfabd02fe13b297350
    137 N1dbefd23ea5245018d1666440ee14b1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Aged
    139 rdf:type schema:DefinedTerm
    140 N3366713c37b9469dbaddf05f39f07d81 rdf:first sg:person.01242177302.57
    141 rdf:rest Nd2752921c2df45809f3264669531c93a
    142 N3be546b6a284427f8a1a7d05db7650a6 schema:name doi
    143 schema:value 10.1038/s41375-018-0089-x
    144 rdf:type schema:PropertyValue
    145 N42066606cc0740249bbfe62740e1ca7d rdf:first sg:person.01214466573.54
    146 rdf:rest Nf4a8e6aa6d124ef3a9bd142c392453b0
    147 N59acbacc6d55479c99827c98d4925ab5 rdf:first sg:person.01015422641.43
    148 rdf:rest N1a66d43753a04686bdc01295c6ad1ed7
    149 N6ccb2e9aa89841fda9bc08e66d449da1 rdf:first sg:person.01211700172.81
    150 rdf:rest Nda5349a68a7e4a6ab1dff75e55e79217
    151 N6ff2b2c81f1c442a8f110fddac1405e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Quality of Life
    153 rdf:type schema:DefinedTerm
    154 N7685f31a6bd2444185d999a937252f0b rdf:first sg:person.01306361566.09
    155 rdf:rest Nc93c0d068a9d47169871c2aaad0b5bf2
    156 N778b47ca5ef44a2bb9449b62f8b6c42d schema:name Springer Nature - SN SciGraph project
    157 rdf:type schema:Organization
    158 N86ace0cbf67f4548bfdb2bf13cc3df22 rdf:first sg:person.0604661367.35
    159 rdf:rest N59acbacc6d55479c99827c98d4925ab5
    160 N8d4da5b12f6b481cacba8ca589289c2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Health Status
    162 rdf:type schema:DefinedTerm
    163 N8e90cf326cb94b7db340827998abf478 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Humans
    165 rdf:type schema:DefinedTerm
    166 N90516aefb78842b18a327e0ca134478d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Female
    168 rdf:type schema:DefinedTerm
    169 N976b7bab8de04f20927c6574bd80933d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Aged, 80 and over
    171 rdf:type schema:DefinedTerm
    172 Na0eee3a430724919a2187dd5c0dcfb01 schema:name dimensions_id
    173 schema:value pub.1101354095
    174 rdf:type schema:PropertyValue
    175 Na1abffb70d1e4ec6ad50078fc37e8b0c rdf:first sg:person.0730110062.04
    176 rdf:rest N0ed8b87b9288410696f2807e4fb5d8af
    177 Na5a3c284a31f4ad99bf70e2559de694e rdf:first sg:person.0706241721.48
    178 rdf:rest Na1abffb70d1e4ec6ad50078fc37e8b0c
    179 Na6ea30d4e4df42cfabd02fe13b297350 rdf:first sg:person.012752673175.83
    180 rdf:rest Nc422eb616cfe400ea129a30b9bbe6c8a
    181 Naa57f4919f7d4f498bcba54c8fcaa1b3 schema:issueNumber 6
    182 rdf:type schema:PublicationIssue
    183 Nad2ad84f8526410085175dcdd6456613 rdf:first sg:person.015730551677.08
    184 rdf:rest rdf:nil
    185 Nb4f90a05c9454e03aa12d3cd41049889 rdf:first sg:person.0766554473.71
    186 rdf:rest N7685f31a6bd2444185d999a937252f0b
    187 Nb51c11489d964fc592667d900e52011f rdf:first sg:person.01070606157.27
    188 rdf:rest Ne956d8ccd5d145b3bf96876c112cad02
    189 Nb861f994ed134a77849f76c9b33e38bf rdf:first sg:person.014765042600.95
    190 rdf:rest Nb4f90a05c9454e03aa12d3cd41049889
    191 Nbfa1dcd20f3e43dcada2b5be32a439e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Age Factors
    193 rdf:type schema:DefinedTerm
    194 Nc20ead160f0d47f894c871f8e00c4892 schema:volumeNumber 32
    195 rdf:type schema:PublicationVolume
    196 Nc422eb616cfe400ea129a30b9bbe6c8a rdf:first sg:person.01314561674.27
    197 rdf:rest Nb51c11489d964fc592667d900e52011f
    198 Nc463bc7e62b74dc3a6709bc4e9598e33 rdf:first sg:person.01015506717.02
    199 rdf:rest N6ccb2e9aa89841fda9bc08e66d449da1
    200 Nc93c0d068a9d47169871c2aaad0b5bf2 rdf:first sg:person.013151467432.56
    201 rdf:rest N0e0ad5b129d44d97aa4c7f3df0f1baf9
    202 Ncab67e9918664b56bb7cbe9b1dd6c9f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Myelodysplastic Syndromes
    204 rdf:type schema:DefinedTerm
    205 Nd1615c844886431592e5a3eeed6881f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Male
    207 rdf:type schema:DefinedTerm
    208 Nd2752921c2df45809f3264669531c93a rdf:first sg:person.01067020547.55
    209 rdf:rest Nc463bc7e62b74dc3a6709bc4e9598e33
    210 Nd9bd58a5906342ce8181bafcdcca6f2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Middle Aged
    212 rdf:type schema:DefinedTerm
    213 Nda5349a68a7e4a6ab1dff75e55e79217 rdf:first sg:person.01362464041.20
    214 rdf:rest N17d12602aac34225bbaad7b2e4a877dd
    215 Ne63c4bae72f84eb5a570d5380a4741f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Sex Characteristics
    217 rdf:type schema:DefinedTerm
    218 Ne956d8ccd5d145b3bf96876c112cad02 rdf:first sg:person.010142003347.01
    219 rdf:rest Nad2ad84f8526410085175dcdd6456613
    220 Nec99ef5785234ddfbe891127e4d33fe9 schema:name pubmed_id
    221 schema:value 29572506
    222 rdf:type schema:PropertyValue
    223 Nf4a8e6aa6d124ef3a9bd142c392453b0 rdf:first sg:person.01133676453.68
    224 rdf:rest Nb861f994ed134a77849f76c9b33e38bf
    225 Nfc50a17e61e346ae8a769fe50ef7e1c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Adult
    227 rdf:type schema:DefinedTerm
    228 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    229 schema:name Medical and Health Sciences
    230 rdf:type schema:DefinedTerm
    231 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Clinical Sciences
    233 rdf:type schema:DefinedTerm
    234 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    235 schema:name Public Health and Health Services
    236 rdf:type schema:DefinedTerm
    237 sg:grant.3938160 http://pending.schema.org/fundedItem sg:pub.10.1038/s41375-018-0089-x
    238 rdf:type schema:MonetaryGrant
    239 sg:grant.6206476 http://pending.schema.org/fundedItem sg:pub.10.1038/s41375-018-0089-x
    240 rdf:type schema:MonetaryGrant
    241 sg:journal.1097065 schema:issn 0887-6924
    242 1476-5551
    243 schema:name Leukemia
    244 schema:publisher Springer Nature
    245 rdf:type schema:Periodical
    246 sg:person.010142003347.01 schema:affiliation grid-institutes:grid.443984.6
    247 schema:familyName Bowen
    248 schema:givenName David
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010142003347.01
    250 rdf:type schema:Person
    251 sg:person.01015422641.43 schema:affiliation grid-institutes:None
    252 schema:familyName Guerci-Bresler
    253 schema:givenName Agnès
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015422641.43
    255 rdf:type schema:Person
    256 sg:person.01015506717.02 schema:affiliation grid-institutes:None
    257 schema:familyName Malcovati
    258 schema:givenName Luca
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015506717.02
    260 rdf:type schema:Person
    261 sg:person.01067020547.55 schema:affiliation grid-institutes:grid.13339.3b
    262 schema:familyName Mądry
    263 schema:givenName Krzysztof
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067020547.55
    265 rdf:type schema:Person
    266 sg:person.01070606157.27 schema:affiliation grid-institutes:grid.5685.e
    267 schema:familyName Smith
    268 schema:givenName Alex
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070606157.27
    270 rdf:type schema:Person
    271 sg:person.01133676453.68 schema:affiliation grid-institutes:grid.5361.1
    272 schema:familyName Koinig
    273 schema:givenName Karin A.
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133676453.68
    275 rdf:type schema:Person
    276 sg:person.01211700172.81 schema:affiliation grid-institutes:grid.415180.9
    277 schema:familyName Tatic
    278 schema:givenName Aurelia
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211700172.81
    280 rdf:type schema:Person
    281 sg:person.01214466573.54 schema:affiliation grid-institutes:grid.5685.e
    282 schema:familyName Yu
    283 schema:givenName Ge
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214466573.54
    285 rdf:type schema:Person
    286 sg:person.01242177302.57 schema:affiliation grid-institutes:grid.154185.c
    287 schema:familyName Holm
    288 schema:givenName Mette Skov
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242177302.57
    290 rdf:type schema:Person
    291 sg:person.012752673175.83 schema:affiliation grid-institutes:grid.10417.33
    292 schema:familyName Droste
    293 schema:givenName Jackie
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012752673175.83
    295 rdf:type schema:Person
    296 sg:person.01306361566.09 schema:affiliation grid-institutes:grid.11047.33
    297 schema:familyName Symeonidis
    298 schema:givenName Argiris
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306361566.09
    300 rdf:type schema:Person
    301 sg:person.01314561674.27 schema:affiliation grid-institutes:grid.428689.9
    302 schema:familyName Efficace
    303 schema:givenName Fabio
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314561674.27
    305 rdf:type schema:Person
    306 sg:person.013151467432.56 schema:affiliation grid-institutes:grid.510933.d
    307 schema:familyName Sanz
    308 schema:givenName Guillermo
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151467432.56
    310 rdf:type schema:Person
    311 sg:person.01362464041.20 schema:affiliation grid-institutes:grid.14778.3d
    312 schema:familyName Germing
    313 schema:givenName Ulrich
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362464041.20
    315 rdf:type schema:Person
    316 sg:person.014765042600.95 schema:affiliation grid-institutes:grid.5685.e
    317 schema:familyName Bagguley
    318 schema:givenName Tim
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014765042600.95
    320 rdf:type schema:Person
    321 sg:person.015730551677.08 schema:affiliation grid-institutes:grid.10417.33
    322 schema:familyName de Witte
    323 schema:givenName Theo
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015730551677.08
    325 rdf:type schema:Person
    326 sg:person.0604661367.35 schema:affiliation grid-institutes:grid.10417.33
    327 schema:familyName van Marrewijk
    328 schema:givenName Corine
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604661367.35
    330 rdf:type schema:Person
    331 sg:person.0617564545.58 schema:affiliation grid-institutes:grid.5361.1
    332 schema:familyName Stauder
    333 schema:givenName Reinhard
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617564545.58
    335 rdf:type schema:Person
    336 sg:person.0624540066.48 schema:affiliation grid-institutes:None
    337 schema:familyName Luño
    338 schema:givenName Elisa
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624540066.48
    340 rdf:type schema:Person
    341 sg:person.0706241721.48 schema:affiliation grid-institutes:grid.12136.37
    342 schema:familyName Mittelman
    343 schema:givenName Moshe
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706241721.48
    345 rdf:type schema:Person
    346 sg:person.0726561165.17 schema:affiliation grid-institutes:grid.419035.a
    347 schema:familyName Cermak
    348 schema:givenName Jaroslav
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726561165.17
    350 rdf:type schema:Person
    351 sg:person.0730110062.04 schema:affiliation grid-institutes:grid.4714.6
    352 schema:familyName Hellström-Lindberg
    353 schema:givenName Eva
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730110062.04
    355 rdf:type schema:Person
    356 sg:person.0763175413.12 schema:affiliation grid-institutes:grid.10822.39
    357 schema:familyName Savic
    358 schema:givenName Aleksandar
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763175413.12
    360 rdf:type schema:Person
    361 sg:person.0766554473.71 schema:affiliation grid-institutes:grid.413328.f
    362 schema:familyName Fenaux
    363 schema:givenName Pierre
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766554473.71
    365 rdf:type schema:Person
    366 sg:person.0775423370.22 schema:affiliation grid-institutes:grid.10417.33
    367 schema:familyName Langemeijer
    368 schema:givenName Saskia
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775423370.22
    370 rdf:type schema:Person
    371 sg:pub.10.1007/s00277-013-2001-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015118319
    372 https://doi.org/10.1007/s00277-013-2001-0
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1007/s00520-016-3344-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013330660
    375 https://doi.org/10.1007/s00520-016-3344-6
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1007/s10198-003-0182-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047715908
    378 https://doi.org/10.1007/s10198-003-0182-5
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1007/s11136-005-8028-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032800504
    381 https://doi.org/10.1007/s11136-005-8028-5
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1007/s11899-016-0343-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000747881
    384 https://doi.org/10.1007/s11899-016-0343-0
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1007/s11899-017-0406-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1091238232
    387 https://doi.org/10.1007/s11899-017-0406-x
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1007/s40266-015-0312-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034409804
    390 https://doi.org/10.1007/s40266-015-0312-7
    391 rdf:type schema:CreativeWork
    392 grid-institutes:None schema:alternateName Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    393 Service d’Hématologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy, France
    394 Servicio d’Hematología, Servicio de Salud del Principado de Asturias Oviedo, Oviedo, Spain
    395 schema:name Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    396 Service d’Hématologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy, France
    397 Servicio d’Hematología, Servicio de Salud del Principado de Asturias Oviedo, Oviedo, Spain
    398 rdf:type schema:Organization
    399 grid-institutes:grid.10417.33 schema:alternateName Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
    400 Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands
    401 schema:name Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
    402 Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands
    403 rdf:type schema:Organization
    404 grid-institutes:grid.10822.39 schema:alternateName Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia
    405 schema:name Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia
    406 rdf:type schema:Organization
    407 grid-institutes:grid.11047.33 schema:alternateName Department of Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece
    408 schema:name Department of Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece
    409 rdf:type schema:Organization
    410 grid-institutes:grid.12136.37 schema:alternateName Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel
    411 schema:name Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel
    412 rdf:type schema:Organization
    413 grid-institutes:grid.13339.3b schema:alternateName Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland
    414 schema:name Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland
    415 rdf:type schema:Organization
    416 grid-institutes:grid.14778.3d schema:alternateName Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany
    417 schema:name Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany
    418 rdf:type schema:Organization
    419 grid-institutes:grid.154185.c schema:alternateName Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
    420 schema:name Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
    421 rdf:type schema:Organization
    422 grid-institutes:grid.413328.f schema:alternateName Service d’Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris, France
    423 schema:name Service d’Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris, France
    424 rdf:type schema:Organization
    425 grid-institutes:grid.415180.9 schema:alternateName Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania
    426 schema:name Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania
    427 rdf:type schema:Organization
    428 grid-institutes:grid.419035.a schema:alternateName Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha, Czech Republic
    429 schema:name Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha, Czech Republic
    430 rdf:type schema:Organization
    431 grid-institutes:grid.428689.9 schema:alternateName Fondazione GIMEMA Onlus, Rome, Italy
    432 schema:name Fondazione GIMEMA Onlus, Rome, Italy
    433 rdf:type schema:Organization
    434 grid-institutes:grid.443984.6 schema:alternateName St. James’s Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom
    435 schema:name St. James’s Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom
    436 rdf:type schema:Organization
    437 grid-institutes:grid.4714.6 schema:alternateName Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden
    438 schema:name Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden
    439 rdf:type schema:Organization
    440 grid-institutes:grid.510933.d schema:alternateName CIBERONC, Instituto Carlos III, Madrid, Spain
    441 schema:name CIBERONC, Instituto Carlos III, Madrid, Spain
    442 Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
    443 rdf:type schema:Organization
    444 grid-institutes:grid.5361.1 schema:alternateName Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria
    445 schema:name Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria
    446 rdf:type schema:Organization
    447 grid-institutes:grid.5685.e schema:alternateName Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom
    448 schema:name Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom
    449 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...