The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Fei Fei, Jie Qu, Kai Liu, Chunyuan Li, Xinlu Wang, Yuwei Li, Shiwu Zhang

ABSTRACT

Polyploid giant cancer cells (PGCCs) are key contributors to cancer heterogeneity, and the formation of PGCCs is associated with changes in the expression of cell-cycle-related proteins. This study investigated the intracellular localization and expression level of multiple cell-cycle-related proteins in PGCCs derived from BT-549 and HEY cells. In addition, the formation of PGCCs and the clinicopathological significance of cell-cycle-related proteins in human breast and ovarian cancer were examined. The expression levels of cell-cycle-related proteins, including cyclin B1, CDC25B, CDC25C, and other cell cycle phosphoproteins, including Chk2, and Aurora-A kinase, were determined using immunostaining and western blotting both in vitro and in vivo. Migration, invasion, and proliferation in control cells, cyclin B1 knockdown cells and their PGCCs following CoCl2 treatment were compared. In addition, human breast and ovarian cancer samples were collected to determine the correlation of number of PGCCs, expression of cell-cycle-related proteins, and tumor pathologic grade and metastasis. Our results confirm that cyclin B1 was localized in the cytoplasm of PGCCs and in the nuclei of their budding daughter cells. The phosphorylated proteins Chk2 and Aurora-A kinase regulated the expression and subcellular localization of cyclin B1, CDC25B, and CDC25C. The rate of positive cytoplasmic staining of cyclin B1 and positive nuclear staining of both CDC25B and CDC25C increased with increase in tumor grade and lymph node metastasis. Cell-cycle-related proteins, including cyclin B1, CDC25B, and CDC25C play an important role in regulating the formation of PGCCs. The inhibition of cyclinB1 and CoCl2 treatment significantly promoted cell proliferation, invasion, and migration abilities. The subcellular localization of these cell-cycle-related proteins was regulated by other cell cycle phosphoproteins, and was associated with pathologic grade and metastasis of tumors in cases of human breast and ovarian cancer. More... »

PAGES

483-498

References to SciGraph publications

  • 2002-04. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation in NATURE GENETICS
  • 2007-07. CDC25 phosphatases in cancer cells: key players? Good targets? in NATURE REVIEWS CANCER
  • 2016-05. Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategies in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2010-12. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes in BMC CANCER
  • 2014-12. Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor in BMC CANCER
  • 2014-01. Generation of cancer stem-like cells through the formation of polyploid giant cancer cells in ONCOGENE
  • 2016-12. Linking genomic reorganization to tumor initiation via the giant cell cycle in ONCOGENESIS
  • 2010-09. Cancer and metastasis: prevention and treatment by green tea in CANCER AND METASTASIS REVIEWS
  • 2010-10. The ploidy conveyor of mature hepatocytes as a source of genetic variation in NATURE
  • 2011-09. Illicit survival of cancer cells during polyploidization and depolyploidization in CELL DEATH & DIFFERENTIATION
  • 2015-12. The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2009-07. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41374-018-0157-x

    DOI

    http://dx.doi.org/10.1038/s41374-018-0157-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110262573

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30487595


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Tianjin People's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417031.0", 
              "name": [
                "Nankai University School of Medicine, Nankai University, 300071, Tianjin, China", 
                "Departments of Pathology, Tianjin Union Medical Center, 300121, Tianjin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fei", 
            "givenName": "Fei", 
            "id": "sg:person.01200261600.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200261600.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tianjin People's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417031.0", 
              "name": [
                "Nankai University School of Medicine, Nankai University, 300071, Tianjin, China", 
                "Departments of Pathology, Tianjin Union Medical Center, 300121, Tianjin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qu", 
            "givenName": "Jie", 
            "id": "sg:person.010033305663.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010033305663.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tianjin Medical University", 
              "id": "https://www.grid.ac/institutes/grid.265021.2", 
              "name": [
                "Tianjin Medical University, 300070, Tianjin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Kai", 
            "id": "sg:person.011327214310.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011327214310.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tianjin People's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417031.0", 
              "name": [
                "Nankai University School of Medicine, Nankai University, 300071, Tianjin, China", 
                "Departments of Pathology, Tianjin Union Medical Center, 300121, Tianjin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Chunyuan", 
            "id": "sg:person.014623503212.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014623503212.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tianjin University of Traditional Chinese Medicine", 
              "id": "https://www.grid.ac/institutes/grid.410648.f", 
              "name": [
                "Departments of Pathology, Tianjin Union Medical Center, 300121, Tianjin, China", 
                "Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Xinlu", 
            "id": "sg:person.015421063612.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015421063612.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tianjin People's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417031.0", 
              "name": [
                "Departments of Colorectal Surgery, Tianjin Union Medical Center, 300121, Tianjin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Yuwei", 
            "id": "sg:person.07746375757.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07746375757.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tianjin People's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417031.0", 
              "name": [
                "Departments of Pathology, Tianjin Union Medical Center, 300121, Tianjin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Shiwu", 
            "id": "sg:person.01270566675.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270566675.99"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.3390/molecules191118414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001628540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules191118414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001628540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdf567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003738329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.133009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005330617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.080531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006597346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0080120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007340205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.21.12.3853-3861.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008367048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopha.2011.11.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009105279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.28319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010603647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.150524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010977294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2012.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012197012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/153303460600500604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012379876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/153303460600500604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012379876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-0520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013508887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/oncsis.2016.75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013680401", 
              "https://doi.org/10.1038/oncsis.2016.75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2015.12.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014078326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.7.2853-2860.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016711176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018711247", 
              "https://doi.org/10.1038/ng856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018711247", 
              "https://doi.org/10.1038/ng856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2008.12.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018999504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13046-015-0277-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022196580", 
              "https://doi.org/10.1186/s13046-015-0277-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.8.4344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022314532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2007.00444.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024104264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024297992", 
              "https://doi.org/10.1038/nrm2718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.55.1.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025521803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(00)00149-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025916982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1157425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026318844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2007.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028304774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.13653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029452377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2010.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030447913", 
              "https://doi.org/10.1038/cdd.2010.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2013.11.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033181262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2015.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034005105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.096552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035379384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1535370216670541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038040759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1535370216670541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038040759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/903542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038489727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-0142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039150346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-5983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040617780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.01108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041843879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042078995", 
              "https://doi.org/10.1186/1471-2407-10-233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-010-9236-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043140649", 
              "https://doi.org/10.1007/s10555-010-9236-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-010-9236-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043140649", 
              "https://doi.org/10.1007/s10555-010-9236-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-016-2693-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043599882", 
              "https://doi.org/10.1007/s11010-016-2693-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044509580", 
              "https://doi.org/10.1038/nature09414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044509580", 
              "https://doi.org/10.1038/nature09414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2011.05.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044529571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046771246", 
              "https://doi.org/10.1038/nrc2169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/432652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046926458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048814522", 
              "https://doi.org/10.1186/1471-2407-14-576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(99)80308-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049830453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050450019", 
              "https://doi.org/10.1038/onc.2013.318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/187152008786847756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069218241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/187152012800617678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069218524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2016.6072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071524732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/15384101.2015.945831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072288318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.4.9.1964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072298383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.5.21.3435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072298700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.4.7846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1994.tb06750.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082397652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1995.tb07153.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082486588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/jca.17012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084002476"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04", 
        "datePublishedReg": "2019-04-01", 
        "description": "Polyploid giant cancer cells (PGCCs) are key contributors to cancer heterogeneity, and the formation of PGCCs is associated with changes in the expression of cell-cycle-related proteins. This study investigated the intracellular localization and expression level of multiple cell-cycle-related proteins in PGCCs derived from BT-549 and HEY cells. In addition, the formation of PGCCs and the clinicopathological significance of cell-cycle-related proteins in human breast and ovarian cancer were examined. The expression levels of cell-cycle-related proteins, including cyclin B1, CDC25B, CDC25C, and other cell cycle phosphoproteins, including Chk2, and Aurora-A kinase, were determined using immunostaining and western blotting both in vitro and in vivo. Migration, invasion, and proliferation in control cells, cyclin B1 knockdown cells and their PGCCs following CoCl2 treatment were compared. In addition, human breast and ovarian cancer samples were collected to determine the correlation of number of PGCCs, expression of cell-cycle-related proteins, and tumor pathologic grade and metastasis. Our results confirm that cyclin B1 was localized in the cytoplasm of PGCCs and in the nuclei of their budding daughter cells. The phosphorylated proteins Chk2 and Aurora-A kinase regulated the expression and subcellular localization of cyclin B1, CDC25B, and CDC25C. The rate of positive cytoplasmic staining of cyclin B1 and positive nuclear staining of both CDC25B and CDC25C increased with increase in tumor grade and lymph node metastasis. Cell-cycle-related proteins, including cyclin B1, CDC25B, and CDC25C play an important role in regulating the formation of PGCCs. The inhibition of cyclinB1 and CoCl2 treatment significantly promoted cell proliferation, invasion, and migration abilities. The subcellular localization of these cell-cycle-related proteins was regulated by other cell cycle phosphoproteins, and was associated with pathologic grade and metastasis of tumors in cases of human breast and ovarian cancer.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41374-018-0157-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1017964", 
            "issn": [
              "0023-6837", 
              "1530-0307"
            ], 
            "name": "Laboratory Investigation", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "99"
          }
        ], 
        "name": "The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance", 
        "pagination": "483-498", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d01350defa2b3e5932ae7c03e8a314163997caa603a640d276d2433ae8dcaeda"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30487595"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0376617"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41374-018-0157-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110262573"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41374-018-0157-x", 
          "https://app.dimensions.ai/details/publication/pub.1110262573"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000366_0000000366/records_112036_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41374-018-0157-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0157-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0157-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0157-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0157-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    297 TRIPLES      21 PREDICATES      84 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41374-018-0157-x schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author Naf0eaae638f34c02b0fbf3fbfa5053f9
    4 schema:citation sg:pub.10.1007/s10555-010-9236-1
    5 sg:pub.10.1007/s11010-016-2693-2
    6 sg:pub.10.1038/cdd.2010.145
    7 sg:pub.10.1038/nature09414
    8 sg:pub.10.1038/ng856
    9 sg:pub.10.1038/nrc2169
    10 sg:pub.10.1038/nrm2718
    11 sg:pub.10.1038/onc.2013.318
    12 sg:pub.10.1038/oncsis.2016.75
    13 sg:pub.10.1186/1471-2407-10-233
    14 sg:pub.10.1186/1471-2407-14-576
    15 sg:pub.10.1186/s13046-015-0277-8
    16 https://doi.org/10.1002/ijc.28319
    17 https://doi.org/10.1002/j.1460-2075.1994.tb06750.x
    18 https://doi.org/10.1002/j.1460-2075.1995.tb07153.x
    19 https://doi.org/10.1016/j.bbamcr.2008.12.015
    20 https://doi.org/10.1016/j.bbrc.2011.05.110
    21 https://doi.org/10.1016/j.biopha.2011.11.016
    22 https://doi.org/10.1016/j.canlet.2012.08.004
    23 https://doi.org/10.1016/j.molonc.2015.12.015
    24 https://doi.org/10.1016/j.stemcr.2013.11.009
    25 https://doi.org/10.1016/j.tig.2007.11.006
    26 https://doi.org/10.1016/j.tig.2015.03.011
    27 https://doi.org/10.1016/s0955-0674(00)00149-6
    28 https://doi.org/10.1016/s0960-9822(99)80308-x
    29 https://doi.org/10.1073/pnas.95.8.4344
    30 https://doi.org/10.1074/jbc.m109.096552
    31 https://doi.org/10.1074/jbc.m110.133009
    32 https://doi.org/10.1074/jbc.m110.150524
    33 https://doi.org/10.1093/emboj/cdf567
    34 https://doi.org/10.1111/j.1349-7006.2007.00444.x
    35 https://doi.org/10.1126/science.1157425
    36 https://doi.org/10.1128/mcb.21.12.3853-3861.2001
    37 https://doi.org/10.1128/mcb.25.7.2853-2860.2005
    38 https://doi.org/10.1136/jcp.55.1.27
    39 https://doi.org/10.1155/2014/432652
    40 https://doi.org/10.1155/2014/903542
    41 https://doi.org/10.1158/0008-5472.can-07-5983
    42 https://doi.org/10.1158/0008-5472.can-09-0142
    43 https://doi.org/10.1158/1078-0432.ccr-08-0520
    44 https://doi.org/10.1177/153303460600500604
    45 https://doi.org/10.1177/1535370216670541
    46 https://doi.org/10.1242/dev.080531
    47 https://doi.org/10.1242/jcs.01108
    48 https://doi.org/10.1371/journal.pone.0080120
    49 https://doi.org/10.18632/oncotarget.13653
    50 https://doi.org/10.2174/187152008786847756
    51 https://doi.org/10.2174/187152012800617678
    52 https://doi.org/10.3390/molecules191118414
    53 https://doi.org/10.3892/mmr.2016.6072
    54 https://doi.org/10.4161/15384101.2015.945831
    55 https://doi.org/10.4161/cc.4.9.1964
    56 https://doi.org/10.4161/cc.5.21.3435
    57 https://doi.org/10.4161/cc.8.4.7846
    58 https://doi.org/10.7150/jca.17012
    59 schema:datePublished 2019-04
    60 schema:datePublishedReg 2019-04-01
    61 schema:description Polyploid giant cancer cells (PGCCs) are key contributors to cancer heterogeneity, and the formation of PGCCs is associated with changes in the expression of cell-cycle-related proteins. This study investigated the intracellular localization and expression level of multiple cell-cycle-related proteins in PGCCs derived from BT-549 and HEY cells. In addition, the formation of PGCCs and the clinicopathological significance of cell-cycle-related proteins in human breast and ovarian cancer were examined. The expression levels of cell-cycle-related proteins, including cyclin B1, CDC25B, CDC25C, and other cell cycle phosphoproteins, including Chk2, and Aurora-A kinase, were determined using immunostaining and western blotting both in vitro and in vivo. Migration, invasion, and proliferation in control cells, cyclin B1 knockdown cells and their PGCCs following CoCl<sub>2</sub> treatment were compared. In addition, human breast and ovarian cancer samples were collected to determine the correlation of number of PGCCs, expression of cell-cycle-related proteins, and tumor pathologic grade and metastasis. Our results confirm that cyclin B1 was localized in the cytoplasm of PGCCs and in the nuclei of their budding daughter cells. The phosphorylated proteins Chk2 and Aurora-A kinase regulated the expression and subcellular localization of cyclin B1, CDC25B, and CDC25C. The rate of positive cytoplasmic staining of cyclin B1 and positive nuclear staining of both CDC25B and CDC25C increased with increase in tumor grade and lymph node metastasis. Cell-cycle-related proteins, including cyclin B1, CDC25B, and CDC25C play an important role in regulating the formation of PGCCs. The inhibition of cyclinB1 and CoCl<sub>2</sub> treatment significantly promoted cell proliferation, invasion, and migration abilities. The subcellular localization of these cell-cycle-related proteins was regulated by other cell cycle phosphoproteins, and was associated with pathologic grade and metastasis of tumors in cases of human breast and ovarian cancer.
    62 schema:genre research_article
    63 schema:inLanguage en
    64 schema:isAccessibleForFree false
    65 schema:isPartOf N36fb158685444dabbbdbe7aba34aa35a
    66 N87d16e0a9cac48b7b03dc0c8c89b5320
    67 sg:journal.1017964
    68 schema:name The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance
    69 schema:pagination 483-498
    70 schema:productId N38c4e2afcf5c4411aa22d9bbf5a82182
    71 N5faf1fc1c13346e3a966909893f8d5e9
    72 N6c6000214aa54ec9ad6c9e5f55f208a3
    73 N959463b5af3540e2a0e8a8ed66fe05dd
    74 Nce373aea8c464e2cb020d5a4ad0dc4e2
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110262573
    76 https://doi.org/10.1038/s41374-018-0157-x
    77 schema:sdDatePublished 2019-04-11T13:04
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher Nef4253838c384e51ac4fe25f688a33fc
    80 schema:url https://www.nature.com/articles/s41374-018-0157-x
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N0e83e5ee3d494aeda3400c821d9ad0d0 rdf:first sg:person.014623503212.43
    85 rdf:rest N91bc1a85aaf04f60b12613253abbd815
    86 N2b82b0a43ace4abf8680ed5c56faa830 rdf:first sg:person.011327214310.39
    87 rdf:rest N0e83e5ee3d494aeda3400c821d9ad0d0
    88 N36fb158685444dabbbdbe7aba34aa35a schema:issueNumber 4
    89 rdf:type schema:PublicationIssue
    90 N38c4e2afcf5c4411aa22d9bbf5a82182 schema:name readcube_id
    91 schema:value d01350defa2b3e5932ae7c03e8a314163997caa603a640d276d2433ae8dcaeda
    92 rdf:type schema:PropertyValue
    93 N5faf1fc1c13346e3a966909893f8d5e9 schema:name nlm_unique_id
    94 schema:value 0376617
    95 rdf:type schema:PropertyValue
    96 N60bcd3b08fe6467282e20857aff3dfc5 rdf:first sg:person.07746375757.44
    97 rdf:rest Nfd39745650294f3ba2b3706f85dac50c
    98 N6c6000214aa54ec9ad6c9e5f55f208a3 schema:name pubmed_id
    99 schema:value 30487595
    100 rdf:type schema:PropertyValue
    101 N7e28e85a297e4207865627be15610b00 rdf:first sg:person.010033305663.03
    102 rdf:rest N2b82b0a43ace4abf8680ed5c56faa830
    103 N87d16e0a9cac48b7b03dc0c8c89b5320 schema:volumeNumber 99
    104 rdf:type schema:PublicationVolume
    105 N91bc1a85aaf04f60b12613253abbd815 rdf:first sg:person.015421063612.23
    106 rdf:rest N60bcd3b08fe6467282e20857aff3dfc5
    107 N959463b5af3540e2a0e8a8ed66fe05dd schema:name doi
    108 schema:value 10.1038/s41374-018-0157-x
    109 rdf:type schema:PropertyValue
    110 Naf0eaae638f34c02b0fbf3fbfa5053f9 rdf:first sg:person.01200261600.17
    111 rdf:rest N7e28e85a297e4207865627be15610b00
    112 Nce373aea8c464e2cb020d5a4ad0dc4e2 schema:name dimensions_id
    113 schema:value pub.1110262573
    114 rdf:type schema:PropertyValue
    115 Nef4253838c384e51ac4fe25f688a33fc schema:name Springer Nature - SN SciGraph project
    116 rdf:type schema:Organization
    117 Nfd39745650294f3ba2b3706f85dac50c rdf:first sg:person.01270566675.99
    118 rdf:rest rdf:nil
    119 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    120 schema:name Medical and Health Sciences
    121 rdf:type schema:DefinedTerm
    122 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    123 schema:name Oncology and Carcinogenesis
    124 rdf:type schema:DefinedTerm
    125 sg:journal.1017964 schema:issn 0023-6837
    126 1530-0307
    127 schema:name Laboratory Investigation
    128 rdf:type schema:Periodical
    129 sg:person.010033305663.03 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
    130 schema:familyName Qu
    131 schema:givenName Jie
    132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010033305663.03
    133 rdf:type schema:Person
    134 sg:person.011327214310.39 schema:affiliation https://www.grid.ac/institutes/grid.265021.2
    135 schema:familyName Liu
    136 schema:givenName Kai
    137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011327214310.39
    138 rdf:type schema:Person
    139 sg:person.01200261600.17 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
    140 schema:familyName Fei
    141 schema:givenName Fei
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200261600.17
    143 rdf:type schema:Person
    144 sg:person.01270566675.99 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
    145 schema:familyName Zhang
    146 schema:givenName Shiwu
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270566675.99
    148 rdf:type schema:Person
    149 sg:person.014623503212.43 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
    150 schema:familyName Li
    151 schema:givenName Chunyuan
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014623503212.43
    153 rdf:type schema:Person
    154 sg:person.015421063612.23 schema:affiliation https://www.grid.ac/institutes/grid.410648.f
    155 schema:familyName Wang
    156 schema:givenName Xinlu
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015421063612.23
    158 rdf:type schema:Person
    159 sg:person.07746375757.44 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
    160 schema:familyName Li
    161 schema:givenName Yuwei
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07746375757.44
    163 rdf:type schema:Person
    164 sg:pub.10.1007/s10555-010-9236-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043140649
    165 https://doi.org/10.1007/s10555-010-9236-1
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1007/s11010-016-2693-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043599882
    168 https://doi.org/10.1007/s11010-016-2693-2
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1038/cdd.2010.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030447913
    171 https://doi.org/10.1038/cdd.2010.145
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1038/nature09414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044509580
    174 https://doi.org/10.1038/nature09414
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1038/ng856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018711247
    177 https://doi.org/10.1038/ng856
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1038/nrc2169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046771246
    180 https://doi.org/10.1038/nrc2169
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1038/nrm2718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024297992
    183 https://doi.org/10.1038/nrm2718
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1038/onc.2013.318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050450019
    186 https://doi.org/10.1038/onc.2013.318
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/oncsis.2016.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013680401
    189 https://doi.org/10.1038/oncsis.2016.75
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1186/1471-2407-10-233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042078995
    192 https://doi.org/10.1186/1471-2407-10-233
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1186/1471-2407-14-576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048814522
    195 https://doi.org/10.1186/1471-2407-14-576
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1186/s13046-015-0277-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022196580
    198 https://doi.org/10.1186/s13046-015-0277-8
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1002/ijc.28319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010603647
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1002/j.1460-2075.1994.tb06750.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082397652
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1002/j.1460-2075.1995.tb07153.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082486588
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.bbamcr.2008.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018999504
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.bbrc.2011.05.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044529571
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.biopha.2011.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009105279
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.canlet.2012.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012197012
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/j.molonc.2015.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014078326
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/j.stemcr.2013.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033181262
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/j.tig.2007.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028304774
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/j.tig.2015.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034005105
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/s0955-0674(00)00149-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025916982
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/s0960-9822(99)80308-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049830453
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1073/pnas.95.8.4344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022314532
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1074/jbc.m109.096552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035379384
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1074/jbc.m110.133009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005330617
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1074/jbc.m110.150524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010977294
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1093/emboj/cdf567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003738329
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1111/j.1349-7006.2007.00444.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024104264
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1126/science.1157425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026318844
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1128/mcb.21.12.3853-3861.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008367048
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1128/mcb.25.7.2853-2860.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016711176
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1136/jcp.55.1.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025521803
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1155/2014/432652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046926458
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1155/2014/903542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038489727
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1158/0008-5472.can-07-5983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040617780
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1158/0008-5472.can-09-0142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039150346
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1158/1078-0432.ccr-08-0520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013508887
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1177/153303460600500604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012379876
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1177/1535370216670541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038040759
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1242/dev.080531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006597346
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1242/jcs.01108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041843879
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1371/journal.pone.0080120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007340205
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.18632/oncotarget.13653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029452377
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.2174/187152008786847756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069218241
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.2174/187152012800617678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069218524
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.3390/molecules191118414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001628540
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.3892/mmr.2016.6072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071524732
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.4161/15384101.2015.945831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072288318
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.4161/cc.4.9.1964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298383
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.4161/cc.5.21.3435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298700
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.4161/cc.8.4.7846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300575
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.7150/jca.17012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084002476
    285 rdf:type schema:CreativeWork
    286 https://www.grid.ac/institutes/grid.265021.2 schema:alternateName Tianjin Medical University
    287 schema:name Tianjin Medical University, 300070, Tianjin, China
    288 rdf:type schema:Organization
    289 https://www.grid.ac/institutes/grid.410648.f schema:alternateName Tianjin University of Traditional Chinese Medicine
    290 schema:name Departments of Pathology, Tianjin Union Medical Center, 300121, Tianjin, China
    291 Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China
    292 rdf:type schema:Organization
    293 https://www.grid.ac/institutes/grid.417031.0 schema:alternateName Tianjin People's Hospital
    294 schema:name Departments of Colorectal Surgery, Tianjin Union Medical Center, 300121, Tianjin, China
    295 Departments of Pathology, Tianjin Union Medical Center, 300121, Tianjin, China
    296 Nankai University School of Medicine, Nankai University, 300071, Tianjin, China
    297 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...