BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10-23

AUTHORS

Jing Cui, Wenwen Zhang, Enyi Huang, Jia Wang, Junyi Liao, Ruidong Li, Xinyi Yu, Chen Zhao, Zongyue Zeng, Yi Shu, Ruyi Zhang, Shujuan Yan, Jiayan Lei, Chao Yang, Ke Wu, Ying Wu, Shifeng Huang, Xiaojuan Ji, Alexander Li, Cheng Gong, Chengfu Yuan, Linghuan Zhang, Wei Liu, Bo Huang, Yixiao Feng, Liping An, Bo Zhang, Zhengyu Dai, Yi Shen, Wenping Luo, Xi Wang, Ailong Huang, Hue H. Luu, Russell R. Reid, Jennifer Moriatis Wolf, Gopal Thinakaran, Michael J. Lee, Tong-Chuan He

ABSTRACT

Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into multiple lineages including osteoblastic lineage. Osteogenic differentiation of MSCs is a cascade that recapitulates most, if not all, of the molecular events occurring during embryonic skeletal development, which is regulated by numerous signaling pathways including bone morphogenetic proteins (BMPs). Through a comprehensive analysis of the osteogenic activity, we previously demonstrated that BMP9 is the most potent BMP for inducing bone formation from MSCs both in vitro and in vivo. However, as one of the least studied BMPs, the essential mediators of BMP9-induced osteogenic signaling remain elusive. Here we show that BMP9-induced osteogenic signaling in MSCs requires intact Notch signaling. While the expression of Notch receptors and ligands are readily detectable in MSCs, Notch inhibitor and dominant-negative Notch1 effectively inhibit BMP9-induced osteogenic differentiation in vitro and ectopic bone formation in vivo. Genetic disruption of Notch pathway severely impairs BMP9-induced osteogenic differentiation and ectopic bone formation from MSCs. Furthermore, while BMP9-induced expression of early-responsive genes is not affected by defective Notch signaling, BMP9 upregulates the expression of Notch receptors and ligands at the intermediate stage of osteogenic differentiation. Taken together, these results demonstrate that Notch signaling may play an essential role in coordinating BMP9-induced osteogenic differentiation of MSCs. More... »

PAGES

1-14

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41374-018-0087-7

DOI

http://dx.doi.org/10.1038/s41374-018-0087-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107793852

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30353129


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China", 
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cui", 
        "givenName": "Jing", 
        "id": "sg:person.01253340340.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253340340.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Stem Cell Research Laboratory, Department of Obstetrics and Gynecology, the Affiliated University-Town Hospital, Chongqing Medical University, 401331, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Wenwen", 
        "id": "sg:person.010537634617.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010537634617.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Enyi", 
        "id": "sg:person.01227572424.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227572424.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Stem Cell Research Laboratory, Department of Obstetrics and Gynecology, the Affiliated University-Town Hospital, Chongqing Medical University, 401331, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Jia", 
        "id": "sg:person.014104247573.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104247573.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liao", 
        "givenName": "Junyi", 
        "id": "sg:person.01060631171.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060631171.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Ruidong", 
        "id": "sg:person.0630135626.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630135626.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Xinyi", 
        "id": "sg:person.016036524775.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016036524775.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Chen", 
        "id": "sg:person.01231200324.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231200324.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeng", 
        "givenName": "Zongyue", 
        "id": "sg:person.01232371311.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232371311.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shu", 
        "givenName": "Yi", 
        "id": "sg:person.016344161513.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016344161513.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Ruyi", 
        "id": "sg:person.0656336530.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656336530.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Shujuan", 
        "id": "sg:person.01323210363.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323210363.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lei", 
        "givenName": "Jiayan", 
        "id": "sg:person.01234625115.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234625115.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Chao", 
        "id": "sg:person.010553113017.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010553113017.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Ke", 
        "id": "sg:person.011350473417.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011350473417.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beijing University of Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.24695.3c", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Department of Immunology and Microbiology, Beijing University of Chinese Medicine, 100029, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Ying", 
        "id": "sg:person.01150053256.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150053256.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Shifeng", 
        "id": "sg:person.0634511134.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634511134.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "Xiaojuan", 
        "id": "sg:person.07644656664.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07644656664.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Alexander", 
        "id": "sg:person.011537342364.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011537342364.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Department of Surgery, the Affiliated Zhongnan Hospital of Wuhan University, 430071, Wuhan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gong", 
        "givenName": "Cheng", 
        "id": "sg:person.010442237264.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010442237264.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "China Three Gorges University", 
          "id": "https://www.grid.ac/institutes/grid.254148.e", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Department of Biochemistry and Molecular Biology, China Three Gorges University School of Medicine, 443002, Yichang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Chengfu", 
        "id": "sg:person.0600010711.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600010711.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Linghuan", 
        "id": "sg:person.012634411446.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012634411446.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Wei", 
        "id": "sg:person.012527070273.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012527070273.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Nanchang University", 
          "id": "https://www.grid.ac/institutes/grid.412455.3", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China", 
            "Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Nanchang University, 330006, Nanchang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Bo", 
        "id": "sg:person.0577403212.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577403212.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Yixiao", 
        "id": "sg:person.0701051051.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701051051.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lanzhou University Second Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411294.b", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Key Laboratory of Orthopaedic Surgery of Gansu Province and the Department of Orthopaedic Surgery, the Second Hospital of Lanzhou University, 730030, Lanzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "An", 
        "givenName": "Liping", 
        "id": "sg:person.0750505222.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750505222.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lanzhou University Second Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411294.b", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Key Laboratory of Orthopaedic Surgery of Gansu Province and the Department of Orthopaedic Surgery, the Second Hospital of Lanzhou University, 730030, Lanzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Bo", 
        "id": "sg:person.015023102264.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015023102264.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Department of Orthopaedic Surgery, Chongqing Hospital of Traditional Chinese Medicine, 400021, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dai", 
        "givenName": "Zhengyu", 
        "id": "sg:person.013465553502.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013465553502.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Department of Orthopaedic Surgery, Xiangya Second Hospital of Central South University, 410011, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Yi", 
        "id": "sg:person.016167132410.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016167132410.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Wenping", 
        "id": "sg:person.0744523120.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744523120.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Chongqing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.412461.4", 
          "name": [
            "Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Ailong", 
        "id": "sg:person.01163316712.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163316712.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luu", 
        "givenName": "Hue H.", 
        "id": "sg:person.01311741573.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311741573.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Department of Surgery, Section of Plastic Surgery, The University of Chicago Medical Center, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reid", 
        "givenName": "Russell R.", 
        "id": "sg:person.0617412056.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617412056.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolf", 
        "givenName": "Jennifer Moriatis", 
        "id": "sg:person.01263475757.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263475757.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Department of Neurobiology, The University of Chicago Medical Center, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thinakaran", 
        "givenName": "Gopal", 
        "id": "sg:person.0630770767.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630770767.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Michael J.", 
        "id": "sg:person.01077105361.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077105361.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA", 
            "Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Tong-Chuan", 
        "id": "sg:person.0733637760.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733637760.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jcb.10744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000263682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000717932", 
          "https://doi.org/10.1038/sj.gt.3302298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000717932", 
          "https://doi.org/10.1038/sj.gt.3302298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000366340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002016948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.130518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003802158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000438591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004317870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000447797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005075873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m801037200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005517791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.34825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006708506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2013.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007897946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008863455", 
          "https://doi.org/10.1038/nprot.2007.135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008863455", 
          "https://doi.org/10.1038/nprot.2007.135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0092908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010652487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.22254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011072105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.22254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011072105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m407810200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013612595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0132666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014251823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2016-1002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015908134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2008.00569.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016774219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2014.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017168566", 
          "https://doi.org/10.1038/gt.2014.40"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2014.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017168566", 
          "https://doi.org/10.1038/gt.2014.40"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.13.1580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017469468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diff.2009.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018025624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.16.1.191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020117978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gendis.2016.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020196995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022753691", 
          "https://doi.org/10.1038/nbt795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022753691", 
          "https://doi.org/10.1038/nbt795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022820444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2014.01.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024551454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024900811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0011917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026300529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gendis.2014.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026965862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0097316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028070260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2014.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030785406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000439268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031855068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m806389200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032167266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2009.02111.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032198773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035430155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.20359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035641784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep17523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037024503", 
          "https://doi.org/10.1038/srep17523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep17523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037024503", 
          "https://doi.org/10.1038/srep17523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gendis.2014.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040210286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.1622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041319437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nbdi.1998.0171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041659737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.284.5411.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0032428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043205997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.1.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044746062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jcmm.12097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045412792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.22427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047190825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.14673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048041102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.14673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048041102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m403344200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048965109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.114231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053163566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20160083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056718110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20160083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056718110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/1748-6041/11/2/025021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059174081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2008.0130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059309858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2013.0580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059310943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5309.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.289.5477.313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062570276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/stke.117pe17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062689434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.136.10.7664647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064279741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-200308000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068895755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156652311795684777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069184635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1568009614666140305105805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069191401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/2819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070914959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078729072", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03401318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078894730", 
          "https://doi.org/10.1007/bf03401318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079338401", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000456885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083530063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.15637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083881929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0172327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084290298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2017.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084537551", 
          "https://doi.org/10.1038/gt.2017.24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000471945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084610057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gendis.2017.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085072653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000475909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085120928"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-10-23", 
    "datePublishedReg": "2018-10-23", 
    "description": "Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into multiple lineages including osteoblastic lineage. Osteogenic differentiation of MSCs is a cascade that recapitulates most, if not all, of the molecular events occurring during embryonic skeletal development, which is regulated by numerous signaling pathways including bone morphogenetic proteins (BMPs). Through a comprehensive analysis of the osteogenic activity, we previously demonstrated that BMP9 is the most potent BMP for inducing bone formation from MSCs both in vitro and in vivo. However, as one of the least studied BMPs, the essential mediators of BMP9-induced osteogenic signaling remain elusive. Here we show that BMP9-induced osteogenic signaling in MSCs requires intact Notch signaling. While the expression of Notch receptors and ligands are readily detectable in MSCs, Notch inhibitor and dominant-negative Notch1 effectively inhibit BMP9-induced osteogenic differentiation in vitro and ectopic bone formation in vivo. Genetic disruption of Notch pathway severely impairs BMP9-induced osteogenic differentiation and ectopic bone formation from MSCs. Furthermore, while BMP9-induced expression of early-responsive genes is not affected by defective Notch signaling, BMP9 upregulates the expression of Notch receptors and ligands at the intermediate stage of osteogenic differentiation. Taken together, these results demonstrate that Notch signaling may play an essential role in coordinating BMP9-induced osteogenic differentiation of MSCs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41374-018-0087-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7519215", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438810", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7209879", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2411554", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705233", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017964", 
        "issn": [
          "0023-6837", 
          "1530-0307"
        ], 
        "name": "Laboratory Investigation", 
        "type": "Periodical"
      }
    ], 
    "name": "BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells", 
    "pagination": "1-14", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ba48b232b3f47a506012c26a40017f2085a727a94d27fa6024787b257eca9f6b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30353129"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0376617"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41374-018-0087-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107793852"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41374-018-0087-7", 
      "https://app.dimensions.ai/details/publication/pub.1107793852"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000570.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41374-018-0087-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0087-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0087-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0087-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0087-7'


 

This table displays all metadata directly associated to this object as RDF triples.

574 TRIPLES      21 PREDICATES      94 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41374-018-0087-7 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Nba7bf60f702d497a81476022aa28e1be
4 schema:citation sg:pub.10.1007/bf03401318
5 sg:pub.10.1038/gt.2014.40
6 sg:pub.10.1038/gt.2017.24
7 sg:pub.10.1038/nbt795
8 sg:pub.10.1038/nprot.2007.135
9 sg:pub.10.1038/sj.gt.3302298
10 sg:pub.10.1038/srep17523
11 https://app.dimensions.ai/details/publication/pub.1078729072
12 https://app.dimensions.ai/details/publication/pub.1079338401
13 https://doi.org/10.1002/jbm.a.34825
14 https://doi.org/10.1002/jbmr.133
15 https://doi.org/10.1002/jbmr.1622
16 https://doi.org/10.1002/jcb.10744
17 https://doi.org/10.1002/jcb.22254
18 https://doi.org/10.1002/jor.20359
19 https://doi.org/10.1002/jor.22427
20 https://doi.org/10.1006/nbdi.1998.0171
21 https://doi.org/10.1016/j.biomaterials.2014.11.007
22 https://doi.org/10.1016/j.bone.2014.01.019
23 https://doi.org/10.1016/j.diff.2009.06.001
24 https://doi.org/10.1016/j.gendis.2014.07.005
25 https://doi.org/10.1016/j.gendis.2014.12.001
26 https://doi.org/10.1016/j.gendis.2016.09.004
27 https://doi.org/10.1016/j.gendis.2017.04.001
28 https://doi.org/10.1016/j.molcel.2013.08.027
29 https://doi.org/10.1016/j.ydbio.2005.05.009
30 https://doi.org/10.1042/bst20160083
31 https://doi.org/10.1074/jbc.m110.130518
32 https://doi.org/10.1074/jbc.m403344200
33 https://doi.org/10.1074/jbc.m407810200
34 https://doi.org/10.1074/jbc.m801037200
35 https://doi.org/10.1074/jbc.m806389200
36 https://doi.org/10.1088/1748-6041/11/2/025021
37 https://doi.org/10.1089/scd.2008.0130
38 https://doi.org/10.1089/scd.2013.0580
39 https://doi.org/10.1101/gad.10.13.1580
40 https://doi.org/10.1111/j.1478-3231.2009.02111.x
41 https://doi.org/10.1111/j.1582-4934.2008.00569.x
42 https://doi.org/10.1111/jcmm.12097
43 https://doi.org/10.1126/science.276.5309.71
44 https://doi.org/10.1126/science.284.5411.143
45 https://doi.org/10.1126/science.289.5477.313
46 https://doi.org/10.1126/stke.117pe17
47 https://doi.org/10.1128/mcb.10.1.28
48 https://doi.org/10.1146/annurev.cellbio.16.1.191
49 https://doi.org/10.1159/000366340
50 https://doi.org/10.1159/000438591
51 https://doi.org/10.1159/000439268
52 https://doi.org/10.1159/000447797
53 https://doi.org/10.1159/000456885
54 https://doi.org/10.1159/000471945
55 https://doi.org/10.1159/000475909
56 https://doi.org/10.1210/endo.136.10.7664647
57 https://doi.org/10.1210/er.2016-1002
58 https://doi.org/10.1242/jcs.114231
59 https://doi.org/10.1371/journal.pone.0011917
60 https://doi.org/10.1371/journal.pone.0032428
61 https://doi.org/10.1371/journal.pone.0092908
62 https://doi.org/10.1371/journal.pone.0097316
63 https://doi.org/10.1371/journal.pone.0132666
64 https://doi.org/10.1371/journal.pone.0172327
65 https://doi.org/10.18632/oncotarget.14673
66 https://doi.org/10.18632/oncotarget.15637
67 https://doi.org/10.18632/oncotarget.6387
68 https://doi.org/10.2106/00004623-200308000-00017
69 https://doi.org/10.2174/156652311795684777
70 https://doi.org/10.2174/1568009614666140305105805
71 https://doi.org/10.2741/2819
72 schema:datePublished 2018-10-23
73 schema:datePublishedReg 2018-10-23
74 schema:description Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into multiple lineages including osteoblastic lineage. Osteogenic differentiation of MSCs is a cascade that recapitulates most, if not all, of the molecular events occurring during embryonic skeletal development, which is regulated by numerous signaling pathways including bone morphogenetic proteins (BMPs). Through a comprehensive analysis of the osteogenic activity, we previously demonstrated that BMP9 is the most potent BMP for inducing bone formation from MSCs both in vitro and in vivo. However, as one of the least studied BMPs, the essential mediators of BMP9-induced osteogenic signaling remain elusive. Here we show that BMP9-induced osteogenic signaling in MSCs requires intact Notch signaling. While the expression of Notch receptors and ligands are readily detectable in MSCs, Notch inhibitor and dominant-negative Notch1 effectively inhibit BMP9-induced osteogenic differentiation in vitro and ectopic bone formation in vivo. Genetic disruption of Notch pathway severely impairs BMP9-induced osteogenic differentiation and ectopic bone formation from MSCs. Furthermore, while BMP9-induced expression of early-responsive genes is not affected by defective Notch signaling, BMP9 upregulates the expression of Notch receptors and ligands at the intermediate stage of osteogenic differentiation. Taken together, these results demonstrate that Notch signaling may play an essential role in coordinating BMP9-induced osteogenic differentiation of MSCs.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree false
78 schema:isPartOf sg:journal.1017964
79 schema:name BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells
80 schema:pagination 1-14
81 schema:productId N8135d709287f4e15a2a834470e8db5b0
82 N8b120d18cf994c1b86c502d1b5131364
83 N9d7413ab82fc4bda97e153ac782d02e1
84 Nb8aad9bb72fa41d690c4a18102271746
85 Ne5951e7218034949a8581ffa4746e2fe
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107793852
87 https://doi.org/10.1038/s41374-018-0087-7
88 schema:sdDatePublished 2019-04-10T21:48
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N35337fe4d7d14a5bba05a89d59623df7
91 schema:url https://www.nature.com/articles/s41374-018-0087-7
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N0588b5e68b7e45e89a2384db19aa8e56 rdf:first sg:person.014104247573.93
96 rdf:rest Nf20f7b7cbac04b8d8a507901106dc9a6
97 N0a34bb2a02f34cf8b3e08eba4c7ec975 rdf:first sg:person.01231200324.17
98 rdf:rest N8e076303b81f4658837f749c65b617bb
99 N0cfee808776d47068f066e2a41cc501a rdf:first sg:person.01323210363.66
100 rdf:rest N9b1f8f98c2b24625b82d5ba4d61bf68b
101 N0d8dbc548f6b4cf79712ad26d904c8be rdf:first sg:person.015023102264.15
102 rdf:rest N0e7066b2466b4e109131d7d4e1bcb025
103 N0d9f44d3603e431a830e2dd785dcdb16 rdf:first sg:person.0701051051.42
104 rdf:rest N541536ef047e4da795fc51c76f90bf6c
105 N0e51999899364505bbb725337ab0e5f7 rdf:first sg:person.011537342364.63
106 rdf:rest Nde52f6d5456845029eae6748eaa59024
107 N0e7066b2466b4e109131d7d4e1bcb025 rdf:first sg:person.013465553502.24
108 rdf:rest Nf390bd99fcfd4a90961bd41d79c95b0e
109 N1223d08145eb4218b4eba065b0d4adfd rdf:first sg:person.01077105361.24
110 rdf:rest Nab229d9b4d3e4e6ab14873d6a46130c9
111 N1282a8588f7c4cd1ba4f4834984cd291 rdf:first sg:person.0630770767.84
112 rdf:rest N1223d08145eb4218b4eba065b0d4adfd
113 N165bf085a26e49a9b3d8b632e965896e rdf:first sg:person.0634511134.93
114 rdf:rest N9743822734904fcc938a8982e8ca6a41
115 N1b0bc2b433894c969441655c225848a8 rdf:first sg:person.010553113017.60
116 rdf:rest N6967721272df413bb5bcee50051c61a9
117 N2689511e72db4222864ee797da70a9e9 rdf:first sg:person.016036524775.97
118 rdf:rest N0a34bb2a02f34cf8b3e08eba4c7ec975
119 N2a13f49e3ca04228b4d2bdf0bcd938ad rdf:first sg:person.0577403212.49
120 rdf:rest N0d9f44d3603e431a830e2dd785dcdb16
121 N2c6562c90c86472aaf1a85f284a1e87e rdf:first sg:person.012527070273.63
122 rdf:rest N2a13f49e3ca04228b4d2bdf0bcd938ad
123 N2ef6d2bb0b3b42b68356e198d1f17344 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
124 schema:familyName Wang
125 schema:givenName Xi
126 rdf:type schema:Person
127 N2f48bf4beaf54724b1ae01afbe22dcbd rdf:first sg:person.01227572424.10
128 rdf:rest N0588b5e68b7e45e89a2384db19aa8e56
129 N35337fe4d7d14a5bba05a89d59623df7 schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 N4a82293467654c998b8190897f9a081e rdf:first sg:person.016344161513.23
132 rdf:rest N9f842d1f7a2241b6a28347663b81466a
133 N53e2f241e6b6408b8a79037bcca71098 rdf:first sg:person.0630135626.60
134 rdf:rest N2689511e72db4222864ee797da70a9e9
135 N541536ef047e4da795fc51c76f90bf6c rdf:first sg:person.0750505222.60
136 rdf:rest N0d8dbc548f6b4cf79712ad26d904c8be
137 N5bcc9aeb2a734c7b92dc84cd3e72f83e rdf:first sg:person.0600010711.11
138 rdf:rest N8bab820f35ef4e788e4397ace2e569e2
139 N69085c69b4304133aa489ea800208970 rdf:first sg:person.0617412056.58
140 rdf:rest Nda278ec8aa8f41709ea75bc36adc9b59
141 N6967721272df413bb5bcee50051c61a9 rdf:first sg:person.011350473417.01
142 rdf:rest N766d6a4e7aa14994b30691fc013a960e
143 N766d6a4e7aa14994b30691fc013a960e rdf:first sg:person.01150053256.44
144 rdf:rest N165bf085a26e49a9b3d8b632e965896e
145 N8135d709287f4e15a2a834470e8db5b0 schema:name doi
146 schema:value 10.1038/s41374-018-0087-7
147 rdf:type schema:PropertyValue
148 N8b120d18cf994c1b86c502d1b5131364 schema:name dimensions_id
149 schema:value pub.1107793852
150 rdf:type schema:PropertyValue
151 N8bab820f35ef4e788e4397ace2e569e2 rdf:first sg:person.012634411446.36
152 rdf:rest N2c6562c90c86472aaf1a85f284a1e87e
153 N8e076303b81f4658837f749c65b617bb rdf:first sg:person.01232371311.85
154 rdf:rest N4a82293467654c998b8190897f9a081e
155 N9743822734904fcc938a8982e8ca6a41 rdf:first sg:person.07644656664.49
156 rdf:rest N0e51999899364505bbb725337ab0e5f7
157 N9b1f8f98c2b24625b82d5ba4d61bf68b rdf:first sg:person.01234625115.28
158 rdf:rest N1b0bc2b433894c969441655c225848a8
159 N9d37e5e2c33f43d089e1be1f425cfc8c rdf:first N2ef6d2bb0b3b42b68356e198d1f17344
160 rdf:rest Ncdde84d16fb04e3b940449b6bb067d70
161 N9d7413ab82fc4bda97e153ac782d02e1 schema:name pubmed_id
162 schema:value 30353129
163 rdf:type schema:PropertyValue
164 N9f842d1f7a2241b6a28347663b81466a rdf:first sg:person.0656336530.45
165 rdf:rest N0cfee808776d47068f066e2a41cc501a
166 Na190f3fd701a46409d9039b15f3a6d34 rdf:first sg:person.01311741573.94
167 rdf:rest N69085c69b4304133aa489ea800208970
168 Nab229d9b4d3e4e6ab14873d6a46130c9 rdf:first sg:person.0733637760.50
169 rdf:rest rdf:nil
170 Nb8aad9bb72fa41d690c4a18102271746 schema:name nlm_unique_id
171 schema:value 0376617
172 rdf:type schema:PropertyValue
173 Nba7bf60f702d497a81476022aa28e1be rdf:first sg:person.01253340340.25
174 rdf:rest Ncc747ab1d08145738321659e13c7b5f6
175 Ncc747ab1d08145738321659e13c7b5f6 rdf:first sg:person.010537634617.23
176 rdf:rest N2f48bf4beaf54724b1ae01afbe22dcbd
177 Ncdde84d16fb04e3b940449b6bb067d70 rdf:first sg:person.01163316712.45
178 rdf:rest Na190f3fd701a46409d9039b15f3a6d34
179 Nd387c85548fb4fd7815e7bdf67f676b5 rdf:first sg:person.0744523120.20
180 rdf:rest N9d37e5e2c33f43d089e1be1f425cfc8c
181 Nda278ec8aa8f41709ea75bc36adc9b59 rdf:first sg:person.01263475757.30
182 rdf:rest N1282a8588f7c4cd1ba4f4834984cd291
183 Nde52f6d5456845029eae6748eaa59024 rdf:first sg:person.010442237264.90
184 rdf:rest N5bcc9aeb2a734c7b92dc84cd3e72f83e
185 Ne5951e7218034949a8581ffa4746e2fe schema:name readcube_id
186 schema:value ba48b232b3f47a506012c26a40017f2085a727a94d27fa6024787b257eca9f6b
187 rdf:type schema:PropertyValue
188 Nf20f7b7cbac04b8d8a507901106dc9a6 rdf:first sg:person.01060631171.17
189 rdf:rest N53e2f241e6b6408b8a79037bcca71098
190 Nf390bd99fcfd4a90961bd41d79c95b0e rdf:first sg:person.016167132410.82
191 rdf:rest Nd387c85548fb4fd7815e7bdf67f676b5
192 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
193 schema:name Biological Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
196 schema:name Genetics
197 rdf:type schema:DefinedTerm
198 sg:grant.2411554 http://pending.schema.org/fundedItem sg:pub.10.1038/s41374-018-0087-7
199 rdf:type schema:MonetaryGrant
200 sg:grant.2438810 http://pending.schema.org/fundedItem sg:pub.10.1038/s41374-018-0087-7
201 rdf:type schema:MonetaryGrant
202 sg:grant.2705233 http://pending.schema.org/fundedItem sg:pub.10.1038/s41374-018-0087-7
203 rdf:type schema:MonetaryGrant
204 sg:grant.7209879 http://pending.schema.org/fundedItem sg:pub.10.1038/s41374-018-0087-7
205 rdf:type schema:MonetaryGrant
206 sg:grant.7519215 http://pending.schema.org/fundedItem sg:pub.10.1038/s41374-018-0087-7
207 rdf:type schema:MonetaryGrant
208 sg:journal.1017964 schema:issn 0023-6837
209 1530-0307
210 schema:name Laboratory Investigation
211 rdf:type schema:Periodical
212 sg:person.010442237264.90 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
213 schema:familyName Gong
214 schema:givenName Cheng
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010442237264.90
216 rdf:type schema:Person
217 sg:person.010537634617.23 schema:affiliation https://www.grid.ac/institutes/grid.203458.8
218 schema:familyName Zhang
219 schema:givenName Wenwen
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010537634617.23
221 rdf:type schema:Person
222 sg:person.010553113017.60 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
223 schema:familyName Yang
224 schema:givenName Chao
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010553113017.60
226 rdf:type schema:Person
227 sg:person.01060631171.17 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
228 schema:familyName Liao
229 schema:givenName Junyi
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060631171.17
231 rdf:type schema:Person
232 sg:person.01077105361.24 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
233 schema:familyName Lee
234 schema:givenName Michael J.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077105361.24
236 rdf:type schema:Person
237 sg:person.011350473417.01 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
238 schema:familyName Wu
239 schema:givenName Ke
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011350473417.01
241 rdf:type schema:Person
242 sg:person.01150053256.44 schema:affiliation https://www.grid.ac/institutes/grid.24695.3c
243 schema:familyName Wu
244 schema:givenName Ying
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150053256.44
246 rdf:type schema:Person
247 sg:person.011537342364.63 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
248 schema:familyName Li
249 schema:givenName Alexander
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011537342364.63
251 rdf:type schema:Person
252 sg:person.01163316712.45 schema:affiliation https://www.grid.ac/institutes/grid.412461.4
253 schema:familyName Huang
254 schema:givenName Ailong
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163316712.45
256 rdf:type schema:Person
257 sg:person.01227572424.10 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
258 schema:familyName Huang
259 schema:givenName Enyi
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227572424.10
261 rdf:type schema:Person
262 sg:person.01231200324.17 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
263 schema:familyName Zhao
264 schema:givenName Chen
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231200324.17
266 rdf:type schema:Person
267 sg:person.01232371311.85 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
268 schema:familyName Zeng
269 schema:givenName Zongyue
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232371311.85
271 rdf:type schema:Person
272 sg:person.01234625115.28 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
273 schema:familyName Lei
274 schema:givenName Jiayan
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234625115.28
276 rdf:type schema:Person
277 sg:person.012527070273.63 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
278 schema:familyName Liu
279 schema:givenName Wei
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012527070273.63
281 rdf:type schema:Person
282 sg:person.01253340340.25 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
283 schema:familyName Cui
284 schema:givenName Jing
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253340340.25
286 rdf:type schema:Person
287 sg:person.012634411446.36 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
288 schema:familyName Zhang
289 schema:givenName Linghuan
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012634411446.36
291 rdf:type schema:Person
292 sg:person.01263475757.30 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
293 schema:familyName Wolf
294 schema:givenName Jennifer Moriatis
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263475757.30
296 rdf:type schema:Person
297 sg:person.01311741573.94 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
298 schema:familyName Luu
299 schema:givenName Hue H.
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311741573.94
301 rdf:type schema:Person
302 sg:person.01323210363.66 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
303 schema:familyName Yan
304 schema:givenName Shujuan
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323210363.66
306 rdf:type schema:Person
307 sg:person.013465553502.24 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
308 schema:familyName Dai
309 schema:givenName Zhengyu
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013465553502.24
311 rdf:type schema:Person
312 sg:person.014104247573.93 schema:affiliation https://www.grid.ac/institutes/grid.203458.8
313 schema:familyName Wang
314 schema:givenName Jia
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104247573.93
316 rdf:type schema:Person
317 sg:person.015023102264.15 schema:affiliation https://www.grid.ac/institutes/grid.411294.b
318 schema:familyName Zhang
319 schema:givenName Bo
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015023102264.15
321 rdf:type schema:Person
322 sg:person.016036524775.97 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
323 schema:familyName Yu
324 schema:givenName Xinyi
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016036524775.97
326 rdf:type schema:Person
327 sg:person.016167132410.82 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
328 schema:familyName Shen
329 schema:givenName Yi
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016167132410.82
331 rdf:type schema:Person
332 sg:person.016344161513.23 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
333 schema:familyName Shu
334 schema:givenName Yi
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016344161513.23
336 rdf:type schema:Person
337 sg:person.0577403212.49 schema:affiliation https://www.grid.ac/institutes/grid.412455.3
338 schema:familyName Huang
339 schema:givenName Bo
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577403212.49
341 rdf:type schema:Person
342 sg:person.0600010711.11 schema:affiliation https://www.grid.ac/institutes/grid.254148.e
343 schema:familyName Yuan
344 schema:givenName Chengfu
345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600010711.11
346 rdf:type schema:Person
347 sg:person.0617412056.58 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
348 schema:familyName Reid
349 schema:givenName Russell R.
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617412056.58
351 rdf:type schema:Person
352 sg:person.0630135626.60 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
353 schema:familyName Li
354 schema:givenName Ruidong
355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630135626.60
356 rdf:type schema:Person
357 sg:person.0630770767.84 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
358 schema:familyName Thinakaran
359 schema:givenName Gopal
360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630770767.84
361 rdf:type schema:Person
362 sg:person.0634511134.93 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
363 schema:familyName Huang
364 schema:givenName Shifeng
365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634511134.93
366 rdf:type schema:Person
367 sg:person.0656336530.45 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
368 schema:familyName Zhang
369 schema:givenName Ruyi
370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656336530.45
371 rdf:type schema:Person
372 sg:person.0701051051.42 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
373 schema:familyName Feng
374 schema:givenName Yixiao
375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701051051.42
376 rdf:type schema:Person
377 sg:person.0733637760.50 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
378 schema:familyName He
379 schema:givenName Tong-Chuan
380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733637760.50
381 rdf:type schema:Person
382 sg:person.0744523120.20 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
383 schema:familyName Luo
384 schema:givenName Wenping
385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744523120.20
386 rdf:type schema:Person
387 sg:person.0750505222.60 schema:affiliation https://www.grid.ac/institutes/grid.411294.b
388 schema:familyName An
389 schema:givenName Liping
390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750505222.60
391 rdf:type schema:Person
392 sg:person.07644656664.49 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
393 schema:familyName Ji
394 schema:givenName Xiaojuan
395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07644656664.49
396 rdf:type schema:Person
397 sg:pub.10.1007/bf03401318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078894730
398 https://doi.org/10.1007/bf03401318
399 rdf:type schema:CreativeWork
400 sg:pub.10.1038/gt.2014.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017168566
401 https://doi.org/10.1038/gt.2014.40
402 rdf:type schema:CreativeWork
403 sg:pub.10.1038/gt.2017.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084537551
404 https://doi.org/10.1038/gt.2017.24
405 rdf:type schema:CreativeWork
406 sg:pub.10.1038/nbt795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022753691
407 https://doi.org/10.1038/nbt795
408 rdf:type schema:CreativeWork
409 sg:pub.10.1038/nprot.2007.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008863455
410 https://doi.org/10.1038/nprot.2007.135
411 rdf:type schema:CreativeWork
412 sg:pub.10.1038/sj.gt.3302298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000717932
413 https://doi.org/10.1038/sj.gt.3302298
414 rdf:type schema:CreativeWork
415 sg:pub.10.1038/srep17523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037024503
416 https://doi.org/10.1038/srep17523
417 rdf:type schema:CreativeWork
418 https://app.dimensions.ai/details/publication/pub.1078729072 schema:CreativeWork
419 https://app.dimensions.ai/details/publication/pub.1079338401 schema:CreativeWork
420 https://doi.org/10.1002/jbm.a.34825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006708506
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1002/jbmr.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022820444
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1002/jbmr.1622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041319437
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1002/jcb.10744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000263682
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1002/jcb.22254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011072105
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1002/jor.20359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035641784
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1002/jor.22427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047190825
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1006/nbdi.1998.0171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041659737
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1016/j.biomaterials.2014.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030785406
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1016/j.bone.2014.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024551454
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1016/j.diff.2009.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018025624
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1016/j.gendis.2014.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026965862
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1016/j.gendis.2014.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040210286
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1016/j.gendis.2016.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020196995
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1016/j.gendis.2017.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085072653
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1016/j.molcel.2013.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007897946
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1016/j.ydbio.2005.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024900811
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1042/bst20160083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056718110
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1074/jbc.m110.130518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003802158
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1074/jbc.m403344200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048965109
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1074/jbc.m407810200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013612595
461 rdf:type schema:CreativeWork
462 https://doi.org/10.1074/jbc.m801037200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005517791
463 rdf:type schema:CreativeWork
464 https://doi.org/10.1074/jbc.m806389200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032167266
465 rdf:type schema:CreativeWork
466 https://doi.org/10.1088/1748-6041/11/2/025021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059174081
467 rdf:type schema:CreativeWork
468 https://doi.org/10.1089/scd.2008.0130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309858
469 rdf:type schema:CreativeWork
470 https://doi.org/10.1089/scd.2013.0580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059310943
471 rdf:type schema:CreativeWork
472 https://doi.org/10.1101/gad.10.13.1580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017469468
473 rdf:type schema:CreativeWork
474 https://doi.org/10.1111/j.1478-3231.2009.02111.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032198773
475 rdf:type schema:CreativeWork
476 https://doi.org/10.1111/j.1582-4934.2008.00569.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016774219
477 rdf:type schema:CreativeWork
478 https://doi.org/10.1111/jcmm.12097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045412792
479 rdf:type schema:CreativeWork
480 https://doi.org/10.1126/science.276.5309.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556263
481 rdf:type schema:CreativeWork
482 https://doi.org/10.1126/science.284.5411.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379237
483 rdf:type schema:CreativeWork
484 https://doi.org/10.1126/science.289.5477.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570276
485 rdf:type schema:CreativeWork
486 https://doi.org/10.1126/stke.117pe17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062689434
487 rdf:type schema:CreativeWork
488 https://doi.org/10.1128/mcb.10.1.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044746062
489 rdf:type schema:CreativeWork
490 https://doi.org/10.1146/annurev.cellbio.16.1.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020117978
491 rdf:type schema:CreativeWork
492 https://doi.org/10.1159/000366340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002016948
493 rdf:type schema:CreativeWork
494 https://doi.org/10.1159/000438591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004317870
495 rdf:type schema:CreativeWork
496 https://doi.org/10.1159/000439268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031855068
497 rdf:type schema:CreativeWork
498 https://doi.org/10.1159/000447797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005075873
499 rdf:type schema:CreativeWork
500 https://doi.org/10.1159/000456885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083530063
501 rdf:type schema:CreativeWork
502 https://doi.org/10.1159/000471945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084610057
503 rdf:type schema:CreativeWork
504 https://doi.org/10.1159/000475909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085120928
505 rdf:type schema:CreativeWork
506 https://doi.org/10.1210/endo.136.10.7664647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064279741
507 rdf:type schema:CreativeWork
508 https://doi.org/10.1210/er.2016-1002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015908134
509 rdf:type schema:CreativeWork
510 https://doi.org/10.1242/jcs.114231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053163566
511 rdf:type schema:CreativeWork
512 https://doi.org/10.1371/journal.pone.0011917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026300529
513 rdf:type schema:CreativeWork
514 https://doi.org/10.1371/journal.pone.0032428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043205997
515 rdf:type schema:CreativeWork
516 https://doi.org/10.1371/journal.pone.0092908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010652487
517 rdf:type schema:CreativeWork
518 https://doi.org/10.1371/journal.pone.0097316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028070260
519 rdf:type schema:CreativeWork
520 https://doi.org/10.1371/journal.pone.0132666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014251823
521 rdf:type schema:CreativeWork
522 https://doi.org/10.1371/journal.pone.0172327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084290298
523 rdf:type schema:CreativeWork
524 https://doi.org/10.18632/oncotarget.14673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048041102
525 rdf:type schema:CreativeWork
526 https://doi.org/10.18632/oncotarget.15637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083881929
527 rdf:type schema:CreativeWork
528 https://doi.org/10.18632/oncotarget.6387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035430155
529 rdf:type schema:CreativeWork
530 https://doi.org/10.2106/00004623-200308000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068895755
531 rdf:type schema:CreativeWork
532 https://doi.org/10.2174/156652311795684777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069184635
533 rdf:type schema:CreativeWork
534 https://doi.org/10.2174/1568009614666140305105805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069191401
535 rdf:type schema:CreativeWork
536 https://doi.org/10.2741/2819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070914959
537 rdf:type schema:CreativeWork
538 https://www.grid.ac/institutes/grid.203458.8 schema:alternateName Chongqing Medical University
539 schema:name Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA
540 Stem Cell Research Laboratory, Department of Obstetrics and Gynecology, the Affiliated University-Town Hospital, Chongqing Medical University, 401331, Chongqing, China
541 rdf:type schema:Organization
542 https://www.grid.ac/institutes/grid.24695.3c schema:alternateName Beijing University of Chinese Medicine
543 schema:name Department of Immunology and Microbiology, Beijing University of Chinese Medicine, 100029, Beijing, China
544 Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA
545 rdf:type schema:Organization
546 https://www.grid.ac/institutes/grid.254148.e schema:alternateName China Three Gorges University
547 schema:name Department of Biochemistry and Molecular Biology, China Three Gorges University School of Medicine, 443002, Yichang, China
548 Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA
549 rdf:type schema:Organization
550 https://www.grid.ac/institutes/grid.411294.b schema:alternateName Lanzhou University Second Hospital
551 schema:name Key Laboratory of Orthopaedic Surgery of Gansu Province and the Department of Orthopaedic Surgery, the Second Hospital of Lanzhou University, 730030, Lanzhou, China
552 Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA
553 rdf:type schema:Organization
554 https://www.grid.ac/institutes/grid.412455.3 schema:alternateName Second Affiliated Hospital of Nanchang University
555 schema:name Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Nanchang University, 330006, Nanchang, China
556 Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China
557 Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA
558 rdf:type schema:Organization
559 https://www.grid.ac/institutes/grid.412461.4 schema:alternateName Second Affiliated Hospital of Chongqing Medical University
560 schema:name Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
561 rdf:type schema:Organization
562 https://www.grid.ac/institutes/grid.412578.d schema:alternateName University of Chicago Medical Center
563 schema:name Department of Neurobiology, The University of Chicago Medical Center, 60637, Chicago, IL, USA
564 Department of Orthopaedic Surgery, Chongqing Hospital of Traditional Chinese Medicine, 400021, Chongqing, China
565 Department of Orthopaedic Surgery, Xiangya Second Hospital of Central South University, 410011, Changsha, China
566 Department of Surgery, Section of Plastic Surgery, The University of Chicago Medical Center, 60637, Chicago, IL, USA
567 Department of Surgery, the Affiliated Zhongnan Hospital of Wuhan University, 430071, Wuhan, China
568 Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
569 Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA
570 rdf:type schema:Organization
571 https://www.grid.ac/institutes/grid.419897.a schema:alternateName Ministry of Education of the People's Republic of China
572 schema:name Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine, and the Affiliated Hospitals of Chongqing Medical University, 400016, Chongqing, China
573 Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, 60637, Chicago, IL, USA
574 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...