S100A4 protects mice from high-fat diet-induced obesity and inflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05-22

AUTHORS

Shasha Hou, Ying Jiao, Qi Yuan, Junfeng Zhai, Tian Tian, Kaiji Sun, Zhinan Chen, Zhenlong Wu, Jinhua Zhang

ABSTRACT

As a member from S100 calcium-binding protein family, S100A4 is ubiquitous and elevated in tumor progression and metastasis, but its role in regulating obesity has not been well characterized. In this study, we showed that S100A4 was mainly expressed by stromal cells in adipose tissue and the S100A4 level in adipose tissue was decreased after high-fat diet (HFD). S100A4 deficient mice exhibited aggravated symptoms of obesity and suppressed insulin signaling after 12 weeks of HFD. Aggravated obesity in S100A4 deficient mice were found to be positively correlated with higher inflammatory status of the liver. Then, we found that extracellular S100A4 or overexpressed S100A4 inhibited adipogenesis and decreased mRNA levels of inflammation gene in 3T3-L1 adipocytes in vitro; whereas small interfering RNA (siRNA)-mediated suppression of S100A4 displayed the opposite results. Additionally, the protective effect induced by S100A4 during HFD-induced obesity was tightly related with activation of Akt signaling in adipose tissues, as well as livers and muscles. Taken together, we demonstrate that S100A4 is an inhibitory factor for obesity and attenuates the inflammatory reaction, while activating the Akt signaling, which suggest that S100A4 is a potential candidate for the treatment of diet-induced obesity and its complications. More... »

PAGES

1025-1038

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41374-018-0067-y

DOI

http://dx.doi.org/10.1038/s41374-018-0067-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104149085

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29789685


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3T3-L1 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet, High-Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "S100 Calcium-Binding Protein A4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China", 
          "id": "http://www.grid.ac/institutes/grid.181531.f", 
          "name": [
            "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hou", 
        "givenName": "Shasha", 
        "id": "sg:person.010026556033.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010026556033.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China", 
          "id": "http://www.grid.ac/institutes/grid.181531.f", 
          "name": [
            "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiao", 
        "givenName": "Ying", 
        "id": "sg:person.015530615533.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015530615533.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China", 
          "id": "http://www.grid.ac/institutes/grid.181531.f", 
          "name": [
            "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Qi", 
        "id": "sg:person.013014460033.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013014460033.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Chinese Academy of Inspection and Quarantine, Beijing, P. R. China", 
          "id": "http://www.grid.ac/institutes/grid.418544.8", 
          "name": [
            "The Chinese Academy of Inspection and Quarantine, Beijing, P. R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhai", 
        "givenName": "Junfeng", 
        "id": "sg:person.01057422157.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057422157.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China", 
          "id": "http://www.grid.ac/institutes/grid.181531.f", 
          "name": [
            "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tian", 
        "givenName": "Tian", 
        "id": "sg:person.0673343734.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673343734.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P. R. China", 
          "id": "http://www.grid.ac/institutes/grid.22935.3f", 
          "name": [
            "The State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P. R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Kaiji", 
        "id": "sg:person.01122432225.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122432225.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Cell Engineering Research Center and Department of Cell Biology, State Key Laboratory of Cancer, Fourth Military Medical University, Xi\u2019an, P. R. China", 
          "id": "http://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China", 
            "The Cell Engineering Research Center and Department of Cell Biology, State Key Laboratory of Cancer, Fourth Military Medical University, Xi\u2019an, P. R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Zhinan", 
        "id": "sg:person.01360725273.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360725273.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P. R. China", 
          "id": "http://www.grid.ac/institutes/grid.22935.3f", 
          "name": [
            "The State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P. R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Zhenlong", 
        "id": "sg:person.0707457671.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707457671.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China", 
          "id": "http://www.grid.ac/institutes/grid.181531.f", 
          "name": [
            "The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jinhua", 
        "id": "sg:person.01124737766.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124737766.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncomms5711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038269899", 
          "https://doi.org/10.1038/ncomms5711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1034-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050803639", 
          "https://doi.org/10.1186/s12885-015-1034-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049110042", 
          "https://doi.org/10.1038/onc.2013.568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2015.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041834955", 
          "https://doi.org/10.1038/nrendo.2015.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014866016", 
          "https://doi.org/10.1038/ncb2211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms2202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008981708", 
          "https://doi.org/10.1038/ncomms2202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034631385", 
          "https://doi.org/10.1038/nature05482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-007-0301-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021186545", 
          "https://doi.org/10.1007/s00109-007-0301-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039565533", 
          "https://doi.org/10.1038/nature07777"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-05-22", 
    "datePublishedReg": "2018-05-22", 
    "description": "As a member from S100 calcium-binding protein family, S100A4 is ubiquitous and elevated in tumor progression and metastasis, but its role in regulating obesity has not been well characterized. In this study, we showed that S100A4 was mainly expressed by stromal cells in adipose tissue and the S100A4 level in adipose tissue was decreased after high-fat diet (HFD). S100A4 deficient mice exhibited aggravated symptoms of obesity and suppressed insulin signaling after 12 weeks of HFD. Aggravated obesity in S100A4 deficient mice were found to be positively correlated with higher inflammatory status of the liver. Then, we found that extracellular S100A4 or overexpressed S100A4 inhibited adipogenesis and decreased mRNA levels of inflammation gene in 3T3-L1 adipocytes in vitro; whereas small interfering RNA (siRNA)-mediated suppression of S100A4 displayed the opposite results. Additionally, the protective effect induced by S100A4 during HFD-induced obesity was tightly related with activation of Akt signaling in adipose tissues, as well as livers and muscles. Taken together, we demonstrate that S100A4 is an inhibitory factor for obesity and attenuates the inflammatory reaction, while activating the Akt signaling, which suggest that S100A4 is a potential candidate for the treatment of diet-induced obesity and its complications.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41374-018-0067-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8370407", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8332079", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017964", 
        "issn": [
          "0023-6837", 
          "1530-0307"
        ], 
        "name": "Laboratory Investigation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "98"
      }
    ], 
    "keywords": [
      "high-fat diet", 
      "diet-induced obesity", 
      "adipose tissue", 
      "deficient mice", 
      "weeks of HFD", 
      "high-fat diet-induced obesity", 
      "high inflammatory status", 
      "suppression of S100A4", 
      "aggravated obesity", 
      "S100 calcium-binding protein family", 
      "inflammatory status", 
      "aggravated symptoms", 
      "activation of Akt", 
      "inflammatory reaction", 
      "inflammation genes", 
      "protective effect", 
      "calcium-binding protein family", 
      "obesity", 
      "inhibitory factor", 
      "tumor progression", 
      "stromal cells", 
      "S100A4", 
      "mice", 
      "mRNA levels", 
      "Akt signaling", 
      "liver", 
      "tissue", 
      "complications", 
      "inflammation", 
      "metastasis", 
      "symptoms", 
      "insulin", 
      "weeks", 
      "progression", 
      "muscle", 
      "opposite results", 
      "diet", 
      "treatment", 
      "levels", 
      "adipocytes", 
      "Akt", 
      "vitro", 
      "adipogenesis", 
      "activation", 
      "potential candidate", 
      "status", 
      "signaling", 
      "cells", 
      "suppression", 
      "factors", 
      "study", 
      "RNA", 
      "role", 
      "protein family", 
      "genes", 
      "effect", 
      "candidates", 
      "family", 
      "members", 
      "results", 
      "reaction"
    ], 
    "name": "S100A4 protects mice from high-fat diet-induced obesity and inflammation", 
    "pagination": "1025-1038", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104149085"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41374-018-0067-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29789685"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41374-018-0067-y", 
      "https://app.dimensions.ai/details/publication/pub.1104149085"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_789.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41374-018-0067-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0067-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0067-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0067-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41374-018-0067-y'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      22 PREDICATES      110 URIs      93 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41374-018-0067-y schema:about N06405877cebd48bb8efcee978658c8b9
2 N0de1ce63524c4c8888fa9aa5bbb1260c
3 N231eae612ad643baaf3ddf56617a3c05
4 N48849d0ead5d408aa0e86b40069fb4c6
5 N547f8e77132d4875b95cf95043d03c11
6 N583a366ee3ae4ae889a2870576758fd5
7 N8535b3fd62fb447d89c45e4345b7a314
8 N8b403e0f96fa46599b218eb52ede1410
9 N9a1d5ac3b73d4f90a0e19cf70e7115fd
10 Nca5a3ca4c5df4279bfea6dfd510b4954
11 Nd13ddd04753d42459125febad8f9a428
12 Nd2eb81f40a734932b69228db515b0334
13 Nf107a09b997f4963a8dcb1ea38f791cb
14 Nf4ff51bcb8e04c3996732a09c0ce211e
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nad005db43e8642b8b6779517db2c4e50
18 schema:citation sg:pub.10.1007/s00109-007-0301-3
19 sg:pub.10.1038/nature05482
20 sg:pub.10.1038/nature07777
21 sg:pub.10.1038/ncb2211
22 sg:pub.10.1038/ncomms2202
23 sg:pub.10.1038/ncomms5711
24 sg:pub.10.1038/nrendo.2015.103
25 sg:pub.10.1038/onc.2013.568
26 sg:pub.10.1186/s12885-015-1034-2
27 schema:datePublished 2018-05-22
28 schema:datePublishedReg 2018-05-22
29 schema:description As a member from S100 calcium-binding protein family, S100A4 is ubiquitous and elevated in tumor progression and metastasis, but its role in regulating obesity has not been well characterized. In this study, we showed that S100A4 was mainly expressed by stromal cells in adipose tissue and the S100A4 level in adipose tissue was decreased after high-fat diet (HFD). S100A4 deficient mice exhibited aggravated symptoms of obesity and suppressed insulin signaling after 12 weeks of HFD. Aggravated obesity in S100A4 deficient mice were found to be positively correlated with higher inflammatory status of the liver. Then, we found that extracellular S100A4 or overexpressed S100A4 inhibited adipogenesis and decreased mRNA levels of inflammation gene in 3T3-L1 adipocytes in vitro; whereas small interfering RNA (siRNA)-mediated suppression of S100A4 displayed the opposite results. Additionally, the protective effect induced by S100A4 during HFD-induced obesity was tightly related with activation of Akt signaling in adipose tissues, as well as livers and muscles. Taken together, we demonstrate that S100A4 is an inhibitory factor for obesity and attenuates the inflammatory reaction, while activating the Akt signaling, which suggest that S100A4 is a potential candidate for the treatment of diet-induced obesity and its complications.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree true
33 schema:isPartOf Nc6d82e9df4dd4dacb3007530764a1b72
34 Nca6e377a65ad41adae4b1f0fd516d62e
35 sg:journal.1017964
36 schema:keywords Akt
37 Akt signaling
38 RNA
39 S100 calcium-binding protein family
40 S100A4
41 activation
42 activation of Akt
43 adipocytes
44 adipogenesis
45 adipose tissue
46 aggravated obesity
47 aggravated symptoms
48 calcium-binding protein family
49 candidates
50 cells
51 complications
52 deficient mice
53 diet
54 diet-induced obesity
55 effect
56 factors
57 family
58 genes
59 high inflammatory status
60 high-fat diet
61 high-fat diet-induced obesity
62 inflammation
63 inflammation genes
64 inflammatory reaction
65 inflammatory status
66 inhibitory factor
67 insulin
68 levels
69 liver
70 mRNA levels
71 members
72 metastasis
73 mice
74 muscle
75 obesity
76 opposite results
77 potential candidate
78 progression
79 protective effect
80 protein family
81 reaction
82 results
83 role
84 signaling
85 status
86 stromal cells
87 study
88 suppression
89 suppression of S100A4
90 symptoms
91 tissue
92 treatment
93 tumor progression
94 vitro
95 weeks
96 weeks of HFD
97 schema:name S100A4 protects mice from high-fat diet-induced obesity and inflammation
98 schema:pagination 1025-1038
99 schema:productId N3ddbd0567b1b43eebcf915ea0f8adbf9
100 N4aef34bcd3cd401f816dee21986f891f
101 Nc2c9d39a925445e58cc01aaf020e0295
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104149085
103 https://doi.org/10.1038/s41374-018-0067-y
104 schema:sdDatePublished 2021-11-01T18:34
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N481283b794b84c77958be043fa31db71
107 schema:url https://doi.org/10.1038/s41374-018-0067-y
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N03b64e261ad44fa2b9b7797c7367551c rdf:first sg:person.013014460033.10
112 rdf:rest N05ed90855377470e888248f160f40ab9
113 N05ed90855377470e888248f160f40ab9 rdf:first sg:person.01057422157.61
114 rdf:rest N9aac7e4fc4d44d3e897fccef77173cca
115 N06405877cebd48bb8efcee978658c8b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Adipose Tissue
117 rdf:type schema:DefinedTerm
118 N0de1ce63524c4c8888fa9aa5bbb1260c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name S100 Calcium-Binding Protein A4
120 rdf:type schema:DefinedTerm
121 N231eae612ad643baaf3ddf56617a3c05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name 3T3-L1 Cells
123 rdf:type schema:DefinedTerm
124 N3ddbd0567b1b43eebcf915ea0f8adbf9 schema:name doi
125 schema:value 10.1038/s41374-018-0067-y
126 rdf:type schema:PropertyValue
127 N3ffc52766a1f4ca1ba528e506ce3e0d9 rdf:first sg:person.01124737766.21
128 rdf:rest rdf:nil
129 N481283b794b84c77958be043fa31db71 schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 N48849d0ead5d408aa0e86b40069fb4c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Animals
133 rdf:type schema:DefinedTerm
134 N4aef34bcd3cd401f816dee21986f891f schema:name pubmed_id
135 schema:value 29789685
136 rdf:type schema:PropertyValue
137 N547f8e77132d4875b95cf95043d03c11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mice, Knockout
139 rdf:type schema:DefinedTerm
140 N583a366ee3ae4ae889a2870576758fd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Obesity
142 rdf:type schema:DefinedTerm
143 N84d54cd5a47340c5a2b73329ab9372d8 rdf:first sg:person.01360725273.77
144 rdf:rest Nfb478cee56b049bfb020bb97ead0d207
145 N8535b3fd62fb447d89c45e4345b7a314 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Inflammation
147 rdf:type schema:DefinedTerm
148 N8b403e0f96fa46599b218eb52ede1410 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name RNA Interference
150 rdf:type schema:DefinedTerm
151 N9a1d5ac3b73d4f90a0e19cf70e7115fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Mice, Inbred C57BL
153 rdf:type schema:DefinedTerm
154 N9aac7e4fc4d44d3e897fccef77173cca rdf:first sg:person.0673343734.23
155 rdf:rest Na279c8908ae9441480070f85cf6982b4
156 Na279c8908ae9441480070f85cf6982b4 rdf:first sg:person.01122432225.95
157 rdf:rest N84d54cd5a47340c5a2b73329ab9372d8
158 Nad005db43e8642b8b6779517db2c4e50 rdf:first sg:person.010026556033.12
159 rdf:rest Nda9b61779fdb49779974aa43ef4a8636
160 Nc2c9d39a925445e58cc01aaf020e0295 schema:name dimensions_id
161 schema:value pub.1104149085
162 rdf:type schema:PropertyValue
163 Nc6d82e9df4dd4dacb3007530764a1b72 schema:volumeNumber 98
164 rdf:type schema:PublicationVolume
165 Nca5a3ca4c5df4279bfea6dfd510b4954 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Insulin Resistance
167 rdf:type schema:DefinedTerm
168 Nca6e377a65ad41adae4b1f0fd516d62e schema:issueNumber 8
169 rdf:type schema:PublicationIssue
170 Nd13ddd04753d42459125febad8f9a428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Signal Transduction
172 rdf:type schema:DefinedTerm
173 Nd2eb81f40a734932b69228db515b0334 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mice
175 rdf:type schema:DefinedTerm
176 Nda9b61779fdb49779974aa43ef4a8636 rdf:first sg:person.015530615533.84
177 rdf:rest N03b64e261ad44fa2b9b7797c7367551c
178 Nf107a09b997f4963a8dcb1ea38f791cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Diet, High-Fat
180 rdf:type schema:DefinedTerm
181 Nf4ff51bcb8e04c3996732a09c0ce211e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Proto-Oncogene Proteins c-akt
183 rdf:type schema:DefinedTerm
184 Nfb478cee56b049bfb020bb97ead0d207 rdf:first sg:person.0707457671.87
185 rdf:rest N3ffc52766a1f4ca1ba528e506ce3e0d9
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
190 schema:name Clinical Sciences
191 rdf:type schema:DefinedTerm
192 sg:grant.8332079 http://pending.schema.org/fundedItem sg:pub.10.1038/s41374-018-0067-y
193 rdf:type schema:MonetaryGrant
194 sg:grant.8370407 http://pending.schema.org/fundedItem sg:pub.10.1038/s41374-018-0067-y
195 rdf:type schema:MonetaryGrant
196 sg:journal.1017964 schema:issn 0023-6837
197 1530-0307
198 schema:name Laboratory Investigation
199 schema:publisher Springer Nature
200 rdf:type schema:Periodical
201 sg:person.010026556033.12 schema:affiliation grid-institutes:grid.181531.f
202 schema:familyName Hou
203 schema:givenName Shasha
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010026556033.12
205 rdf:type schema:Person
206 sg:person.01057422157.61 schema:affiliation grid-institutes:grid.418544.8
207 schema:familyName Zhai
208 schema:givenName Junfeng
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057422157.61
210 rdf:type schema:Person
211 sg:person.01122432225.95 schema:affiliation grid-institutes:grid.22935.3f
212 schema:familyName Sun
213 schema:givenName Kaiji
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122432225.95
215 rdf:type schema:Person
216 sg:person.01124737766.21 schema:affiliation grid-institutes:grid.181531.f
217 schema:familyName Zhang
218 schema:givenName Jinhua
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124737766.21
220 rdf:type schema:Person
221 sg:person.013014460033.10 schema:affiliation grid-institutes:grid.181531.f
222 schema:familyName Yuan
223 schema:givenName Qi
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013014460033.10
225 rdf:type schema:Person
226 sg:person.01360725273.77 schema:affiliation grid-institutes:grid.233520.5
227 schema:familyName Chen
228 schema:givenName Zhinan
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360725273.77
230 rdf:type schema:Person
231 sg:person.015530615533.84 schema:affiliation grid-institutes:grid.181531.f
232 schema:familyName Jiao
233 schema:givenName Ying
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015530615533.84
235 rdf:type schema:Person
236 sg:person.0673343734.23 schema:affiliation grid-institutes:grid.181531.f
237 schema:familyName Tian
238 schema:givenName Tian
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673343734.23
240 rdf:type schema:Person
241 sg:person.0707457671.87 schema:affiliation grid-institutes:grid.22935.3f
242 schema:familyName Wu
243 schema:givenName Zhenlong
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707457671.87
245 rdf:type schema:Person
246 sg:pub.10.1007/s00109-007-0301-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021186545
247 https://doi.org/10.1007/s00109-007-0301-3
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nature05482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034631385
250 https://doi.org/10.1038/nature05482
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nature07777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039565533
253 https://doi.org/10.1038/nature07777
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/ncb2211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014866016
256 https://doi.org/10.1038/ncb2211
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/ncomms2202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008981708
259 https://doi.org/10.1038/ncomms2202
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/ncomms5711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038269899
262 https://doi.org/10.1038/ncomms5711
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/nrendo.2015.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041834955
265 https://doi.org/10.1038/nrendo.2015.103
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/onc.2013.568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049110042
268 https://doi.org/10.1038/onc.2013.568
269 rdf:type schema:CreativeWork
270 sg:pub.10.1186/s12885-015-1034-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050803639
271 https://doi.org/10.1186/s12885-015-1034-2
272 rdf:type schema:CreativeWork
273 grid-institutes:grid.181531.f schema:alternateName The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China
274 schema:name The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China
275 rdf:type schema:Organization
276 grid-institutes:grid.22935.3f schema:alternateName The State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P. R. China
277 schema:name The State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P. R. China
278 rdf:type schema:Organization
279 grid-institutes:grid.233520.5 schema:alternateName The Cell Engineering Research Center and Department of Cell Biology, State Key Laboratory of Cancer, Fourth Military Medical University, Xi’an, P. R. China
280 schema:name The Cell Engineering Research Center and Department of Cell Biology, State Key Laboratory of Cancer, Fourth Military Medical University, Xi’an, P. R. China
281 The College of Life Science and Bioengineering, Beijing Jiaotong University, No.3 Shangyuancun Road, Beijing, P.R. China
282 rdf:type schema:Organization
283 grid-institutes:grid.418544.8 schema:alternateName The Chinese Academy of Inspection and Quarantine, Beijing, P. R. China
284 schema:name The Chinese Academy of Inspection and Quarantine, Beijing, P. R. China
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...