Histological chorioamnionitis at term according to labor onset: a prospective controlled study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Hadas Ganer Herman, Letizia Schreiber, Hadas Miremberg, Masha Ben Zvi, Jacob Bar, Michal Kovo

ABSTRACT

OBJECTIVE: To study the incidence of histological chorioamnionitis (HCA) in term pregnancies according to labor onset. STUDY DESIGN: During 2013-6, term pregnancy placentas were prospectively sent to histopathology evaluation, and compared between patients with spontaneous onset labor, pre-labor ROM, labor induction and elective cesarean deliveries. RESULTS: A total of 260 placentas were obtained, 65 from each group. Rates of HCA for the spontaneous labor, PROM, induction and CD groups were: 49, 32, 24 and 4%, respectively (p < 0.001). Composite neonatal outcome was non-significant between the study groups, and between cases with and without HCA. In a logistic regression model, after controlling for parity - gestational age, mode of delivery, ROM > 12 h and spontaneous onset of labor were found to be independent risk factors for HCA. CONCLUSION: HCA at term is prevalent in spontaneous labor and supports the association between the inflammatory processes and activation of the physiological signals of parturition. More... »

PAGES

581-587

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41372-019-0327-8

DOI

http://dx.doi.org/10.1038/s41372-019-0327-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111917181

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30723280


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