The effects of antihypertensive medications on severity and outcomes of hypertensive patients with COVID-19 View Full Text


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Article Info

DATE

2022-07-05

AUTHORS

Samira Nakhaie, Rostam Yazdani, Mohammadreza Shakibi, Soheila Torabian, Sara Pezeshki, Maliheh Sadat Bazrafshani, Maryam Azimi, Faranak Salajegheh

ABSTRACT

In Covid-19 pandemic, specific comorbidities are associated with the increased risk of worse outcomes and increased severity of lung injury and mortality. the aim of this study was to investigate the effects of antihypertensive medications on the severity and outcomes of hypertensive patients with COVID-19. This retrospective observational study conducted on patients with COVID-19 who referred to Afzalipour Hospital, Kerman, Iran during the six months from 19 February 2020 to 20 July 2020. The data were collected through medical chart reviews. We assessed 265 patients with Covid-19 and they stratified based on hypertension and type of antihypertension medications. The data were described and Student’s t-test, Mann–Whitney U and Fisher exact test were run to compare the patients ‘demographical and clinical information. The qualitative variables were compared using the by SPSS software version 23. The results of the present study showed that hypertension was a prevalent comorbidity among patients with COVID-19 and hypertensive patients compared to other patients without any comorbidity who were older (P-value: 0.03). The oxygen saturation was higher for the patients in the control group than hypertensive patients (P-value: 0.01). The severity of COVID-19 and its outcome were not different between the patients who took or did not take antihypertensive medications and also the type of antihypertensive medications. Hypertensive patients did not show any significant difference in survival, hospital stay, ICU admission, disease severity, and invasive medical ventilation in other normotensive patients with COVID-19. More... »

PAGES

1-8

References to SciGraph publications

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  • 2020-09-14. Prevalence and incidence of pre-hypertension and hypertension (awareness/control) in Iran: findings from Kerman coronary artery diseases risk factors study 2 (KERCADRS) in JOURNAL OF HUMAN HYPERTENSION
  • 2017-11-28. A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia in BMC HEMATOLOGY
  • 2020-09-19. Impact of Treatment with Renin–Angiotensin System Inhibitors on Clinical Outcomes in Hypertensive Patients Hospitalized with COVID-19 in HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
  • 2021-07-27. Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19 in BMC EMERGENCY MEDICINE
  • 2013-11-04. Effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on hemoglobin levels in BMC RESEARCH NOTES
  • 2012-05-17. Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes in CARDIOVASCULAR DIABETOLOGY
  • 2004-09-09. Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension in JOURNAL OF HUMAN HYPERTENSION
  • 2019-05-02. The relationship between Plasma Markers and Essential Hypertension in Middle-aged and Elderly Chinese Population: A Community Based Cross-sectional Study in SCIENTIFIC REPORTS
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    http://scigraph.springernature.com/pub.10.1038/s41371-022-00716-7

    DOI

    http://dx.doi.org/10.1038/s41371-022-00716-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149235306

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35790875


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