Electrocardiographic-left ventricular hypertrophy and incident stroke among Chinese hypertensive adults View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-10

AUTHORS

Yan Zhao, Xiao Huang, Peng-Pai Zhang, Huihui Bao, Yaren Yu, Min Zhao, Rui Gu, Wei Li, Jun Wang, Quan-Fu Xu, Fangfang Fan, Jianping Li, Yan Zhang, Yu Wang, Genfu Tang, Yefeng Cai, Qiang Dong, Delu Yin, Xiaoshu Cheng, Mingli He, Binyan Wang, Xianhui Qin, Yong Huo, Yi-Gang Li

ABSTRACT

The relationship between electrocardiographic-left ventricular hypertrophy (ECG-LVH) and stroke has been well established in the Western population with limited information in the Chinese population. This study evaluated the association between ECG-LVH and stroke outcome. A total of 19,815 (95.7%) subjects from the China Stroke Primary Prevention Trial (CSPPT) with baseline ECG were included. ECG-LVH by sex-unspecific Sokolow-Lyon criteria was detected in 1599 participants (8.1%) at baseline. After a mean follow-up of 4.5 years, 605 (3.1%) subjects were detected with new-onset stroke over the total population, baseline ECG-LVH was present in 72 (4.5%) of them during follow-up. After adjusting for various cofounders, ECG-LVH remained as an independent risk factor for stroke events in the total population (HR = 1.43; 95% CI, 1.10-1.84; P = 0.007) and male population (HR = 1.47; 95% CI, 1.07-2.03; P = 0.019). Subgroup analysis showed that baseline ECG-LVH was a risk factor for stroke in individuals younger than 65 years of age(HR = 1.80, 95% CI, 1.31-2.47 vs. HR = 1.02, 95% CI, 0.66-1.59, P value for interaction = 0.047). In summary, LVH diagnosed by ECG is associated with an excess risk for stroke in Chinese hypertensive population, especially in the age group of younger than 65 years. More... »

PAGES

1-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41371-018-0155-x

DOI

http://dx.doi.org/10.1038/s41371-018-0155-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111323392

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30631128


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