MicroRNAs and immunity in periodontal health and disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-09

AUTHORS

Xianghong Luan, Xiaofeng Zhou, Afsar Naqvi, Marybeth Francis, Deborah Foyle, Salvador Nares, Thomas G. H. Diekwisch

ABSTRACT

MicroRNAs (miRNAs) are critical regulators of the host immune and inflammatory response against bacterial pathogens. In the present review, we discuss target genes, target gene functions, the potential regulatory role of miRNAs in periodontal tissues, and the potential role of miRNAs as biomarkers and therapeutics. In periodontal disease, miRNAs exert control over all aspects of innate and adaptive immunity, including the functions of neutrophils, macrophages, dendritic cells and T and B cells. Previous human studies have highlighted some key miRNAs that are dysregulated in periodontitis patients. In the present study, we mapped the major miRNAs that were altered in our reproducible periodontitis mouse model relative to control animals. The miRNAs that were upregulated as a result of periodontal disease in both human and mouse studies included miR-15a, miR-29b, miR-125a, miR-146a, miR-148/148a and miR-223, whereas miR-92 was downregulated. The association of individual miRNAs with unique aspects of periodontal disease and their stability in gingival crevicular fluid underscores their potential as markers for periodontal disease progression or healthy restitution. Moreover, miRNA therapeutics hold great promise for the future of periodontal therapy because of their ability to modulate the immune response to infection when applied in conjunction with synthetic antagomirs and/or relatively straightforward delivery strategies. More... »

PAGES

24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41368-018-0025-y

DOI

http://dx.doi.org/10.1038/s41368-018-0025-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105743382

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30078842


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