Metabolism and memory: α-synuclein level in children with obesity and children with type 1 diabetes; relation to glucotoxicity, lipotoxicity and ... View Full Text


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Article Info

DATE

2022-09-24

AUTHORS

Nouran Yousef Salah, Sara Ibrahim Taha, Safeya Hassan, Mai Seif ElDin Abdeen, Mostafa Ahmad Hashim, Rana Mahmoud

ABSTRACT

Background/ObjectivesChildren with obesity and those with type 1diabetes (T1D) exhibit subtle neurocognitive deficits, the mechanism of which remains unknown. α-synuclein plays a fundamental role in neurodegeneration. Moreover, its role in glucose and lipids metabolism is emerging. This study aims to assess whether α-synuclein is correlated with the degree of neurodegeneration in children with obesity and those with T1D in comparison to healthy controls and correlate it to various neurocognitive and metabolic parameters.Subjects/MethodsForty children with obesity, 40 children with T1D and 40 matched-healthy controls were assessed for anthropometric measurements and blood-pressure. Cognitive evaluation was performed using Stanford–Binet scale and Barkley Deficits in Executive Functioning (EF) Scale-Children and Adolescents. α-synuclein, fasting lipids and glucose were measured with calculation of the homeostatic model of insulin-resistance and estimated-glucose disposal rate.ResultsChildren with obesity and those with T1D had significantly higher α-synuclein (p < 0.001) and total EF percentile (p = 0.001) than controls. α-synuclein was negatively correlated to total IQ (p < 0.001 and p = 0.001), and positively correlated with total EF percentile (p = 0.009 and p = 0.001) and EF symptom count percentile (p = 0.005 and p < 0.001) in children with T1D and obesity, respectively. Multivariate-regression revealed that α-synuclein was independently related to age (p = 0.028), diabetes-duration (p = 0.006), HbA1C% (p = 0.034), total IQ (p = 0.013) and EF symptom count percentile (p = 0.003) among children with T1D, and to diastolic blood-pressure percentile (p = 0.013), waist/hip ratio SDS (p = 0.007), total EF percentile (P = 0.033) and EF symptom count percentile (p < 0.001) in children with obesity.Conclusionα-synuclein could have a mechanistic role in neurocognitive deficit among children with obesity and T1D. More... »

PAGES

2040-2049

References to SciGraph publications

  • 2019-09-04. Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities in TRANSLATIONAL NEURODEGENERATION
  • 2017-10-12. Childhood Obesity and Cognitive Function in PEDIATRIC OBESITY
  • 2022-03-07. Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model in TRANSLATIONAL NEURODEGENERATION
  • 2020-03-09. Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers? in BMC NEUROLOGY
  • 2015-03-31. Hypothalamic innate immune reaction in obesity in NATURE REVIEWS ENDOCRINOLOGY
  • 2014-10-13. Obesity-associated biomarkers and executive function in children in PEDIATRIC RESEARCH
  • 2015-07-10. Low alpha-synuclein levels in the blood are associated with insulin resistance in SCIENTIFIC REPORTS
  • 2020-11-11. A comparative study of executive functions among children with attention deficit and hyperactivity disorder and those with learning disabilities in MIDDLE EAST CURRENT PSYCHIATRY
  • 2018-03-13. Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies in ACTA NEUROPATHOLOGICA
  • 2019-12-02. Reducing effect of insulin resistance on alpha-synuclein gene expression in skeletal muscle in DIABETOLOGY & METABOLIC SYNDROME
  • 2021-02-04. Body mass index trajectories and the risk for Alzheimer’s disease among older adults in SCIENTIFIC REPORTS
  • 2018-12-13. Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study in DIABETOLOGIA
  • 2008-11. First reference curves of waist circumference for German children in comparison to international values: the PEP Family Heart Study in WORLD JOURNAL OF PEDIATRICS
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/s41366-022-01222-z

    DOI

    http://dx.doi.org/10.1038/s41366-022-01222-z

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/36153375


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