Four weeks treatment with the GLP-1 receptor analogue liraglutide lowers liver fat and concomitantly circulating glucagon in individuals with overweight View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-08-18

AUTHORS

Maria S. Svane, Helle H. Johannesen, Adam E. Hansen, Christoffer Martinussen, Kirstine N. Bojsen-Møller, Martin Lundsgaard Hansen, Carolyn F. Deacon, Sune H. Keller, Thomas L. Klausen, Annika Loft, Andreas Kjaer, Johan Löfgren, Sten Madsbad, Jens J. Holst, Nicolai J. Wewer Albrechtsen

ABSTRACT

We investigated the effect of pharmacologically induced weight loss on markers of glucagon resistance in individuals with overweight during treatment with the glucagon-like peptide-1 receptor agonist liraglutide. We performed an open-label study in 14 men with overweight (age 38 ± 11 years, BMI 32 ± 4 kg/m2) without simultaneously diabetes. Subjects were treated with liraglutide, initiated and titrated with 0.6 mg/day/week to reach the final dose of 3.0 mg/day. Subjects were examined at baseline, during titration (Week 4), after 2 weeks of steady state (Week 6) of final dosing of liraglutide and 3 weeks after discontinuation of liraglutide (follow-up). Study participants lost 3.3 ± 1.9 kg (3%) total body weight during the first 4 weeks of treatment with liraglutide. Simultaneously, liver fat content decreased from 12.4 ± 11.6% to 10.2 ± 11.1%, p = 0.025, whereas fat content in the spleen and subcutaneous tissue was unaltered. Markers of glucagon resistance, including plasma glucagon and the glucagon-alanine-index, also decreased significantly during treatment, but total and individual plasma amino acid concentrations did not. Insulin resistance (HOMA-IR) was unchanged during treatment, whereas insulin clearance increased. Treatment with the GLP-1 receptor analogue liraglutide decreased liver fat content, and simultaneously attenuated glucagon concentrations and the glucagon-alanine index in individuals with overweight without diabetes. More... »

PAGES

2058-2062

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41366-022-01207-y

DOI

http://dx.doi.org/10.1038/s41366-022-01207-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1150305308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35982119


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22 schema:description We investigated the effect of pharmacologically induced weight loss on markers of glucagon resistance in individuals with overweight during treatment with the glucagon-like peptide-1 receptor agonist liraglutide. We performed an open-label study in 14 men with overweight (age 38 ± 11 years, BMI 32 ± 4 kg/m2) without simultaneously diabetes. Subjects were treated with liraglutide, initiated and titrated with 0.6 mg/day/week to reach the final dose of 3.0 mg/day. Subjects were examined at baseline, during titration (Week 4), after 2 weeks of steady state (Week 6) of final dosing of liraglutide and 3 weeks after discontinuation of liraglutide (follow-up). Study participants lost 3.3 ± 1.9 kg (3%) total body weight during the first 4 weeks of treatment with liraglutide. Simultaneously, liver fat content decreased from 12.4 ± 11.6% to 10.2 ± 11.1%, p = 0.025, whereas fat content in the spleen and subcutaneous tissue was unaltered. Markers of glucagon resistance, including plasma glucagon and the glucagon-alanine-index, also decreased significantly during treatment, but total and individual plasma amino acid concentrations did not. Insulin resistance (HOMA-IR) was unchanged during treatment, whereas insulin clearance increased. Treatment with the GLP-1 receptor analogue liraglutide decreased liver fat content, and simultaneously attenuated glucagon concentrations and the glucagon-alanine index in individuals with overweight without diabetes.
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29 amino acid concentrations
30 analogue liraglutide
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33 clearance
34 concentration
35 content
36 days
37 days/week
38 diabetes
39 discontinuation
40 discontinuation of liraglutide
41 dose
42 dosing
43 effect
44 fat
45 fat content
46 final dose
47 final dosing
48 glucagon
49 glucagon concentrations
50 glucagon resistance
51 glucagon-like peptide-1 receptor agonist liraglutide
52 index
53 individual plasma amino acid concentrations
54 individuals
55 insulin clearance
56 insulin resistance
57 liraglutide
58 liver fat
59 liver fat content
60 loss
61 markers
62 men
63 open-label study
64 overweight
65 participants
66 peptide-1 receptor agonist liraglutide
67 plasma amino acid concentrations
68 plasma glucagon
69 resistance
70 state
71 steady state
72 study
73 study participants
74 subcutaneous tissue
75 subjects
76 tissue
77 titration
78 total body weight
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