Ontology type: schema:ScholarlyArticle
2018-05-17
AUTHORSL. L. Hui, A. M. Li, E. A. S. Nelson, G. M. Leung, S. L. Lee, C. M. Schooling
ABSTRACTBackground/objectivesShort-term breastfeeding from mothers with gestational diabetes (GDM) may programme metabolism and increase offspring diabetes risk. We examined the association of in utero GDM exposure with adiposity from infancy to adolescence, and whether any association was modified by breastfeeding during early infancy.MethodsIn the prospective Chinese birth cohort “Children of 1997” (n = 7342, 88% follow-up rate), generalised estimate equations with multiple imputation were used to assess associations of in utero GDM exposure with age- and sex-specific body mass index (BMI) z-score during infancy (3 and 9 months), childhood (2– < 8 years) and adolescence (8–16 years), adjusted for sex, parity, maternal age, birth place, preeclampisa, smoking, and family socio-economic position. We also tested whether the associations differed by mode of infant feeding (always formula-fed, mixed, always breastfed) during the first three months of life.ResultsIn utero GDM exposure (7.5%) was associated with a lower BMI z-score during infancy (−0.13, 95% confidence interval (CI) −0.22, −0.05) but higher BMI z-scores during childhood (0.14, 95% CI 0.03, 0.25) and adolescence (0.25 95% CI 0.11, 0.38). Breastfeeding for the first three months did not modify the association of in utero GDM status with subsequent BMI (all p values for interaction >0.4).ConclusionsIn utero GDM exposure was associated with greater adiposity during childhood and adolescence. Breastfeeding in early infancy from mothers with GDM was not associated with greater adiposity in children and thus should still be encouraged. More... »
PAGES1317-1325
http://scigraph.springernature.com/pub.10.1038/s41366-018-0077-2
DOIhttp://dx.doi.org/10.1038/s41366-018-0077-2
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29777227
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