Ontology type: schema:ScholarlyArticle Open Access: True
2018-05-01
AUTHORSMidori Honma, Shojiro Sawada, Yoshiyuki Ueno, Keigo Murakami, Tetsuya Yamada, Junhong Gao, Shinjiro Kodama, Tomohito Izumi, Kei Takahashi, Sohei Tsukita, Kenji Uno, Junta Imai, Eiji Kakazu, Yasuteru Kondo, Kei Mizuno, Naoki Kawagishi, Tooru Shimosegawa, Hideki Katagiri
ABSTRACTBackground/objective:Insulin signals, via the regulation of key enzyme expression, both suppress gluconeogenesis and enhance lipid synthesis in the liver. Animal studies have revealed insulin signaling favoring gluconeogenesis suppression to be selectively impaired in steatotic livers. However, whether, and if so how, such selective insulin resistance occurs in human steatotic livers remains unknown. Our aim was to investigate selective insulin resistance in human livers with non-alcoholic fatty liver disease (NAFLD).Subjects/methods:We examined mRNA expressions of key molecules for insulin signaling, gluconeogenesis and lipogenesis in human liver biopsy samples obtained from 51 non-diabetic subjects: 9 healthy controls and 42 NAFLD patients, and analyzed associations of these molecules with each other and with detailed pathological and clinical biochemistry data.Results:In NAFLD patients, insulin receptor substrate (IRS)-2 expression was decreased, while those of key enzymes for gluconeogenesis were increased. These alterations of IRS-2 and gluconeogenesis enzymes were induced both in simple steatosis (SS) and non-alcoholic steatohepatitis (NASH), while these expression levels did not differ between SS and NASH. Furthermore, alterations in the expressions of IRS-2 and gluconeogenesis enzymes showed strong negative correlations and were concurrently induced in the early histological stage of NAFLD. In contrast, fatty acid synthase (FAS) expression was not decreased in NAFLD, despite IRS-2 downregulation, but correlated strongly with IRS-1 expression. Furthermore, no histological scores were associated with these molecules. Thus, IRS-1 signaling, which is not impaired in NAFLD, appears to modulate FAS expression.Conclusion:These analyses revealed that selective insulin resistance is present in human NAFLD livers and occurs in its early phases. The effect of insulin, during the IRS step, on gene expressions for lipogenesis and gluconeogenesis are apparently distinct and preferential downregulation of IRS-2 may contribute to selective resistance to the suppressive effects of insulin on gluconeogenesis. More... »
PAGES1544-1555
http://scigraph.springernature.com/pub.10.1038/s41366-018-0062-9
DOIhttp://dx.doi.org/10.1038/s41366-018-0062-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1103689854
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29717275
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biopsy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Case-Control Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin Receptor Substrate Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin Resistance",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Non-alcoholic Fatty Liver Disease",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Honma",
"givenName": "Midori",
"id": "sg:person.015433216133.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015433216133.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Sawada",
"givenName": "Shojiro",
"id": "sg:person.01264270414.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264270414.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japan Agency for Medical Research and Development, CREST, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.480536.c",
"name": [
"Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan",
"Japan Agency for Medical Research and Development, CREST, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Ueno",
"givenName": "Yoshiyuki",
"id": "sg:person.010427522032.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010427522032.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Murakami",
"givenName": "Keigo",
"id": "sg:person.01142407026.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142407026.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Yamada",
"givenName": "Tetsuya",
"id": "sg:person.01343321656.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343321656.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Gao",
"givenName": "Junhong",
"id": "sg:person.0722266435.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722266435.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Kodama",
"givenName": "Shinjiro",
"id": "sg:person.01272145150.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272145150.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Izumi",
"givenName": "Tomohito",
"id": "sg:person.01030314210.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030314210.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Takahashi",
"givenName": "Kei",
"id": "sg:person.0646631700.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646631700.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Tsukita",
"givenName": "Sohei",
"id": "sg:person.0603136414.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603136414.81"
],
"type": "Person"
},
{
"familyName": "Uno",
"givenName": "Kenji",
"id": "sg:person.0716766352.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716766352.19"
],
"type": "Person"
},
{
"familyName": "Imai",
"givenName": "Junta",
"id": "sg:person.0643255040.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643255040.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Kakazu",
"givenName": "Eiji",
"id": "sg:person.0704634134.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704634134.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Kondo",
"givenName": "Yasuteru",
"id": "sg:person.01264265721.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264265721.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan",
"id": "http://www.grid.ac/institutes/grid.268394.2",
"name": [
"Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan"
],
"type": "Organization"
},
"familyName": "Mizuno",
"givenName": "Kei",
"id": "sg:person.01164106722.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164106722.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.412757.2",
"name": [
"Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Kawagishi",
"givenName": "Naoki",
"id": "sg:person.01345464520.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345464520.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan",
"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Shimosegawa",
"givenName": "Tooru",
"id": "sg:person.01255535707.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan",
"Japan Agency for Medical Research and Development, CREST, Tokyo, Japan",
"Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Katagiri",
"givenName": "Hideki",
"id": "sg:person.01101503716.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101503716.31"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/ijo.2012.181",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009999572",
"https://doi.org/10.1038/ijo.2012.181"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11892-009-0034-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011237758",
"https://doi.org/10.1007/s11892-009-0034-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-008-8322-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029759544",
"https://doi.org/10.1007/s00018-008-8322-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm4074",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020513835",
"https://doi.org/10.1038/nrm4074"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12038-010-0052-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025296298",
"https://doi.org/10.1007/s12038-010-0052-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/hr.2014.20",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044401479",
"https://doi.org/10.1038/hr.2014.20"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1572-0241.1999.01377.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015032643",
"https://doi.org/10.1111/j.1572-0241.1999.01377.x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1662",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039117182",
"https://doi.org/10.1038/nm1662"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms12977",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036117907",
"https://doi.org/10.1038/ncomms12977"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/414799a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000331422",
"https://doi.org/10.1038/414799a"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/hr.2013.80",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041803518",
"https://doi.org/10.1038/hr.2013.80"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-05-01",
"datePublishedReg": "2018-05-01",
"description": "Background/objective:Insulin signals, via the regulation of key enzyme expression, both suppress gluconeogenesis and enhance lipid synthesis in the liver. Animal studies have revealed insulin signaling favoring gluconeogenesis suppression to be selectively impaired in steatotic livers. However, whether, and if so how, such selective insulin resistance occurs in human steatotic livers remains unknown. Our aim was to investigate selective insulin resistance in human livers with non-alcoholic fatty liver disease (NAFLD).Subjects/methods:We examined mRNA expressions of key molecules for insulin signaling, gluconeogenesis and lipogenesis in human liver biopsy samples obtained from 51 non-diabetic subjects: 9 healthy controls and 42 NAFLD patients, and analyzed associations of these molecules with each other and with detailed pathological and clinical biochemistry data.Results:In NAFLD patients, insulin receptor substrate (IRS)-2 expression was decreased, while those of key enzymes for gluconeogenesis were increased. These alterations of IRS-2 and gluconeogenesis enzymes were induced both in simple steatosis (SS) and non-alcoholic steatohepatitis (NASH), while these expression levels did not differ between SS and NASH. Furthermore, alterations in the expressions of IRS-2 and gluconeogenesis enzymes showed strong negative correlations and were concurrently induced in the early histological stage of NAFLD. In contrast, fatty acid synthase (FAS) expression was not decreased in NAFLD, despite IRS-2 downregulation, but correlated strongly with IRS-1 expression. Furthermore, no histological scores were associated with these molecules. Thus, IRS-1 signaling, which is not impaired in NAFLD, appears to modulate FAS expression.Conclusion:These analyses revealed that selective insulin resistance is present in human NAFLD livers and occurs in its early phases. The effect of insulin, during the IRS step, on gene expressions for lipogenesis and gluconeogenesis are apparently distinct and preferential downregulation of IRS-2 may contribute to selective resistance to the suppressive effects of insulin on gluconeogenesis.",
"genre": "article",
"id": "sg:pub.10.1038/s41366-018-0062-9",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.9341932",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6835318",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7522408",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5909462",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5915768",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7522407",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7543051",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6112009",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1035838",
"issn": [
"0307-0565",
"1476-5497"
],
"name": "International Journal of Obesity",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "42"
}
],
"keywords": [
"non-alcoholic fatty liver disease",
"non-alcoholic steatohepatitis",
"selective insulin resistance",
"insulin resistance",
"simple steatosis",
"NAFLD patients",
"steatotic livers",
"NAFLD livers",
"IRS-2",
"human steatotic liver",
"early histological stages",
"fatty acid synthase expression",
"non-diabetic subjects",
"fatty liver disease",
"gluconeogenesis enzymes",
"liver biopsy samples",
"IRS-1 expression",
"effect of insulin",
"human liver biopsy samples",
"IRS-1 signaling",
"liver disease",
"healthy controls",
"histological stage",
"histological scores",
"insulin receptor substrate",
"synthase expression",
"animal studies",
"gluconeogenesis suppression",
"biopsy samples",
"suppressive effect",
"FAS expression",
"biochemistry data",
"clinical biochemistry data",
"mRNA expression",
"liver",
"human liver",
"insulin",
"preferential downregulation",
"insulin signaling",
"key molecules",
"enzyme expression",
"expression levels",
"patients",
"IRS-1",
"suppress gluconeogenesis",
"receptor substrate",
"gluconeogenesis",
"selective resistance",
"lipogenesis",
"early phase",
"lipid synthesis",
"insulin signal",
"downregulation",
"differential expression",
"negative correlation",
"strong negative correlation",
"expression",
"key enzyme expression",
"alterations",
"gene expression",
"signaling",
"steatohepatitis",
"steatosis",
"key enzyme",
"disease",
"resistance",
"scores",
"association",
"enzyme",
"subjects",
"effect",
"aim",
"suppression",
"levels",
"control",
"study",
"regulation",
"correlation",
"contrast",
"molecules",
"stage",
"samples",
"data",
"analysis",
"synthesis",
"phase",
"signals",
"step",
"substrate"
],
"name": "Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers",
"pagination": "1544-1555",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1103689854"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41366-018-0062-9"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29717275"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41366-018-0062-9",
"https://app.dimensions.ai/details/publication/pub.1103689854"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:07",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_765.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41366-018-0062-9"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41366-018-0062-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41366-018-0062-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41366-018-0062-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41366-018-0062-9'
This table displays all metadata directly associated to this object as RDF triples.
388 TRIPLES
21 PREDICATES
136 URIs
117 LITERALS
18 BLANK NODES