Effect of C60 fullerene nanoparticles on the diet-induced obesity in rats View Full Text


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Article Info

DATE

2018-01-30

AUTHORS

Tetiana Halenova, Nataliia Raksha, Tetiana Vovk, Olexii Savchuk, Ludmila Ostapchenko, Yuriy Prylutskyy, Olena Kyzyma, Uwe Ritter, Peter Scharff

ABSTRACT

ABSTRACTBackgroundObesity is a growing global health problem. Since increased oxidative stress is one of the key pathological mechanisms underpinning overweight and strongly correlates with progression of obesity-related complications we hypothesized that C60 fullerene nanoparticles, due to their strong antioxidant capacity, could be the promising therapeutic agent in the treatment of this disease. Here we investigated whether the C60 fullerenes can alleviate diet-induced obesity (DIO) and metabolic impairments associated with it.MethodsTo determine the effect of C60 fullerenes on some nutritional and metabolic parameters, rats were fed either a normal diet (6.7% fat, 15.27 kJ·g−1) or a high-fat diet (38.8% fat, 28.71 kJ·g−1) for 70 days and were simultaneously treated per os with pristine C60 fullerene aqueous solution (C60FAS; 0.3 mg·kg−1 every other day) since the 28th day from the start of the experiment.ResultsRats fed with high fat diet had significantly increased body mass index (BMI), levels of insulin, glucose, glycosilated hemoglobin (HbA1c) and serum pro-inflammatory cytokines compared with control rats fed with low-fat chow. C60 fullerenes normalized the metabolic parameters and partially reduced BMI in DIO animals. Pro-inflammatory cytokines (IL-1b, IL-12, INFγ) were also decreased in serum of DIO rats treated with C60 fullerenes while anti-inflammatory cytokines (IL-4, IL-10) were at the control levels. High fat diet caused the increased level of oxidative stress products, and this was accompanied by decreased activity both the superoxide dismutase and catalase, whereas the administration of C60 fullerenes markedly decreased level of oxidative stress and enhanced antioxidant enzyme activities.ConclusionThese data indicate that water-soluble pristine C60 fullerenes reduce chronic inflammation, restore glucose homeostasis as well as positively affects on prooxidant-antioxidant homeostasis. C60 fullerenes could be represented as a promising therapeutic agent in the treatment of obesity and its related complications. More... »

PAGES

1987-1998

References to SciGraph publications

  • 2011-08-18. A novel approach to study the reaction of adrenaline autooxidation: A possibility for polarographic determination of superoxide dismutase activity and antioxidant properties of various preparations in BIOCHEMISTRY (MOSCOW), SUPPLEMENT SERIES B: BIOMEDICAL CHEMISTRY
  • 2017-01-13. Fullerene C60 Penetration into Leukemic Cells and Its Photoinduced Cytotoxic Effects in NANOSCALE RESEARCH LETTERS
  • 1998-03. Increased interleukin-12 plasma concentrations in both, insulin-dependent and non-insulin-dependent diabetes mellitus in DIABETOLOGIA
  • 2011-01-21. Adipokines in inflammation and metabolic disease in NATURE REVIEWS IMMUNOLOGY
  • 2017-02-14. C60 Fullerene as Promising Therapeutic Agent for the Prevention and Correction of Skeletal Muscle Functioning at Ischemic Injury in NANOSCALE RESEARCH LETTERS
  • 2014-12-12. C60 Fullerene as Synergistic Agent in Tumor-Inhibitory Doxorubicin Treatment in DRUGS IN R&D
  • 2001-05. Structure and Thermophysical Properties of Fullerene C60 Aqueous Solutions in INTERNATIONAL JOURNAL OF THERMOPHYSICS
  • 2016-07-12. Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function in MULTIDISCIPLINARY RESPIRATORY MEDICINE
  • 2017-01-13. C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue in JOURNAL OF NANOBIOTECHNOLOGY
  • 2006-12-13. Inflammation and metabolic disorders in NATURE
  • 2017-01-05. Comparative Analysis of the Antineoplastic Activity of C60 Fullerene with 5-Fluorouracil and Pyrrole Derivative In Vivo in NANOSCALE RESEARCH LETTERS
  • 2005-07-15. Mitochondrial fission in apoptosis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
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    http://scigraph.springernature.com/pub.10.1038/s41366-018-0016-2

    DOI

    http://dx.doi.org/10.1038/s41366-018-0016-2

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30401827


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    31 schema:description ABSTRACTBackgroundObesity is a growing global health problem. Since increased oxidative stress is one of the key pathological mechanisms underpinning overweight and strongly correlates with progression of obesity-related complications we hypothesized that C60 fullerene nanoparticles, due to their strong antioxidant capacity, could be the promising therapeutic agent in the treatment of this disease. Here we investigated whether the C60 fullerenes can alleviate diet-induced obesity (DIO) and metabolic impairments associated with it.MethodsTo determine the effect of C60 fullerenes on some nutritional and metabolic parameters, rats were fed either a normal diet (6.7% fat, 15.27 kJ·g−1) or a high-fat diet (38.8% fat, 28.71 kJ·g−1) for 70 days and were simultaneously treated per os with pristine C60 fullerene aqueous solution (C60FAS; 0.3 mg·kg−1 every other day) since the 28th day from the start of the experiment.ResultsRats fed with high fat diet had significantly increased body mass index (BMI), levels of insulin, glucose, glycosilated hemoglobin (HbA1c) and serum pro-inflammatory cytokines compared with control rats fed with low-fat chow. C60 fullerenes normalized the metabolic parameters and partially reduced BMI in DIO animals. Pro-inflammatory cytokines (IL-1b, IL-12, INFγ) were also decreased in serum of DIO rats treated with C60 fullerenes while anti-inflammatory cytokines (IL-4, IL-10) were at the control levels. High fat diet caused the increased level of oxidative stress products, and this was accompanied by decreased activity both the superoxide dismutase and catalase, whereas the administration of C60 fullerenes markedly decreased level of oxidative stress and enhanced antioxidant enzyme activities.ConclusionThese data indicate that water-soluble pristine C60 fullerenes reduce chronic inflammation, restore glucose homeostasis as well as positively affects on prooxidant-antioxidant homeostasis. C60 fullerenes could be represented as a promising therapeutic agent in the treatment of obesity and its related complications.
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