Synergistic cycles of protease activity and inflammation via PPARγ degradation in chronic obstructive pulmonary disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-21

AUTHORS

Nakwon Kwak, Kyoung-Hee Lee, Jisu Woo, Jiyeon Kim, Chang-Hoon Lee, Chul-Gyu Yoo

ABSTRACT

Inflammation, oxidative stress, and protease–antiprotease imbalance have been suggested to be a pathogenic triad in chronic obstructive pulmonary disease (COPD). However, it is not clear how proteases interact with components of inflammatory pathways. Therefore, this study aimed to evaluate the effect of neutrophil elastase (NE) on lipopolysaccharide (LPS)-induced interleukin 8 (IL-8) production and determine the molecular mechanism in human bronchial epithelial cells (HBECs). Immortalized bronchial epithelial cells and primary HBECs were used to investigate the impact of NE on LPS-induced IL-8 production. The molecular mechanism by which NE modulated LPS-induced IL-8 production was confirmed in elastase-treated C57BL/6 mice and primary HBECs obtained from COPD patients and healthy controls. The results showed that NE treatment synergistically augmented LPS-induced IL-8 production in both immortalized bronchial epithelial cells and primary HBECs. NE partially degraded peroxisome proliferator-activated receptor gamma (PPARγ), which is known to regulate IL-8 production in the nucleus. Treatment with a PPARγ agonist and overexpression of PPARγ reversed the NE-induced synergistic increase in LPS-induced IL-8 production. Moreover, PPARγ levels were lower in lung homogenates and lung epithelial cells from elastase-treated mice than in those from saline-treated mice. In accordance with the findings in mice, PPARγ levels were lower in primary HBECs from COPD patients than in those from healthy never-smokers or healthy smokers. In conclusion, a vicious cycle of mutual augmentation of protease activity and inflammation resulting from PPARγ degradation plays a role in the pathogenesis of COPD. More... »

PAGES

947-955

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s12276-021-00626-7

DOI

http://dx.doi.org/10.1038/s12276-021-00626-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138215099

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34021254


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0304", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medicinal and Biomolecular Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Susceptibility", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocyte Elastase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipopolysaccharides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-kappa B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PPAR gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Hydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Disease, Chronic Obstructive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toll-Like Receptor 4", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwak", 
        "givenName": "Nakwon", 
        "id": "sg:person.0711211055.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711211055.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyoung-Hee", 
        "id": "sg:person.01245047024.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245047024.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woo", 
        "givenName": "Jisu", 
        "id": "sg:person.01212002650.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212002650.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jiyeon", 
        "id": "sg:person.013650033257.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013650033257.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Chang-Hoon", 
        "id": "sg:person.0743464132.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743464132.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Chul-Gyu", 
        "id": "sg:person.01355161055.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355161055.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm1361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044738635", 
          "https://doi.org/10.1038/nm1361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12931-019-1261-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1123786775", 
          "https://doi.org/10.1186/s12931-019-1261-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s12276-018-0122-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105765641", 
          "https://doi.org/10.1038/s12276-018-0122-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrdp.2015.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012847430", 
          "https://doi.org/10.1038/nrdp.2015.76"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12272-020-01235-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1127730579", 
          "https://doi.org/10.1007/s12272-020-01235-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2213-0802-1-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019291444", 
          "https://doi.org/10.1186/2213-0802-1-13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s12276-018-0114-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105340377", 
          "https://doi.org/10.1038/s12276-018-0114-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s12276-018-0187-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110403290", 
          "https://doi.org/10.1038/s12276-018-0187-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1710-1492-10-34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020874160", 
          "https://doi.org/10.1186/1710-1492-10-34"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-05-21", 
    "datePublishedReg": "2021-05-21", 
    "description": "Inflammation, oxidative stress, and protease\u2013antiprotease imbalance have been suggested to be a pathogenic triad in chronic obstructive pulmonary disease (COPD). However, it is not clear how proteases interact with components of inflammatory pathways. Therefore, this study aimed to evaluate the effect of neutrophil elastase (NE) on lipopolysaccharide (LPS)-induced interleukin 8 (IL-8) production and determine the molecular mechanism in human bronchial epithelial cells (HBECs). Immortalized bronchial epithelial cells and primary HBECs were used to investigate the impact of NE on LPS-induced IL-8 production. The molecular mechanism by which NE modulated LPS-induced IL-8 production was confirmed in elastase-treated C57BL/6 mice and primary HBECs obtained from COPD patients and healthy controls. The results showed that NE treatment synergistically augmented LPS-induced IL-8 production in both immortalized bronchial epithelial cells and primary HBECs. NE partially degraded peroxisome proliferator-activated receptor gamma (PPAR\u03b3), which is known to regulate IL-8 production in the nucleus. Treatment with a PPAR\u03b3 agonist and overexpression of PPAR\u03b3 reversed the NE-induced synergistic increase in LPS-induced IL-8 production. Moreover, PPAR\u03b3 levels were lower in lung homogenates and lung epithelial cells from elastase-treated mice than in those from saline-treated mice. In accordance with the findings in mice, PPAR\u03b3 levels were lower in primary HBECs from COPD patients than in those from healthy never-smokers or healthy smokers. In conclusion, a vicious cycle of mutual augmentation of protease activity and inflammation resulting from PPAR\u03b3 degradation plays a role in the pathogenesis of COPD.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s12276-021-00626-7", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1085098", 
        "issn": [
          "1226-3613", 
          "2092-6413"
        ], 
        "name": "Experimental & Molecular Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "53"
      }
    ], 
    "keywords": [
      "chronic obstructive pulmonary disease", 
      "primary human bronchial epithelial cells", 
      "IL-8 production", 
      "human bronchial epithelial cells", 
      "obstructive pulmonary disease", 
      "bronchial epithelial cells", 
      "neutrophil elastase", 
      "immortalized bronchial epithelial cells", 
      "COPD patients", 
      "pulmonary disease", 
      "epithelial cells", 
      "PPAR\u03b3 levels", 
      "pathogenesis of COPD", 
      "peroxisome proliferator-activated receptor gamma", 
      "elastase-treated mice", 
      "saline-treated mice", 
      "protease-antiprotease imbalance", 
      "PPAR\u03b3 degradation", 
      "proliferator-activated receptor gamma", 
      "overexpression of PPAR\u03b3", 
      "interleukin-8 production", 
      "lung epithelial cells", 
      "pathogenic triad", 
      "healthy smokers", 
      "C57BL/6 mice", 
      "inflammatory pathways", 
      "molecular mechanisms", 
      "lung homogenates", 
      "healthy controls", 
      "PPAR\u03b3 agonists", 
      "NE treatment", 
      "receptor gamma", 
      "inflammation", 
      "LPS", 
      "mice", 
      "oxidative stress", 
      "vicious cycle", 
      "smokers", 
      "patients", 
      "protease activity", 
      "synergistic increase", 
      "disease", 
      "mutual augmentation", 
      "treatment", 
      "cells", 
      "pathogenesis", 
      "agonists", 
      "PPAR\u03b3", 
      "lipopolysaccharide", 
      "elastase", 
      "levels", 
      "homogenates", 
      "synergistic cycles", 
      "activity", 
      "overexpression", 
      "conclusion", 
      "augmentation", 
      "pathway", 
      "mechanism", 
      "findings", 
      "imbalance", 
      "gamma", 
      "triad", 
      "production", 
      "control", 
      "protease", 
      "study", 
      "role", 
      "nucleus", 
      "increase", 
      "effect", 
      "cycle", 
      "stress", 
      "impact", 
      "results", 
      "accordance", 
      "components", 
      "degradation"
    ], 
    "name": "Synergistic cycles of protease activity and inflammation via PPAR\u03b3 degradation in chronic obstructive pulmonary disease", 
    "pagination": "947-955", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1138215099"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s12276-021-00626-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34021254"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s12276-021-00626-7", 
      "https://app.dimensions.ai/details/publication/pub.1138215099"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_905.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s12276-021-00626-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s12276-021-00626-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s12276-021-00626-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s12276-021-00626-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s12276-021-00626-7'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      21 PREDICATES      133 URIs      116 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s12276-021-00626-7 schema:about N1d532afc292d4404852b6a6c02b8f030
2 N2f396d716b6c4d24981f1e3427f6522f
3 N34c6a64cc21a40489896a89529a8328a
4 N3a22c2252aaa4c7096b6861e68f300af
5 N4df93ec12b394ec88139c403d1d56808
6 N4f7424b1ae7f45029d8baf41e12426df
7 N5f25dde9b5374a12b38e0bf477d4621f
8 N77d81541c5b6428eb03001cfc7a43a9e
9 N9ee2d003a5344d1e816816a8684c8c86
10 Na0630596ed314bf3a3fce52c1f0099e8
11 Na7e76909cfc14bb4a561ff66f045952f
12 Nbbdc8d04292a411192bb207983edfba2
13 Nbf63d25a9d0f4faeb85da60300614aae
14 Nc287da15daa8431187049efb4dc2c880
15 Nd8585666eb674eed91e1d93b484bf493
16 Nde26d3b33d7243d88f129993e2cd8929
17 Ne3147cee8d3a42e784a038bbdfa11975
18 Ne89411a4760f46f7a4efe763a35d34a5
19 Nee18f2cf9ffc4bea8067797ff5aaad9d
20 Nf2d260c6c61c4ad68c8662e09ce80561
21 Nfd8f98a11b054e16bccd2062f2ce8d51
22 anzsrc-for:03
23 anzsrc-for:0304
24 schema:author Nd40cd22889f64a438b90b3838a13a4f1
25 schema:citation sg:pub.10.1007/s12272-020-01235-0
26 sg:pub.10.1038/nm1361
27 sg:pub.10.1038/nrdp.2015.76
28 sg:pub.10.1038/s12276-018-0114-1
29 sg:pub.10.1038/s12276-018-0122-1
30 sg:pub.10.1038/s12276-018-0187-x
31 sg:pub.10.1186/1710-1492-10-34
32 sg:pub.10.1186/2213-0802-1-13
33 sg:pub.10.1186/s12931-019-1261-1
34 schema:datePublished 2021-05-21
35 schema:datePublishedReg 2021-05-21
36 schema:description Inflammation, oxidative stress, and protease–antiprotease imbalance have been suggested to be a pathogenic triad in chronic obstructive pulmonary disease (COPD). However, it is not clear how proteases interact with components of inflammatory pathways. Therefore, this study aimed to evaluate the effect of neutrophil elastase (NE) on lipopolysaccharide (LPS)-induced interleukin 8 (IL-8) production and determine the molecular mechanism in human bronchial epithelial cells (HBECs). Immortalized bronchial epithelial cells and primary HBECs were used to investigate the impact of NE on LPS-induced IL-8 production. The molecular mechanism by which NE modulated LPS-induced IL-8 production was confirmed in elastase-treated C57BL/6 mice and primary HBECs obtained from COPD patients and healthy controls. The results showed that NE treatment synergistically augmented LPS-induced IL-8 production in both immortalized bronchial epithelial cells and primary HBECs. NE partially degraded peroxisome proliferator-activated receptor gamma (PPARγ), which is known to regulate IL-8 production in the nucleus. Treatment with a PPARγ agonist and overexpression of PPARγ reversed the NE-induced synergistic increase in LPS-induced IL-8 production. Moreover, PPARγ levels were lower in lung homogenates and lung epithelial cells from elastase-treated mice than in those from saline-treated mice. In accordance with the findings in mice, PPARγ levels were lower in primary HBECs from COPD patients than in those from healthy never-smokers or healthy smokers. In conclusion, a vicious cycle of mutual augmentation of protease activity and inflammation resulting from PPARγ degradation plays a role in the pathogenesis of COPD.
37 schema:genre article
38 schema:isAccessibleForFree true
39 schema:isPartOf N082c59474b5447f69b9440ebbfb5e7fd
40 N20d03eea27c04eb898f355935e622978
41 sg:journal.1085098
42 schema:keywords C57BL/6 mice
43 COPD patients
44 IL-8 production
45 LPS
46 NE treatment
47 PPARγ
48 PPARγ agonists
49 PPARγ degradation
50 PPARγ levels
51 accordance
52 activity
53 agonists
54 augmentation
55 bronchial epithelial cells
56 cells
57 chronic obstructive pulmonary disease
58 components
59 conclusion
60 control
61 cycle
62 degradation
63 disease
64 effect
65 elastase
66 elastase-treated mice
67 epithelial cells
68 findings
69 gamma
70 healthy controls
71 healthy smokers
72 homogenates
73 human bronchial epithelial cells
74 imbalance
75 immortalized bronchial epithelial cells
76 impact
77 increase
78 inflammation
79 inflammatory pathways
80 interleukin-8 production
81 levels
82 lipopolysaccharide
83 lung epithelial cells
84 lung homogenates
85 mechanism
86 mice
87 molecular mechanisms
88 mutual augmentation
89 neutrophil elastase
90 nucleus
91 obstructive pulmonary disease
92 overexpression
93 overexpression of PPARγ
94 oxidative stress
95 pathogenesis
96 pathogenesis of COPD
97 pathogenic triad
98 pathway
99 patients
100 peroxisome proliferator-activated receptor gamma
101 primary human bronchial epithelial cells
102 production
103 proliferator-activated receptor gamma
104 protease
105 protease activity
106 protease-antiprotease imbalance
107 pulmonary disease
108 receptor gamma
109 results
110 role
111 saline-treated mice
112 smokers
113 stress
114 study
115 synergistic cycles
116 synergistic increase
117 treatment
118 triad
119 vicious cycle
120 schema:name Synergistic cycles of protease activity and inflammation via PPARγ degradation in chronic obstructive pulmonary disease
121 schema:pagination 947-955
122 schema:productId Nad152372c8fb4ba78a782f8f18b033d8
123 Nfa45d3ca50114d7ea7ab7c5024210af2
124 Nfd6f61d0bf994c3e88ca6bce11a0d900
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1138215099
126 https://doi.org/10.1038/s12276-021-00626-7
127 schema:sdDatePublished 2022-09-02T16:06
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher N1734e6b6d07e4f53800507285e30ca32
130 schema:url https://doi.org/10.1038/s12276-021-00626-7
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N082c59474b5447f69b9440ebbfb5e7fd schema:volumeNumber 53
135 rdf:type schema:PublicationVolume
136 N1734e6b6d07e4f53800507285e30ca32 schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 N1d532afc292d4404852b6a6c02b8f030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Toll-Like Receptor 4
140 rdf:type schema:DefinedTerm
141 N20d03eea27c04eb898f355935e622978 schema:issueNumber 5
142 rdf:type schema:PublicationIssue
143 N2493772550f14b64916e9d6620839c6c rdf:first sg:person.01355161055.28
144 rdf:rest rdf:nil
145 N2f396d716b6c4d24981f1e3427f6522f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Epithelial Cells
147 rdf:type schema:DefinedTerm
148 N34c6a64cc21a40489896a89529a8328a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Pulmonary Disease, Chronic Obstructive
150 rdf:type schema:DefinedTerm
151 N3a22c2252aaa4c7096b6861e68f300af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Cell Line
153 rdf:type schema:DefinedTerm
154 N4df93ec12b394ec88139c403d1d56808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Proteolysis
156 rdf:type schema:DefinedTerm
157 N4f7424b1ae7f45029d8baf41e12426df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Interleukin-8
159 rdf:type schema:DefinedTerm
160 N5f25dde9b5374a12b38e0bf477d4621f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Leukocyte Elastase
162 rdf:type schema:DefinedTerm
163 N66576a34bf274ce5b176cc102fd9b20b rdf:first sg:person.013650033257.20
164 rdf:rest Nd283eff2547b4e399d6216153bb662bc
165 N77d81541c5b6428eb03001cfc7a43a9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 N9ee2d003a5344d1e816816a8684c8c86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name NF-kappa B
170 rdf:type schema:DefinedTerm
171 Na0630596ed314bf3a3fce52c1f0099e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Lipopolysaccharides
173 rdf:type schema:DefinedTerm
174 Na2a58b27f4b34cc191d3f0170ef86a00 rdf:first sg:person.01212002650.32
175 rdf:rest N66576a34bf274ce5b176cc102fd9b20b
176 Na7e76909cfc14bb4a561ff66f045952f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Disease Susceptibility
178 rdf:type schema:DefinedTerm
179 Nad152372c8fb4ba78a782f8f18b033d8 schema:name doi
180 schema:value 10.1038/s12276-021-00626-7
181 rdf:type schema:PropertyValue
182 Nbbdc8d04292a411192bb207983edfba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Animals
184 rdf:type schema:DefinedTerm
185 Nbc90b76b1567409d9056eddb879c7aae rdf:first sg:person.01245047024.67
186 rdf:rest Na2a58b27f4b34cc191d3f0170ef86a00
187 Nbf63d25a9d0f4faeb85da60300614aae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name PPAR gamma
189 rdf:type schema:DefinedTerm
190 Nc287da15daa8431187049efb4dc2c880 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Biomarkers
192 rdf:type schema:DefinedTerm
193 Nd283eff2547b4e399d6216153bb662bc rdf:first sg:person.0743464132.81
194 rdf:rest N2493772550f14b64916e9d6620839c6c
195 Nd40cd22889f64a438b90b3838a13a4f1 rdf:first sg:person.0711211055.17
196 rdf:rest Nbc90b76b1567409d9056eddb879c7aae
197 Nd8585666eb674eed91e1d93b484bf493 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Gene Expression Regulation
199 rdf:type schema:DefinedTerm
200 Nde26d3b33d7243d88f129993e2cd8929 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Respiratory Mucosa
202 rdf:type schema:DefinedTerm
203 Ne3147cee8d3a42e784a038bbdfa11975 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Cells, Cultured
205 rdf:type schema:DefinedTerm
206 Ne89411a4760f46f7a4efe763a35d34a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Female
208 rdf:type schema:DefinedTerm
209 Nee18f2cf9ffc4bea8067797ff5aaad9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Mice
211 rdf:type schema:DefinedTerm
212 Nf2d260c6c61c4ad68c8662e09ce80561 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Signal Transduction
214 rdf:type schema:DefinedTerm
215 Nfa45d3ca50114d7ea7ab7c5024210af2 schema:name pubmed_id
216 schema:value 34021254
217 rdf:type schema:PropertyValue
218 Nfd6f61d0bf994c3e88ca6bce11a0d900 schema:name dimensions_id
219 schema:value pub.1138215099
220 rdf:type schema:PropertyValue
221 Nfd8f98a11b054e16bccd2062f2ce8d51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Peptide Hydrolases
223 rdf:type schema:DefinedTerm
224 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
225 schema:name Chemical Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:0304 schema:inDefinedTermSet anzsrc-for:
228 schema:name Medicinal and Biomolecular Chemistry
229 rdf:type schema:DefinedTerm
230 sg:journal.1085098 schema:issn 1226-3613
231 2092-6413
232 schema:name Experimental & Molecular Medicine
233 schema:publisher Springer Nature
234 rdf:type schema:Periodical
235 sg:person.01212002650.32 schema:affiliation grid-institutes:grid.412484.f
236 schema:familyName Woo
237 schema:givenName Jisu
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212002650.32
239 rdf:type schema:Person
240 sg:person.01245047024.67 schema:affiliation grid-institutes:grid.412484.f
241 schema:familyName Lee
242 schema:givenName Kyoung-Hee
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245047024.67
244 rdf:type schema:Person
245 sg:person.01355161055.28 schema:affiliation grid-institutes:grid.31501.36
246 schema:familyName Yoo
247 schema:givenName Chul-Gyu
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355161055.28
249 rdf:type schema:Person
250 sg:person.013650033257.20 schema:affiliation grid-institutes:grid.412484.f
251 schema:familyName Kim
252 schema:givenName Jiyeon
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013650033257.20
254 rdf:type schema:Person
255 sg:person.0711211055.17 schema:affiliation grid-institutes:grid.31501.36
256 schema:familyName Kwak
257 schema:givenName Nakwon
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711211055.17
259 rdf:type schema:Person
260 sg:person.0743464132.81 schema:affiliation grid-institutes:grid.31501.36
261 schema:familyName Lee
262 schema:givenName Chang-Hoon
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743464132.81
264 rdf:type schema:Person
265 sg:pub.10.1007/s12272-020-01235-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127730579
266 https://doi.org/10.1007/s12272-020-01235-0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nm1361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044738635
269 https://doi.org/10.1038/nm1361
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nrdp.2015.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012847430
272 https://doi.org/10.1038/nrdp.2015.76
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/s12276-018-0114-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105340377
275 https://doi.org/10.1038/s12276-018-0114-1
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/s12276-018-0122-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105765641
278 https://doi.org/10.1038/s12276-018-0122-1
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/s12276-018-0187-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1110403290
281 https://doi.org/10.1038/s12276-018-0187-x
282 rdf:type schema:CreativeWork
283 sg:pub.10.1186/1710-1492-10-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020874160
284 https://doi.org/10.1186/1710-1492-10-34
285 rdf:type schema:CreativeWork
286 sg:pub.10.1186/2213-0802-1-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019291444
287 https://doi.org/10.1186/2213-0802-1-13
288 rdf:type schema:CreativeWork
289 sg:pub.10.1186/s12931-019-1261-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123786775
290 https://doi.org/10.1186/s12931-019-1261-1
291 rdf:type schema:CreativeWork
292 grid-institutes:grid.31501.36 schema:alternateName Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
293 schema:name Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
294 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
295 rdf:type schema:Organization
296 grid-institutes:grid.412484.f schema:alternateName Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
297 schema:name Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...