Coronary stents with inducible VEGF/HGF-secreting UCB-MSCs reduced restenosis and increased re-endothelialization in a swine model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Hyun-Kyung Chang, Pyung-Hwan Kim, Dong Wook Kim, Hyun-Min Cho, Mi Jin Jeong, Dea Han Kim, Yoon Ki Joung, Kyung Seob Lim, Han Byul Kim, Han Cheol Lim, Dong Keun Han, Young Joon Hong, Je-Yoel Cho

ABSTRACT

Atherosclerotic plaques within the vasculature may eventually lead to heart failure. Currently, cardiac stenting is the most effective and least invasive approach to treat this disease. However, in-stent restenosis is a complex chronic side effect of stenting treatment. This study used coronary stents coated with stem cells secreting angiogenic growth factors via an inducible genome-editing system to reduce stent restenosis and induce re-endothelialization within the artery. The characteristics of the cells and their adhesion properties on the stents were confirmed, and the stents were transplanted into a swine model to evaluate restenosis and the potential therapeutic use of stents with stem cells. Restenosis was evaluated using optical coherence tomography (OCT), microcomputed tomography (mCT) and angiography, and re-endothelialization was evaluated by immunostaining after cardiac stent treatment. Compared to a bare metal stent (BMS) or a parental umbilical cord blood-derived mesenchymal stem cell (UCB-MSC)-coated stent, the stents with stem cells capable of the controlled release of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) successfully reduced restenosis within the stent and induced natural re-endothelialization. Furthermore, UCB-MSCs exhibited the ability to differentiate into endothelial cells in Matrigel, and HGF and VEGF improved this differentiation. Our study indicates that stents coated with UCB-MSCs secreting VEGF/HGF reduce the restenosis side effects of cardiac stenting with improved re-endothelialization. More... »

PAGES

114

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s12276-018-0143-9

DOI

http://dx.doi.org/10.1038/s12276-018-0143-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106476018

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30174328


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s12276-018-0143-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s12276-018-0143-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s12276-018-0143-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s12276-018-0143-9'


 

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286 schema:name Center for Biomaterials, Korea Institute of Science and Technology, Seoul, South Korea
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288 https://www.grid.ac/institutes/grid.410886.3 schema:alternateName CHA University
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292 schema:name Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea
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295 https://www.grid.ac/institutes/grid.411597.f schema:alternateName Chonnam National University Hospital
296 schema:name Chonnam National University Hospital, Gwangju, South Korea
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