Targeting of epigenetic regulators in neuroblastoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04

AUTHORS

Luz Jubierre, Carlos Jiménez, Eric Rovira, Aroa Soriano, Constantino Sábado, Luis Gros, Anna Llort, Raquel Hladun, Josep Roma, Josep Sánchez de Toledo, Soledad Gallego, Miguel F. Segura

ABSTRACT

Approximately 15,000 new cases of pediatric cancer are diagnosed yearly in Europe, with 8-10% corresponding to neuroblastoma, a rare disease with an incidence of 8-9 cases per million children <15 years of age. Although the survival rate for low-risk and intermediate-risk patients is excellent, half of children with high-risk, refractory, or relapsed tumors will be cured, and two-thirds of the other half will suffer major side effects and life-long disabilities. Epigenetic therapies aimed at reversing the oncogenic alterations in chromatin structure and function are an emerging alternative against aggressive tumors that are or will become resistant to conventional treatments. This approach proposes targeting epigenetic regulators, which are proteins that are involved in the creation, detection, and interpretation of epigenetic signals, such as methylation or histone post-translational modifications. In this review, we focused on the most promising epigenetic regulators for targeting and current drugs that have already reached clinical trials. More... »

PAGES

51

References to SciGraph publications

  • 2013-03. The histone deacetylase SIRT2 stabilizes Myc oncoproteins in CELL DEATH & DIFFERENTIATION
  • 2006-12. Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio in BMC CANCER
  • 2017-03. Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival in CELL DEATH & DISEASE
  • 2008-12. Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells in MOLECULAR CANCER
  • 2007-11. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours in BRITISH JOURNAL OF CANCER
  • 2011-04. CLU blocks HDACI-mediated killing of neuroblastoma in TUMOR BIOLOGY
  • 2010-12. Selective inhibition of BET bromodomains in NATURE
  • 2004-11. Sodium Butyrate Induces Apoptosis in MSN Neuroblastoma Cells in a Calcium Independent Pathway in NEUROCHEMICAL RESEARCH
  • 2015-12. DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy in BMC CANCER
  • 2010-12. Suppression of inflammation by a synthetic histone mimic in NATURE
  • 2004-02. Satelite Symposium V, Meet-the-Professor Sessions I and II, Main Sessions I-IX in ANNALS OF HEMATOLOGY
  • 2016-08. Mechanisms of tumor cell resistance to the current targeted-therapy agents in TUMOR BIOLOGY
  • 2012-05. Histone methylation: a dynamic mark in health, disease and inheritance in NATURE REVIEWS GENETICS
  • 2015-12. A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma in TARGETED ONCOLOGY
  • 2014-06. Histone deacetylase 5 blocks neuroblastoma cell differentiation by interacting with N-Myc in ONCOGENE
  • 1999-06. Structure and ligand of a histone acetyltransferase bromodomain in NATURE
  • 2015-02. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo in ONCOGENESIS
  • 2009-09. Protein methyltransferases as a target class for drug discovery in NATURE REVIEWS DRUG DISCOVERY
  • 2017-12. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma in BMC CANCER
  • 2011-10. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia in NATURE
  • 2015-02-19. Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation in CELL DEATH & DISEASE
  • 2007-12. Enhancing the anti-angiogenic action of histone deacetylase inhibitors in MOLECULAR CANCER
  • 2005-02. Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells in BRITISH JOURNAL OF CANCER
  • 2016-12. Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy in CLINICAL EPIGENETICS
  • 2009-05. Linking DNA methylation and histone modification: patterns and paradigms in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s12276-018-0077-2

    DOI

    http://dx.doi.org/10.1038/s12276-018-0077-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103640940

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29700278


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