Previously undescribed thyroid-specific miRNA sequences in papillary thyroid carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Mateus Camargo Barros-Filho, Michelle Pewarchuk, Brenda de Carvalho Minatel, Adam P. Sage, Erin A. Marshall, Victor D. Martinez, Leigha D. Rock, Gavin MacAulay, Luiz Paulo Kowalski, Silvia Regina Rogatto, Cathie Garnis, Wan L. Lam

ABSTRACT

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, wherein diagnostic limitations and lack of accurate prognostic factors are important clinical challenges. In this study, we report the discovery of 234 novel miRNAs in non-neoplastic thyroid and PTC samples, obtained from publicly available small RNA sequencing datasets (TCGA and GEO). These sequences were observed to display similar molecular features compared to currently annotated miRNAs. These potentially novel miRNAs presented tissue-specificity and largely decreased expression in PTC compared to non-neoplastic samples. We showed that the disrupted novel miRNAs have diagnostic and prognostic potential, and were associated with BRAF mutation, a frequent alteration related to more aggressive PTC. In conclusion, our results expand the miRNA repertoire in thyroid tissues and highlight the potential biological role and clinical utility of previously unannotated miRNAs. More... »

PAGES

1-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s10038-019-0583-7

DOI

http://dx.doi.org/10.1038/s10038-019-0583-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112575423

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30842597


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