Detection of de novo single nucleotide variants in offspring of atomic-bomb survivors close to the hypocenter by whole-genome sequencing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-26

AUTHORS

Makiko Horai, Hiroyuki Mishima, Chisa Hayashida, Akira Kinoshita, Yoshibumi Nakane, Tatsuki Matsuo, Kazuto Tsuruda, Katsunori Yanagihara, Shinya Sato, Daisuke Imanishi, Yoshitaka Imaizumi, Tomoko Hata, Yasushi Miyazaki, Koh-ichiro Yoshiura

ABSTRACT

Ionizing radiation released by the atomic bombs at Hiroshima and Nagasaki, Japan, in 1945 caused many long-term illnesses, including increased risks of malignancies such as leukemia and solid tumours. Radiation has demonstrated genetic effects in animal models, leading to concerns over the potential hereditary effects of atomic bomb-related radiation. However, no direct analyses of whole DNA have yet been reported. We therefore investigated de novo variants in offspring of atomic-bomb survivors by whole-genome sequencing (WGS). We collected peripheral blood from three trios, each comprising a father (atomic-bomb survivor with acute radiation symptoms), a non-exposed mother, and their child, none of whom had any past history of haematological disorders. One trio of non-exposed individuals was included as a control. DNA was extracted and the numbers of de novo single nucleotide variants in the children were counted by WGS with sequencing confirmation. Gross structural variants were also analysed. Written informed consent was obtained from all participants prior to the study. There were 62, 81, and 42 de novo single nucleotide variants in the children of atomic-bomb survivors, compared with 48 in the control trio. There were no gross structural variants in any trio. These findings are in accord with previously published results that also showed no significant genetic effects of atomic-bomb radiation on second-generation survivors. More... »

PAGES

357-363

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s10038-017-0392-9

DOI

http://dx.doi.org/10.1038/s10038-017-0392-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099939072

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29279608


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37 analysis
38 animal models
39 atomic bomb
40 atomic bomb radiation
41 atomic bomb survivors
42 blood
43 bomb
44 children
45 concern
46 confirmation
47 consent
48 control
49 control trios
50 de novo single nucleotide variants
51 de novo variants
52 detection
53 direct analysis
54 disorders
55 effect
56 fathers
57 findings
58 genetic effects
59 haematological disorders
60 hereditary effects
61 history
62 hypocenters
63 illness
64 individuals
65 informed consent
66 leukemia
67 long-term illness
68 malignancy
69 model
70 mothers
71 non-exposed individuals
72 non-exposed mothers
73 novo single nucleotide variants
74 novo variants
75 nucleotide variants
76 number
77 offspring
78 participants
79 past history
80 peripheral blood
81 radiation
82 results
83 risk
84 risk of malignancy
85 second-generation survivors
86 sequencing
87 significant genetic effects
88 single nucleotide variants
89 solid tumors
90 structural variants
91 study
92 survivors
93 trios
94 tumors
95 variants
96 whole DNA
97 whole-genome sequencing
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