Cytokine responses in primary and secondary respiratory syncytial virus infections View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06

AUTHORS

Kelechi Ugonna, Konstantinos Douros, Colin D. Bingle, Mark L. Everard

ABSTRACT

BACKGROUND: Primary respiratory syncytial virus (RSV) infections are characterized by high levels of IL-8 and an intense neutrophilia. Little is known about the cytokine responses in secondary infections. Preschool children experiencing RSV secondary infections were recruited from the siblings of infants admitted to hospital with RSV acute bronchiolitis. METHODS: Fifty-one infants with acute bronchiolitis (39 RSV positive, 12 RSV negative) and 20 age-matched control infants were recruited. In addition, seven older siblings of infants from the RSV-positive cohort and confirmed RSV infection were recruited. Samples of nasal secretions were obtained using a flocked swab, and secretions extracted using centrifugation. Cytokine bead array was used to obtain levels of interleukin (IL)-17A, IL-8, IL-6, IL-21, and tumor necrosis factor-α. RESULTS: Levels of IL-8 and IL-6 were significantly lower in the RSV-positive siblings compared with the RSV-positive infants. There were no significant differences between levels of the other cytokines in the primary and secondary infections. CONCLUSION: The very high levels of IL-8 and IL-6 response characteristic of the primary RSV infection was not observed in secondary RSV-positive infections and this did not appear to be due to a global reduction in cytokine production. More... »

PAGES

946-950

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/pr.2016.29

DOI

http://dx.doi.org/10.1038/pr.2016.29

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049202806

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26882371


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