Ontology type: schema:ScholarlyArticle Open Access: True
2016-06
AUTHORSJudith Pichler, Christina Ong, Neil Shah, Neil Sebire, Fevronia Kiparrissi, Osvaldo Borrelli, Clarissa Pilkington, Mamoun Elawad
ABSTRACTBACKGROUND: The association between inflammatory bowel disease and joint involvement is well established. There is a paucity of data describing histopathological features of the gut in relation to juvenile idiopathic arthritis (JIA). METHODS: We retrospectively identified 33 (21 male) children aged 3-16 y with JIA (11 with oligoarthritis, 5 with polyarthritis, 8 with systemic onset arthritis, 8 with enthesitis-related arthritis (ERA), and 1 with psoriatic arthritis) with significant gastrointestinal (GI) symptoms who underwent upper and/or lower endoscopy. The histopathological findings were reviewed in addition to presence of autoantibodies and concomitant treatment. RESULTS: The most common GI indications for endoscopy were persistent abdominal pain (14/33 (42%)) and diarrhea (10/33 (30%)). Of the 33 children, 28 (85%) had gut mucosal inflammation, mostly affecting the colon (80%). Active inflammation of the gut was found in 5 of 28 (17%) children, and 15 of 28 (53%) children showed mild nonspecific inflammation. Eight patients (27%) had predominantly an eosinophilic infiltrate. Twenty-six patients had previously received treatment for JIA. There was a negative association with the use of immunomodulators and the presence of eosinophil inflammation. CONCLUSION: The majority of children with JIA and GI symptoms have histological evidence of mild nonspecific inflammation, but some having active colitis and prominent eosinophil infiltrate. More... »
PAGES895-901
http://scigraph.springernature.com/pub.10.1038/pr.2016.27
DOIhttp://dx.doi.org/10.1038/pr.2016.27
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26882369
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"type": "ScholarlyArticle",
"url": "http://www.nature.com/pr/journal/v79/n6/full/pr201627a.html"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/pr.2016.27'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/pr.2016.27'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/pr.2016.27'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/pr.2016.27'
This table displays all metadata directly associated to this object as RDF triples.
316 TRIPLES
21 PREDICATES
86 URIs
37 LITERALS
25 BLANK NODES