Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11

AUTHORS

Anna Viitasalo, Aino-Maija Eloranta, Mustafa Atalay, Stefano Romeo, Jussi Pihlajamäki, Timo A. Lakka

ABSTRACT

BACKGROUND: We studied for the first time among children differences in plasma alanine aminotransferase (ALT) among genotypes of the rs641738 polymorphism in the MBOAT7 gene that has been associated with increased risk of nonalcoholic fatty liver disease among adults. We also investigated the associations of a genetic risk score combining information from the MBOAT7, PNPLA3, and TM6SF2 polymorphisms with plasma ALT. METHODS: We performed a 2-y follow-up study in 467 Caucasian children aged 6-9 y, genotyped the MBOAT7, PNPLA3, and TM6SF2 polymorphisms, calculated a genetic risk score from these polymorphisms (scored 0-3) and assessed plasma ALT. RESULTS: Children carrying the T allele of the MBOAT7 polymorphism had 7% higher plasma ALT at baseline (17.8 vs. 19.1 U/l, P = 0.022) and 10% higher plasma ALT at 2-y follow-up (18.0 vs. 19.7 U/l, P = 0.022) than the noncarriers. A higher genetic risk score was associated with higher plasma ALT at baseline (17.5, 18.5, 19.2, and 22.8 U/l, P = 0.008 for linear trend) and 2-y follow-up (18.2, 18.9, 18.9, and 32.8 U/l, P = 0.017 for linear trend). CONCLUSION: Children carrying the T allele of the MBOAT7 polymorphism had higher plasma ALT than the noncarriers. Children with the MBOAT7, PNPLA3, and TM6SF2 variants had the highest plasma ALT. More... »

PAGES

651

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/pr.2016.139

DOI

http://dx.doi.org/10.1038/pr.2016.139

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000706868

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27411039


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acyltransferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alanine Transaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Association Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Non-alcoholic Fatty Liver Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Eastern Finland", 
          "id": "https://www.grid.ac/institutes/grid.9668.1", 
          "name": [
            "Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viitasalo", 
        "givenName": "Anna", 
        "id": "sg:person.0756030446.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756030446.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Finland", 
          "id": "https://www.grid.ac/institutes/grid.9668.1", 
          "name": [
            "Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eloranta", 
        "givenName": "Aino-Maija", 
        "id": "sg:person.01255773251.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255773251.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Finland", 
          "id": "https://www.grid.ac/institutes/grid.9668.1", 
          "name": [
            "Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atalay", 
        "givenName": "Mustafa", 
        "id": "sg:person.0710032356.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710032356.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sahlgrenska University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1649.a", 
          "name": [
            "Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden", 
            "Department of Medical and Surgical Sciences, Clinical Nutrition Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy", 
            "Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romeo", 
        "givenName": "Stefano", 
        "id": "sg:person.01075540443.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075540443.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kuopio University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410705.7", 
          "name": [
            "Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland", 
            "Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pihlajam\u00e4ki", 
        "givenName": "Jussi", 
        "id": "sg:person.01257265235.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257265235.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kuopion Liikuntal\u00e4\u00e4ketieteen Tutkimuslaitos", 
          "id": "https://www.grid.ac/institutes/grid.419013.e", 
          "name": [
            "Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland", 
            "Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland", 
            "Kuopio Research Institute of Exercise Medicine, Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lakka", 
        "givenName": "Timo A.", 
        "id": "sg:person.01205012472.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205012472.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/ijpo.12032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002046935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2013.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002121143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008453458", 
          "https://doi.org/10.1038/ng.2901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5868-11-55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014974780", 
          "https://doi.org/10.1186/1479-5868-11-55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/519795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019061180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2010.02.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022062896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2016.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026400145", 
          "https://doi.org/10.1038/pr.2016.3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexmp.2015.01.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026595254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijo.2012.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034456532", 
          "https://doi.org/10.1038/ijo.2012.89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.27490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039935900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ijpo.234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041922956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07853890.2010.515603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043895279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045345124", 
          "https://doi.org/10.1038/ng.257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047403286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2016.01.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049459904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m806194200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052196461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2006-1212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053617366"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-11", 
    "datePublishedReg": "2016-11-01", 
    "description": "BACKGROUND: We studied for the first time among children differences in plasma alanine aminotransferase (ALT) among genotypes of the rs641738 polymorphism in the MBOAT7 gene that has been associated with increased risk of nonalcoholic fatty liver disease among adults. We also investigated the associations of a genetic risk score combining information from the MBOAT7, PNPLA3, and TM6SF2 polymorphisms with plasma ALT.\nMETHODS: We performed a 2-y follow-up study in 467 Caucasian children aged 6-9 y, genotyped the MBOAT7, PNPLA3, and TM6SF2 polymorphisms, calculated a genetic risk score from these polymorphisms (scored 0-3) and assessed plasma ALT.\nRESULTS: Children carrying the T allele of the MBOAT7 polymorphism had 7% higher plasma ALT at baseline (17.8 vs. 19.1\u2009U/l, P = 0.022) and 10% higher plasma ALT at 2-y follow-up (18.0 vs. 19.7\u2009U/l, P = 0.022) than the noncarriers. A higher genetic risk score was associated with higher plasma ALT at baseline (17.5, 18.5, 19.2, and 22.8\u2009U/l, P = 0.008 for linear trend) and 2-y follow-up (18.2, 18.9, 18.9, and 32.8\u2009U/l, P = 0.017 for linear trend).\nCONCLUSION: Children carrying the T allele of the MBOAT7 polymorphism had higher plasma ALT than the noncarriers. Children with the MBOAT7, PNPLA3, and TM6SF2 variants had the highest plasma ALT.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/pr.2016.139", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "80"
      }
    ], 
    "name": "Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study", 
    "pagination": "651", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "035dbae3c139763e2439a4d7088b8dd2dfa6417c3dbd595d1fc91b3a2e86bf52"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27411039"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0100714"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/pr.2016.139"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000706868"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/pr.2016.139", 
      "https://app.dimensions.ai/details/publication/pub.1000706868"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/pr2016139"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/pr.2016.139'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/pr.2016.139'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/pr.2016.139'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/pr.2016.139'


 

This table displays all metadata directly associated to this object as RDF triples.

246 TRIPLES      21 PREDICATES      64 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/pr.2016.139 schema:about N0cb35d852e71457794e07dba09a89848
2 N1d3110e4276b4bee84301d05ccd8a86f
3 N251bfe729f204b9090cfb748b54905e6
4 N39a8f69dd28341d99d4ea9796959654a
5 N4d21ab24322641f9847994c53d32e998
6 N4e6de2999e5942098b3787924e6bc65e
7 N4e73c87247274fefbfba4b92e3f4a5d9
8 N56776975a0464093a7804d4b349f9465
9 N68d558fea69e4fdabb56e7c28bbf257b
10 N6901dd94d3444b9a9b6412115289c512
11 N70e0fb5032bf401397270ee5a5ca16f3
12 N7bf712e5ef604dedb4d82ef50cecc564
13 N7d750e38b79c4c29830b9efe8b2ea63b
14 N7f2747f2d0de45bab7528338b0a995ad
15 Na819e65fe67c4270b1db41242a0362cd
16 Nd699907cb8f5426e9ce9c52c9b785560
17 Ne83f4b01a14d49ac8f0a6f1375ccd023
18 Nee1681068612487bb54e47921908846c
19 anzsrc-for:11
20 anzsrc-for:1117
21 schema:author N87b208d59e094d869ea1fbee716b7aee
22 schema:citation sg:pub.10.1038/ijo.2012.89
23 sg:pub.10.1038/ng.257
24 sg:pub.10.1038/ng.2901
25 sg:pub.10.1038/pr.2016.3
26 sg:pub.10.1186/1479-5868-11-55
27 https://doi.org/10.1002/hep.22726
28 https://doi.org/10.1002/hep.27490
29 https://doi.org/10.1016/j.bbamem.2013.10.003
30 https://doi.org/10.1016/j.jhep.2010.02.034
31 https://doi.org/10.1016/j.yexmp.2015.01.012
32 https://doi.org/10.1053/j.gastro.2016.01.032
33 https://doi.org/10.1074/jbc.m806194200
34 https://doi.org/10.1086/519795
35 https://doi.org/10.1111/ijpo.12032
36 https://doi.org/10.1111/ijpo.234
37 https://doi.org/10.1542/peds.2006-1212
38 https://doi.org/10.3109/07853890.2010.515603
39 schema:datePublished 2016-11
40 schema:datePublishedReg 2016-11-01
41 schema:description BACKGROUND: We studied for the first time among children differences in plasma alanine aminotransferase (ALT) among genotypes of the rs641738 polymorphism in the MBOAT7 gene that has been associated with increased risk of nonalcoholic fatty liver disease among adults. We also investigated the associations of a genetic risk score combining information from the MBOAT7, PNPLA3, and TM6SF2 polymorphisms with plasma ALT. METHODS: We performed a 2-y follow-up study in 467 Caucasian children aged 6-9 y, genotyped the MBOAT7, PNPLA3, and TM6SF2 polymorphisms, calculated a genetic risk score from these polymorphisms (scored 0-3) and assessed plasma ALT. RESULTS: Children carrying the T allele of the MBOAT7 polymorphism had 7% higher plasma ALT at baseline (17.8 vs. 19.1 U/l, P = 0.022) and 10% higher plasma ALT at 2-y follow-up (18.0 vs. 19.7 U/l, P = 0.022) than the noncarriers. A higher genetic risk score was associated with higher plasma ALT at baseline (17.5, 18.5, 19.2, and 22.8 U/l, P = 0.008 for linear trend) and 2-y follow-up (18.2, 18.9, 18.9, and 32.8 U/l, P = 0.017 for linear trend). CONCLUSION: Children carrying the T allele of the MBOAT7 polymorphism had higher plasma ALT than the noncarriers. Children with the MBOAT7, PNPLA3, and TM6SF2 variants had the highest plasma ALT.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree true
45 schema:isPartOf N6b7f9b23e4e44f47af3bce4548abf0f0
46 Nf1a582d614704cc9b74aefa07e3d4371
47 sg:journal.1007352
48 schema:name Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study
49 schema:pagination 651
50 schema:productId N1f0e0aeb693840dab8327ba576a30839
51 N29f9efc7840a440fb9144802a7aa009a
52 N5c12470227d947c38da73b2931da477d
53 N68def12ede6948ca887fd58688d9392b
54 Neef839afdccd4123b9c6bf4c370a2f09
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000706868
56 https://doi.org/10.1038/pr.2016.139
57 schema:sdDatePublished 2019-04-10T16:30
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N25519cb33c92472b8094a1a23d04b33b
60 schema:url https://www.nature.com/articles/pr2016139
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N0cb35d852e71457794e07dba09a89848 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Membrane Proteins
66 rdf:type schema:DefinedTerm
67 N1d3110e4276b4bee84301d05ccd8a86f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Follow-Up Studies
69 rdf:type schema:DefinedTerm
70 N1f0e0aeb693840dab8327ba576a30839 schema:name nlm_unique_id
71 schema:value 0100714
72 rdf:type schema:PropertyValue
73 N251bfe729f204b9090cfb748b54905e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Non-alcoholic Fatty Liver Disease
75 rdf:type schema:DefinedTerm
76 N25519cb33c92472b8094a1a23d04b33b schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N29f9efc7840a440fb9144802a7aa009a schema:name pubmed_id
79 schema:value 27411039
80 rdf:type schema:PropertyValue
81 N3304b80de1624a60bf232dce47a79247 rdf:first sg:person.01255773251.16
82 rdf:rest N47fd793652a44339ba3c8e1194c80f6f
83 N39a8f69dd28341d99d4ea9796959654a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Lipase
85 rdf:type schema:DefinedTerm
86 N47fd793652a44339ba3c8e1194c80f6f rdf:first sg:person.0710032356.10
87 rdf:rest N9945d64624d44e05a571ee1c0afc44ab
88 N4d21ab24322641f9847994c53d32e998 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Humans
90 rdf:type schema:DefinedTerm
91 N4e6de2999e5942098b3787924e6bc65e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Alanine Transaminase
93 rdf:type schema:DefinedTerm
94 N4e73c87247274fefbfba4b92e3f4a5d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Alleles
96 rdf:type schema:DefinedTerm
97 N56776975a0464093a7804d4b349f9465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Genetic Predisposition to Disease
99 rdf:type schema:DefinedTerm
100 N5c12470227d947c38da73b2931da477d schema:name dimensions_id
101 schema:value pub.1000706868
102 rdf:type schema:PropertyValue
103 N68d558fea69e4fdabb56e7c28bbf257b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Male
105 rdf:type schema:DefinedTerm
106 N68def12ede6948ca887fd58688d9392b schema:name readcube_id
107 schema:value 035dbae3c139763e2439a4d7088b8dd2dfa6417c3dbd595d1fc91b3a2e86bf52
108 rdf:type schema:PropertyValue
109 N6901dd94d3444b9a9b6412115289c512 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Risk Factors
111 rdf:type schema:DefinedTerm
112 N6b7f9b23e4e44f47af3bce4548abf0f0 schema:issueNumber 5
113 rdf:type schema:PublicationIssue
114 N70e0fb5032bf401397270ee5a5ca16f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Polymorphism, Single Nucleotide
116 rdf:type schema:DefinedTerm
117 N7bf712e5ef604dedb4d82ef50cecc564 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Acyltransferases
119 rdf:type schema:DefinedTerm
120 N7d750e38b79c4c29830b9efe8b2ea63b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 N7f2747f2d0de45bab7528338b0a995ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Heterozygote
125 rdf:type schema:DefinedTerm
126 N87b208d59e094d869ea1fbee716b7aee rdf:first sg:person.0756030446.09
127 rdf:rest N3304b80de1624a60bf232dce47a79247
128 N8ed129ff57274d298aa3a396833f19a2 rdf:first sg:person.01257265235.25
129 rdf:rest Nf175ceb497ee4ac49ea43bd9dcb6f5a5
130 N9945d64624d44e05a571ee1c0afc44ab rdf:first sg:person.01075540443.55
131 rdf:rest N8ed129ff57274d298aa3a396833f19a2
132 Na819e65fe67c4270b1db41242a0362cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Genotype
134 rdf:type schema:DefinedTerm
135 Nd699907cb8f5426e9ce9c52c9b785560 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Genetic Association Studies
137 rdf:type schema:DefinedTerm
138 Ne83f4b01a14d49ac8f0a6f1375ccd023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Homozygote
140 rdf:type schema:DefinedTerm
141 Nee1681068612487bb54e47921908846c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Child
143 rdf:type schema:DefinedTerm
144 Neef839afdccd4123b9c6bf4c370a2f09 schema:name doi
145 schema:value 10.1038/pr.2016.139
146 rdf:type schema:PropertyValue
147 Nf175ceb497ee4ac49ea43bd9dcb6f5a5 rdf:first sg:person.01205012472.24
148 rdf:rest rdf:nil
149 Nf1a582d614704cc9b74aefa07e3d4371 schema:volumeNumber 80
150 rdf:type schema:PublicationVolume
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
155 schema:name Public Health and Health Services
156 rdf:type schema:DefinedTerm
157 sg:journal.1007352 schema:issn 0031-3998
158 1530-0447
159 schema:name Pediatric Research
160 rdf:type schema:Periodical
161 sg:person.01075540443.55 schema:affiliation https://www.grid.ac/institutes/grid.1649.a
162 schema:familyName Romeo
163 schema:givenName Stefano
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075540443.55
165 rdf:type schema:Person
166 sg:person.01205012472.24 schema:affiliation https://www.grid.ac/institutes/grid.419013.e
167 schema:familyName Lakka
168 schema:givenName Timo A.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205012472.24
170 rdf:type schema:Person
171 sg:person.01255773251.16 schema:affiliation https://www.grid.ac/institutes/grid.9668.1
172 schema:familyName Eloranta
173 schema:givenName Aino-Maija
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255773251.16
175 rdf:type schema:Person
176 sg:person.01257265235.25 schema:affiliation https://www.grid.ac/institutes/grid.410705.7
177 schema:familyName Pihlajamäki
178 schema:givenName Jussi
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257265235.25
180 rdf:type schema:Person
181 sg:person.0710032356.10 schema:affiliation https://www.grid.ac/institutes/grid.9668.1
182 schema:familyName Atalay
183 schema:givenName Mustafa
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710032356.10
185 rdf:type schema:Person
186 sg:person.0756030446.09 schema:affiliation https://www.grid.ac/institutes/grid.9668.1
187 schema:familyName Viitasalo
188 schema:givenName Anna
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756030446.09
190 rdf:type schema:Person
191 sg:pub.10.1038/ijo.2012.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034456532
192 https://doi.org/10.1038/ijo.2012.89
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/ng.257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045345124
195 https://doi.org/10.1038/ng.257
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/ng.2901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008453458
198 https://doi.org/10.1038/ng.2901
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/pr.2016.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026400145
201 https://doi.org/10.1038/pr.2016.3
202 rdf:type schema:CreativeWork
203 sg:pub.10.1186/1479-5868-11-55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014974780
204 https://doi.org/10.1186/1479-5868-11-55
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/hep.22726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047403286
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/hep.27490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039935900
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.bbamem.2013.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002121143
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.jhep.2010.02.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022062896
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.yexmp.2015.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026595254
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1053/j.gastro.2016.01.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049459904
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1074/jbc.m806194200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052196461
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1111/ijpo.12032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002046935
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1111/ijpo.234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041922956
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1542/peds.2006-1212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053617366
227 rdf:type schema:CreativeWork
228 https://doi.org/10.3109/07853890.2010.515603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043895279
229 rdf:type schema:CreativeWork
230 https://www.grid.ac/institutes/grid.1649.a schema:alternateName Sahlgrenska University Hospital
231 schema:name Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden
232 Department of Medical and Surgical Sciences, Clinical Nutrition Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy
233 Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.410705.7 schema:alternateName Kuopio University Hospital
236 schema:name Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland
237 Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.419013.e schema:alternateName Kuopion Liikuntalääketieteen Tutkimuslaitos
240 schema:name Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
241 Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland
242 Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.9668.1 schema:alternateName University of Eastern Finland
245 schema:name Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland
246 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...