Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia–ischemia: a potential marker ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Nathalie Bednarek, Pernilla Svedin, Roselyne Garnotel, Géraldine Favrais, Gauthier Loron, Leslie Schwendiman, Henrik Hagberg, Patrice Morville, Carina Mallard, Pierre Gressens

ABSTRACT

INTRODUCTION: To implement neuroprotective strategies in newborns, sensitive and specific biomarkers are needed for identifying those who are at risk for brain damage. We evaluated the effectiveness of matrix metalloproteinases (MMPs) and their naturally occurring tissue inhibitors of metalloproteinases (TIMPs) in predicting neonatal encephalopathy (NE) damage in newborns. RESULTS: Plasma MMP-9 and TIMP-1 levels were upregulated as early as 1 h after the HI insult but not did not show such elevations after other types of injury (ibotenate-induced excitotoxicity, hypoxia, lipopolysaccharide-induced inflammation), and brain levels reflected this increase soon thereafter. We confirmed these results by carrying out plasma MMP-9 and TIMP-1 measurements in human newborns with NE. In these infants, protein levels of MMP-9 and TIMP-1 were found to be elevated during a short window up to 6 h after birth. DISCUSSION: This feature is particularly useful in identifying newborns in need of neuroprotection. A second peak observed 72 h after birth is possibly related to the second phase of energy failure after a HI insult. Our data, although preliminary, support the use of MMP-9 and TIMP-1 as early biomarkers for the presence and extent of perinatal brain injury in human term newborns. METHODS: We first used a mouse model of neonatal HI injury to explore mechanistic aspects such as the time course of these markers after the hypoxia-ischemia event, and the correlation between the levels of these candidate markers in brain and plasma. More... »

PAGES

pr20113

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/pr.2011.3

DOI

http://dx.doi.org/10.1038/pr.2011.3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005481405

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22289852


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gestational Age", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoxia-Ischemia, Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn, Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Inhibitor of Metalloproteinase-1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Inserm, H\u00f4pital Robert Debr\u00e9, Paris, France", 
            "Universit\u00e9 Paris 7, Facult\u00e9 de M\u00e9decine Denis Diderot, Paris, France", 
            "PremUP, Paris, France", 
            "Neonatalogy Department, Alix de Champagne, Reims, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bednarek", 
        "givenName": "Nathalie", 
        "id": "sg:person.0746467141.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746467141.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Gothenburg", 
          "id": "https://www.grid.ac/institutes/grid.8761.8", 
          "name": [
            "G\u00f6teborg University, G\u00f6teborg, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Svedin", 
        "givenName": "Pernilla", 
        "id": "sg:person.01221176364.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221176364.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Reims Champagne-Ardenne", 
          "id": "https://www.grid.ac/institutes/grid.11667.37", 
          "name": [
            "CNRS UMR 6237, Universit\u00e9 de Reims Champagne-Ardennes, Reims, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garnotel", 
        "givenName": "Roselyne", 
        "id": "sg:person.01352220636.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352220636.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Inserm, H\u00f4pital Robert Debr\u00e9, Paris, France", 
            "Universit\u00e9 Paris 7, Facult\u00e9 de M\u00e9decine Denis Diderot, Paris, France", 
            "PremUP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Favrais", 
        "givenName": "G\u00e9raldine", 
        "id": "sg:person.01131030741.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131030741.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Inserm, H\u00f4pital Robert Debr\u00e9, Paris, France", 
            "Universit\u00e9 Paris 7, Facult\u00e9 de M\u00e9decine Denis Diderot, Paris, France", 
            "PremUP, Paris, France", 
            "Neonatalogy Department, Alix de Champagne, Reims, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loron", 
        "givenName": "Gauthier", 
        "id": "sg:person.01205731263.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205731263.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Inserm, H\u00f4pital Robert Debr\u00e9, Paris, France", 
            "Universit\u00e9 Paris 7, Facult\u00e9 de M\u00e9decine Denis Diderot, Paris, France", 
            "PremUP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwendiman", 
        "givenName": "Leslie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Institute for Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagberg", 
        "givenName": "Henrik", 
        "id": "sg:person.01166227175.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166227175.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Neonatalogy Department, Alix de Champagne, Reims, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morville", 
        "givenName": "Patrice", 
        "id": "sg:person.01361505741.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361505741.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Gothenburg", 
          "id": "https://www.grid.ac/institutes/grid.8761.8", 
          "name": [
            "G\u00f6teborg University, G\u00f6teborg, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mallard", 
        "givenName": "Carina", 
        "id": "sg:person.01074522122.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074522122.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Inserm, H\u00f4pital Robert Debr\u00e9, Paris, France", 
            "Universit\u00e9 Paris 7, Facult\u00e9 de M\u00e9decine Denis Diderot, Paris, France", 
            "PremUP, Paris, France", 
            "Institute for Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gressens", 
        "givenName": "Pierre", 
        "id": "sg:person.0643134421.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.cir.0000046451.38849.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000088472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.braindev.2008.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001954677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003459355", 
          "https://doi.org/10.1038/nm1387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003459355", 
          "https://doi.org/10.1038/nm1387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1976.00500100030012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004561882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4391-06.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004808607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-7799(92)90214-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004977439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-7799(92)90214-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004977439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2007-0770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005104446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2007.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005541619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2008.07.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007247837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199505000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011135625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2004.03.070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012122554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hs1201.99512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012677388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012833247", 
          "https://doi.org/10.1038/sj.gt.3302894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044-7431(02)00024-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015853027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044-7431(02)00024-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015853027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000314624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018348113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2009.06362.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026686674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2009.06362.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026686674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181973aee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028082515", 
          "https://doi.org/10.1203/pdr.0b013e3181973aee"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181973aee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028082515", 
          "https://doi.org/10.1203/pdr.0b013e3181973aee"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.2003.02127.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030741311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dneu.20770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032925514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dneu.20770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032925514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036175576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0953-816x.2001.01474.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036696638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410090206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039014419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awl239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044861621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.32.8.1759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045276503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000075563.45920.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046526365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000075563.45920.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046526365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199412000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051439584", 
          "https://doi.org/10.1203/00006450-199412000-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2009.0959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059301019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/08830738060210091101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063854354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/08830738060210091101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063854354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.20-18-07037.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074700587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077800877", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.17-11-04223.1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083089624"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01", 
    "datePublishedReg": "2012-01-01", 
    "description": "INTRODUCTION: To implement neuroprotective strategies in newborns, sensitive and specific biomarkers are needed for identifying those who are at risk for brain damage. We evaluated the effectiveness of matrix metalloproteinases (MMPs) and their naturally occurring tissue inhibitors of metalloproteinases (TIMPs) in predicting neonatal encephalopathy (NE) damage in newborns.\nRESULTS: Plasma MMP-9 and TIMP-1 levels were upregulated as early as 1 h after the HI insult but not did not show such elevations after other types of injury (ibotenate-induced excitotoxicity, hypoxia, lipopolysaccharide-induced inflammation), and brain levels reflected this increase soon thereafter. We confirmed these results by carrying out plasma MMP-9 and TIMP-1 measurements in human newborns with NE. In these infants, protein levels of MMP-9 and TIMP-1 were found to be elevated during a short window up to 6 h after birth.\nDISCUSSION: This feature is particularly useful in identifying newborns in need of neuroprotection. A second peak observed 72 h after birth is possibly related to the second phase of energy failure after a HI insult. Our data, although preliminary, support the use of MMP-9 and TIMP-1 as early biomarkers for the presence and extent of perinatal brain injury in human term newborns.\nMETHODS: We first used a mouse model of neonatal HI injury to explore mechanistic aspects such as the time course of these markers after the hypoxia-ischemia event, and the correlation between the levels of these candidate markers in brain and plasma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/pr.2011.3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "71"
      }
    ], 
    "name": "Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia\u2013ischemia: a potential marker of neonatal encephalopathy", 
    "pagination": "pr20113", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1a1e4ab866f23ad56152d82184c10c40d86288099d60512bcc9409c48362f421"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22289852"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0100714"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/pr.2011.3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005481405"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/pr.2011.3", 
      "https://app.dimensions.ai/details/publication/pub.1005481405"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/pr20113"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/pr.2011.3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/pr.2011.3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/pr.2011.3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/pr.2011.3'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      21 PREDICATES      75 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/pr.2011.3 schema:about N2b457fdd32a74416b11b39dfc3b9c357
2 N3652cd345b7c4a87bfa4913e3bb26904
3 N44ee3b9db15f4617bce48e21219bd48e
4 N460196ac2c6b4b88911c2e648efcbfe9
5 N4f33856ffc4c40d4945c6a5d5ff7b58c
6 N5097cef45f7440f2b159f7897916bbb8
7 N50c83aa36e704df38a362c4f4dfee808
8 N912bc3b44a2e4bdc9f394c2ccfd9edaa
9 Naf3cbb9b1ab042c191fa87dfd2b2d56f
10 Nb5c7fa8ef6714eb4a4947752ea11da60
11 Nb93413986b424c4aa5adbac4ad5faa51
12 Nc2cb7649dd1f47dabb9a30e77c010660
13 Ne58f286f814944d9b743bc273ba09135
14 Ned26548158f441bc85bcdf4df92551ef
15 Nfb905f7de51c4bab8a1d87560d661a7f
16 anzsrc-for:11
17 anzsrc-for:1114
18 schema:author N69551dd525664aa7a1fae62ae81d1c5b
19 schema:citation sg:pub.10.1038/nm1387
20 sg:pub.10.1038/sj.gt.3302894
21 sg:pub.10.1203/00006450-199412000-00003
22 sg:pub.10.1203/pdr.0b013e3181973aee
23 https://app.dimensions.ai/details/publication/pub.1077800877
24 https://doi.org/10.1001/archneur.1976.00500100030012
25 https://doi.org/10.1002/ana.410090206
26 https://doi.org/10.1002/dneu.20770
27 https://doi.org/10.1002/glia.20169
28 https://doi.org/10.1016/0167-7799(92)90214-g
29 https://doi.org/10.1016/j.braindev.2008.09.001
30 https://doi.org/10.1016/j.febslet.2004.03.070
31 https://doi.org/10.1016/j.neuroscience.2008.07.069
32 https://doi.org/10.1016/j.semcdb.2007.06.003
33 https://doi.org/10.1016/s1044-7431(02)00024-6
34 https://doi.org/10.1046/j.0953-816x.2001.01474.x
35 https://doi.org/10.1046/j.1365-2249.2003.02127.x
36 https://doi.org/10.1089/neu.2009.0959
37 https://doi.org/10.1093/brain/awl239
38 https://doi.org/10.1097/00005072-199505000-00009
39 https://doi.org/10.1111/j.1471-4159.2009.06362.x
40 https://doi.org/10.1159/000314624
41 https://doi.org/10.1161/01.cir.0000046451.38849.90
42 https://doi.org/10.1161/01.str.0000075563.45920.24
43 https://doi.org/10.1161/01.str.32.8.1759
44 https://doi.org/10.1161/hs1201.99512
45 https://doi.org/10.1177/08830738060210091101
46 https://doi.org/10.1523/jneurosci.17-11-04223.1997
47 https://doi.org/10.1523/jneurosci.20-18-07037.2000
48 https://doi.org/10.1523/jneurosci.4391-06.2007
49 https://doi.org/10.1542/peds.2007-0770
50 schema:datePublished 2012-01
51 schema:datePublishedReg 2012-01-01
52 schema:description INTRODUCTION: To implement neuroprotective strategies in newborns, sensitive and specific biomarkers are needed for identifying those who are at risk for brain damage. We evaluated the effectiveness of matrix metalloproteinases (MMPs) and their naturally occurring tissue inhibitors of metalloproteinases (TIMPs) in predicting neonatal encephalopathy (NE) damage in newborns. RESULTS: Plasma MMP-9 and TIMP-1 levels were upregulated as early as 1 h after the HI insult but not did not show such elevations after other types of injury (ibotenate-induced excitotoxicity, hypoxia, lipopolysaccharide-induced inflammation), and brain levels reflected this increase soon thereafter. We confirmed these results by carrying out plasma MMP-9 and TIMP-1 measurements in human newborns with NE. In these infants, protein levels of MMP-9 and TIMP-1 were found to be elevated during a short window up to 6 h after birth. DISCUSSION: This feature is particularly useful in identifying newborns in need of neuroprotection. A second peak observed 72 h after birth is possibly related to the second phase of energy failure after a HI insult. Our data, although preliminary, support the use of MMP-9 and TIMP-1 as early biomarkers for the presence and extent of perinatal brain injury in human term newborns. METHODS: We first used a mouse model of neonatal HI injury to explore mechanistic aspects such as the time course of these markers after the hypoxia-ischemia event, and the correlation between the levels of these candidate markers in brain and plasma.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N3f04178fa1344981828411ee041dc909
57 Nf348636e369945fd95dbd2294cbf14d8
58 sg:journal.1007352
59 schema:name Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia–ischemia: a potential marker of neonatal encephalopathy
60 schema:pagination pr20113
61 schema:productId N1db5b45deb7c4726b336a8acab41e7fa
62 N8ba703cb39884833815e9fcbde1a0eb5
63 Na894632c94d947dc852454bda8ef70c7
64 Nc0ea62a529434309b5927db0f4b66da0
65 Nc9c7a7d56f9d496483aa9d84f7c583ba
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005481405
67 https://doi.org/10.1038/pr.2011.3
68 schema:sdDatePublished 2019-04-10T23:11
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N3bba43701eb2429fadab8179f07864e0
71 schema:url http://www.nature.com/articles/pr20113
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N06be550540c541e3a60b25b73d83ee9a schema:name Neonatalogy Department, Alix de Champagne, Reims, France
76 rdf:type schema:Organization
77 N1235517b4c3347e4aa49fcdf2b294f93 rdf:first sg:person.01361505741.44
78 rdf:rest N19870a90f73f42c282e0aff4d245b14f
79 N19870a90f73f42c282e0aff4d245b14f rdf:first sg:person.01074522122.76
80 rdf:rest N5378b92726404b93909fd98164c0d2d6
81 N1db5b45deb7c4726b336a8acab41e7fa schema:name nlm_unique_id
82 schema:value 0100714
83 rdf:type schema:PropertyValue
84 N2b457fdd32a74416b11b39dfc3b9c357 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Tissue Inhibitor of Metalloproteinase-1
86 rdf:type schema:DefinedTerm
87 N3652cd345b7c4a87bfa4913e3bb26904 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Matrix Metalloproteinase 9
89 rdf:type schema:DefinedTerm
90 N3bba43701eb2429fadab8179f07864e0 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N3f04178fa1344981828411ee041dc909 schema:volumeNumber 71
93 rdf:type schema:PublicationVolume
94 N44ee3b9db15f4617bce48e21219bd48e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Biomarkers
96 rdf:type schema:DefinedTerm
97 N460196ac2c6b4b88911c2e648efcbfe9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N4f33856ffc4c40d4945c6a5d5ff7b58c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Infant, Newborn, Diseases
102 rdf:type schema:DefinedTerm
103 N5097cef45f7440f2b159f7897916bbb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Animals
105 rdf:type schema:DefinedTerm
106 N50c83aa36e704df38a362c4f4dfee808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Brain
108 rdf:type schema:DefinedTerm
109 N5378b92726404b93909fd98164c0d2d6 rdf:first sg:person.0643134421.39
110 rdf:rest rdf:nil
111 N5d134a0a598e4dae9f0979a12d02d3bb rdf:first sg:person.01352220636.76
112 rdf:rest N6e38a32cdbf347a681ee104cc626f0cb
113 N69551dd525664aa7a1fae62ae81d1c5b rdf:first sg:person.0746467141.07
114 rdf:rest N97e6e764db664991926cffdb5b00c4b6
115 N6e38a32cdbf347a681ee104cc626f0cb rdf:first sg:person.01131030741.23
116 rdf:rest Nbedc755af7b34cbc9b4d6b874ae46c5e
117 N89e5d0be2b2c41d4ac4ca1a25dbf4d56 rdf:first sg:person.01166227175.33
118 rdf:rest N1235517b4c3347e4aa49fcdf2b294f93
119 N8ba703cb39884833815e9fcbde1a0eb5 schema:name doi
120 schema:value 10.1038/pr.2011.3
121 rdf:type schema:PropertyValue
122 N912bc3b44a2e4bdc9f394c2ccfd9edaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Animals, Newborn
124 rdf:type schema:DefinedTerm
125 N97e6e764db664991926cffdb5b00c4b6 rdf:first sg:person.01221176364.17
126 rdf:rest N5d134a0a598e4dae9f0979a12d02d3bb
127 Na894632c94d947dc852454bda8ef70c7 schema:name readcube_id
128 schema:value 1a1e4ab866f23ad56152d82184c10c40d86288099d60512bcc9409c48362f421
129 rdf:type schema:PropertyValue
130 Naf3cbb9b1ab042c191fa87dfd2b2d56f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Mice, Inbred C57BL
132 rdf:type schema:DefinedTerm
133 Nb5c7fa8ef6714eb4a4947752ea11da60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Infant, Newborn
135 rdf:type schema:DefinedTerm
136 Nb93413986b424c4aa5adbac4ad5faa51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Male
138 rdf:type schema:DefinedTerm
139 Nbedc755af7b34cbc9b4d6b874ae46c5e rdf:first sg:person.01205731263.15
140 rdf:rest Nf70f46dac7ad40f48a1acabe8c5625b2
141 Nc0ea62a529434309b5927db0f4b66da0 schema:name pubmed_id
142 schema:value 22289852
143 rdf:type schema:PropertyValue
144 Nc2cb7649dd1f47dabb9a30e77c010660 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Hypoxia-Ischemia, Brain
146 rdf:type schema:DefinedTerm
147 Nc9c7a7d56f9d496483aa9d84f7c583ba schema:name dimensions_id
148 schema:value pub.1005481405
149 rdf:type schema:PropertyValue
150 Ne58f286f814944d9b743bc273ba09135 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Gestational Age
152 rdf:type schema:DefinedTerm
153 Ned26548158f441bc85bcdf4df92551ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Female
155 rdf:type schema:DefinedTerm
156 Nee49ee66e83d45bcbf8178f15d77b104 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
157 schema:familyName Schwendiman
158 schema:givenName Leslie
159 rdf:type schema:Person
160 Nf348636e369945fd95dbd2294cbf14d8 schema:issueNumber 1
161 rdf:type schema:PublicationIssue
162 Nf70f46dac7ad40f48a1acabe8c5625b2 rdf:first Nee49ee66e83d45bcbf8178f15d77b104
163 rdf:rest N89e5d0be2b2c41d4ac4ca1a25dbf4d56
164 Nfb905f7de51c4bab8a1d87560d661a7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mice
166 rdf:type schema:DefinedTerm
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
171 schema:name Paediatrics and Reproductive Medicine
172 rdf:type schema:DefinedTerm
173 sg:journal.1007352 schema:issn 0031-3998
174 1530-0447
175 schema:name Pediatric Research
176 rdf:type schema:Periodical
177 sg:person.01074522122.76 schema:affiliation https://www.grid.ac/institutes/grid.8761.8
178 schema:familyName Mallard
179 schema:givenName Carina
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074522122.76
181 rdf:type schema:Person
182 sg:person.01131030741.23 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
183 schema:familyName Favrais
184 schema:givenName Géraldine
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131030741.23
186 rdf:type schema:Person
187 sg:person.01166227175.33 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
188 schema:familyName Hagberg
189 schema:givenName Henrik
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166227175.33
191 rdf:type schema:Person
192 sg:person.01205731263.15 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
193 schema:familyName Loron
194 schema:givenName Gauthier
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205731263.15
196 rdf:type schema:Person
197 sg:person.01221176364.17 schema:affiliation https://www.grid.ac/institutes/grid.8761.8
198 schema:familyName Svedin
199 schema:givenName Pernilla
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221176364.17
201 rdf:type schema:Person
202 sg:person.01352220636.76 schema:affiliation https://www.grid.ac/institutes/grid.11667.37
203 schema:familyName Garnotel
204 schema:givenName Roselyne
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352220636.76
206 rdf:type schema:Person
207 sg:person.01361505741.44 schema:affiliation N06be550540c541e3a60b25b73d83ee9a
208 schema:familyName Morville
209 schema:givenName Patrice
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361505741.44
211 rdf:type schema:Person
212 sg:person.0643134421.39 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
213 schema:familyName Gressens
214 schema:givenName Pierre
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39
216 rdf:type schema:Person
217 sg:person.0746467141.07 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
218 schema:familyName Bednarek
219 schema:givenName Nathalie
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746467141.07
221 rdf:type schema:Person
222 sg:pub.10.1038/nm1387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003459355
223 https://doi.org/10.1038/nm1387
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/sj.gt.3302894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012833247
226 https://doi.org/10.1038/sj.gt.3302894
227 rdf:type schema:CreativeWork
228 sg:pub.10.1203/00006450-199412000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051439584
229 https://doi.org/10.1203/00006450-199412000-00003
230 rdf:type schema:CreativeWork
231 sg:pub.10.1203/pdr.0b013e3181973aee schema:sameAs https://app.dimensions.ai/details/publication/pub.1028082515
232 https://doi.org/10.1203/pdr.0b013e3181973aee
233 rdf:type schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1077800877 schema:CreativeWork
235 https://doi.org/10.1001/archneur.1976.00500100030012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004561882
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/ana.410090206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039014419
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/dneu.20770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032925514
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/glia.20169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036175576
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0167-7799(92)90214-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1004977439
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.braindev.2008.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001954677
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.febslet.2004.03.070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012122554
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.neuroscience.2008.07.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007247837
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.semcdb.2007.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005541619
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s1044-7431(02)00024-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015853027
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1046/j.0953-816x.2001.01474.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036696638
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1046/j.1365-2249.2003.02127.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030741311
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1089/neu.2009.0959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059301019
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/brain/awl239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044861621
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1097/00005072-199505000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011135625
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1111/j.1471-4159.2009.06362.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026686674
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1159/000314624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018348113
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1161/01.cir.0000046451.38849.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000088472
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1161/01.str.0000075563.45920.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046526365
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1161/01.str.32.8.1759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045276503
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1161/hs1201.99512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012677388
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1177/08830738060210091101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063854354
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1523/jneurosci.17-11-04223.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083089624
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1523/jneurosci.20-18-07037.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074700587
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1523/jneurosci.4391-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004808607
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1542/peds.2007-0770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005104446
286 rdf:type schema:CreativeWork
287 https://www.grid.ac/institutes/grid.11667.37 schema:alternateName University of Reims Champagne-Ardenne
288 schema:name CNRS UMR 6237, Université de Reims Champagne-Ardennes, Reims, France
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
291 schema:name Inserm, Hôpital Robert Debré, Paris, France
292 Institute for Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London, UK
293 PremUP, Paris, France
294 Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.7452.4 schema:alternateName Paris Diderot University
297 schema:name Inserm, Hôpital Robert Debré, Paris, France
298 Neonatalogy Department, Alix de Champagne, Reims, France
299 PremUP, Paris, France
300 Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.8761.8 schema:alternateName University of Gothenburg
303 schema:name Göteborg University, Göteborg, Sweden
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...