Treatment of M1a/M1b prostate cancer with or without radical prostatectomy at diagnosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

M Moschini, A Morlacco, E Kwon, L J Rangel, R J Karnes

ABSTRACT

BACKGROUND: The aim of the study was to evaluate survival and perioperative outcomes of metastatic prostate cancer (mPCa) patients treated with surgery or androgen deprivation treatment (ADT) only. METHODS: We retrospectively selected 47 metastatic PCa patients treated at a single center (Mayo Clinic, Rochester, MN) by two urologists (RJK and EK) between 2007 and 2014. Overall, 31 (66%) underwent radical prostatectomy (RP) with or without adjuvant therapies and 16 (34%) underwent ADT only. Surgical patients were treated by a single surgeon (RJK). Complications and functional outcomes were recorded for surgery group. Cancer-specific mortality (CSM) was analyzed by Kaplan-Meier estimation. Univariable Cox regression analyses were used to test the risk factors associated with CSM in mPCa patients treated with RP. RESULTS: Median age at diagnosis was 61 years. During median follow-up 38.8 months, 12 deaths were recorded. At 5 years, the overall CSM-free survival rate of the whole cohort was 57.9%. When patients were stratified according to the treatment, CSM-free survival rate at 5 years was 62% and 46% for patients who underwent surgery and ADT, respectively (P=0.3). Median length of stay was 3 days, with a 30 days readmission rate of 9.7%. The 30-day all complication rate was 29% (n=9). Specifically, we recorded: 2 lymphoceles (6.5%), 2 wound infection (6.5%), 2 ileus (6.5%), 2 hematoma (6.5%) and 1 anastomosis leak (3.2%). Within 90 days after surgery, 2 (6.5%) and 5 (16.1%) patients needed 1-2 supportive and 3 or more pads, respectively. However, continence was achieved by all treated patients during the follow-up period. CONCLUSIONS: We demonstrated the feasibility of local surgical treatment of primary tumor in mPCa patients. However, in the short term, no survival benefits have been observed for patients treated with surgery when compared with patients treated with ADT only. Further prospective studies are warranted to explore the treatment of M1a/M1b prostate cancer patients. More... »

PAGES

117

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/pcan.2016.63

DOI

http://dx.doi.org/10.1038/pcan.2016.63

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004807308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28045114


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Urology, Mayo Clinic, Rochester, MN, USA", 
            "Department of Urology, Urological Research Institute, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moschini", 
        "givenName": "M", 
        "id": "sg:person.01231501506.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231501506.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Urology, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morlacco", 
        "givenName": "A", 
        "id": "sg:person.01201506002.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201506002.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Urology, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwon", 
        "givenName": "E", 
        "id": "sg:person.01340532575.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340532575.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Health Science Research, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rangel", 
        "givenName": "L J", 
        "id": "sg:person.01307044477.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307044477.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Urology, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karnes", 
        "givenName": "R J", 
        "id": "sg:person.0650161446.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650161446.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.canep.2014.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001552075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2015.05.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007662037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa003013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009470130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2014.08.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011552444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2013.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017035598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2015.02.084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017111468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2013.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019201054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019704095", 
          "https://doi.org/10.1038/nrc2621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019704095", 
          "https://doi.org/10.1038/nrc2621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2014.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022465118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.10.218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034108390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2011.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034445570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2016.04.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038691365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.26031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040551217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042664529", 
          "https://doi.org/10.1038/nrc1098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042664529", 
          "https://doi.org/10.1038/nrc1098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.28485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044200688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2013.05.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045536776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2014.09.089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046781709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/spc.0000000000000218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048643231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/spc.0000000000000218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048643231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pcan.2016.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052410418", 
          "https://doi.org/10.1038/pcan.2016.52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.5.1248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077498744", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2014.0072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078907823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2014.0072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078907823"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03", 
    "datePublishedReg": "2017-03-01", 
    "description": "BACKGROUND: The aim of the study was to evaluate survival and perioperative outcomes of metastatic prostate cancer (mPCa) patients treated with surgery or androgen deprivation treatment (ADT) only.\nMETHODS: We retrospectively selected 47 metastatic PCa patients treated at a single center (Mayo Clinic, Rochester, MN) by two urologists (RJK and EK) between 2007 and 2014. Overall, 31 (66%) underwent radical prostatectomy (RP) with or without adjuvant therapies and 16 (34%) underwent ADT only. Surgical patients were treated by a single surgeon (RJK). Complications and functional outcomes were recorded for surgery group. Cancer-specific mortality (CSM) was analyzed by Kaplan-Meier estimation. Univariable Cox regression analyses were used to test the risk factors associated with CSM in mPCa patients treated with RP.\nRESULTS: Median age at diagnosis was 61 years. During median follow-up 38.8 months, 12 deaths were recorded. At 5 years, the overall CSM-free survival rate of the whole cohort was 57.9%. When patients were stratified according to the treatment, CSM-free survival rate at 5 years was 62% and 46% for patients who underwent surgery and ADT, respectively (P=0.3). Median length of stay was 3 days, with a 30 days readmission rate of 9.7%. The 30-day all complication rate was 29% (n=9). Specifically, we recorded: 2 lymphoceles (6.5%), 2 wound infection (6.5%), 2 ileus (6.5%), 2 hematoma (6.5%) and 1 anastomosis leak (3.2%). Within 90 days after surgery, 2 (6.5%) and 5 (16.1%) patients needed 1-2 supportive and 3 or more pads, respectively. However, continence was achieved by all treated patients during the follow-up period.\nCONCLUSIONS: We demonstrated the feasibility of local surgical treatment of primary tumor in mPCa patients. However, in the short term, no survival benefits have been observed for patients treated with surgery when compared with patients treated with ADT only. Further prospective studies are warranted to explore the treatment of M1a/M1b prostate cancer patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/pcan.2016.63", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1119336", 
        "issn": [
          "1365-7852", 
          "1476-5608"
        ], 
        "name": "Prostate Cancer and Prostatic Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Treatment of M1a/M1b prostate cancer with or without radical prostatectomy at diagnosis", 
    "pagination": "117", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "16e7fb09fa2e25cf17d68db371cf86b3a2d5dfc9a004732fd0781a9a482cd1a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28045114"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9815755"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/pcan.2016.63"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004807308"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/pcan.2016.63", 
      "https://app.dimensions.ai/details/publication/pub.1004807308"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/pcan201663"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/pcan.2016.63'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/pcan.2016.63'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/pcan.2016.63'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/pcan.2016.63'


 

This table displays all metadata directly associated to this object as RDF triples.

234 TRIPLES      21 PREDICATES      68 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/pcan.2016.63 schema:about N00b87268109147fdafafef5f74d23856
2 N0a3ad913acf34de58ae28e2336eb45a2
3 N0bd0387243364b2185e82704d5c90ab0
4 N33051db25b0a42b9aa1918958ed11ac2
5 N37fc1d48ed0240d2a62593c08e8f2c68
6 N3971b766fb03475787ddbaa6276e7898
7 N4f3559d2cc97463699424cf301d12678
8 N4f36ee6c5f8a4b58bf6e00fd004fd6e2
9 N718ea81181ae42af803fa7f8e03d871d
10 N919973ba867d4fa3be973bb4571485c9
11 Nc26f994a8e9144d59b8f5f77f1d51185
12 Ncc915115aca24a2ebadb88ba774f0345
13 Nd53f8cc4f5cc4187a78ffa4a01357661
14 Ndafb753a08824fc4a68049460f232868
15 Nf09f9aacfaca4475a951ea4ad67a9da9
16 Nf2c12e586eae4cd3823fa62b84099f36
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N769509f69ebc41a39e4639c08d410b95
20 schema:citation sg:pub.10.1038/nrc1098
21 sg:pub.10.1038/nrc2621
22 sg:pub.10.1038/pcan.2016.52
23 https://app.dimensions.ai/details/publication/pub.1077498744
24 https://doi.org/10.1002/cncr.28485
25 https://doi.org/10.1002/ijc.26031
26 https://doi.org/10.1016/j.canep.2014.04.002
27 https://doi.org/10.1016/j.ejca.2011.03.002
28 https://doi.org/10.1016/j.eururo.2013.05.023
29 https://doi.org/10.1016/j.eururo.2013.11.002
30 https://doi.org/10.1016/j.eururo.2013.11.012
31 https://doi.org/10.1016/j.eururo.2014.04.009
32 https://doi.org/10.1016/j.eururo.2014.08.056
33 https://doi.org/10.1016/j.eururo.2015.05.023
34 https://doi.org/10.1016/j.eururo.2016.04.031
35 https://doi.org/10.1016/j.juro.2014.09.089
36 https://doi.org/10.1016/j.juro.2015.02.084
37 https://doi.org/10.1056/nejmoa003013
38 https://doi.org/10.1097/01.sla.0000133083.54934.ae
39 https://doi.org/10.1097/spc.0000000000000218
40 https://doi.org/10.1200/jco.20.5.1248
41 https://doi.org/10.1200/jco.2004.10.218
42 https://doi.org/10.6004/jnccn.2014.0072
43 schema:datePublished 2017-03
44 schema:datePublishedReg 2017-03-01
45 schema:description BACKGROUND: The aim of the study was to evaluate survival and perioperative outcomes of metastatic prostate cancer (mPCa) patients treated with surgery or androgen deprivation treatment (ADT) only. METHODS: We retrospectively selected 47 metastatic PCa patients treated at a single center (Mayo Clinic, Rochester, MN) by two urologists (RJK and EK) between 2007 and 2014. Overall, 31 (66%) underwent radical prostatectomy (RP) with or without adjuvant therapies and 16 (34%) underwent ADT only. Surgical patients were treated by a single surgeon (RJK). Complications and functional outcomes were recorded for surgery group. Cancer-specific mortality (CSM) was analyzed by Kaplan-Meier estimation. Univariable Cox regression analyses were used to test the risk factors associated with CSM in mPCa patients treated with RP. RESULTS: Median age at diagnosis was 61 years. During median follow-up 38.8 months, 12 deaths were recorded. At 5 years, the overall CSM-free survival rate of the whole cohort was 57.9%. When patients were stratified according to the treatment, CSM-free survival rate at 5 years was 62% and 46% for patients who underwent surgery and ADT, respectively (P=0.3). Median length of stay was 3 days, with a 30 days readmission rate of 9.7%. The 30-day all complication rate was 29% (n=9). Specifically, we recorded: 2 lymphoceles (6.5%), 2 wound infection (6.5%), 2 ileus (6.5%), 2 hematoma (6.5%) and 1 anastomosis leak (3.2%). Within 90 days after surgery, 2 (6.5%) and 5 (16.1%) patients needed 1-2 supportive and 3 or more pads, respectively. However, continence was achieved by all treated patients during the follow-up period. CONCLUSIONS: We demonstrated the feasibility of local surgical treatment of primary tumor in mPCa patients. However, in the short term, no survival benefits have been observed for patients treated with surgery when compared with patients treated with ADT only. Further prospective studies are warranted to explore the treatment of M1a/M1b prostate cancer patients.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N3406204da4f4417392b0b81e7b8ae4c7
50 Nf642bfa69dfa4fcab9268d04c695df77
51 sg:journal.1119336
52 schema:name Treatment of M1a/M1b prostate cancer with or without radical prostatectomy at diagnosis
53 schema:pagination 117
54 schema:productId N424b78ffd81c4a908ca723c384ca8aac
55 N8ce1f5c642b7474586b517ab18f0edfe
56 Nc91492ab92da43989786f4cd73132f12
57 Ndd6b7f305fc441d59e30a2ac3d03c690
58 Nedd9048e2ad640d49fab1a846cc29404
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004807308
60 https://doi.org/10.1038/pcan.2016.63
61 schema:sdDatePublished 2019-04-10T20:34
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nf9f3f40b474c403f9c13a90a77126ed7
64 schema:url https://www.nature.com/articles/pcan201663
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N00b87268109147fdafafef5f74d23856 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Retrospective Studies
70 rdf:type schema:DefinedTerm
71 N0a3ad913acf34de58ae28e2336eb45a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Prostatectomy
73 rdf:type schema:DefinedTerm
74 N0b9101dbe9e34009b8e2f60aacff6114 rdf:first sg:person.0650161446.99
75 rdf:rest rdf:nil
76 N0bd0387243364b2185e82704d5c90ab0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Biopsy
78 rdf:type schema:DefinedTerm
79 N1dc0d23960794b8fa8b54e265b586d96 rdf:first sg:person.01307044477.22
80 rdf:rest N0b9101dbe9e34009b8e2f60aacff6114
81 N33051db25b0a42b9aa1918958ed11ac2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Aged
83 rdf:type schema:DefinedTerm
84 N3406204da4f4417392b0b81e7b8ae4c7 schema:volumeNumber 20
85 rdf:type schema:PublicationVolume
86 N37fc1d48ed0240d2a62593c08e8f2c68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Follow-Up Studies
88 rdf:type schema:DefinedTerm
89 N3971b766fb03475787ddbaa6276e7898 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Neoplasm Metastasis
91 rdf:type schema:DefinedTerm
92 N424b78ffd81c4a908ca723c384ca8aac schema:name dimensions_id
93 schema:value pub.1004807308
94 rdf:type schema:PropertyValue
95 N4f3559d2cc97463699424cf301d12678 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N4f36ee6c5f8a4b58bf6e00fd004fd6e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Treatment Outcome
100 rdf:type schema:DefinedTerm
101 N718ea81181ae42af803fa7f8e03d871d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Kaplan-Meier Estimate
103 rdf:type schema:DefinedTerm
104 N769509f69ebc41a39e4639c08d410b95 rdf:first sg:person.01231501506.89
105 rdf:rest Nf39b0c9877424c64bde7a5516e9746ab
106 N8ce1f5c642b7474586b517ab18f0edfe schema:name doi
107 schema:value 10.1038/pcan.2016.63
108 rdf:type schema:PropertyValue
109 N919973ba867d4fa3be973bb4571485c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Neoplasm Grading
111 rdf:type schema:DefinedTerm
112 Nc26f994a8e9144d59b8f5f77f1d51185 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Proportional Hazards Models
114 rdf:type schema:DefinedTerm
115 Nc91492ab92da43989786f4cd73132f12 schema:name readcube_id
116 schema:value 16e7fb09fa2e25cf17d68db371cf86b3a2d5dfc9a004732fd0781a9a482cd1a0
117 rdf:type schema:PropertyValue
118 Ncc915115aca24a2ebadb88ba774f0345 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Neoplasm Staging
120 rdf:type schema:DefinedTerm
121 Nd53f8cc4f5cc4187a78ffa4a01357661 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Middle Aged
123 rdf:type schema:DefinedTerm
124 Ndafb753a08824fc4a68049460f232868 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Male
126 rdf:type schema:DefinedTerm
127 Ndbd4fd77b0814616b18107ca3d2018a7 rdf:first sg:person.01340532575.78
128 rdf:rest N1dc0d23960794b8fa8b54e265b586d96
129 Ndd6b7f305fc441d59e30a2ac3d03c690 schema:name nlm_unique_id
130 schema:value 9815755
131 rdf:type schema:PropertyValue
132 Nedd9048e2ad640d49fab1a846cc29404 schema:name pubmed_id
133 schema:value 28045114
134 rdf:type schema:PropertyValue
135 Nf09f9aacfaca4475a951ea4ad67a9da9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Combined Modality Therapy
137 rdf:type schema:DefinedTerm
138 Nf2c12e586eae4cd3823fa62b84099f36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Prostatic Neoplasms
140 rdf:type schema:DefinedTerm
141 Nf39b0c9877424c64bde7a5516e9746ab rdf:first sg:person.01201506002.15
142 rdf:rest Ndbd4fd77b0814616b18107ca3d2018a7
143 Nf642bfa69dfa4fcab9268d04c695df77 schema:issueNumber 1
144 rdf:type schema:PublicationIssue
145 Nf9f3f40b474c403f9c13a90a77126ed7 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
151 schema:name Clinical Sciences
152 rdf:type schema:DefinedTerm
153 sg:journal.1119336 schema:issn 1365-7852
154 1476-5608
155 schema:name Prostate Cancer and Prostatic Diseases
156 rdf:type schema:Periodical
157 sg:person.01201506002.15 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
158 schema:familyName Morlacco
159 schema:givenName A
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201506002.15
161 rdf:type schema:Person
162 sg:person.01231501506.89 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
163 schema:familyName Moschini
164 schema:givenName M
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231501506.89
166 rdf:type schema:Person
167 sg:person.01307044477.22 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
168 schema:familyName Rangel
169 schema:givenName L J
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307044477.22
171 rdf:type schema:Person
172 sg:person.01340532575.78 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
173 schema:familyName Kwon
174 schema:givenName E
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340532575.78
176 rdf:type schema:Person
177 sg:person.0650161446.99 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
178 schema:familyName Karnes
179 schema:givenName R J
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650161446.99
181 rdf:type schema:Person
182 sg:pub.10.1038/nrc1098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042664529
183 https://doi.org/10.1038/nrc1098
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/nrc2621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019704095
186 https://doi.org/10.1038/nrc2621
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/pcan.2016.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052410418
189 https://doi.org/10.1038/pcan.2016.52
190 rdf:type schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1077498744 schema:CreativeWork
192 https://doi.org/10.1002/cncr.28485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044200688
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/ijc.26031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040551217
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.canep.2014.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001552075
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.ejca.2011.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034445570
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.eururo.2013.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045536776
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.eururo.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019201054
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.eururo.2013.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017035598
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.eururo.2014.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022465118
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.eururo.2014.08.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011552444
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.eururo.2015.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007662037
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.eururo.2016.04.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038691365
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.juro.2014.09.089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046781709
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.juro.2015.02.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017111468
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1056/nejmoa003013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009470130
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1097/01.sla.0000133083.54934.ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1024049438
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1097/spc.0000000000000218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048643231
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1200/jco.20.5.1248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202847
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1200/jco.2004.10.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034108390
227 rdf:type schema:CreativeWork
228 https://doi.org/10.6004/jnccn.2014.0072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078907823
229 rdf:type schema:CreativeWork
230 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
231 schema:name Department of Health Science Research, Mayo Clinic, Rochester, MN, USA
232 Department of Urology, Mayo Clinic, Rochester, MN, USA
233 Department of Urology, Urological Research Institute, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
234 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...