Evaluation of models predicting insignificant prostate cancer to select men for active surveillance of prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

L-M Wong, D E Neal, A Finelli, S Davis, C Bonner, J Kapoor, J Trachtenberg, B Thomas, C M Hovens, A J Costello, N M Corcoran

ABSTRACT

BACKGROUND: In an era of personalized medicine, individualized risk assessment using easily available tools on the internet and the literature are appealing. However, uninformed use by clinicians and the public raises potential problems. Herein, we assess the performance of published models to predict insignificant prostate cancer (PCa), using a multi-national low-risk population that may be considered for active surveillance (AS) based on contemporary practice. METHODS: Data on men suitable for AS but undergoing upfront radical prostatectomy were pooled from three international academic institutions in Cambridge (UK), Toronto (Canada) and Melbourne (Australia). Four predictive models identified from literature review were assessed for their ability to predict the presence of four definitions of insignificant PCa. Evaluation was performed using area under the curve (AUC) of receiver operating characteristic curves and Brier scores for discrimination, calibration curves and decision curve analysis. RESULTS: A cohort of 460 men meeting the inclusion criteria of all four nomograms was identified. The highest AUCs calculated for any of the four models ranged from 0.618 to 0.664, suggesting weak positive discrimination at best. Models had best discriminative ability for a definition of insignificant disease characterized by organ-confined Gleason score ⩽6 with a total volume ⩽0.5 ml or 1.3 ml. Calibration plots showed moderate range of predictive ability for the Kattan model though this model did not perform well at decision curve analysis. CONCLUSIONS: External assessment of models predicting insignificant PCa showed moderate performance at best. Uninformed interpretation may cause undue anxiety or false reassurance and they should be used with caution. More... »

PAGES

137

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/pcan.2015.1

DOI

http://dx.doi.org/10.1038/pcan.2015.1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002484392

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25667108


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy, Needle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Decision Support Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nomograms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Selection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precision Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostate-Specific Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Urology and Surgery, St Vincent's Hospital, Fitzroy, Victoria , Australia", 
            "Department of Urology and Surgery, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "L-M", 
        "id": "sg:person.01050436060.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050436060.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK Cambridge Institute", 
          "id": "https://www.grid.ac/institutes/grid.470869.4", 
          "name": [
            "Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neal", 
        "givenName": "D E", 
        "id": "sg:person.0603012530.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603012530.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Division of Uro-oncology, Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finelli", 
        "givenName": "A", 
        "id": "sg:person.01056041745.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056041745.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Australian Prostate Cancer Centre at Epworth and Departments of Urology and Surgery, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davis", 
        "givenName": "S", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Australian Prostate Cancer Centre at Epworth and Departments of Urology and Surgery, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonner", 
        "givenName": "C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Australian Prostate Cancer Centre at Epworth and Departments of Urology and Surgery, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kapoor", 
        "givenName": "J", 
        "id": "sg:person.01160031540.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160031540.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Division of Uro-oncology, Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trachtenberg", 
        "givenName": "J", 
        "id": "sg:person.0616222407.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616222407.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK Cambridge Institute", 
          "id": "https://www.grid.ac/institutes/grid.470869.4", 
          "name": [
            "Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "B", 
        "id": "sg:person.01157675754.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157675754.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Australian Prostate Cancer Centre at Epworth and Departments of Urology and Surgery, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hovens", 
        "givenName": "C M", 
        "id": "sg:person.0663746741.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663746741.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Australian Prostate Cancer Centre at Epworth and Departments of Urology and Surgery, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costello", 
        "givenName": "A J", 
        "id": "sg:person.013673364542.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013673364542.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Australian Prostate Cancer Centre at Epworth and Departments of Urology and Surgery, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corcoran", 
        "givenName": "N M", 
        "id": "sg:person.01236431544.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236431544.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2010.31.4252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000338036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2012.400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000685592", 
          "https://doi.org/10.1038/bjc.2012.400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001172738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djr500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002131885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.24.2180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000173646.99337.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003431780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000173646.99337.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003431780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000173646.99337.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003431780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bju.12554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004999283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2010.09.095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005274276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2012.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012427067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2011.10730.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013238071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.32.8112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013310665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2013.04.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015043934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000091806.70171.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015561582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000091806.70171.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015561582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x06295361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017511050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x06295361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017511050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1113135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020486628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2006.08.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022404583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urology.2013.01.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022997447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2005.05446.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023141076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2011.10119.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025993938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026506816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2013.02.3184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034742952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1994.03510290050036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043168040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930201)71:3+<933::aid-cncr2820711408>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044440208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2011.06.060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045043594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)00957-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047791600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.11102066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049636952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urology.2010.06.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051149400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2010.08.082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052122649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2013.02.2040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053631680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2013.02.2040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053631680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.143.1.7063747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082130998"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06", 
    "datePublishedReg": "2015-06-01", 
    "description": "BACKGROUND: In an era of personalized medicine, individualized risk assessment using easily available tools on the internet and the literature are appealing. However, uninformed use by clinicians and the public raises potential problems. Herein, we assess the performance of published models to predict insignificant prostate cancer (PCa), using a multi-national low-risk population that may be considered for active surveillance (AS) based on contemporary practice.\nMETHODS: Data on men suitable for AS but undergoing upfront radical prostatectomy were pooled from three international academic institutions in Cambridge (UK), Toronto (Canada) and Melbourne (Australia). Four predictive models identified from literature review were assessed for their ability to predict the presence of four definitions of insignificant PCa. Evaluation was performed using area under the curve (AUC) of receiver operating characteristic curves and Brier scores for discrimination, calibration curves and decision curve analysis.\nRESULTS: A cohort of 460 men meeting the inclusion criteria of all four nomograms was identified. The highest AUCs calculated for any of the four models ranged from 0.618 to 0.664, suggesting weak positive discrimination at best. Models had best discriminative ability for a definition of insignificant disease characterized by organ-confined Gleason score \u2a7d6 with a total volume \u2a7d0.5\u2009ml or 1.3\u2009ml. Calibration plots showed moderate range of predictive ability for the Kattan model though this model did not perform well at decision curve analysis.\nCONCLUSIONS: External assessment of models predicting insignificant PCa showed moderate performance at best. Uninformed interpretation may cause undue anxiety or false reassurance and they should be used with caution.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/pcan.2015.1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1119336", 
        "issn": [
          "1365-7852", 
          "1476-5608"
        ], 
        "name": "Prostate Cancer and Prostatic Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Evaluation of models predicting insignificant prostate cancer to select men for active surveillance of prostate cancer", 
    "pagination": "137", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0bd405a9d084cb68c8cce1d474fa4c913b21d57c3addd94ec9cb020e6386c083"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25667108"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9815755"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/pcan.2015.1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002484392"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/pcan.2015.1", 
      "https://app.dimensions.ai/details/publication/pub.1002484392"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/pcan20151"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/pcan.2015.1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/pcan.2015.1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/pcan.2015.1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/pcan.2015.1'


 

This table displays all metadata directly associated to this object as RDF triples.

284 TRIPLES      21 PREDICATES      71 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/pcan.2015.1 schema:about N28472b4134c44d9fbee5acd42baa4246
2 N377a0642a4774e50b70dd5254608acca
3 N3dd42419a9d24d2f8dbd46bf7e4fe4dd
4 N41514ab6eb2e4731867d66cfe6fed4a2
5 N8a2efe50cd894918ba994d31e1cabc25
6 N9b95721ab34d4015b6b29558bc59b772
7 Nabd008cbba04488dbd87a9525d7efcd2
8 Nc4ef810f6fff4688bc80c64e55220397
9 Nce42ebbe324a49478db51201fb127a12
10 Ne51f89eeea8642db90317915269adf1e
11 Ne62c81ecb4eb44f79cf5f50ba434c7b1
12 Nf5e17caed28d4bf7950ff141fbb498ed
13 anzsrc-for:11
14 anzsrc-for:1117
15 schema:author N353e5b1b55d44d9b8170b28ac4d2faff
16 schema:citation sg:pub.10.1038/bjc.2012.400
17 https://doi.org/10.1001/jama.1994.03510290050036
18 https://doi.org/10.1002/1097-0142(19930201)71:3+<933::aid-cncr2820711408>3.0.co;2-l
19 https://doi.org/10.1002/cncr.23055
20 https://doi.org/10.1002/cncr.23610
21 https://doi.org/10.1016/j.eururo.2012.11.005
22 https://doi.org/10.1016/j.eururo.2013.04.038
23 https://doi.org/10.1016/j.juro.2006.08.068
24 https://doi.org/10.1016/j.juro.2010.08.082
25 https://doi.org/10.1016/j.juro.2010.09.095
26 https://doi.org/10.1016/j.juro.2011.06.060
27 https://doi.org/10.1016/j.juro.2013.02.2040
28 https://doi.org/10.1016/j.juro.2013.02.3184
29 https://doi.org/10.1016/j.urology.2010.06.019
30 https://doi.org/10.1016/j.urology.2013.01.062
31 https://doi.org/10.1016/s0022-5347(05)00957-2
32 https://doi.org/10.1056/nejmoa1113135
33 https://doi.org/10.1093/jnci/djr500
34 https://doi.org/10.1097/01.ju.0000091806.70171.41
35 https://doi.org/10.1097/01.pas.0000173646.99337.b1
36 https://doi.org/10.1111/bju.12554
37 https://doi.org/10.1111/j.1464-410x.2005.05446.x
38 https://doi.org/10.1111/j.1464-410x.2011.10119.x
39 https://doi.org/10.1111/j.1464-410x.2011.10730.x
40 https://doi.org/10.1148/radiol.11102066
41 https://doi.org/10.1148/radiology.143.1.7063747
42 https://doi.org/10.1177/0272989x06295361
43 https://doi.org/10.1200/jco.2009.24.2180
44 https://doi.org/10.1200/jco.2010.31.4252
45 https://doi.org/10.1200/jco.2010.32.8112
46 schema:datePublished 2015-06
47 schema:datePublishedReg 2015-06-01
48 schema:description BACKGROUND: In an era of personalized medicine, individualized risk assessment using easily available tools on the internet and the literature are appealing. However, uninformed use by clinicians and the public raises potential problems. Herein, we assess the performance of published models to predict insignificant prostate cancer (PCa), using a multi-national low-risk population that may be considered for active surveillance (AS) based on contemporary practice. METHODS: Data on men suitable for AS but undergoing upfront radical prostatectomy were pooled from three international academic institutions in Cambridge (UK), Toronto (Canada) and Melbourne (Australia). Four predictive models identified from literature review were assessed for their ability to predict the presence of four definitions of insignificant PCa. Evaluation was performed using area under the curve (AUC) of receiver operating characteristic curves and Brier scores for discrimination, calibration curves and decision curve analysis. RESULTS: A cohort of 460 men meeting the inclusion criteria of all four nomograms was identified. The highest AUCs calculated for any of the four models ranged from 0.618 to 0.664, suggesting weak positive discrimination at best. Models had best discriminative ability for a definition of insignificant disease characterized by organ-confined Gleason score ⩽6 with a total volume ⩽0.5 ml or 1.3 ml. Calibration plots showed moderate range of predictive ability for the Kattan model though this model did not perform well at decision curve analysis. CONCLUSIONS: External assessment of models predicting insignificant PCa showed moderate performance at best. Uninformed interpretation may cause undue anxiety or false reassurance and they should be used with caution.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N1ad675a97bf74bc2898c5af4d90a7a23
53 N46ee26db83694c36825f1fb5240c3f2b
54 sg:journal.1119336
55 schema:name Evaluation of models predicting insignificant prostate cancer to select men for active surveillance of prostate cancer
56 schema:pagination 137
57 schema:productId N4790e0177cf2442a9406b7dd49377f4b
58 N4ca0773c5d924aafadefda14c667982c
59 N6030434b15b34b2981a8e689e1ab6cfb
60 N6ea5895397eb41af9fad2599bf78e73e
61 Nc4a755cea0fe49bdbb30c6f45109f19f
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002484392
63 https://doi.org/10.1038/pcan.2015.1
64 schema:sdDatePublished 2019-04-11T00:03
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher Nb7842a3cae9e49f389c5d6343fea6ed1
67 schema:url https://www.nature.com/articles/pcan20151
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N026e9745e14d4246b5b8f97ea62a3e34 rdf:first sg:person.01160031540.63
72 rdf:rest N20add000b2064f05a7d1b17922795545
73 N1ad675a97bf74bc2898c5af4d90a7a23 schema:volumeNumber 18
74 rdf:type schema:PublicationVolume
75 N20add000b2064f05a7d1b17922795545 rdf:first sg:person.0616222407.48
76 rdf:rest Neb47a6594290411fa37b2ba1331dda4b
77 N2585495a1b724e41b16b3b1808b41c38 rdf:first sg:person.01236431544.30
78 rdf:rest rdf:nil
79 N28472b4134c44d9fbee5acd42baa4246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Precision Medicine
81 rdf:type schema:DefinedTerm
82 N3013b763fa93415e91f1e1de9c06e4a7 rdf:first sg:person.0663746741.90
83 rdf:rest Naaac145b33e44c2ca6dc6940db450331
84 N353e5b1b55d44d9b8170b28ac4d2faff rdf:first sg:person.01050436060.00
85 rdf:rest Nbe049e4f68bb44ad812b94892f6a85be
86 N377a0642a4774e50b70dd5254608acca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Neoplasm Grading
88 rdf:type schema:DefinedTerm
89 N3dd42419a9d24d2f8dbd46bf7e4fe4dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Biopsy, Needle
91 rdf:type schema:DefinedTerm
92 N41514ab6eb2e4731867d66cfe6fed4a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Prostatectomy
94 rdf:type schema:DefinedTerm
95 N427cf3813f184de28a56606f57831b4a schema:affiliation https://www.grid.ac/institutes/grid.1008.9
96 schema:familyName Bonner
97 schema:givenName C
98 rdf:type schema:Person
99 N46ee26db83694c36825f1fb5240c3f2b schema:issueNumber 2
100 rdf:type schema:PublicationIssue
101 N4790e0177cf2442a9406b7dd49377f4b schema:name pubmed_id
102 schema:value 25667108
103 rdf:type schema:PropertyValue
104 N4ca0773c5d924aafadefda14c667982c schema:name doi
105 schema:value 10.1038/pcan.2015.1
106 rdf:type schema:PropertyValue
107 N6030434b15b34b2981a8e689e1ab6cfb schema:name readcube_id
108 schema:value 0bd405a9d084cb68c8cce1d474fa4c913b21d57c3addd94ec9cb020e6386c083
109 rdf:type schema:PropertyValue
110 N6ea5895397eb41af9fad2599bf78e73e schema:name nlm_unique_id
111 schema:value 9815755
112 rdf:type schema:PropertyValue
113 N719d38bcddd44fbe8c60d59195683024 rdf:first N7300d003c80148cd91db845a2c103c33
114 rdf:rest Nd9162c7a58964bd4b67563732833961f
115 N7300d003c80148cd91db845a2c103c33 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
116 schema:familyName Davis
117 schema:givenName S
118 rdf:type schema:Person
119 N8a2efe50cd894918ba994d31e1cabc25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Prostate-Specific Antigen
121 rdf:type schema:DefinedTerm
122 N9b95721ab34d4015b6b29558bc59b772 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Decision Support Techniques
124 rdf:type schema:DefinedTerm
125 Naaac145b33e44c2ca6dc6940db450331 rdf:first sg:person.013673364542.81
126 rdf:rest N2585495a1b724e41b16b3b1808b41c38
127 Nabd008cbba04488dbd87a9525d7efcd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Male
129 rdf:type schema:DefinedTerm
130 Nb7842a3cae9e49f389c5d6343fea6ed1 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 Nbe049e4f68bb44ad812b94892f6a85be rdf:first sg:person.0603012530.33
133 rdf:rest Ncaff58b2e5c14075a0b7980966128877
134 Nc4a755cea0fe49bdbb30c6f45109f19f schema:name dimensions_id
135 schema:value pub.1002484392
136 rdf:type schema:PropertyValue
137 Nc4ef810f6fff4688bc80c64e55220397 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Patient Selection
139 rdf:type schema:DefinedTerm
140 Ncaff58b2e5c14075a0b7980966128877 rdf:first sg:person.01056041745.47
141 rdf:rest N719d38bcddd44fbe8c60d59195683024
142 Nce42ebbe324a49478db51201fb127a12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Prostatic Neoplasms
144 rdf:type schema:DefinedTerm
145 Nd9162c7a58964bd4b67563732833961f rdf:first N427cf3813f184de28a56606f57831b4a
146 rdf:rest N026e9745e14d4246b5b8f97ea62a3e34
147 Ne51f89eeea8642db90317915269adf1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Nomograms
149 rdf:type schema:DefinedTerm
150 Ne62c81ecb4eb44f79cf5f50ba434c7b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Risk Factors
152 rdf:type schema:DefinedTerm
153 Neb47a6594290411fa37b2ba1331dda4b rdf:first sg:person.01157675754.99
154 rdf:rest N3013b763fa93415e91f1e1de9c06e4a7
155 Nf5e17caed28d4bf7950ff141fbb498ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Humans
157 rdf:type schema:DefinedTerm
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
162 schema:name Public Health and Health Services
163 rdf:type schema:DefinedTerm
164 sg:journal.1119336 schema:issn 1365-7852
165 1476-5608
166 schema:name Prostate Cancer and Prostatic Diseases
167 rdf:type schema:Periodical
168 sg:person.01050436060.00 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
169 schema:familyName Wong
170 schema:givenName L-M
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050436060.00
172 rdf:type schema:Person
173 sg:person.01056041745.47 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
174 schema:familyName Finelli
175 schema:givenName A
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056041745.47
177 rdf:type schema:Person
178 sg:person.01157675754.99 schema:affiliation https://www.grid.ac/institutes/grid.470869.4
179 schema:familyName Thomas
180 schema:givenName B
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157675754.99
182 rdf:type schema:Person
183 sg:person.01160031540.63 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
184 schema:familyName Kapoor
185 schema:givenName J
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160031540.63
187 rdf:type schema:Person
188 sg:person.01236431544.30 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
189 schema:familyName Corcoran
190 schema:givenName N M
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236431544.30
192 rdf:type schema:Person
193 sg:person.013673364542.81 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
194 schema:familyName Costello
195 schema:givenName A J
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013673364542.81
197 rdf:type schema:Person
198 sg:person.0603012530.33 schema:affiliation https://www.grid.ac/institutes/grid.470869.4
199 schema:familyName Neal
200 schema:givenName D E
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603012530.33
202 rdf:type schema:Person
203 sg:person.0616222407.48 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
204 schema:familyName Trachtenberg
205 schema:givenName J
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616222407.48
207 rdf:type schema:Person
208 sg:person.0663746741.90 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
209 schema:familyName Hovens
210 schema:givenName C M
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663746741.90
212 rdf:type schema:Person
213 sg:pub.10.1038/bjc.2012.400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000685592
214 https://doi.org/10.1038/bjc.2012.400
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1001/jama.1994.03510290050036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043168040
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/1097-0142(19930201)71:3+<933::aid-cncr2820711408>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1044440208
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/cncr.23055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001172738
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/cncr.23610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026506816
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.eururo.2012.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012427067
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.eururo.2013.04.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015043934
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.juro.2006.08.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022404583
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.juro.2010.08.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052122649
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.juro.2010.09.095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005274276
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.juro.2011.06.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045043594
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.juro.2013.02.2040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053631680
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.juro.2013.02.3184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034742952
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.urology.2010.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051149400
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.urology.2013.01.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022997447
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0022-5347(05)00957-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047791600
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmoa1113135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020486628
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/jnci/djr500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002131885
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1097/01.ju.0000091806.70171.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015561582
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1097/01.pas.0000173646.99337.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003431780
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/bju.12554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004999283
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/j.1464-410x.2005.05446.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023141076
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1464-410x.2011.10119.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025993938
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1111/j.1464-410x.2011.10730.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013238071
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1148/radiol.11102066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049636952
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1148/radiology.143.1.7063747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082130998
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1177/0272989x06295361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017511050
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1200/jco.2009.24.2180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002695176
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1200/jco.2010.31.4252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000338036
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1200/jco.2010.32.8112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013310665
273 rdf:type schema:CreativeWork
274 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
275 schema:name Department of Urology and Surgery, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
276 Department of Urology and Surgery, St Vincent's Hospital, Fitzroy, Victoria , Australia
277 The Australian Prostate Cancer Centre at Epworth and Departments of Urology and Surgery, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
280 schema:name Division of Uro-oncology, Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.
281 rdf:type schema:Organization
282 https://www.grid.ac/institutes/grid.470869.4 schema:alternateName Cancer Research UK Cambridge Institute
283 schema:name Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK
284 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...