Successful whole-exome sequencing from a prostate cancer bone metastasis biopsy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03

AUTHORS

E M Van Allen, A Foye, N Wagle, W Kim, S L Carter, A McKenna, J P Simko, L A Garraway, P G Febbo

ABSTRACT

BACKGROUND: Comprehensive molecular characterization of cancer that has metastasized to bone has proved challenging, which may limit the diagnostic and potential therapeutic opportunities for patients with bone-only metastatic disease. METHODS: We describe successful tissue acquisition, DNA extraction, and whole-exome sequencing from a bone metastasis of a patient with metastatic, castration-resistant prostate cancer (PCa). RESULTS: The resulting high-quality tumor sequencing identified plausibly actionable somatic genomic alterations that dysregulate the phosphoinostide 3-kinase pathway, as well as a theoretically actionable germline variant in the BRCA2 gene. CONCLUSIONS: We demonstrate the feasibility of diagnostic bone metastases profiling and analysis that will be required for the widespread application of prospective 'precision medicine' to men with advanced PCa. More... »

PAGES

23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/pcan.2013.37

DOI

http://dx.doi.org/10.1038/pcan.2013.37

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24366412


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