MicroRNA-645 is an oncogenic regulator in colon cancer View Full Text


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Article Info

DATE

2017-05-15

AUTHORS

S T Guo, X Y Guo, J Wang, C Y Wang, R H Yang, F H Wang, X Y Li, H Hondermarck, R F Thorne, Y F Wang, L Jin, X D Zhang, C C Jiang

ABSTRACT

Despite advances in early diagnosis and the development of molecularly targeted therapy, curative treatment of colon cancer once it has metastasized is yet to be accomplished. This is closely associated with deregulated CRC cell proliferation and resistance to apoptosis. Here we reveal that upregulation of microRNA-645 (miR-645) through DNA copy number gain is responsible for enhanced proliferation and resistance to apoptosis in colon cancer. MiR-645 was upregulated in most colon cancer tissues related to adjacent normal mucosa. This appeared to be associated with amplification of a section of chromosome 20q13.13, where miR-645 is located. Inhibition of miR-645 reduced proliferation and enhanced sensitivity to apoptosis triggered by the chemotherapeutic drugs 5-fluorouracil and cisplatin in CRC cells, and retarded colon cancer xenograft growth. Conversely, overexpression of miR-645 in normal colon epithelial cells enhanced proliferation and triggered anchorage-independent cell growth. Although SRY-related HMG-box 30 (SOX30) was identified as a miR-645 target, its expression was only partially affected by miR-645, suggesting that miR-645 is a fine-tuning mechanism of SOX30 expression. Moreover, overexpression of SOX30 only moderately inhibited promotion of CRC cell proliferation by miR-645, indicating that miR-645 may have more targets that contribute to its pro-proliferation effect in colon cancer. Together, this study reveals that miR-645 can regulate oncogenesis in colon cancer with SOX30 being one of its targets. More... »

PAGES

e335-e335

References to SciGraph publications

  • 2015-09-17. Dysregulated miR-645 affects the proliferation and invasion of head and neck cancer cell in CANCER CELL INTERNATIONAL
  • 1990-07. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes in NATURE
  • 2014-12-01. SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer in ONCOGENE
  • 2015-09-02. High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma in SCIENTIFIC REPORTS
  • 2013-08-09. Negative regulation of lncRNA GAS5 by miR-21 in CELL DEATH & DIFFERENTIATION
  • 2016-04-20. Chemoprevention of hereditary colon cancers: time for new strategies in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2011-03-10. Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer in MEDICAL ONCOLOGY
  • 2014-08-29. MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2 in BMC CANCER
  • 2013-01-28. Targeted therapies in colorectal cancer—an integrative view by PPPM in EPMA JOURNAL
  • 2013-12-20. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-09-28. INPP4B is an oncogenic regulator in human colon cancer in ONCOGENE
  • 2004-09-29. A custom microarray platform for analysis of microRNA gene expression in NATURE METHODS
  • 2010-12-11. Characterization, phylogeny, alternative splicing and expression of Sox30 gene in BMC MOLECULAR AND CELL BIOLOGY
  • 2016-04-25. Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers in NATURE MEDICINE
  • 2013-02-27. Replication stress links structural and numerical cancer chromosomal instability in NATURE
  • 2012-06-18. MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer in ONCOGENE
  • 2013-09-16. Epigenetic and genetic features of 24 colon cancer cell lines in ONCOGENESIS
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    DOI

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    DIMENSIONS

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    25 schema:description Despite advances in early diagnosis and the development of molecularly targeted therapy, curative treatment of colon cancer once it has metastasized is yet to be accomplished. This is closely associated with deregulated CRC cell proliferation and resistance to apoptosis. Here we reveal that upregulation of microRNA-645 (miR-645) through DNA copy number gain is responsible for enhanced proliferation and resistance to apoptosis in colon cancer. MiR-645 was upregulated in most colon cancer tissues related to adjacent normal mucosa. This appeared to be associated with amplification of a section of chromosome 20q13.13, where miR-645 is located. Inhibition of miR-645 reduced proliferation and enhanced sensitivity to apoptosis triggered by the chemotherapeutic drugs 5-fluorouracil and cisplatin in CRC cells, and retarded colon cancer xenograft growth. Conversely, overexpression of miR-645 in normal colon epithelial cells enhanced proliferation and triggered anchorage-independent cell growth. Although SRY-related HMG-box 30 (SOX30) was identified as a miR-645 target, its expression was only partially affected by miR-645, suggesting that miR-645 is a fine-tuning mechanism of SOX30 expression. Moreover, overexpression of SOX30 only moderately inhibited promotion of CRC cell proliferation by miR-645, indicating that miR-645 may have more targets that contribute to its pro-proliferation effect in colon cancer. Together, this study reveals that miR-645 can regulate oncogenesis in colon cancer with SOX30 being one of its targets.
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