Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11

AUTHORS

K Aden, A Breuer, A Rehman, H Geese, F Tran, J Sommer, G H Waetzig, T M Reinheimer, S Schreiber, S Rose-John, J Scheller, P Rosenstiel

ABSTRACT

Inflammatory bowel disease is characterized by disturbed cytokine signalling in the mucosa. Inhibition of the proinflammatory interleukin (IL)-6 pathway is a promising new therapeutic strategy, but safety concerns arise as IL-6 signalling also contributes to epithelial repair of the intestinal mucosa. To which extent IL-6 classic or trans-signalling contributes to intestinal repair remains elusive. We tested the influence of IL-6 classic signalling on intestinal repair and proliferation. Whereas IL-6 induced STAT3 phosphorylation in the colonic cancer cell lines, primary non-malignant intestinal organoids did not respond to IL-6 classic signalling. Mice deficient in intestinal IL-6R (IL-6RΔIEC mice) did not display increased susceptibility to acute dextran sulfate sodium (DSS)-induced colitis. In the azoxymethane DSS model IL-6RΔIEC mice were not protected from inflammation-induced carcinogenesis but showed comparable tumor load to wild-type mice. These data indicate that classic signalling is not the major pathway to transduce IL-6 stimuli into the intestinal epithelium. More... »

PAGES

e270

References to SciGraph publications

  • 2007-02. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro in NATURE PROTOCOLS
  • 2011-11. Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: a systematic literature review in CLINICAL RHEUMATOLOGY
  • 2015-12. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration in NATURE
  • 2015-12. Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway in BMC CANCER
  • 2015-12. Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells in BMC CANCER
  • 2010-12. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci in NATURE GENETICS
  • 2012-11. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease in NATURE
  • 2009-05. Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche in NATURE
  • 1997-02. A bioactive designer cytokine for human hematopoietic progenitor cell expansion in NATURE BIOTECHNOLOGY
  • 2013-11. Paneth cells as a site of origin for intestinal inflammation in NATURE
  • 2000-05. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo in NATURE MEDICINE
  • 2007-03. Chemically induced mouse models of intestinal inflammation in NATURE PROTOCOLS
  • 2015-07. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth in ONCOGENE
  • 2011-03. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/oncsis.2016.71

    DOI

    http://dx.doi.org/10.1038/oncsis.2016.71

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021556992

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27869785


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