Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06

AUTHORS

P Daniel, G Filiz, D V Brown, F Hollande, M Gonzales, G D’Abaco, N Papalexis, W A Phillips, J Malaterre, R G Ramsay, T Mantamadiotis

ABSTRACT

The cyclic-AMP response element binding (CREB) protein has been shown to have a pivotal role in cell survival and cell proliferation. Transgenic rodent models have revealed a role for CREB in higher-order brain functions, such as memory and drug addiction behaviors. CREB overexpression in transgenic animals imparts oncogenic properties on cells in various tissues, and aberrant CREB expression is associated with tumours. It is the central position of CREB, downstream from key developmental and growth signalling pathways, which gives CREB this ability to influence a spectrum of cellular activities, such as cell survival, growth and differentiation, in both normal and cancer cells. We show that CREB is highly expressed and constitutively activated in patient glioma tissue and that this activation closely correlates with tumour grade. The mechanism by which CREB regulates glioblastoma (GBM) tumour cell proliferation involves activities downstream from both the mitogen-activated protein kinase and phosphoinositide 3-kinase (PI3K) pathways that then modulate the expression of three key cell cycle factors, cyclin B, D and proliferating cell nuclear antigen (PCNA). Cyclin D1 is highly CREB-dependent, whereas cyclin B1 and PCNA are co-regulated by both CREB-dependent and -independent mechanisms. The precise regulatory network involved appears to differ depending on the tumour-suppressor phosphatase and tensin homolog status of the GBM cells, which in turn allows CREB to regulate the activity of the PI3K itself. Given that CREB sits at the hub of key cancer cell signalling pathways, understanding the role of glioma-specific CREB function may lead to improved novel combinatorial anti-tumour therapies, which can complement existing PI3K-specific drugs undergoing early phase clinical trials. More... »

PAGES

e108

References to SciGraph publications

  • 2007-08. cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis in ONCOGENE
  • 2002-12. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis in NEUROMOLECULAR MEDICINE
  • 2007-05. The protein kinase C-η isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway in ONCOGENE
  • 2009-04. High cyclin B1 expression is associated with poor survival in breast cancer in BRITISH JOURNAL OF CANCER
  • 2008-10-02. Modelling Myc inhibition as a cancer therapy in NATURE
  • 2004-04. Gastrin-mediated activation of cyclin D1 transcription involves β-catenin and CREB pathways in gastric cancer cells in ONCOGENE
  • 2001-08. Transcriptional regulation by the phosphorylation-dependent factor CREB in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2002-05. Disruption of CREB function in brain leads to neurodegeneration in NATURE GENETICS
  • 2012-09. Involvement of the cAMP response element binding protein, CREB, and cyclin D1 in LPA-induced proliferation of P19 embryonic carcinoma cells in MOLECULES AND CELLS
  • 2012-12. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB in MOLECULAR BRAIN
  • 2013-04. The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis in CELL DEATH & DISEASE
  • 2010-04. Nestin expression in astrocytic tumors delineates tumor infiltration in BRAIN TUMOR PATHOLOGY
  • 2013-12. A melanocyte lineage program confers resistance to MAP kinase pathway inhibition in NATURE
  • 2010-04. The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/oncsis.2014.21

    DOI

    http://dx.doi.org/10.1038/oncsis.2014.21

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039236350

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24979279


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