MRE11 stability is regulated by CK2-dependent interaction with R2TP complex View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-24

AUTHORS

P von Morgen, K Burdova, T G Flower, N J O'Reilly, S J Boulton, S J Smerdon, L Macurek, Z Hořejší

ABSTRACT

The MRN (MRE11-RAD50-NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts with PIH1D1, a subunit of heat-shock protein 90 cochaperone R2TP complex, which is required for the assembly of large protein complexes, such as RNA polymerase II, small nucleolar ribonucleoproteins and mammalian target of rapamycin complex 1. The MRE11-PIH1D1 interaction is dependent on casein kinase 2 (CK2) phosphorylation of two acidic sequences within the MRE11 C terminus containing serines 558/561 and 688/689. Conversely, the PIH1D1 phospho-binding domain PIH-N is required for association with MRE11 phosphorylated by CK2. Consistent with these findings, depletion of PIH1D1 resulted in MRE11 destabilization and affected DNA-damage repair processes dependent on MRE11. Additionally, mutations of serines 688/689, which abolish PIH1D1 binding, also resulted in decreased MRE11 stability. As depletion of R2TP frequently leads to instability of its substrates and as truncation mutation of MRE11 lacking serines 688/689 leads to decreased levels of the MRN complex both in ATLD patients and an ATLD mouse model, our results suggest that the MRN complex is a novel R2TP complex substrate and that their interaction is regulated by CK2 phosphorylation. More... »

PAGES

4943-4950

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2017.99

DOI

http://dx.doi.org/10.1038/onc.2017.99

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085050408

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28436950


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ataxia Telangiectasia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ataxia Telangiectasia Mutated Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Casein Kinase II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair Enzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heat-Shock Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Polymerase II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribonucleoproteins, Small Nucleolar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TOR Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Charles University", 
          "id": "https://www.grid.ac/institutes/grid.4491.8", 
          "name": [
            "Department of Cancer Cell Biology, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.", 
            "Faculty of Science, Charles University, Prague, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "von Morgen", 
        "givenName": "P", 
        "id": "sg:person.0633250604.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633250604.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Molecular Genetics", 
          "id": "https://www.grid.ac/institutes/grid.418827.0", 
          "name": [
            "Department of Cancer Cell Biology, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burdova", 
        "givenName": "K", 
        "id": "sg:person.0677632435.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677632435.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Structural Biology of DNA-damage Signalling Laboratory, The Francis Crick Institute, London,UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flower", 
        "givenName": "T G", 
        "id": "sg:person.01170353144.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170353144.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Peptide Chemistry, The Francis Crick Institute, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Reilly", 
        "givenName": "N J", 
        "id": "sg:person.0576172002.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576172002.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "DSB Repair Metabolism Laboratory, The Francis Crick Institute, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boulton", 
        "givenName": "S J", 
        "id": "sg:person.0607405440.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607405440.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Structural Biology of DNA-damage Signalling Laboratory, The Francis Crick Institute, London,UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smerdon", 
        "givenName": "S J", 
        "id": "sg:person.010727525727.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010727525727.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Molecular Genetics", 
          "id": "https://www.grid.ac/institutes/grid.418827.0", 
          "name": [
            "Department of Cancer Cell Biology, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macurek", 
        "givenName": "L", 
        "id": "sg:person.01275321607.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275321607.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Department of Cancer Cell Biology, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.", 
            "Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Centre, Charterhouse Square, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ho\u0159ej\u0161\u00ed", 
        "givenName": "Z", 
        "id": "sg:person.01251017655.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251017655.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.celrep.2014.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003327028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms11883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005369769", 
          "https://doi.org/10.1038/ncomms11883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.02025-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006419437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2016.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006615339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007242691", 
          "https://doi.org/10.1038/nsmb.2212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m808174200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010678605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80097-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011526034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2010.07.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012164957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.12.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012417767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-61779-998-3_27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017524929", 
          "https://doi.org/10.1007/978-1-61779-998-3_27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020817249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10059-013-0138-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024298703", 
          "https://doi.org/10.1007/s10059-013-0138-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81547-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024972519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00455-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026769640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molonc.2008.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026901982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1306328110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028638511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.08.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029454400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2010.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030217771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200709061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032341220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201504005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034885986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2004.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037751176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2014.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037894616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddt368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039067371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039576536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039684062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041281133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgi360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041482366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2011.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044039356", 
          "https://doi.org/10.1038/cr.2011.128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046087692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2016.11.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046319064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046626982", 
          "https://doi.org/10.1038/nature13771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81174-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048096465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.breast.2016.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049305820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.034942.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049984583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m113.499608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050401771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2014.02.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051159752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2003906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062683006"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08-24", 
    "datePublishedReg": "2017-08-24", 
    "description": "The MRN (MRE11-RAD50-NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts with PIH1D1, a subunit of heat-shock protein 90 cochaperone R2TP complex, which is required for the assembly of large protein complexes, such as RNA polymerase II, small nucleolar ribonucleoproteins and mammalian target of rapamycin complex 1. The MRE11-PIH1D1 interaction is dependent on casein kinase 2 (CK2) phosphorylation of two acidic sequences within the MRE11 C terminus containing serines 558/561 and 688/689. Conversely, the PIH1D1 phospho-binding domain PIH-N is required for association with MRE11 phosphorylated by CK2. Consistent with these findings, depletion of PIH1D1 resulted in MRE11 destabilization and affected DNA-damage repair processes dependent on MRE11. Additionally, mutations of serines 688/689, which abolish PIH1D1 binding, also resulted in decreased MRE11 stability. As depletion of R2TP frequently leads to instability of its substrates and as truncation mutation of MRE11 lacking serines 688/689 leads to decreased levels of the MRN complex both in ATLD patients and an ATLD mouse model, our results suggest that the MRN complex is a novel R2TP complex substrate and that their interaction is regulated by CK2 phosphorylation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2017.99", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6886396", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3788029", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6798160", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6798238", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6665501", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2760226", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4578942", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "34", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "MRE11 stability is regulated by CK2-dependent interaction with R2TP complex", 
    "pagination": "4943-4950", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "73610980e7603b0627a3f7d0a75b851b4b3b84fa21b302def08f927cd9c11e08"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28436950"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2017.99"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085050408"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2017.99", 
      "https://app.dimensions.ai/details/publication/pub.1085050408"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000470.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/onc/journal/v36/n34/full/onc201799a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.99'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.99'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.99'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.99'


 

This table displays all metadata directly associated to this object as RDF triples.

346 TRIPLES      21 PREDICATES      86 URIs      41 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2017.99 schema:about N068cc50864d045f7969352f3c9ba77fb
2 N092a85b75b7d4125871334631dbe281d
3 N1a1e1c781dfc46dba4ac5cf09570008f
4 N20cdbc60ca394d8d8a35537553f75074
5 N22f3f97066b24e4eb6fd6f8c6cb5395d
6 N4d353a72b8144302aba0e4f0da2f2559
7 N544dce09496144a2991b482ae2aa35c7
8 N7ce81c72d73548f9bfd20e4303ad176c
9 N942c880a3de34373bc24f30ad9ac8796
10 Na586757c0c8b497c97b21e6bf745fc43
11 Na7820d3479764e9aa28e6334f69a6070
12 Nb20771cd0b944867bb134531aa4305cd
13 Nb4613fd598cd4fbe8823d8b31b1576cc
14 Nb66c7e1cbd634968a727b01188866efe
15 Nd2cb874645154dd996c59b0d446b1b3a
16 Nd80e1d7d38f742c295e1043fdcc47aa5
17 Nda05dc103a60415991fde2f58cc84638
18 Nda987cadf56f4ce9a56837ff2f7a4679
19 Ne9ae64a6032f4a40aa4191cb211b91c3
20 Nf720bbf1bb2d49a3b8acd83a44bca7e8
21 Nfb76874bc7be48a4a85bf6edf80aa2a7
22 anzsrc-for:06
23 anzsrc-for:0601
24 schema:author Ncbdb876a4b9648dc899ae4312b2c60a7
25 schema:citation sg:pub.10.1007/978-1-61779-998-3_27
26 sg:pub.10.1007/s10059-013-0138-2
27 sg:pub.10.1038/cr.2011.128
28 sg:pub.10.1038/nature13771
29 sg:pub.10.1038/ncomms11883
30 sg:pub.10.1038/nsmb.2212
31 https://doi.org/10.1016/j.breast.2016.05.006
32 https://doi.org/10.1016/j.cell.2004.12.024
33 https://doi.org/10.1016/j.celrep.2014.03.013
34 https://doi.org/10.1016/j.dnarep.2004.04.009
35 https://doi.org/10.1016/j.dnarep.2010.10.001
36 https://doi.org/10.1016/j.febslet.2010.07.029
37 https://doi.org/10.1016/j.molcel.2010.08.023
38 https://doi.org/10.1016/j.molcel.2010.08.037
39 https://doi.org/10.1016/j.molcel.2014.02.020
40 https://doi.org/10.1016/j.molcel.2016.10.010
41 https://doi.org/10.1016/j.molcel.2016.11.028
42 https://doi.org/10.1016/j.molonc.2008.09.007
43 https://doi.org/10.1016/j.str.2014.04.001
44 https://doi.org/10.1016/s0092-8674(00)81174-5
45 https://doi.org/10.1016/s0092-8674(00)81547-0
46 https://doi.org/10.1016/s1097-2765(00)80097-0
47 https://doi.org/10.1016/s1097-2765(03)00455-6
48 https://doi.org/10.1073/pnas.1306328110
49 https://doi.org/10.1074/jbc.m113.499608
50 https://doi.org/10.1074/jbc.m808174200
51 https://doi.org/10.1083/jcb.200709061
52 https://doi.org/10.1083/jcb.201504005
53 https://doi.org/10.1093/carcin/bgi360
54 https://doi.org/10.1093/hmg/ddt368
55 https://doi.org/10.1093/nar/gkt1131
56 https://doi.org/10.1093/nar/gkt171
57 https://doi.org/10.1093/nar/gkv754
58 https://doi.org/10.1126/scisignal.2003906
59 https://doi.org/10.1128/mcb.02025-07
60 https://doi.org/10.1261/rna.034942.112
61 https://doi.org/10.1371/journal.pgen.1000683
62 schema:datePublished 2017-08-24
63 schema:datePublishedReg 2017-08-24
64 schema:description The MRN (MRE11-RAD50-NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts with PIH1D1, a subunit of heat-shock protein 90 cochaperone R2TP complex, which is required for the assembly of large protein complexes, such as RNA polymerase II, small nucleolar ribonucleoproteins and mammalian target of rapamycin complex 1. The MRE11-PIH1D1 interaction is dependent on casein kinase 2 (CK2) phosphorylation of two acidic sequences within the MRE11 C terminus containing serines 558/561 and 688/689. Conversely, the PIH1D1 phospho-binding domain PIH-N is required for association with MRE11 phosphorylated by CK2. Consistent with these findings, depletion of PIH1D1 resulted in MRE11 destabilization and affected DNA-damage repair processes dependent on MRE11. Additionally, mutations of serines 688/689, which abolish PIH1D1 binding, also resulted in decreased MRE11 stability. As depletion of R2TP frequently leads to instability of its substrates and as truncation mutation of MRE11 lacking serines 688/689 leads to decreased levels of the MRN complex both in ATLD patients and an ATLD mouse model, our results suggest that the MRN complex is a novel R2TP complex substrate and that their interaction is regulated by CK2 phosphorylation.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N7e56946bd85d4cc09a6e9f5e9a26b4f5
69 Ndc84eebc966844a98ed36efb9a1f1562
70 sg:journal.1097543
71 schema:name MRE11 stability is regulated by CK2-dependent interaction with R2TP complex
72 schema:pagination 4943-4950
73 schema:productId N0f00958fd75b456a9799f0fea4c89f84
74 N55791226641040889afaf7cf9a8b5b9b
75 Nb3b382bb631c4f4c961d3bf2f60a048f
76 Nc59fa8f3bcbb4ff2a683f850dee98bc5
77 Nf58d072e984642108c969b8d05bd8c89
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085050408
79 https://doi.org/10.1038/onc.2017.99
80 schema:sdDatePublished 2019-04-11T00:59
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N4f22d98dff0442dab2e408acbd072860
83 schema:url http://www.nature.com/onc/journal/v36/n34/full/onc201799a.html
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N068cc50864d045f7969352f3c9ba77fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name TOR Serine-Threonine Kinases
89 rdf:type schema:DefinedTerm
90 N092a85b75b7d4125871334631dbe281d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Mice
92 rdf:type schema:DefinedTerm
93 N0c7f19d584de440b987ac5e81e92787d rdf:first sg:person.01170353144.24
94 rdf:rest N8325abc6ec5a48e3b5a474343209bb0d
95 N0f00958fd75b456a9799f0fea4c89f84 schema:name pubmed_id
96 schema:value 28436950
97 rdf:type schema:PropertyValue
98 N1a1e1c781dfc46dba4ac5cf09570008f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Casein Kinase II
100 rdf:type schema:DefinedTerm
101 N20cdbc60ca394d8d8a35537553f75074 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Nuclear Proteins
103 rdf:type schema:DefinedTerm
104 N22f3f97066b24e4eb6fd6f8c6cb5395d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Ribonucleoproteins, Small Nucleolar
106 rdf:type schema:DefinedTerm
107 N4d353a72b8144302aba0e4f0da2f2559 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Apoptosis Regulatory Proteins
109 rdf:type schema:DefinedTerm
110 N4f22d98dff0442dab2e408acbd072860 schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 N533fd12ff13f4258ae640ab481c09836 rdf:first sg:person.01275321607.07
113 rdf:rest Na0cfd7a7522048639b352107f501c08e
114 N544dce09496144a2991b482ae2aa35c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Heat-Shock Proteins
116 rdf:type schema:DefinedTerm
117 N55791226641040889afaf7cf9a8b5b9b schema:name readcube_id
118 schema:value 73610980e7603b0627a3f7d0a75b851b4b3b84fa21b302def08f927cd9c11e08
119 rdf:type schema:PropertyValue
120 N5a7f82c7246147df9c84d047d8855bd0 rdf:first sg:person.010727525727.84
121 rdf:rest N533fd12ff13f4258ae640ab481c09836
122 N7a2222d88db74107904fd25c484bd8e8 rdf:first sg:person.0607405440.37
123 rdf:rest N5a7f82c7246147df9c84d047d8855bd0
124 N7ce81c72d73548f9bfd20e4303ad176c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name DNA Repair
126 rdf:type schema:DefinedTerm
127 N7e56946bd85d4cc09a6e9f5e9a26b4f5 schema:issueNumber 34
128 rdf:type schema:PublicationIssue
129 N8325abc6ec5a48e3b5a474343209bb0d rdf:first sg:person.0576172002.47
130 rdf:rest N7a2222d88db74107904fd25c484bd8e8
131 N942c880a3de34373bc24f30ad9ac8796 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 Na0cfd7a7522048639b352107f501c08e rdf:first sg:person.01251017655.13
135 rdf:rest rdf:nil
136 Na586757c0c8b497c97b21e6bf745fc43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name RNA Polymerase II
138 rdf:type schema:DefinedTerm
139 Na7820d3479764e9aa28e6334f69a6070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Animals
141 rdf:type schema:DefinedTerm
142 Na86af192e7374a138f273ba5d4111162 rdf:first sg:person.0677632435.32
143 rdf:rest N0c7f19d584de440b987ac5e81e92787d
144 Nb20771cd0b944867bb134531aa4305cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Ataxia Telangiectasia
146 rdf:type schema:DefinedTerm
147 Nb3b382bb631c4f4c961d3bf2f60a048f schema:name dimensions_id
148 schema:value pub.1085050408
149 rdf:type schema:PropertyValue
150 Nb4613fd598cd4fbe8823d8b31b1576cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Serine
152 rdf:type schema:DefinedTerm
153 Nb66c7e1cbd634968a727b01188866efe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name DNA Repair Enzymes
155 rdf:type schema:DefinedTerm
156 Nc59fa8f3bcbb4ff2a683f850dee98bc5 schema:name doi
157 schema:value 10.1038/onc.2017.99
158 rdf:type schema:PropertyValue
159 Ncbdb876a4b9648dc899ae4312b2c60a7 rdf:first sg:person.0633250604.49
160 rdf:rest Na86af192e7374a138f273ba5d4111162
161 Nd2cb874645154dd996c59b0d446b1b3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cell Nucleus
163 rdf:type schema:DefinedTerm
164 Nd80e1d7d38f742c295e1043fdcc47aa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Protein Binding
166 rdf:type schema:DefinedTerm
167 Nda05dc103a60415991fde2f58cc84638 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Phosphorylation
169 rdf:type schema:DefinedTerm
170 Nda987cadf56f4ce9a56837ff2f7a4679 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Mutation
172 rdf:type schema:DefinedTerm
173 Ndc84eebc966844a98ed36efb9a1f1562 schema:volumeNumber 36
174 rdf:type schema:PublicationVolume
175 Ne9ae64a6032f4a40aa4191cb211b91c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name DNA-Binding Proteins
177 rdf:type schema:DefinedTerm
178 Nf58d072e984642108c969b8d05bd8c89 schema:name nlm_unique_id
179 schema:value 8711562
180 rdf:type schema:PropertyValue
181 Nf720bbf1bb2d49a3b8acd83a44bca7e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Ataxia Telangiectasia Mutated Proteins
183 rdf:type schema:DefinedTerm
184 Nfb76874bc7be48a4a85bf6edf80aa2a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name DNA Damage
186 rdf:type schema:DefinedTerm
187 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
188 schema:name Biological Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
191 schema:name Biochemistry and Cell Biology
192 rdf:type schema:DefinedTerm
193 sg:grant.2760226 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.99
194 rdf:type schema:MonetaryGrant
195 sg:grant.3788029 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.99
196 rdf:type schema:MonetaryGrant
197 sg:grant.4578942 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.99
198 rdf:type schema:MonetaryGrant
199 sg:grant.6665501 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.99
200 rdf:type schema:MonetaryGrant
201 sg:grant.6798160 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.99
202 rdf:type schema:MonetaryGrant
203 sg:grant.6798238 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.99
204 rdf:type schema:MonetaryGrant
205 sg:grant.6886396 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.99
206 rdf:type schema:MonetaryGrant
207 sg:journal.1097543 schema:issn 0950-9232
208 1476-5594
209 schema:name Oncogene
210 rdf:type schema:Periodical
211 sg:person.010727525727.84 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
212 schema:familyName Smerdon
213 schema:givenName S J
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010727525727.84
215 rdf:type schema:Person
216 sg:person.01170353144.24 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
217 schema:familyName Flower
218 schema:givenName T G
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170353144.24
220 rdf:type schema:Person
221 sg:person.01251017655.13 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
222 schema:familyName Hořejší
223 schema:givenName Z
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251017655.13
225 rdf:type schema:Person
226 sg:person.01275321607.07 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
227 schema:familyName Macurek
228 schema:givenName L
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275321607.07
230 rdf:type schema:Person
231 sg:person.0576172002.47 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
232 schema:familyName O'Reilly
233 schema:givenName N J
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576172002.47
235 rdf:type schema:Person
236 sg:person.0607405440.37 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
237 schema:familyName Boulton
238 schema:givenName S J
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607405440.37
240 rdf:type schema:Person
241 sg:person.0633250604.49 schema:affiliation https://www.grid.ac/institutes/grid.4491.8
242 schema:familyName von Morgen
243 schema:givenName P
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633250604.49
245 rdf:type schema:Person
246 sg:person.0677632435.32 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
247 schema:familyName Burdova
248 schema:givenName K
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677632435.32
250 rdf:type schema:Person
251 sg:pub.10.1007/978-1-61779-998-3_27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017524929
252 https://doi.org/10.1007/978-1-61779-998-3_27
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s10059-013-0138-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024298703
255 https://doi.org/10.1007/s10059-013-0138-2
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/cr.2011.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044039356
258 https://doi.org/10.1038/cr.2011.128
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/nature13771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046626982
261 https://doi.org/10.1038/nature13771
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/ncomms11883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005369769
264 https://doi.org/10.1038/ncomms11883
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nsmb.2212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007242691
267 https://doi.org/10.1038/nsmb.2212
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.breast.2016.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049305820
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.cell.2004.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012417767
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.celrep.2014.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003327028
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.dnarep.2004.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037751176
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.dnarep.2010.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030217771
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.febslet.2010.07.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012164957
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.molcel.2010.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041281133
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.molcel.2010.08.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029454400
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.molcel.2014.02.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051159752
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.molcel.2016.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006615339
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.molcel.2016.11.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046319064
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.molonc.2008.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026901982
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.str.2014.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037894616
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0092-8674(00)81174-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048096465
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0092-8674(00)81547-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024972519
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s1097-2765(00)80097-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011526034
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s1097-2765(03)00455-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026769640
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1073/pnas.1306328110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028638511
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m113.499608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050401771
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1074/jbc.m808174200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010678605
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1083/jcb.200709061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032341220
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1083/jcb.201504005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034885986
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/carcin/bgi360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041482366
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/hmg/ddt368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039067371
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/nar/gkt1131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039684062
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/nar/gkt171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020817249
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/nar/gkv754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046087692
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1126/scisignal.2003906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062683006
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1128/mcb.02025-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006419437
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1261/rna.034942.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049984583
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1371/journal.pgen.1000683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039576536
330 rdf:type schema:CreativeWork
331 https://www.grid.ac/institutes/grid.418827.0 schema:alternateName Institute of Molecular Genetics
332 schema:name Department of Cancer Cell Biology, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.4491.8 schema:alternateName Charles University
335 schema:name Department of Cancer Cell Biology, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.
336 Faculty of Science, Charles University, Prague, Czech Republic.
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
339 schema:name DSB Repair Metabolism Laboratory, The Francis Crick Institute, London, UK.
340 Peptide Chemistry, The Francis Crick Institute, London, UK.
341 Structural Biology of DNA-damage Signalling Laboratory, The Francis Crick Institute, London,UK.
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.4868.2 schema:alternateName Queen Mary University of London
344 schema:name Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Centre, Charterhouse Square, London, UK.
345 Department of Cancer Cell Biology, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.
346 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...