P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

M Batisse-Lignier, I Sahut-Barnola, F Tissier, T Dumontet, M Mathieu, C Drelon, J-C Pointud, C Damon-Soubeyrand, G Marceau, J-L Kemeny, J Bertherat, I Tauveron, P Val, A Martinez, A-M Lefrançois-Martinez

ABSTRACT

Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Pan-genomic analyses identified p53/Rb and WNT/β-catenin signaling pathways as main contributors to the disease. However, isolated β-catenin constitutive activation failed to induce malignant progression in mouse adrenocortical tumors. Therefore, there still was a need for a relevant animal model to study ACC pathogenesis and to test new therapeutic approaches. Here, we have developed a transgenic mice model with adrenocortical specific expression of SV40 large T-antigen (AdTAg mice), to test the oncogenic potential of p53/Rb inhibition in the adrenal gland. All AdTAg mice develop large adrenal carcinomas that eventually metastasize to the liver and lungs, resulting in decreased overall survival. Consistent with ACC in patients, adrenal tumors in AdTAg mice autonomously produce large amounts of glucocorticoids and spontaneously activate WNT/β-catenin signaling pathway during malignant progression. We show that this activation is associated with downregulation of secreted frizzled related proteins (Sfrp) and Znrf3 that act as inhibitors of the WNT signaling. We also show that mTORC1 pathway activation is an early event during neoplasia expansion and further demonstrate that mTORC1 pathway is activated in ACC patients. Preclinical inhibition of mTORC1 activity induces a marked reduction in tumor size, associated with induction of apoptosis and inhibition of proliferation that results in normalization of corticosterone plasma levels in AdTAg mice. Altogether, these data establish AdTAg mice as the first preclinical model for metastatic ACC. More... »

PAGES

4445

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2017.54

DOI

http://dx.doi.org/10.1038/onc.2017.54

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084509004

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28368424


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenocortical Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Polyomavirus Transforming", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mechanistic Target of Rapamycin Complex 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiprotein Complexes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinoblastoma Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sirolimus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TOR Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Signaling Pathway", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Clermont-Ferrand", 
          "id": "https://www.grid.ac/institutes/grid.411163.0", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France.", 
            "Centre Hospitalier Universitaire, Endocrinology Diabetology &Metabolic Diseases Department, School of Medicine, Clermont-Ferrand, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Batisse-Lignier", 
        "givenName": "M", 
        "id": "sg:person.0703671367.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703671367.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sahut-Barnola", 
        "givenName": "I", 
        "id": "sg:person.01324375171.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324375171.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Department of Pathology, Reference Center for Rare Adrenal Diseases, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Cochin, Paris, France.", 
            "Department of Pathology, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Universit\u00e9 Pierre &Marie Curie, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tissier", 
        "givenName": "F", 
        "id": "sg:person.0702737573.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702737573.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dumontet", 
        "givenName": "T", 
        "id": "sg:person.01206077604.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206077604.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mathieu", 
        "givenName": "M", 
        "id": "sg:person.01076077641.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076077641.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drelon", 
        "givenName": "C", 
        "id": "sg:person.01062372067.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062372067.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pointud", 
        "givenName": "J-C", 
        "id": "sg:person.0615170555.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615170555.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Damon-Soubeyrand", 
        "givenName": "C", 
        "id": "sg:person.01111043147.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111043147.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Clermont-Ferrand", 
          "id": "https://www.grid.ac/institutes/grid.411163.0", 
          "name": [
            "Centre Hospitalier Universitaire, Department of Biochemistry and Molecular Biology, Clermont-Ferrand, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marceau", 
        "givenName": "G", 
        "id": "sg:person.01320524350.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320524350.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anatomopathology, Clermont-Ferrand Hospital, Clermont-Ferrand, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kemeny", 
        "givenName": "J-L", 
        "id": "sg:person.015162364244.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015162364244.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Cochin", 
          "id": "https://www.grid.ac/institutes/grid.462098.1", 
          "name": [
            "Department of Pathology, Reference Center for Rare Adrenal Diseases, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Cochin, Paris, France.", 
            "Institut Cochin, Universit\u00e9 Paris Descartes, INSERM U1016, CNRS UMR8104, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bertherat", 
        "givenName": "J", 
        "id": "sg:person.01251720754.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251720754.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Clermont-Ferrand", 
          "id": "https://www.grid.ac/institutes/grid.411163.0", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France.", 
            "Centre Hospitalier Universitaire, Endocrinology Diabetology &Metabolic Diseases Department, School of Medicine, Clermont-Ferrand, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tauveron", 
        "givenName": "I", 
        "id": "sg:person.0663662016.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663662016.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Val", 
        "givenName": "P", 
        "id": "sg:person.01107250557.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107250557.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez", 
        "givenName": "A", 
        "id": "sg:person.01371557114.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371557114.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "CNRS UMR6293, GReD, INSERM U1103, Universit\u00e9 Clermont Auvergne, Aubi\u00e8re, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lefran\u00e7ois-Martinez", 
        "givenName": "A-M", 
        "id": "sg:person.01107706210.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107706210.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/pas.0b013e31825a6308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002808474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31825a6308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002808474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-10-0012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002840854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-3310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004032790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2012.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004037668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2015.494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006650418", 
          "https://doi.org/10.1038/onc.2015.494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2013.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007662516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008759879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2010.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009296743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010126751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.5678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011555800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/erc-13-0112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013041491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-2085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014168049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014818100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015581577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017838792", 
          "https://doi.org/10.1038/sj.onc.1209046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017838792", 
          "https://doi.org/10.1038/sj.onc.1209046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017838792", 
          "https://doi.org/10.1038/sj.onc.1209046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddq029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017850351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12672-011-0088-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018008452", 
          "https://doi.org/10.1007/s12672-011-0088-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.1.02004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019627855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020862651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/erc-11-0270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021286574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-3970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022549268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-1067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022962210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-13-0778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025862761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2016.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027041306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2002-220275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027950404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.161479898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030767494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0502857102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032477204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1200966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033372540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-13-0788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034112124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2013.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039444985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2014-3282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041157999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12020-013-9878-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041176115", 
          "https://doi.org/10.1007/s12020-013-9878-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2012.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042023566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042292889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2013-1029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046545168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2009.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046768982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-15-1118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047965460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.088047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048537432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/90.8.606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050052014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ecl.2015.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050480194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0044171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050507003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1500809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050643196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1500809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050643196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1500809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050643196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052056080", 
          "https://doi.org/10.1038/ng.2953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)70081-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053089877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddw136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059645899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2005-1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2007-0925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2005-2639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064288977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2005-2730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064289005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2014-3182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064295455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.78.3.790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064297364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.78.3.8126158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064318622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.86.10.7957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064323921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.10.12.8961275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.2835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072290007"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08", 
    "datePublishedReg": "2017-08-01", 
    "description": "Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Pan-genomic analyses identified p53/Rb and WNT/\u03b2-catenin signaling pathways as main contributors to the disease. However, isolated \u03b2-catenin constitutive activation failed to induce malignant progression in mouse adrenocortical tumors. Therefore, there still was a need for a relevant animal model to study ACC pathogenesis and to test new therapeutic approaches. Here, we have developed a transgenic mice model with adrenocortical specific expression of SV40 large T-antigen (AdTAg mice), to test the oncogenic potential of p53/Rb inhibition in the adrenal gland. All AdTAg mice develop large adrenal carcinomas that eventually metastasize to the liver and lungs, resulting in decreased overall survival. Consistent with ACC in patients, adrenal tumors in AdTAg mice autonomously produce large amounts of glucocorticoids and spontaneously activate WNT/\u03b2-catenin signaling pathway during malignant progression. We show that this activation is associated with downregulation of secreted frizzled related proteins (Sfrp) and Znrf3 that act as inhibitors of the WNT signaling. We also show that mTORC1 pathway activation is an early event during neoplasia expansion and further demonstrate that mTORC1 pathway is activated in ACC patients. Preclinical inhibition of mTORC1 activity induces a marked reduction in tumor size, associated with induction of apoptosis and inhibition of proliferation that results in normalization of corticosterone plasma levels in AdTAg mice. Altogether, these data establish AdTAg mice as the first preclinical model for metastatic ACC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2017.54", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4519625", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "31", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model", 
    "pagination": "4445", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ed9a6789aa9a3f1396b764060f4798e0e42fc20e5653e6c3cafe9a4ab7d8e445"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28368424"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2017.54"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084509004"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2017.54", 
      "https://app.dimensions.ai/details/publication/pub.1084509004"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000427.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc201754"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.54'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.54'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.54'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.54'


 

This table displays all metadata directly associated to this object as RDF triples.

420 TRIPLES      21 PREDICATES      101 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2017.54 schema:about N0a525cb9cdbc4abf9acdbc29a1fcde42
2 N26498f8bc02e43d882e5dda0e707f5a8
3 N2aef0c4c151e401ab511949f141834fc
4 N2cd1b09e292543ac9de8c8c33df4cb25
5 N3808b000eb094621ba977d621361816b
6 N59e980c637b34c319b782b0ff978f7ea
7 N6f9acbf47e8b47dd8f76425d24aa49b8
8 N77ea2d0c6ea54b97a76e70b8be96fe8a
9 N7e2fd0b96222422d8d85a547ac766e2f
10 N80301e306efc4859b0cdc003d1b1b174
11 N882417e06838419bb0d37019ab407fcb
12 N8bb3c03a18e742d98298a5b59ac855f0
13 Nc4e06bf8163743f68e36cba25d4e4dfd
14 Nc8ba31b249374f07b867137c074f5d74
15 Ncb0392e287b7418dbeba72e03712cfd5
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author Ne58363ddf5024e87ba88e76fd8c11713
19 schema:citation sg:pub.10.1007/s12020-013-9878-1
20 sg:pub.10.1007/s12672-011-0088-0
21 sg:pub.10.1038/ng.2953
22 sg:pub.10.1038/onc.2015.494
23 sg:pub.10.1038/sj.onc.1209046
24 https://doi.org/10.1016/j.ajpath.2012.05.026
25 https://doi.org/10.1016/j.bbcan.2013.11.004
26 https://doi.org/10.1016/j.ccell.2016.04.002
27 https://doi.org/10.1016/j.ecl.2015.03.001
28 https://doi.org/10.1016/j.eururo.2013.11.006
29 https://doi.org/10.1016/j.mce.2012.08.014
30 https://doi.org/10.1016/j.tcb.2010.03.004
31 https://doi.org/10.1016/j.tem.2009.12.009
32 https://doi.org/10.1016/s1470-2045(15)70081-1
33 https://doi.org/10.1056/nejmoa1200966
34 https://doi.org/10.1073/pnas.0502857102
35 https://doi.org/10.1073/pnas.161479898
36 https://doi.org/10.1093/hmg/ddq029
37 https://doi.org/10.1093/hmg/ddw136
38 https://doi.org/10.1093/jnci/90.8.606
39 https://doi.org/10.1097/pas.0b013e31825a6308
40 https://doi.org/10.1158/0008-5472.can-07-5203
41 https://doi.org/10.1158/0008-5472.can-09-3970
42 https://doi.org/10.1158/0008-5472.can-10-2014
43 https://doi.org/10.1158/1078-0432.ccr-06-2085
44 https://doi.org/10.1158/1078-0432.ccr-08-1067
45 https://doi.org/10.1158/1078-0432.ccr-10-2006
46 https://doi.org/10.1158/1078-0432.ccr-10-2061
47 https://doi.org/10.1158/1078-0432.ccr-10-2979
48 https://doi.org/10.1158/1535-7163.mct-10-0012
49 https://doi.org/10.1200/jco.2008.18.5678
50 https://doi.org/10.1210/en.2002-220275
51 https://doi.org/10.1210/en.2005-1279
52 https://doi.org/10.1210/en.2006-1100
53 https://doi.org/10.1210/en.2006-1509
54 https://doi.org/10.1210/en.2007-0925
55 https://doi.org/10.1210/er.2013-1029
56 https://doi.org/10.1210/jc.2005-2639
57 https://doi.org/10.1210/jc.2005-2730
58 https://doi.org/10.1210/jc.2012-3310
59 https://doi.org/10.1210/jc.2014-3182
60 https://doi.org/10.1210/jc.2014-3282
61 https://doi.org/10.1210/jc.78.3.790
62 https://doi.org/10.1210/jcem.78.3.8126158
63 https://doi.org/10.1210/jcem.86.10.7957
64 https://doi.org/10.1210/mend.10.12.8961275
65 https://doi.org/10.1242/dev.088047
66 https://doi.org/10.1371/journal.pone.0007309
67 https://doi.org/10.1371/journal.pone.0044171
68 https://doi.org/10.1530/eje-13-0778
69 https://doi.org/10.1530/eje-13-0788
70 https://doi.org/10.1530/eje-15-1118
71 https://doi.org/10.1530/eje.0.1500809
72 https://doi.org/10.1530/eje.1.02004
73 https://doi.org/10.1530/erc-11-0270
74 https://doi.org/10.1530/erc-13-0112
75 https://doi.org/10.4161/auto.2835
76 schema:datePublished 2017-08
77 schema:datePublishedReg 2017-08-01
78 schema:description Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Pan-genomic analyses identified p53/Rb and WNT/β-catenin signaling pathways as main contributors to the disease. However, isolated β-catenin constitutive activation failed to induce malignant progression in mouse adrenocortical tumors. Therefore, there still was a need for a relevant animal model to study ACC pathogenesis and to test new therapeutic approaches. Here, we have developed a transgenic mice model with adrenocortical specific expression of SV40 large T-antigen (AdTAg mice), to test the oncogenic potential of p53/Rb inhibition in the adrenal gland. All AdTAg mice develop large adrenal carcinomas that eventually metastasize to the liver and lungs, resulting in decreased overall survival. Consistent with ACC in patients, adrenal tumors in AdTAg mice autonomously produce large amounts of glucocorticoids and spontaneously activate WNT/β-catenin signaling pathway during malignant progression. We show that this activation is associated with downregulation of secreted frizzled related proteins (Sfrp) and Znrf3 that act as inhibitors of the WNT signaling. We also show that mTORC1 pathway activation is an early event during neoplasia expansion and further demonstrate that mTORC1 pathway is activated in ACC patients. Preclinical inhibition of mTORC1 activity induces a marked reduction in tumor size, associated with induction of apoptosis and inhibition of proliferation that results in normalization of corticosterone plasma levels in AdTAg mice. Altogether, these data establish AdTAg mice as the first preclinical model for metastatic ACC.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree false
82 schema:isPartOf Nb3d09eedbbce41f9aef67629decfdbf8
83 Nf3436993b91542e6866a6af8fcb2cd24
84 sg:journal.1097543
85 schema:name P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model
86 schema:pagination 4445
87 schema:productId N07f1034dd99347ea980a5b0d323320dd
88 N2bd557f62e154b648fe64f0942aced07
89 N600010ea3fb1498ea1120f1732db3042
90 Nb7cf7c206973481186538e0f4c54825f
91 Ne1c07b95688a4a22a5e2185f6329f046
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084509004
93 https://doi.org/10.1038/onc.2017.54
94 schema:sdDatePublished 2019-04-10T13:56
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N92dc5902fcc64a40a143345b7d591061
97 schema:url https://www.nature.com/articles/onc201754
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N0619bcdbe008472bb5890d7d0214f948 rdf:first sg:person.01107706210.41
102 rdf:rest rdf:nil
103 N07f1034dd99347ea980a5b0d323320dd schema:name readcube_id
104 schema:value ed9a6789aa9a3f1396b764060f4798e0e42fc20e5653e6c3cafe9a4ab7d8e445
105 rdf:type schema:PropertyValue
106 N0a525cb9cdbc4abf9acdbc29a1fcde42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Mice
108 rdf:type schema:DefinedTerm
109 N0ef654fa521f43a08900821afbdc89c9 rdf:first sg:person.01062372067.75
110 rdf:rest Nd1b6c4719f5140cbad5d148f37afa1e3
111 N19e348d412144e388e0652df894239a0 rdf:first sg:person.01107250557.01
112 rdf:rest Nec8432bc03e54e4fb6ae2e612c17cf22
113 N26498f8bc02e43d882e5dda0e707f5a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Multiprotein Complexes
115 rdf:type schema:DefinedTerm
116 N2aef0c4c151e401ab511949f141834fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Adrenocortical Carcinoma
118 rdf:type schema:DefinedTerm
119 N2bd557f62e154b648fe64f0942aced07 schema:name dimensions_id
120 schema:value pub.1084509004
121 rdf:type schema:PropertyValue
122 N2cd1b09e292543ac9de8c8c33df4cb25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Wnt Signaling Pathway
124 rdf:type schema:DefinedTerm
125 N3808b000eb094621ba977d621361816b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Animals
127 rdf:type schema:DefinedTerm
128 N486fe386e77944be85858644ef41477e rdf:first sg:person.0702737573.84
129 rdf:rest N4d288d48a1f9497ab2d72d4ca3a705d7
130 N4d288d48a1f9497ab2d72d4ca3a705d7 rdf:first sg:person.01206077604.81
131 rdf:rest Na5232897120a4ab5acc9c7415ab9c99c
132 N59e980c637b34c319b782b0ff978f7ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Retinoblastoma Protein
134 rdf:type schema:DefinedTerm
135 N5d51bea292694059abb79895024292a7 rdf:first sg:person.01320524350.98
136 rdf:rest Na77f4568a90349d9a9fb6f055392f9b9
137 N600010ea3fb1498ea1120f1732db3042 schema:name nlm_unique_id
138 schema:value 8711562
139 rdf:type schema:PropertyValue
140 N6f9acbf47e8b47dd8f76425d24aa49b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Sirolimus
142 rdf:type schema:DefinedTerm
143 N77ea2d0c6ea54b97a76e70b8be96fe8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Tumor Suppressor Protein p53
145 rdf:type schema:DefinedTerm
146 N796cddca903e4121bd3f3bd260661be7 rdf:first sg:person.0663662016.17
147 rdf:rest N19e348d412144e388e0652df894239a0
148 N7e2fd0b96222422d8d85a547ac766e2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Antigens, Polyomavirus Transforming
150 rdf:type schema:DefinedTerm
151 N80301e306efc4859b0cdc003d1b1b174 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Neoplasm Metastasis
153 rdf:type schema:DefinedTerm
154 N882417e06838419bb0d37019ab407fcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name beta Catenin
156 rdf:type schema:DefinedTerm
157 N8bb3c03a18e742d98298a5b59ac855f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mechanistic Target of Rapamycin Complex 1
159 rdf:type schema:DefinedTerm
160 N9193115778434963a24f5cf0b5802f61 rdf:first sg:person.01111043147.35
161 rdf:rest N5d51bea292694059abb79895024292a7
162 N92dc5902fcc64a40a143345b7d591061 schema:name Springer Nature - SN SciGraph project
163 rdf:type schema:Organization
164 Na5232897120a4ab5acc9c7415ab9c99c rdf:first sg:person.01076077641.00
165 rdf:rest N0ef654fa521f43a08900821afbdc89c9
166 Na77f4568a90349d9a9fb6f055392f9b9 rdf:first sg:person.015162364244.37
167 rdf:rest Ne40dbe6576d849d7ac652c2a4dcc1780
168 Nb3d09eedbbce41f9aef67629decfdbf8 schema:volumeNumber 36
169 rdf:type schema:PublicationVolume
170 Nb7cf7c206973481186538e0f4c54825f schema:name pubmed_id
171 schema:value 28368424
172 rdf:type schema:PropertyValue
173 Nc4e06bf8163743f68e36cba25d4e4dfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Humans
175 rdf:type schema:DefinedTerm
176 Nc8ba31b249374f07b867137c074f5d74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Mice, Transgenic
178 rdf:type schema:DefinedTerm
179 Ncb0392e287b7418dbeba72e03712cfd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name TOR Serine-Threonine Kinases
181 rdf:type schema:DefinedTerm
182 Ncc2020bc97a5427f84c917074095ae37 rdf:first sg:person.01324375171.82
183 rdf:rest N486fe386e77944be85858644ef41477e
184 Nce409257a71d44a5bdddf31f2de08c1f schema:name Department of Anatomopathology, Clermont-Ferrand Hospital, Clermont-Ferrand, France.
185 rdf:type schema:Organization
186 Nd1b6c4719f5140cbad5d148f37afa1e3 rdf:first sg:person.0615170555.02
187 rdf:rest N9193115778434963a24f5cf0b5802f61
188 Ne1c07b95688a4a22a5e2185f6329f046 schema:name doi
189 schema:value 10.1038/onc.2017.54
190 rdf:type schema:PropertyValue
191 Ne40dbe6576d849d7ac652c2a4dcc1780 rdf:first sg:person.01251720754.50
192 rdf:rest N796cddca903e4121bd3f3bd260661be7
193 Ne58363ddf5024e87ba88e76fd8c11713 rdf:first sg:person.0703671367.15
194 rdf:rest Ncc2020bc97a5427f84c917074095ae37
195 Nec8432bc03e54e4fb6ae2e612c17cf22 rdf:first sg:person.01371557114.16
196 rdf:rest N0619bcdbe008472bb5890d7d0214f948
197 Nf3436993b91542e6866a6af8fcb2cd24 schema:issueNumber 31
198 rdf:type schema:PublicationIssue
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
203 schema:name Oncology and Carcinogenesis
204 rdf:type schema:DefinedTerm
205 sg:grant.4519625 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.54
206 rdf:type schema:MonetaryGrant
207 sg:journal.1097543 schema:issn 0950-9232
208 1476-5594
209 schema:name Oncogene
210 rdf:type schema:Periodical
211 sg:person.01062372067.75 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
212 schema:familyName Drelon
213 schema:givenName C
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062372067.75
215 rdf:type schema:Person
216 sg:person.01076077641.00 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
217 schema:familyName Mathieu
218 schema:givenName M
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076077641.00
220 rdf:type schema:Person
221 sg:person.01107250557.01 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
222 schema:familyName Val
223 schema:givenName P
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107250557.01
225 rdf:type schema:Person
226 sg:person.01107706210.41 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
227 schema:familyName Lefrançois-Martinez
228 schema:givenName A-M
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107706210.41
230 rdf:type schema:Person
231 sg:person.01111043147.35 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
232 schema:familyName Damon-Soubeyrand
233 schema:givenName C
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111043147.35
235 rdf:type schema:Person
236 sg:person.01206077604.81 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
237 schema:familyName Dumontet
238 schema:givenName T
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206077604.81
240 rdf:type schema:Person
241 sg:person.01251720754.50 schema:affiliation https://www.grid.ac/institutes/grid.462098.1
242 schema:familyName Bertherat
243 schema:givenName J
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251720754.50
245 rdf:type schema:Person
246 sg:person.01320524350.98 schema:affiliation https://www.grid.ac/institutes/grid.411163.0
247 schema:familyName Marceau
248 schema:givenName G
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320524350.98
250 rdf:type schema:Person
251 sg:person.01324375171.82 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
252 schema:familyName Sahut-Barnola
253 schema:givenName I
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324375171.82
255 rdf:type schema:Person
256 sg:person.01371557114.16 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
257 schema:familyName Martinez
258 schema:givenName A
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371557114.16
260 rdf:type schema:Person
261 sg:person.015162364244.37 schema:affiliation Nce409257a71d44a5bdddf31f2de08c1f
262 schema:familyName Kemeny
263 schema:givenName J-L
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015162364244.37
265 rdf:type schema:Person
266 sg:person.0615170555.02 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
267 schema:familyName Pointud
268 schema:givenName J-C
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615170555.02
270 rdf:type schema:Person
271 sg:person.0663662016.17 schema:affiliation https://www.grid.ac/institutes/grid.411163.0
272 schema:familyName Tauveron
273 schema:givenName I
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663662016.17
275 rdf:type schema:Person
276 sg:person.0702737573.84 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
277 schema:familyName Tissier
278 schema:givenName F
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702737573.84
280 rdf:type schema:Person
281 sg:person.0703671367.15 schema:affiliation https://www.grid.ac/institutes/grid.411163.0
282 schema:familyName Batisse-Lignier
283 schema:givenName M
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703671367.15
285 rdf:type schema:Person
286 sg:pub.10.1007/s12020-013-9878-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041176115
287 https://doi.org/10.1007/s12020-013-9878-1
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s12672-011-0088-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018008452
290 https://doi.org/10.1007/s12672-011-0088-0
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/ng.2953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052056080
293 https://doi.org/10.1038/ng.2953
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/onc.2015.494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006650418
296 https://doi.org/10.1038/onc.2015.494
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/sj.onc.1209046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017838792
299 https://doi.org/10.1038/sj.onc.1209046
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.ajpath.2012.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004037668
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.bbcan.2013.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007662516
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.ccell.2016.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027041306
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.ecl.2015.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050480194
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.eururo.2013.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039444985
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.mce.2012.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042023566
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.tcb.2010.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009296743
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.tem.2009.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046768982
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s1470-2045(15)70081-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053089877
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1056/nejmoa1200966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033372540
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1073/pnas.0502857102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032477204
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1073/pnas.161479898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030767494
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/hmg/ddq029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017850351
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/hmg/ddw136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645899
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/jnci/90.8.606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050052014
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1097/pas.0b013e31825a6308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002808474
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/0008-5472.can-07-5203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008759879
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1158/0008-5472.can-09-3970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022549268
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1158/0008-5472.can-10-2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015581577
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1158/1078-0432.ccr-06-2085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014168049
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1158/1078-0432.ccr-08-1067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022962210
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1158/1078-0432.ccr-10-2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042292889
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1158/1078-0432.ccr-10-2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014818100
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1158/1078-0432.ccr-10-2979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020862651
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1158/1535-7163.mct-10-0012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002840854
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1200/jco.2008.18.5678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011555800
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1210/en.2002-220275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027950404
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1210/en.2005-1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247759
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1210/en.2006-1100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248273
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1210/en.2006-1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248418
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1210/en.2007-0925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248858
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1210/er.2013-1029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046545168
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1210/jc.2005-2639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288977
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1210/jc.2005-2730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289005
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1210/jc.2012-3310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004032790
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1210/jc.2014-3182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064295455
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1210/jc.2014-3282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041157999
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1210/jc.78.3.790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064297364
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1210/jcem.78.3.8126158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064318622
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1210/jcem.86.10.7957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064323921
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1210/mend.10.12.8961275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331245
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1242/dev.088047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048537432
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1371/journal.pone.0007309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010126751
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1371/journal.pone.0044171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050507003
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1530/eje-13-0778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025862761
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1530/eje-13-0788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034112124
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1530/eje-15-1118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047965460
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1530/eje.0.1500809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050643196
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1530/eje.1.02004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019627855
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1530/erc-11-0270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021286574
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1530/erc-13-0112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013041491
402 rdf:type schema:CreativeWork
403 https://doi.org/10.4161/auto.2835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290007
404 rdf:type schema:CreativeWork
405 https://www.grid.ac/institutes/grid.411163.0 schema:alternateName Centre Hospitalier Universitaire de Clermont-Ferrand
406 schema:name CNRS UMR6293, GReD, INSERM U1103, Université Clermont Auvergne, Aubière, France.
407 Centre Hospitalier Universitaire, Department of Biochemistry and Molecular Biology, Clermont-Ferrand, France.
408 Centre Hospitalier Universitaire, Endocrinology Diabetology &Metabolic Diseases Department, School of Medicine, Clermont-Ferrand, France.
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.411784.f schema:alternateName Hôpital Cochin
411 schema:name Department of Pathology, Hôpital Pitié-Salpêtrière, Université Pierre &Marie Curie, Paris, France.
412 Department of Pathology, Reference Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France.
413 rdf:type schema:Organization
414 https://www.grid.ac/institutes/grid.462098.1 schema:alternateName Institut Cochin
415 schema:name Department of Pathology, Reference Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France.
416 Institut Cochin, Université Paris Descartes, INSERM U1016, CNRS UMR8104, Paris, France.
417 rdf:type schema:Organization
418 https://www.grid.ac/institutes/grid.463855.9 schema:alternateName Genetique Reproduction and Developpement
419 schema:name CNRS UMR6293, GReD, INSERM U1103, Université Clermont Auvergne, Aubière, France.
420 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...