Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-07

AUTHORS

J-L Park, Y-S Lee, M-J Song, S-H Hong, J-H Ahn, E-H Seo, S-P Shin, S-J Lee, B H Johnson, M R Stampfer, H-P Kim, S-Y Kim, Y S Lee

ABSTRACT

RNA polymerase III (Pol III) transcribes medium-sized non-coding RNAs (collectively termed Pol III genes). Emerging diverse roles of Pol III genes suggest that individual Pol III genes are exquisitely regulated by transcription and epigenetic factors. Here we report global Pol III expression/methylation profiles and molecular mechanisms of Pol III regulation that have not been as extensively studied, using nc886 as a representative Pol III gene. In a human mammary epithelial cell system that recapitulates early breast tumorigenesis, the fraction of actively transcribed Pol III genes increases reaching a plateau during immortalization. Hyper-methylation of Pol III genes inhibits Pol III binding to DNA via inducing repressed chromatin and is a determinant for the Pol III repertoire. When Pol III genes are hypo-methylated, MYC amplifies their transcription, regardless of its recognition DNA motif. Thus, Pol III expression during tumorigenesis is delineated by methylation and magnified by MYC. More... »

PAGES

6793

References to SciGraph publications

  • 2015-12. SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation in NATURE COMMUNICATIONS
  • 2016-01. 184AA3: a xenograft model of ER+ breast adenocarcinoma in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-05. Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2004-04. RNA polymerase III transcription and cancer in ONCOGENE
  • 2006-07. Myc-binding-site recognition in the human genome is determined by chromatin context in NATURE CELL BIOLOGY
  • 2003-08. Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines in ONCOGENE
  • 2015-12. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment in GENOME BIOLOGY
  • 2003-01. Direct activation of RNA polymerase III transcription by c-Myc in NATURE
  • 2014-04. CTCF: an architectural protein bridging genome topology and function in NATURE REVIEWS GENETICS
  • 2002-08. DNA methylation in cancer: too much, but also too little in ONCOGENE
  • 2010-05. Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-05. Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013. An Integrated Human Mammary Epithelial Cell Culture System for Studying Carcinogenesis and Aging in CELL AND MOLECULAR BIOLOGY OF BREAST CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2017.285

    DOI

    http://dx.doi.org/10.1038/onc.2017.285

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091372347

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28846112


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epithelial Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-myc", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Polymerase III", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Untranslated", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Korea University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.412786.e", 
              "name": [
                "Personalized Genomic Medicine Research Center, KRIBB, Daejeon, Korea.", 
                "Department of Functional Genomics, University of Science and Technology, Daejeon, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "J-L", 
            "id": "sg:person.0655654316.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655654316.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.410914.9", 
              "name": [
                "Rare Cancer Branch, Research Institute, National Cancer Center, Goyang-si, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Y-S", 
            "id": "sg:person.01174621145.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174621145.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yonsei University", 
              "id": "https://www.grid.ac/institutes/grid.15444.30", 
              "name": [
                "Department of Environmental Medical Biology, Yonsei University College of Medicine, Seoul, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "M-J", 
            "id": "sg:person.01162771470.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162771470.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.410914.9", 
              "name": [
                "Rare Cancer Branch, Research Institute, National Cancer Center, Goyang-si, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hong", 
            "givenName": "S-H", 
            "id": "sg:person.01277644467.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277644467.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyung Hee University", 
              "id": "https://www.grid.ac/institutes/grid.289247.2", 
              "name": [
                "Department of Life and Nanopharmaceutical Sciences and Department of Oriental Pharmacy, Kyung Hee University, Seoul, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ahn", 
            "givenName": "J-H", 
            "id": "sg:person.0730006700.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730006700.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Korea University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.412786.e", 
              "name": [
                "Personalized Genomic Medicine Research Center, KRIBB, Daejeon, Korea.", 
                "Department of Functional Genomics, University of Science and Technology, Daejeon, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Seo", 
            "givenName": "E-H", 
            "id": "sg:person.01050701267.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050701267.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.410914.9", 
              "name": [
                "Immunotherapeutics Branch, Research Institute, National Cancer Center, Goyang-si, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shin", 
            "givenName": "S-P", 
            "id": "sg:person.01055103052.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055103052.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.410914.9", 
              "name": [
                "Immunotherapeutics Branch, Research Institute, National Cancer Center, Goyang-si, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "S-J", 
            "id": "sg:person.01330177464.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330177464.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Medical Branch at Galveston", 
              "id": "https://www.grid.ac/institutes/grid.176731.5", 
              "name": [
                "Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnson", 
            "givenName": "B H", 
            "id": "sg:person.015152610427.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015152610427.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lawrence Berkeley National Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.184769.5", 
              "name": [
                "Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stampfer", 
            "givenName": "M R", 
            "id": "sg:person.01225174422.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225174422.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yonsei University", 
              "id": "https://www.grid.ac/institutes/grid.15444.30", 
              "name": [
                "Department of Environmental Medical Biology, Yonsei University College of Medicine, Seoul, Korea.", 
                "Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea.", 
                "Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "H-P", 
            "id": "sg:person.01346105672.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346105672.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Korea University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.412786.e", 
              "name": [
                "Personalized Genomic Medicine Research Center, KRIBB, Daejeon, Korea.", 
                "Department of Functional Genomics, University of Science and Technology, Daejeon, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "S-Y", 
            "id": "sg:person.01301571713.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301571713.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.410914.9", 
              "name": [
                "Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, USA.", 
                "Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Y S", 
            "id": "sg:person.01113742431.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113742431.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/978-1-62703-634-4_15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002244782", 
              "https://doi.org/10.1007/978-1-62703-634-4_15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199711)183:3<345::aid-path930>3.0.co;2-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004552397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-4977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005292871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-015-0660-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007815824", 
              "https://doi.org/10.1186/s13059-015-0660-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-015-0660-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007815824", 
              "https://doi.org/10.1186/s13059-015-0660-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagrm.2013.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009203669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2012.07.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009619858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.82.8.2394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010030555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/21.6.1351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011422753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.1927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011681499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.1927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011681499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(96)00453-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012060381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012935976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-06-362541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016934416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017831086", 
              "https://doi.org/10.1038/nrg3663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018592560", 
              "https://doi.org/10.1038/nsmb.1801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020496443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020496443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0913836107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020616531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.11852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022163030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.285601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022547406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022739314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022769786", 
              "https://doi.org/10.1038/sj.onc.1206667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022769786", 
              "https://doi.org/10.1038/sj.onc.1206667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023014918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.10.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024564479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026016926", 
              "https://doi.org/10.1038/nature01327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026016926", 
              "https://doi.org/10.1038/nature01327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0085648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027319912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.101337.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027696877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-3055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028248013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/18.2.333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029427412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagrm.2008.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030667126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030851998", 
              "https://doi.org/10.1038/sj.onc.1207547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030851998", 
              "https://doi.org/10.1038/sj.onc.1207547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0702909104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033235506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033290711", 
              "https://doi.org/10.1038/ncb1434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033290711", 
              "https://doi.org/10.1038/ncb1434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.230224097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033889265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.2047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033910967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033974084", 
              "https://doi.org/10.1038/sj.onc.1205651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033974084", 
              "https://doi.org/10.1038/sj.onc.1205651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-015-3649-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033998553", 
              "https://doi.org/10.1007/s10549-015-3649-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-0270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034573739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034800339", 
              "https://doi.org/10.1038/nsmb.1806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3791/50011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035055709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.2701111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035281730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0111020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037384605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m201333200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038223535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038613513", 
              "https://doi.org/10.1038/nsmb.1794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5808/gi.2015.13.4.94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040686040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2008.01.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040760043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2005.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042606459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2005.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043588919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.2037511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043751872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044590847", 
              "https://doi.org/10.1038/ncomms7569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047284773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1018902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047555566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(90)81193-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050013701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/22.6.1087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051422608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.130286.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052718748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fcell.2015.00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052765132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/15384101.2014.954456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072288134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.2.3.375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072296756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.6.15.4519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072299046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.28323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072302775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/epi-2016-0108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074200873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078026647", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12-07", 
        "datePublishedReg": "2017-12-07", 
        "description": "RNA polymerase III (Pol III) transcribes medium-sized non-coding RNAs (collectively termed Pol III genes). Emerging diverse roles of Pol III genes suggest that individual Pol III genes are exquisitely regulated by transcription and epigenetic factors. Here we report global Pol III expression/methylation profiles and molecular mechanisms of Pol III regulation that have not been as extensively studied, using nc886 as a representative Pol III gene. In a human mammary epithelial cell system that recapitulates early breast tumorigenesis, the fraction of actively transcribed Pol III genes increases reaching a plateau during immortalization. Hyper-methylation of Pol III genes inhibits Pol III binding to DNA via inducing repressed chromatin and is a determinant for the Pol III repertoire. When Pol III genes are hypo-methylated, MYC amplifies their transcription, regardless of its recognition DNA motif. Thus, Pol III expression during tumorigenesis is delineated by methylation and magnified by MYC.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/onc.2017.285", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7491431", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "49", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "36"
          }
        ], 
        "name": "Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis", 
        "pagination": "6793", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8b47d9d6d2bd688edebd914f15aa13d2e807f10eb810d327695362fb07333611"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28846112"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2017.285"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1091372347"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2017.285", 
          "https://app.dimensions.ai/details/publication/pub.1091372347"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000427.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/onc2017285"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.285'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.285'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.285'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.285'


     

    This table displays all metadata directly associated to this object as RDF triples.

    424 TRIPLES      21 PREDICATES      102 URIs      34 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2017.285 schema:about N0fdcdfa39dae421db7ebe0475072edd7
    2 N17bde5320fed4d71a4141faf2bb2c967
    3 N1b7374161e6c4fcfadbcee6d94d141e4
    4 N1d03936897e346308219947106edc1bc
    5 N33903479335b4c6382f8a566c3b386ff
    6 N554f0d2b1eab4528885fee88705a19cc
    7 N715f00eebd5a43cab05b86c03f521c1d
    8 N735abbe11306465bb4c5f177b827645e
    9 N8a953b7b8e4246cea499087bcf850d47
    10 Naf33278e4d4447f9851e14e7011e4b8f
    11 Nd04a249779ef4724ab685ec692d38b8e
    12 Nd61addfa21b4430b8c3510865db0b4c6
    13 Nddf760216f80432ebbfc3b0166b1132c
    14 Ned813ad8d0af403cadf76cda1fdc98b1
    15 anzsrc-for:06
    16 anzsrc-for:0604
    17 schema:author N60034495fb074d9ea81ed41c3319861e
    18 schema:citation sg:pub.10.1007/978-1-62703-634-4_15
    19 sg:pub.10.1007/s10549-015-3649-z
    20 sg:pub.10.1038/nature01327
    21 sg:pub.10.1038/ncb1434
    22 sg:pub.10.1038/ncomms7569
    23 sg:pub.10.1038/nrg3663
    24 sg:pub.10.1038/nsmb.1794
    25 sg:pub.10.1038/nsmb.1801
    26 sg:pub.10.1038/nsmb.1806
    27 sg:pub.10.1038/sj.onc.1205651
    28 sg:pub.10.1038/sj.onc.1206667
    29 sg:pub.10.1038/sj.onc.1207547
    30 sg:pub.10.1186/s13059-015-0660-y
    31 https://app.dimensions.ai/details/publication/pub.1078026647
    32 https://doi.org/10.1002/(sici)1096-9896(199711)183:3<345::aid-path930>3.0.co;2-8
    33 https://doi.org/10.1016/0014-5793(90)81193-r
    34 https://doi.org/10.1016/j.bbagrm.2008.07.002
    35 https://doi.org/10.1016/j.bbagrm.2013.05.005
    36 https://doi.org/10.1016/j.biocel.2012.07.013
    37 https://doi.org/10.1016/j.cell.2010.10.012
    38 https://doi.org/10.1016/j.cell.2012.03.003
    39 https://doi.org/10.1016/j.cell.2012.08.026
    40 https://doi.org/10.1016/j.febslet.2008.01.042
    41 https://doi.org/10.1016/j.gde.2005.08.002
    42 https://doi.org/10.1016/j.molcel.2010.05.004
    43 https://doi.org/10.1016/j.tibs.2005.12.008
    44 https://doi.org/10.1016/s0959-8049(96)00453-4
    45 https://doi.org/10.1073/pnas.0702909104
    46 https://doi.org/10.1073/pnas.0913836107
    47 https://doi.org/10.1073/pnas.230224097
    48 https://doi.org/10.1073/pnas.82.8.2394
    49 https://doi.org/10.1074/jbc.m111.285601
    50 https://doi.org/10.1074/jbc.m201333200
    51 https://doi.org/10.1093/bioinformatics/18.2.333
    52 https://doi.org/10.1093/bioinformatics/btp352
    53 https://doi.org/10.1093/nar/21.6.1351
    54 https://doi.org/10.1093/nar/22.6.1087
    55 https://doi.org/10.1093/nar/gkr737
    56 https://doi.org/10.1101/gad.1018902
    57 https://doi.org/10.1101/gad.2037511
    58 https://doi.org/10.1101/gr.101337.109
    59 https://doi.org/10.1101/gr.130286.111
    60 https://doi.org/10.1158/0008-5472.can-08-4977
    61 https://doi.org/10.1158/0008-5472.can-09-0270
    62 https://doi.org/10.1158/0008-5472.can-12-3055
    63 https://doi.org/10.1182/blood-2011-06-362541
    64 https://doi.org/10.1189/jlb.0111020
    65 https://doi.org/10.1261/rna.2701111
    66 https://doi.org/10.1371/journal.pone.0085648
    67 https://doi.org/10.18632/oncotarget.11852
    68 https://doi.org/10.18632/oncotarget.1927
    69 https://doi.org/10.18632/oncotarget.2047
    70 https://doi.org/10.2217/epi-2016-0108
    71 https://doi.org/10.3389/fcell.2015.00013
    72 https://doi.org/10.3791/50011
    73 https://doi.org/10.4161/15384101.2014.954456
    74 https://doi.org/10.4161/cc.2.3.375
    75 https://doi.org/10.4161/cc.6.15.4519
    76 https://doi.org/10.4161/epi.28323
    77 https://doi.org/10.5808/gi.2015.13.4.94
    78 schema:datePublished 2017-12-07
    79 schema:datePublishedReg 2017-12-07
    80 schema:description RNA polymerase III (Pol III) transcribes medium-sized non-coding RNAs (collectively termed Pol III genes). Emerging diverse roles of Pol III genes suggest that individual Pol III genes are exquisitely regulated by transcription and epigenetic factors. Here we report global Pol III expression/methylation profiles and molecular mechanisms of Pol III regulation that have not been as extensively studied, using nc886 as a representative Pol III gene. In a human mammary epithelial cell system that recapitulates early breast tumorigenesis, the fraction of actively transcribed Pol III genes increases reaching a plateau during immortalization. Hyper-methylation of Pol III genes inhibits Pol III binding to DNA via inducing repressed chromatin and is a determinant for the Pol III repertoire. When Pol III genes are hypo-methylated, MYC amplifies their transcription, regardless of its recognition DNA motif. Thus, Pol III expression during tumorigenesis is delineated by methylation and magnified by MYC.
    81 schema:genre research_article
    82 schema:inLanguage en
    83 schema:isAccessibleForFree true
    84 schema:isPartOf N21aaa206f62745f790fd5389fb74630f
    85 N7b46d49e805443ae9b46d40d1b6f4202
    86 sg:journal.1097543
    87 schema:name Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis
    88 schema:pagination 6793
    89 schema:productId N02078b4fa69b40e794d125d183e4f671
    90 N6d7bfea169354198931a58fb0e1c3c3c
    91 N87dab2bd3f8d458b88b4274f384ccac5
    92 N94b9af25af224ac38615edd612163786
    93 Nef0f545b10f24d18b1628b4497f00692
    94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091372347
    95 https://doi.org/10.1038/onc.2017.285
    96 schema:sdDatePublished 2019-04-11T00:55
    97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    98 schema:sdPublisher N272061e4ee644c5cb9316d2a46e0ba01
    99 schema:url https://www.nature.com/articles/onc2017285
    100 sgo:license sg:explorer/license/
    101 sgo:sdDataset articles
    102 rdf:type schema:ScholarlyArticle
    103 N02078b4fa69b40e794d125d183e4f671 schema:name doi
    104 schema:value 10.1038/onc.2017.285
    105 rdf:type schema:PropertyValue
    106 N0f941ee6d07d452b85ca7788af04c3ce rdf:first sg:person.015152610427.30
    107 rdf:rest N503dda94844641a9b6928a43932089a5
    108 N0fdcdfa39dae421db7ebe0475072edd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Humans
    110 rdf:type schema:DefinedTerm
    111 N126c48d57bdf42f7b7706d0a34515c10 rdf:first sg:person.01113742431.03
    112 rdf:rest rdf:nil
    113 N17bde5320fed4d71a4141faf2bb2c967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Chromatin
    115 rdf:type schema:DefinedTerm
    116 N1b7374161e6c4fcfadbcee6d94d141e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name DNA Methylation
    118 rdf:type schema:DefinedTerm
    119 N1d03936897e346308219947106edc1bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Epithelial Cells
    121 rdf:type schema:DefinedTerm
    122 N1e83eb67b9274038b67f6250db943db9 rdf:first sg:person.0730006700.75
    123 rdf:rest Nbd7dea1ca1a64430bbc7d8e5df47d0a0
    124 N21aaa206f62745f790fd5389fb74630f schema:issueNumber 49
    125 rdf:type schema:PublicationIssue
    126 N272061e4ee644c5cb9316d2a46e0ba01 schema:name Springer Nature - SN SciGraph project
    127 rdf:type schema:Organization
    128 N2ba1d24e1a844c6db7bcf24e07bea84a rdf:first sg:person.01330177464.35
    129 rdf:rest N0f941ee6d07d452b85ca7788af04c3ce
    130 N33903479335b4c6382f8a566c3b386ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Cells, Cultured
    132 rdf:type schema:DefinedTerm
    133 N503dda94844641a9b6928a43932089a5 rdf:first sg:person.01225174422.19
    134 rdf:rest N9e6b6d93811d45368945bb9a1e9d5768
    135 N554f0d2b1eab4528885fee88705a19cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name RNA Polymerase III
    137 rdf:type schema:DefinedTerm
    138 N60034495fb074d9ea81ed41c3319861e rdf:first sg:person.0655654316.25
    139 rdf:rest Na8bbc29981964197bb3e2d7e234cead6
    140 N6d7bfea169354198931a58fb0e1c3c3c schema:name pubmed_id
    141 schema:value 28846112
    142 rdf:type schema:PropertyValue
    143 N715f00eebd5a43cab05b86c03f521c1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Breast
    145 rdf:type schema:DefinedTerm
    146 N735abbe11306465bb4c5f177b827645e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Cell Transformation, Neoplastic
    148 rdf:type schema:DefinedTerm
    149 N7b46d49e805443ae9b46d40d1b6f4202 schema:volumeNumber 36
    150 rdf:type schema:PublicationVolume
    151 N87dab2bd3f8d458b88b4274f384ccac5 schema:name readcube_id
    152 schema:value 8b47d9d6d2bd688edebd914f15aa13d2e807f10eb810d327695362fb07333611
    153 rdf:type schema:PropertyValue
    154 N8a953b7b8e4246cea499087bcf850d47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Proto-Oncogene Proteins c-myc
    156 rdf:type schema:DefinedTerm
    157 N94b9af25af224ac38615edd612163786 schema:name dimensions_id
    158 schema:value pub.1091372347
    159 rdf:type schema:PropertyValue
    160 N9b12c4f849224011b671cbc4f866833e rdf:first sg:person.01277644467.31
    161 rdf:rest N1e83eb67b9274038b67f6250db943db9
    162 N9e6b6d93811d45368945bb9a1e9d5768 rdf:first sg:person.01346105672.35
    163 rdf:rest Nf8da596520f541d69e895a18c81f2a61
    164 Na538ef52f5f3458db4afd771e487ab23 rdf:first sg:person.01162771470.03
    165 rdf:rest N9b12c4f849224011b671cbc4f866833e
    166 Na8bbc29981964197bb3e2d7e234cead6 rdf:first sg:person.01174621145.24
    167 rdf:rest Na538ef52f5f3458db4afd771e487ab23
    168 Naf33278e4d4447f9851e14e7011e4b8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name RNA, Untranslated
    170 rdf:type schema:DefinedTerm
    171 Nbd7dea1ca1a64430bbc7d8e5df47d0a0 rdf:first sg:person.01050701267.56
    172 rdf:rest Nde361bff6927489db0f2cc570337c6e1
    173 Nd04a249779ef4724ab685ec692d38b8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Epigenesis, Genetic
    175 rdf:type schema:DefinedTerm
    176 Nd61addfa21b4430b8c3510865db0b4c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Protein Binding
    178 rdf:type schema:DefinedTerm
    179 Nddf760216f80432ebbfc3b0166b1132c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name DNA
    181 rdf:type schema:DefinedTerm
    182 Nde361bff6927489db0f2cc570337c6e1 rdf:first sg:person.01055103052.60
    183 rdf:rest N2ba1d24e1a844c6db7bcf24e07bea84a
    184 Ned813ad8d0af403cadf76cda1fdc98b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Transcription, Genetic
    186 rdf:type schema:DefinedTerm
    187 Nef0f545b10f24d18b1628b4497f00692 schema:name nlm_unique_id
    188 schema:value 8711562
    189 rdf:type schema:PropertyValue
    190 Nf8da596520f541d69e895a18c81f2a61 rdf:first sg:person.01301571713.52
    191 rdf:rest N126c48d57bdf42f7b7706d0a34515c10
    192 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    193 schema:name Biological Sciences
    194 rdf:type schema:DefinedTerm
    195 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    196 schema:name Genetics
    197 rdf:type schema:DefinedTerm
    198 sg:grant.7491431 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.285
    199 rdf:type schema:MonetaryGrant
    200 sg:journal.1097543 schema:issn 0950-9232
    201 1476-5594
    202 schema:name Oncogene
    203 rdf:type schema:Periodical
    204 sg:person.01050701267.56 schema:affiliation https://www.grid.ac/institutes/grid.412786.e
    205 schema:familyName Seo
    206 schema:givenName E-H
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050701267.56
    208 rdf:type schema:Person
    209 sg:person.01055103052.60 schema:affiliation https://www.grid.ac/institutes/grid.410914.9
    210 schema:familyName Shin
    211 schema:givenName S-P
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055103052.60
    213 rdf:type schema:Person
    214 sg:person.01113742431.03 schema:affiliation https://www.grid.ac/institutes/grid.410914.9
    215 schema:familyName Lee
    216 schema:givenName Y S
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113742431.03
    218 rdf:type schema:Person
    219 sg:person.01162771470.03 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
    220 schema:familyName Song
    221 schema:givenName M-J
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162771470.03
    223 rdf:type schema:Person
    224 sg:person.01174621145.24 schema:affiliation https://www.grid.ac/institutes/grid.410914.9
    225 schema:familyName Lee
    226 schema:givenName Y-S
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174621145.24
    228 rdf:type schema:Person
    229 sg:person.01225174422.19 schema:affiliation https://www.grid.ac/institutes/grid.184769.5
    230 schema:familyName Stampfer
    231 schema:givenName M R
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225174422.19
    233 rdf:type schema:Person
    234 sg:person.01277644467.31 schema:affiliation https://www.grid.ac/institutes/grid.410914.9
    235 schema:familyName Hong
    236 schema:givenName S-H
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277644467.31
    238 rdf:type schema:Person
    239 sg:person.01301571713.52 schema:affiliation https://www.grid.ac/institutes/grid.412786.e
    240 schema:familyName Kim
    241 schema:givenName S-Y
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301571713.52
    243 rdf:type schema:Person
    244 sg:person.01330177464.35 schema:affiliation https://www.grid.ac/institutes/grid.410914.9
    245 schema:familyName Lee
    246 schema:givenName S-J
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330177464.35
    248 rdf:type schema:Person
    249 sg:person.01346105672.35 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
    250 schema:familyName Kim
    251 schema:givenName H-P
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346105672.35
    253 rdf:type schema:Person
    254 sg:person.015152610427.30 schema:affiliation https://www.grid.ac/institutes/grid.176731.5
    255 schema:familyName Johnson
    256 schema:givenName B H
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015152610427.30
    258 rdf:type schema:Person
    259 sg:person.0655654316.25 schema:affiliation https://www.grid.ac/institutes/grid.412786.e
    260 schema:familyName Park
    261 schema:givenName J-L
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655654316.25
    263 rdf:type schema:Person
    264 sg:person.0730006700.75 schema:affiliation https://www.grid.ac/institutes/grid.289247.2
    265 schema:familyName Ahn
    266 schema:givenName J-H
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730006700.75
    268 rdf:type schema:Person
    269 sg:pub.10.1007/978-1-62703-634-4_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002244782
    270 https://doi.org/10.1007/978-1-62703-634-4_15
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s10549-015-3649-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033998553
    273 https://doi.org/10.1007/s10549-015-3649-z
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature01327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026016926
    276 https://doi.org/10.1038/nature01327
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/ncb1434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033290711
    279 https://doi.org/10.1038/ncb1434
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/ncomms7569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044590847
    282 https://doi.org/10.1038/ncomms7569
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nrg3663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017831086
    285 https://doi.org/10.1038/nrg3663
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nsmb.1794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038613513
    288 https://doi.org/10.1038/nsmb.1794
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nsmb.1801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018592560
    291 https://doi.org/10.1038/nsmb.1801
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nsmb.1806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034800339
    294 https://doi.org/10.1038/nsmb.1806
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/sj.onc.1205651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033974084
    297 https://doi.org/10.1038/sj.onc.1205651
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/sj.onc.1206667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022769786
    300 https://doi.org/10.1038/sj.onc.1206667
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/sj.onc.1207547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030851998
    303 https://doi.org/10.1038/sj.onc.1207547
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1186/s13059-015-0660-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1007815824
    306 https://doi.org/10.1186/s13059-015-0660-y
    307 rdf:type schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1078026647 schema:CreativeWork
    309 https://doi.org/10.1002/(sici)1096-9896(199711)183:3<345::aid-path930>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004552397
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/0014-5793(90)81193-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1050013701
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.bbagrm.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030667126
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.bbagrm.2013.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009203669
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.biocel.2012.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009619858
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.cell.2010.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024564479
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.cell.2012.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047284773
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.cell.2012.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020496443
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.febslet.2008.01.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040760043
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.gde.2005.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043588919
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.molcel.2010.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012935976
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.tibs.2005.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042606459
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s0959-8049(96)00453-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012060381
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1073/pnas.0702909104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033235506
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1073/pnas.0913836107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020616531
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1073/pnas.230224097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033889265
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1073/pnas.82.8.2394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010030555
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1074/jbc.m111.285601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022547406
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1074/jbc.m201333200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038223535
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1093/bioinformatics/18.2.333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029427412
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1093/bioinformatics/btp352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014918
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1093/nar/21.6.1351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011422753
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1093/nar/22.6.1087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051422608
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1093/nar/gkr737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022739314
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1101/gad.1018902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047555566
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1101/gad.2037511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043751872
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1101/gr.101337.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027696877
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1101/gr.130286.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052718748
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1158/0008-5472.can-08-4977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005292871
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1158/0008-5472.can-09-0270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034573739
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1158/0008-5472.can-12-3055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028248013
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1182/blood-2011-06-362541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016934416
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1189/jlb.0111020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037384605
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1261/rna.2701111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035281730
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1371/journal.pone.0085648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027319912
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.18632/oncotarget.11852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022163030
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.18632/oncotarget.1927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011681499
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.18632/oncotarget.2047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033910967
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.2217/epi-2016-0108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074200873
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.3389/fcell.2015.00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052765132
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.3791/50011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035055709
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.4161/15384101.2014.954456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072288134
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.4161/cc.2.3.375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072296756
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.4161/cc.6.15.4519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299046
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.4161/epi.28323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072302775
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.5808/gi.2015.13.4.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040686040
    400 rdf:type schema:CreativeWork
    401 https://www.grid.ac/institutes/grid.15444.30 schema:alternateName Yonsei University
    402 schema:name Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
    403 Department of Environmental Medical Biology, Yonsei University College of Medicine, Seoul, Korea.
    404 Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea.
    405 rdf:type schema:Organization
    406 https://www.grid.ac/institutes/grid.176731.5 schema:alternateName The University of Texas Medical Branch at Galveston
    407 schema:name Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, USA.
    408 rdf:type schema:Organization
    409 https://www.grid.ac/institutes/grid.184769.5 schema:alternateName Lawrence Berkeley National Laboratory
    410 schema:name Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
    411 rdf:type schema:Organization
    412 https://www.grid.ac/institutes/grid.289247.2 schema:alternateName Kyung Hee University
    413 schema:name Department of Life and Nanopharmaceutical Sciences and Department of Oriental Pharmacy, Kyung Hee University, Seoul, Korea.
    414 rdf:type schema:Organization
    415 https://www.grid.ac/institutes/grid.410914.9 schema:alternateName National Cancer Center
    416 schema:name Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, USA.
    417 Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
    418 Immunotherapeutics Branch, Research Institute, National Cancer Center, Goyang-si, Korea.
    419 Rare Cancer Branch, Research Institute, National Cancer Center, Goyang-si, Korea.
    420 rdf:type schema:Organization
    421 https://www.grid.ac/institutes/grid.412786.e schema:alternateName Korea University of Science and Technology
    422 schema:name Department of Functional Genomics, University of Science and Technology, Daejeon, Korea.
    423 Personalized Genomic Medicine Research Center, KRIBB, Daejeon, Korea.
    424 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...