Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-23

AUTHORS

P A Guerrero, J H Tchaicha, Z Chen, J E Morales, N McCarty, Q Wang, E P Sulman, G Fuller, F F Lang, G Rao, J H McCarty

ABSTRACT

Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche influence self-renewal, differentiation and drug resistance, although the pathways underlying these events remain largely unknown. Here, we report that the integrin αvβ8 and its latent transforming growth factor β1 (TGFβ1) protein ligand have central roles in promoting niche co-option and GBM initiation. αvβ8 integrin is highly expressed in GSCs and is essential for self-renewal and lineage commitment in vitro. Fractionation of β8high cells from freshly resected human GBM samples also reveals a requirement for this integrin in tumorigenesis in vivo. Whole-transcriptome sequencing reveals that αvβ8 integrin regulates tumor development, in part, by driving TGFβ1-induced DNA replication and mitotic checkpoint progression. Collectively, these data identify the αvβ8 integrin-TGFβ1 signaling axis as crucial for exploitation of the perivascular niche and identify potential therapeutic targets for inhibiting tumor growth and progression in patients with GBM. More... »

PAGES

6568

References to SciGraph publications

  • 2009-03. Cancer: The nuances of therapy in NATURE
  • 2012-01. Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery in JOURNAL OF NEURO-ONCOLOGY
  • 2017-03. Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations in NEUROMOLECULAR MEDICINE
  • 2007-08. Angiogenesis in brain tumours in NATURE REVIEWS NEUROSCIENCE
  • 2016-10. The complexity of integrins in cancer and new scopes for therapeutic targeting in BRITISH JOURNAL OF CANCER
  • 2016-09. ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells in SCIENTIFIC REPORTS
  • 2007-10. Making a tumour's bed: glioblastoma stem cells and the vascular niche in NATURE REVIEWS CANCER
  • 2011-02-17. MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8 in ONCOGENE
  • 2016-12. Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice in TRANSLATIONAL STROKE RESEARCH
  • 2006-12. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response in NATURE
  • 2008-10-23. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation in NATURE
  • 2004-05. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer in NATURE REVIEWS DRUG DISCOVERY
  • 2008-08. Modes of resistance to anti-angiogenic therapy in NATURE REVIEWS CANCER
  • 2016-12-07. Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma in NATURE COMMUNICATIONS
  • 2010-08. A mosaic mouse model of astrocytoma identifies αvβ8 integrin as a negative regulator of tumor angiogenesis in ONCOGENE
  • 2004-11. Identification of human brain tumour initiating cells in NATURE
  • 2011-11. TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development in LABORATORY INVESTIGATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2017.248

    DOI

    http://dx.doi.org/10.1038/onc.2017.248

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091082650

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28783169


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "AC133 Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Self Renewal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioblastoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Integrin beta Chains", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Integrins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "M Phase Cell Cycle Checkpoints", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, SCID", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplastic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Primary Cell Culture", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "SOXB1 Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transforming Growth Factor beta1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Xenograft Model Antitumor Assays", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guerrero", 
            "givenName": "P A", 
            "id": "sg:person.014542513475.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014542513475.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tchaicha", 
            "givenName": "J H", 
            "id": "sg:person.0661436702.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661436702.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Z", 
            "id": "sg:person.010227763675.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010227763675.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morales", 
            "givenName": "J E", 
            "id": "sg:person.01220363117.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220363117.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Health Science Center at Houston", 
              "id": "https://www.grid.ac/institutes/grid.267308.8", 
              "name": [
                "The Brown Institute for Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCarty", 
            "givenName": "N", 
            "id": "sg:person.0775664447.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775664447.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Radiation Oncology, M. D. Anderson Cancer Center, Houston, TX, USA", 
                "Department of Genomic Medicine, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Q", 
            "id": "sg:person.012626135537.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012626135537.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Radiation Oncology, M. D. Anderson Cancer Center, Houston, TX, USA", 
                "Department of Genomic Medicine, M. D. Anderson Cancer Center, Houston, TX, USA", 
                "Department of Translational Molecular Pathology, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sulman", 
            "givenName": "E P", 
            "id": "sg:person.012363700077.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012363700077.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Departments of Pathology, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fuller", 
            "givenName": "G", 
            "id": "sg:person.013732343337.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732343337.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lang", 
            "givenName": "F F", 
            "id": "sg:person.012270527477.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012270527477.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rao", 
            "givenName": "G", 
            "id": "sg:person.01023174621.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023174621.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, M. D. Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCarty", 
            "givenName": "J H", 
            "id": "sg:person.01277212676.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277212676.91"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.02.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000626525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2009.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000640841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)62497-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000759107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.05.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002678261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-0834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002724280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-011-0650-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003840525", 
              "https://doi.org/10.1007/s11060-011-0650-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.107193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004338873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12017-016-8429-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004452435", 
              "https://doi.org/10.1007/s12017-016-8429-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12017-016-8429-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004452435", 
              "https://doi.org/10.1007/s12017-016-8429-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.10.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006377507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006489607", 
              "https://doi.org/10.1038/nrd1381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006489607", 
              "https://doi.org/10.1038/nrd1381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200708176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009165863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-3354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012276878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2008.12.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012564726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012998751", 
              "https://doi.org/10.1038/nature07443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/458290a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013102055", 
              "https://doi.org/10.1038/458290a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/458290a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013102055", 
              "https://doi.org/10.1038/458290a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3467-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013141914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013569659", 
              "https://doi.org/10.1038/nrn2175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013847179", 
              "https://doi.org/10.1038/nrc2442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014402050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/13543784.2014.856880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014890753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0039336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015602866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016137263", 
              "https://doi.org/10.1038/nrc2246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.02.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016308317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1102454108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019813663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5648-11.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022693672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022988025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.11.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023020063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2010.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023080256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023188941", 
              "https://doi.org/10.1038/onc.2010.199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023188941", 
              "https://doi.org/10.1038/onc.2010.199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-1949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023360577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-0991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026580242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2010.090453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026964774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027226854", 
              "https://doi.org/10.1038/nature03128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027226854", 
              "https://doi.org/10.1038/nature03128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/humu.22044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029434196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031277658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e12-07-0521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031286117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.113746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031380771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.043257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031423488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031770006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.6.4.419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032777570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.3467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036542519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms13568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036655840", 
              "https://doi.org/10.1038/ncomms13568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037108428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.22.21.7667-7677.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039343415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra043666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040422233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra043666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040422233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00112-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040548723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041233330", 
              "https://doi.org/10.1038/nature05236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041233330", 
              "https://doi.org/10.1038/nature05236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041233330", 
              "https://doi.org/10.1038/nature05236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.02.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042209217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043022730", 
              "https://doi.org/10.1038/onc.2010.465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.261982.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043286434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0b013e32832a07eb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043307253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0b013e32832a07eb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043307253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0b013e32832a07eb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043307253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1176009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043407449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2016.312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045446009", 
              "https://doi.org/10.1038/bjc.2016.312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2015.11.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045786977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2011.124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046707691", 
              "https://doi.org/10.1038/labinvest.2011.124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2009.080920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046756069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1254257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046815039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a006478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046821190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-016-0478-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047545100", 
              "https://doi.org/10.1007/s12975-016-0478-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-016-0478-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047545100", 
              "https://doi.org/10.1007/s12975-016-0478-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.21199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049172040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1265-15.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049285459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.069153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049611414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051837332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep25956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052741914", 
              "https://doi.org/10.1038/srep25956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20160065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056718100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20160065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056718100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a021907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060407080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2005379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062683621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1541-7786.mcr-16-0251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063277754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078821053", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082398645", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-11-23", 
        "datePublishedReg": "2017-11-23", 
        "description": "Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche influence self-renewal, differentiation and drug resistance, although the pathways underlying these events remain largely unknown. Here, we report that the integrin \u03b1v\u03b28 and its latent transforming growth factor \u03b21 (TGF\u03b21) protein ligand have central roles in promoting niche co-option and GBM initiation. \u03b1v\u03b28 integrin is highly expressed in GSCs and is essential for self-renewal and lineage commitment in vitro. Fractionation of \u03b28high cells from freshly resected human GBM samples also reveals a requirement for this integrin in tumorigenesis in vivo. Whole-transcriptome sequencing reveals that \u03b1v\u03b28 integrin regulates tumor development, in part, by driving TGF\u03b21-induced DNA replication and mitotic checkpoint progression. Collectively, these data identify the \u03b1v\u03b28 integrin-TGF\u03b21 signaling axis as crucial for exploitation of the perivascular niche and identify potential therapeutic targets for inhibiting tumor growth and progression in patients with GBM.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/onc.2017.248", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7051550", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440223", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3802582", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5476695", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438826", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2563326", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "47", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "36"
          }
        ], 
        "name": "Glioblastoma stem cells exploit the \u03b1v\u03b28 integrin-TGF\u03b21 signaling axis to drive tumor initiation and progression", 
        "pagination": "6568", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ecc4d58f4abff45a72ad531bdf488ca1b93eb22d6094729bb7cb48810562c8c4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28783169"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2017.248"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1091082650"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2017.248", 
          "https://app.dimensions.ai/details/publication/pub.1091082650"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000493.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/onc2017248"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.248'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.248'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.248'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2017.248'


     

    This table displays all metadata directly associated to this object as RDF triples.

    471 TRIPLES      21 PREDICATES      120 URIs      42 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2017.248 schema:about N1a8435d1cdb04125b4fed90baf9dce36
    2 N1fcf317adc014ce09aa8923910059ffe
    3 N3381ebdbeec1430db547169264635480
    4 N4115f219410a47d5b732c72c4b2d6c9d
    5 N4856f7716439477c96d826e8db9bd37b
    6 N52fd0a18d6b64ed79d488f7c93d3097e
    7 N5ca98ddae32b4777af8e5e78ef6c4e35
    8 N6139246ccaac4654bf8156f0505db282
    9 N6fec68cb01b14929bc761c6de5033ad8
    10 N71f074c69331461f9a3fdc2f8f2b4e96
    11 N7f1e00677e5d49d68519d7c5aac495db
    12 N8ae0652b05314f57b24efe595aee2391
    13 N8dc8aa6cd6104adf82ff736ce3d643f8
    14 N95bb9316d5974aa18c611125b63170ef
    15 Na83661ff751747e1b41d2bca6ae84c5d
    16 Nafb6623c922a4bbd826cc84f0caa060e
    17 Nb39771d568d54643bc0a566d0e5ed52e
    18 Nb4944ea325ea4193b57a287d812c6106
    19 Nb64bd6a7ae0949e69f509cc1d883534c
    20 Nc250b1e3b95342db8807bbb292eae26b
    21 Nce7fc9e9ee7341e589ac2eb4ed1382cc
    22 Nde2f9bb400ec49bbb3b4ac2eab8107f6
    23 anzsrc-for:11
    24 anzsrc-for:1112
    25 schema:author N7bd6c45caa8548fda5e9bb645676864f
    26 schema:citation sg:pub.10.1007/s11060-011-0650-1
    27 sg:pub.10.1007/s12017-016-8429-3
    28 sg:pub.10.1007/s12975-016-0478-2
    29 sg:pub.10.1038/458290a
    30 sg:pub.10.1038/bjc.2016.312
    31 sg:pub.10.1038/labinvest.2011.124
    32 sg:pub.10.1038/nature03128
    33 sg:pub.10.1038/nature05236
    34 sg:pub.10.1038/nature07443
    35 sg:pub.10.1038/ncomms13568
    36 sg:pub.10.1038/nrc2246
    37 sg:pub.10.1038/nrc2442
    38 sg:pub.10.1038/nrd1381
    39 sg:pub.10.1038/nrn2175
    40 sg:pub.10.1038/onc.2010.199
    41 sg:pub.10.1038/onc.2010.465
    42 sg:pub.10.1038/srep25956
    43 https://app.dimensions.ai/details/publication/pub.1078821053
    44 https://app.dimensions.ai/details/publication/pub.1082398645
    45 https://doi.org/10.1002/glia.21199
    46 https://doi.org/10.1002/humu.22044
    47 https://doi.org/10.1016/j.bbamcr.2009.02.001
    48 https://doi.org/10.1016/j.ccr.2006.11.023
    49 https://doi.org/10.1016/j.ccr.2008.12.006
    50 https://doi.org/10.1016/j.ccr.2009.02.008
    51 https://doi.org/10.1016/j.ccr.2009.02.011
    52 https://doi.org/10.1016/j.ccr.2010.10.023
    53 https://doi.org/10.1016/j.ccr.2012.05.037
    54 https://doi.org/10.1016/j.cell.2008.07.001
    55 https://doi.org/10.1016/j.celrep.2015.11.021
    56 https://doi.org/10.1016/j.stem.2010.02.018
    57 https://doi.org/10.1016/j.tibs.2010.08.002
    58 https://doi.org/10.1016/s0002-9440(10)62497-2
    59 https://doi.org/10.1042/bst20160065
    60 https://doi.org/10.1056/nejmra043666
    61 https://doi.org/10.1073/pnas.1102454108
    62 https://doi.org/10.1083/jcb.200708176
    63 https://doi.org/10.1091/mbc.6.4.419
    64 https://doi.org/10.1091/mbc.e12-07-0521
    65 https://doi.org/10.1097/moh.0b013e32832a07eb
    66 https://doi.org/10.1101/cshperspect.a006478
    67 https://doi.org/10.1101/cshperspect.a021907
    68 https://doi.org/10.1101/gad.261982.115
    69 https://doi.org/10.1126/science.1176009
    70 https://doi.org/10.1126/science.1254257
    71 https://doi.org/10.1126/scisignal.2005379
    72 https://doi.org/10.1128/mcb.00112-15
    73 https://doi.org/10.1128/mcb.22.21.7667-7677.2002
    74 https://doi.org/10.1158/0008-5472.can-03-3354
    75 https://doi.org/10.1158/0008-5472.can-08-1949
    76 https://doi.org/10.1158/0008-5472.can-11-0991
    77 https://doi.org/10.1158/1078-0432.ccr-09-1983
    78 https://doi.org/10.1158/1078-0432.ccr-12-1281
    79 https://doi.org/10.1158/1078-0432.ccr-12-1557
    80 https://doi.org/10.1158/1078-0432.ccr-13-0051
    81 https://doi.org/10.1158/1078-0432.ccr-14-0834
    82 https://doi.org/10.1158/1541-7786.mcr-16-0251
    83 https://doi.org/10.1158/2159-8290.cd-12-0353
    84 https://doi.org/10.1242/dev.069153
    85 https://doi.org/10.1242/dev.107193
    86 https://doi.org/10.1242/dev.113746
    87 https://doi.org/10.1242/jcs.043257
    88 https://doi.org/10.1371/journal.pone.0039336
    89 https://doi.org/10.1517/13543784.2014.856880
    90 https://doi.org/10.1523/jneurosci.1265-15.2015
    91 https://doi.org/10.1523/jneurosci.3467-05.2005
    92 https://doi.org/10.1523/jneurosci.5648-11.2012
    93 https://doi.org/10.18632/oncotarget.3467
    94 https://doi.org/10.2353/ajpath.2009.080920
    95 https://doi.org/10.2353/ajpath.2010.090453
    96 schema:datePublished 2017-11-23
    97 schema:datePublishedReg 2017-11-23
    98 schema:description Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche influence self-renewal, differentiation and drug resistance, although the pathways underlying these events remain largely unknown. Here, we report that the integrin αvβ8 and its latent transforming growth factor β1 (TGFβ1) protein ligand have central roles in promoting niche co-option and GBM initiation. αvβ8 integrin is highly expressed in GSCs and is essential for self-renewal and lineage commitment in vitro. Fractionation of β8<sup>high</sup> cells from freshly resected human GBM samples also reveals a requirement for this integrin in tumorigenesis in vivo. Whole-transcriptome sequencing reveals that αvβ8 integrin regulates tumor development, in part, by driving TGFβ1-induced DNA replication and mitotic checkpoint progression. Collectively, these data identify the αvβ8 integrin-TGFβ1 signaling axis as crucial for exploitation of the perivascular niche and identify potential therapeutic targets for inhibiting tumor growth and progression in patients with GBM.
    99 schema:genre research_article
    100 schema:inLanguage en
    101 schema:isAccessibleForFree true
    102 schema:isPartOf Na47b0b3216704e4d8438036b2e32ea52
    103 Nfc19528dbddb4de2bd87b69d7ff9876e
    104 sg:journal.1097543
    105 schema:name Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression
    106 schema:pagination 6568
    107 schema:productId N09b26558cb364043b3cb90d4ef102809
    108 N7861a96793e641efacdd4383234fcbff
    109 Na38c32b3bc05487c8c347bf46fa30dc0
    110 Ne003198a39bd4be2959fef354d5eafe8
    111 Nef054575e86f4356bb5f656d99aadea2
    112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091082650
    113 https://doi.org/10.1038/onc.2017.248
    114 schema:sdDatePublished 2019-04-11T01:55
    115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    116 schema:sdPublisher N1dbefa149ec04276a3dc37a9c0303581
    117 schema:url https://www.nature.com/articles/onc2017248
    118 sgo:license sg:explorer/license/
    119 sgo:sdDataset articles
    120 rdf:type schema:ScholarlyArticle
    121 N023c98e719bd44328ec8e7d4e2b36c65 rdf:first sg:person.01220363117.00
    122 rdf:rest N5d0ae26c7f7a4a17b7b7a7f406e9ed89
    123 N09b26558cb364043b3cb90d4ef102809 schema:name nlm_unique_id
    124 schema:value 8711562
    125 rdf:type schema:PropertyValue
    126 N0f70cab178aa4a88b8166216a712d533 rdf:first sg:person.01023174621.88
    127 rdf:rest N9ef895de84394df49ced6b17d94f4ca3
    128 N0fb61b6b45334c14832f8db6771e1edb rdf:first sg:person.012363700077.87
    129 rdf:rest Na891e0adb2b14612a1a3a86584770028
    130 N1a8435d1cdb04125b4fed90baf9dce36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Cell Differentiation
    132 rdf:type schema:DefinedTerm
    133 N1dbefa149ec04276a3dc37a9c0303581 schema:name Springer Nature - SN SciGraph project
    134 rdf:type schema:Organization
    135 N1fcf317adc014ce09aa8923910059ffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Cell Self Renewal
    137 rdf:type schema:DefinedTerm
    138 N256fda9f20024a30b563f518fae60959 rdf:first sg:person.012270527477.93
    139 rdf:rest N0f70cab178aa4a88b8166216a712d533
    140 N3381ebdbeec1430db547169264635480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Integrins
    142 rdf:type schema:DefinedTerm
    143 N4115f219410a47d5b732c72c4b2d6c9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Signal Transduction
    145 rdf:type schema:DefinedTerm
    146 N4856f7716439477c96d826e8db9bd37b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Biomarkers, Tumor
    148 rdf:type schema:DefinedTerm
    149 N52fd0a18d6b64ed79d488f7c93d3097e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Humans
    151 rdf:type schema:DefinedTerm
    152 N5ca98ddae32b4777af8e5e78ef6c4e35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Cell Line, Tumor
    154 rdf:type schema:DefinedTerm
    155 N5d0ae26c7f7a4a17b7b7a7f406e9ed89 rdf:first sg:person.0775664447.28
    156 rdf:rest N867dcc1020b54e1bb7ba6300a04a5b47
    157 N6139246ccaac4654bf8156f0505db282 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name AC133 Antigen
    159 rdf:type schema:DefinedTerm
    160 N6fec68cb01b14929bc761c6de5033ad8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Animals
    162 rdf:type schema:DefinedTerm
    163 N71f074c69331461f9a3fdc2f8f2b4e96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Transforming Growth Factor beta1
    165 rdf:type schema:DefinedTerm
    166 N7861a96793e641efacdd4383234fcbff schema:name dimensions_id
    167 schema:value pub.1091082650
    168 rdf:type schema:PropertyValue
    169 N7bd6c45caa8548fda5e9bb645676864f rdf:first sg:person.014542513475.08
    170 rdf:rest N903a49bcb6254a05a80982a5a772a558
    171 N7f1e00677e5d49d68519d7c5aac495db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Glioblastoma
    173 rdf:type schema:DefinedTerm
    174 N867dcc1020b54e1bb7ba6300a04a5b47 rdf:first sg:person.012626135537.18
    175 rdf:rest N0fb61b6b45334c14832f8db6771e1edb
    176 N8ae0652b05314f57b24efe595aee2391 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Primary Cell Culture
    178 rdf:type schema:DefinedTerm
    179 N8dc8aa6cd6104adf82ff736ce3d643f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Integrin beta Chains
    181 rdf:type schema:DefinedTerm
    182 N903a49bcb6254a05a80982a5a772a558 rdf:first sg:person.0661436702.95
    183 rdf:rest Nd90d2e683aac430389d964d692b65cc4
    184 N95bb9316d5974aa18c611125b63170ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Neoplastic Stem Cells
    186 rdf:type schema:DefinedTerm
    187 N9ef895de84394df49ced6b17d94f4ca3 rdf:first sg:person.01277212676.91
    188 rdf:rest rdf:nil
    189 Na38c32b3bc05487c8c347bf46fa30dc0 schema:name pubmed_id
    190 schema:value 28783169
    191 rdf:type schema:PropertyValue
    192 Na47b0b3216704e4d8438036b2e32ea52 schema:issueNumber 47
    193 rdf:type schema:PublicationIssue
    194 Na83661ff751747e1b41d2bca6ae84c5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Brain Neoplasms
    196 rdf:type schema:DefinedTerm
    197 Na891e0adb2b14612a1a3a86584770028 rdf:first sg:person.013732343337.08
    198 rdf:rest N256fda9f20024a30b563f518fae60959
    199 Nafb6623c922a4bbd826cc84f0caa060e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Xenograft Model Antitumor Assays
    201 rdf:type schema:DefinedTerm
    202 Nb39771d568d54643bc0a566d0e5ed52e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Carcinogenesis
    204 rdf:type schema:DefinedTerm
    205 Nb4944ea325ea4193b57a287d812c6106 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name M Phase Cell Cycle Checkpoints
    207 rdf:type schema:DefinedTerm
    208 Nb64bd6a7ae0949e69f509cc1d883534c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name SOXB1 Transcription Factors
    210 rdf:type schema:DefinedTerm
    211 Nc250b1e3b95342db8807bbb292eae26b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Disease Progression
    213 rdf:type schema:DefinedTerm
    214 Nce7fc9e9ee7341e589ac2eb4ed1382cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Mice, SCID
    216 rdf:type schema:DefinedTerm
    217 Nd90d2e683aac430389d964d692b65cc4 rdf:first sg:person.010227763675.80
    218 rdf:rest N023c98e719bd44328ec8e7d4e2b36c65
    219 Nde2f9bb400ec49bbb3b4ac2eab8107f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Mice
    221 rdf:type schema:DefinedTerm
    222 Ne003198a39bd4be2959fef354d5eafe8 schema:name readcube_id
    223 schema:value ecc4d58f4abff45a72ad531bdf488ca1b93eb22d6094729bb7cb48810562c8c4
    224 rdf:type schema:PropertyValue
    225 Nef054575e86f4356bb5f656d99aadea2 schema:name doi
    226 schema:value 10.1038/onc.2017.248
    227 rdf:type schema:PropertyValue
    228 Nfc19528dbddb4de2bd87b69d7ff9876e schema:volumeNumber 36
    229 rdf:type schema:PublicationVolume
    230 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Medical and Health Sciences
    232 rdf:type schema:DefinedTerm
    233 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    234 schema:name Oncology and Carcinogenesis
    235 rdf:type schema:DefinedTerm
    236 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.248
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.2440223 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.248
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.2563326 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.248
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.3802582 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.248
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.5476695 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.248
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.7051550 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2017.248
    247 rdf:type schema:MonetaryGrant
    248 sg:journal.1097543 schema:issn 0950-9232
    249 1476-5594
    250 schema:name Oncogene
    251 rdf:type schema:Periodical
    252 sg:person.010227763675.80 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    253 schema:familyName Chen
    254 schema:givenName Z
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010227763675.80
    256 rdf:type schema:Person
    257 sg:person.01023174621.88 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    258 schema:familyName Rao
    259 schema:givenName G
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023174621.88
    261 rdf:type schema:Person
    262 sg:person.01220363117.00 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    263 schema:familyName Morales
    264 schema:givenName J E
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220363117.00
    266 rdf:type schema:Person
    267 sg:person.012270527477.93 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    268 schema:familyName Lang
    269 schema:givenName F F
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012270527477.93
    271 rdf:type schema:Person
    272 sg:person.012363700077.87 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    273 schema:familyName Sulman
    274 schema:givenName E P
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012363700077.87
    276 rdf:type schema:Person
    277 sg:person.012626135537.18 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    278 schema:familyName Wang
    279 schema:givenName Q
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012626135537.18
    281 rdf:type schema:Person
    282 sg:person.01277212676.91 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    283 schema:familyName McCarty
    284 schema:givenName J H
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277212676.91
    286 rdf:type schema:Person
    287 sg:person.013732343337.08 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    288 schema:familyName Fuller
    289 schema:givenName G
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732343337.08
    291 rdf:type schema:Person
    292 sg:person.014542513475.08 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    293 schema:familyName Guerrero
    294 schema:givenName P A
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014542513475.08
    296 rdf:type schema:Person
    297 sg:person.0661436702.95 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    298 schema:familyName Tchaicha
    299 schema:givenName J H
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661436702.95
    301 rdf:type schema:Person
    302 sg:person.0775664447.28 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
    303 schema:familyName McCarty
    304 schema:givenName N
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775664447.28
    306 rdf:type schema:Person
    307 sg:pub.10.1007/s11060-011-0650-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003840525
    308 https://doi.org/10.1007/s11060-011-0650-1
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s12017-016-8429-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004452435
    311 https://doi.org/10.1007/s12017-016-8429-3
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/s12975-016-0478-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047545100
    314 https://doi.org/10.1007/s12975-016-0478-2
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/458290a schema:sameAs https://app.dimensions.ai/details/publication/pub.1013102055
    317 https://doi.org/10.1038/458290a
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/bjc.2016.312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045446009
    320 https://doi.org/10.1038/bjc.2016.312
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/labinvest.2011.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046707691
    323 https://doi.org/10.1038/labinvest.2011.124
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nature03128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027226854
    326 https://doi.org/10.1038/nature03128
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nature05236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041233330
    329 https://doi.org/10.1038/nature05236
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nature07443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012998751
    332 https://doi.org/10.1038/nature07443
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/ncomms13568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036655840
    335 https://doi.org/10.1038/ncomms13568
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/nrc2246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016137263
    338 https://doi.org/10.1038/nrc2246
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nrc2442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013847179
    341 https://doi.org/10.1038/nrc2442
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/nrd1381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006489607
    344 https://doi.org/10.1038/nrd1381
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/nrn2175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013569659
    347 https://doi.org/10.1038/nrn2175
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/onc.2010.199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023188941
    350 https://doi.org/10.1038/onc.2010.199
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/onc.2010.465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043022730
    353 https://doi.org/10.1038/onc.2010.465
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/srep25956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052741914
    356 https://doi.org/10.1038/srep25956
    357 rdf:type schema:CreativeWork
    358 https://app.dimensions.ai/details/publication/pub.1078821053 schema:CreativeWork
    359 https://app.dimensions.ai/details/publication/pub.1082398645 schema:CreativeWork
    360 https://doi.org/10.1002/glia.21199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049172040
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1002/humu.22044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029434196
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/j.bbamcr.2009.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000640841
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/j.ccr.2006.11.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023020063
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/j.ccr.2008.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012564726
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/j.ccr.2009.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042209217
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1016/j.ccr.2009.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000626525
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/j.ccr.2010.10.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006377507
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/j.ccr.2012.05.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002678261
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/j.cell.2008.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037108428
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/j.celrep.2015.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045786977
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/j.stem.2010.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016308317
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/j.tibs.2010.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023080256
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/s0002-9440(10)62497-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000759107
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1042/bst20160065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056718100
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1056/nejmra043666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040422233
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1073/pnas.1102454108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019813663
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1083/jcb.200708176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009165863
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1091/mbc.6.4.419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032777570
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1091/mbc.e12-07-0521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031286117
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1097/moh.0b013e32832a07eb schema:sameAs https://app.dimensions.ai/details/publication/pub.1043307253
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1101/cshperspect.a006478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046821190
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1101/cshperspect.a021907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407080
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1101/gad.261982.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043286434
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1126/science.1176009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043407449
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1126/science.1254257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046815039
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1126/scisignal.2005379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062683621
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1128/mcb.00112-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040548723
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1128/mcb.22.21.7667-7677.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039343415
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1158/0008-5472.can-03-3354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012276878
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1158/0008-5472.can-08-1949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023360577
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1158/0008-5472.can-11-0991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026580242
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1158/1078-0432.ccr-09-1983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051837332
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1158/1078-0432.ccr-12-1281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014402050
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1158/1078-0432.ccr-12-1557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031770006
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1158/1078-0432.ccr-13-0051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022988025
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1158/1078-0432.ccr-14-0834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002724280
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1158/1541-7786.mcr-16-0251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063277754
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1158/2159-8290.cd-12-0353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031277658
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1242/dev.069153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049611414
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1242/dev.107193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004338873
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1242/dev.113746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031380771
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1242/jcs.043257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031423488
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1371/journal.pone.0039336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015602866
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1517/13543784.2014.856880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014890753
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1523/jneurosci.1265-15.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049285459
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1523/jneurosci.3467-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013141914
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1523/jneurosci.5648-11.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022693672
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.18632/oncotarget.3467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036542519
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.2353/ajpath.2009.080920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046756069
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.2353/ajpath.2010.090453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026964774
    461 rdf:type schema:CreativeWork
    462 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
    463 schema:name Department of Genomic Medicine, M. D. Anderson Cancer Center, Houston, TX, USA
    464 Department of Neurosurgery, M. D. Anderson Cancer Center, Houston, TX, USA
    465 Department of Radiation Oncology, M. D. Anderson Cancer Center, Houston, TX, USA
    466 Department of Translational Molecular Pathology, M. D. Anderson Cancer Center, Houston, TX, USA
    467 Departments of Pathology, M. D. Anderson Cancer Center, Houston, TX, USA
    468 rdf:type schema:Organization
    469 https://www.grid.ac/institutes/grid.267308.8 schema:alternateName The University of Texas Health Science Center at Houston
    470 schema:name The Brown Institute for Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
    471 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...