The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02

AUTHORS

C Cao, T Zhang, D Zhang, L Xie, X Zou, L Lei, D Wu, L Liu

ABSTRACT

The expression of long non-coding RNAs (lncRNAs) is dysregulated in hepatocellular carcinoma (HCC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of SNHG6-003 in HCC. We found that five SNHG6 transcripts were differentially expressed in HCC tissues while only the SNHG6-003 had an oncogenic function. Ectopic expression of SNHG6-003 in HCC cells promoted cell proliferation and induced drug resistance, whereas SNHG6-003 knockdown promoted apoptosis. Moreover, SNHG6-003 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-26a/b and thereby modulating the expression of transforming growth factor-β-activated kinase 1 (TAK1). Importantly, expression analysis revealed that both SNHG6-003 and TAK1 were upregulated in human cancers, exhibiting a co-expression pattern. In HCC patients, high expression of SNHG6-003 closely correlated with tumor progression and shorter survival. Thus, targeting the ceRNA network involving SNHG6-003 may be used as a treatment strategy against HCC. More... »

PAGES

1112-1122

References to SciGraph publications

  • 2014-12. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer in MOLECULAR CANCER
  • 2014-01. The multilayered complexity of ceRNA crosstalk and competition in NATURE
  • 2015-12. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation in SCIENTIFIC REPORTS
  • 2015-05. 3′UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network in SCIENTIFIC REPORTS
  • 2015-01. Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p in CELL DEATH & DISEASE
  • 2013-03. Natural RNA circles function as efficient microRNA sponges in NATURE
  • 2014-06. LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis in CELL DEATH & DISEASE
  • 2013-10. TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy in APOPTOSIS
  • 2014-12. Genome-wide screening and functional analysis identify a large number of long noncoding RNAs involved in the sexual reproduction of rice in GENOME BIOLOGY
  • 2014-01. HMGA2 functions as a competing endogenous RNA to promote lung cancer progression in NATURE
  • 2015-02. The 3′UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1 in BREAST CANCER RESEARCH AND TREATMENT
  • 2014-12. A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma in CELL DEATH & DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2016.278

    DOI

    http://dx.doi.org/10.1038/onc.2016.278

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039316214

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27530352


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