An antibody to amphiregulin, an abundant growth factor in patients’ fluids, inhibits ovarian tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-01

AUTHORS

S Carvalho, M Lindzen, M Lauriola, N Shirazi, S Sinha, A Abdul-Hai, K Levanon, J Korach, I Barshack, Y Cohen, A Onn, G Mills, Y Yarden

ABSTRACT

Growth factors of the epidermal growth factor (EGF)/neuregulin family are involved in tumor progression and, accordingly, antibodies that intercept a cognate receptor, epidermal growth factor receptor (EGFR)/ERBB1, or a co-receptor, HER2, have been approved for cancer therapy. Although they might improve safety and delay onset of chemoresistance, no anti-ligand antibodies have been clinically approved. To identify suitable ligands, we surveyed fluids from ovarian and lung cancer patients and found that amphiregulin (AREG) is the most abundant and generalized ligand secreted by advanced tumors. AREG is a low affinity EGFR ligand, which is upregulated following treatment with chemotherapeutic drugs. Because AREG depletion retarded growth of xenografted ovarian tumors in mice, we generated a neutralizing monoclonal anti-AREG antibody. The antibody inhibited growth of ovarian cancer xenografts and strongly enhanced chemotherapy efficacy. Taken together, these results raise the possibility that AREG and other low- or high-affinity binders of EGFR might serve as potential targets for cancer therapy. More... »

PAGES

438-447

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2015.93

DOI

http://dx.doi.org/10.1038/onc.2015.93

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017412310

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25915843


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amphiregulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Culture Media, Conditioned", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "EGF Family of Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Targeted Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carvalho", 
        "givenName": "S", 
        "id": "sg:person.01263220361.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263220361.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindzen", 
        "givenName": "M", 
        "id": "sg:person.01270120714.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270120714.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lauriola", 
        "givenName": "M", 
        "id": "sg:person.01317446441.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317446441.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shirazi", 
        "givenName": "N", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sinha", 
        "givenName": "S", 
        "id": "sg:person.01314206071.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314206071.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaplan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.415014.5", 
          "name": [
            "Kaplan Medical Center, Rehovot, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abdul-Hai", 
        "givenName": "A", 
        "id": "sg:person.0611244470.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611244470.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sheba Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413795.d", 
          "name": [
            "The Dr. Pinchas Borenstein Talpiot Medical Leadership Program and Institute of Oncology, The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levanon", 
        "givenName": "K", 
        "id": "sg:person.0647422152.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647422152.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sheba Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413795.d", 
          "name": [
            "Department of Gynecologic Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korach", 
        "givenName": "J", 
        "id": "sg:person.01117111100.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117111100.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sheba Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413795.d", 
          "name": [
            "Department of Pathology, Sheba Medical Center, Ramat Gan, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barshack", 
        "givenName": "I", 
        "id": "sg:person.01063177331.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063177331.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sheba Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413795.d", 
          "name": [
            "Institutional Tissue Banks, Sheba Medical Center, Ramat Gan, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cohen", 
        "givenName": "Y", 
        "id": "sg:person.014561627411.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014561627411.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Pulmonary Oncology, Chaim Sheba Medical Center Ramat Gan, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onn", 
        "givenName": "A", 
        "id": "sg:person.0763552054.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763552054.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mills", 
        "givenName": "G", 
        "id": "sg:person.012742742357.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yarden", 
        "givenName": "Y", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1242/dev.01966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005560291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201002032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007247275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0051964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009634829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e31815d060d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010040184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e31815d060d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010040184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2012.02.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011258951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0024071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011372415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20071505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012943866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20071505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012943866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013979828", 
          "https://doi.org/10.1038/nrc3309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m413919200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015067879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1296-1696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017995436", 
          "https://doi.org/10.1038/nbt1296-1696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08977194.2011.649918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018809349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2014.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019655151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0611647104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022070356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023984989", 
          "https://doi.org/10.1038/onc.2010.24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.10.5437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024397161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025407429", 
          "https://doi.org/10.1038/onc.2011.518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025684743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2011.177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026352636", 
          "https://doi.org/10.1038/nrclinonc.2011.177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m606532200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027369903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2008.00870.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027661515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m706287200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028273374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2008.10.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029731968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2011.03.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030467690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2002.0807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031199057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032102166", 
          "https://doi.org/10.1038/ng1987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08977190802312844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033872167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2008.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034397580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198010093031511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034540108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034620303", 
          "https://doi.org/10.1038/onc.2013.259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034620303", 
          "https://doi.org/10.1038/onc.2013.259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(99)00283-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038957543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canep.2012.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039045607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canep.2012.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039045607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.12.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040149871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0409610102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040944878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2010.100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043449389", 
          "https://doi.org/10.1038/labinvest.2010.100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2010.100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043449389", 
          "https://doi.org/10.1038/labinvest.2010.100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0083-6729(00)59005-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043984153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2010/568938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044339178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2009.00943.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044842102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2009.00943.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044842102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drup.2011.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046508203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048437103", 
          "https://doi.org/10.1038/nrc2644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048437103", 
          "https://doi.org/10.1038/nrc2644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-1417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048455958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.2.8.599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048909941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdt475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049323916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00045.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049963202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-008-9123-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050581660", 
          "https://doi.org/10.1007/s10555-008-9123-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-008-9123-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050581660", 
          "https://doi.org/10.1007/s10555-008-9123-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1006218107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051443947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-006-0054-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051605769", 
          "https://doi.org/10.1007/s00109-006-0054-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-006-0054-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051605769", 
          "https://doi.org/10.1007/s00109-006-0054-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.23.3663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052582133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.20.5948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053680649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi801771g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055209161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi801771g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055209161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2466334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062538899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1389450053765879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069180255"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-01", 
    "datePublishedReg": "2016-01-01", 
    "description": "Growth factors of the epidermal growth factor (EGF)/neuregulin family are involved in tumor progression and, accordingly, antibodies that intercept a cognate receptor, epidermal growth factor receptor (EGFR)/ERBB1, or a co-receptor, HER2, have been approved for cancer therapy. Although they might improve safety and delay onset of chemoresistance, no anti-ligand antibodies have been clinically approved. To identify suitable ligands, we surveyed fluids from ovarian and lung cancer patients and found that amphiregulin (AREG) is the most abundant and generalized ligand secreted by advanced tumors. AREG is a low affinity EGFR ligand, which is upregulated following treatment with chemotherapeutic drugs. Because AREG depletion retarded growth of xenografted ovarian tumors in mice, we generated a neutralizing monoclonal anti-AREG antibody. The antibody inhibited growth of ovarian cancer xenografts and strongly enhanced chemotherapy efficacy. Taken together, these results raise the possibility that AREG and other low- or high-affinity binders of EGFR might serve as potential targets for cancer therapy. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2015.93", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440196", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "name": "An antibody to amphiregulin, an abundant growth factor in patients\u2019 fluids, inhibits ovarian tumors", 
    "pagination": "438-447", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "52f591201cafc9b8a7f09f983f49d4d88f6d0d8aed247884ac4a4bd78e957565"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25915843"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2015.93"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017412310"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2015.93", 
      "https://app.dimensions.ai/details/publication/pub.1017412310"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/onc/journal/v35/n4/full/onc201593a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.93'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.93'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.93'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.93'


 

This table displays all metadata directly associated to this object as RDF triples.

402 TRIPLES      21 PREDICATES      98 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2015.93 schema:about N15b81a1a6b1a4fc1ada9dfcaa0d971fe
2 N1699855131674c62997629f0f8600fd4
3 N1e6a32674778475487beac6ea934c562
4 N2306344976a54b769eb67c38524cca65
5 N314e4870612c4281b9dd8a11c75e55ce
6 N403859a9361341c3bc218fde7a1b6025
7 N5722d0a69a6a45aca66ec4d9e9561a48
8 N62ced2dc4b0441f793675248c54ec993
9 N66f101e209774939a97e07ee75b84c80
10 N7a411f9a12234c4b963ac2fceeab8ac8
11 N8b02e3ade49e4d05807356e6344df011
12 N8c49564db42f4d0eb1b8b910ac48db4e
13 Nbe50db0644b04e00ad33d66a57811590
14 Nc20d23e492a9441ba49e6048d2c0be98
15 Ncfc1a3cea81e434986b691526b91e5ed
16 Nd60252b423f94f74b4a6d8fe26da7f40
17 Nf3c3314efd3749cc9e297febfa176eaf
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author Na6fe0acfabbe471baa02732a50f69fcf
21 schema:citation sg:pub.10.1007/s00109-006-0054-4
22 sg:pub.10.1007/s10555-008-9123-1
23 sg:pub.10.1038/labinvest.2010.100
24 sg:pub.10.1038/nbt1296-1696
25 sg:pub.10.1038/ng1987
26 sg:pub.10.1038/nrc2644
27 sg:pub.10.1038/nrc3309
28 sg:pub.10.1038/nrclinonc.2011.177
29 sg:pub.10.1038/onc.2010.24
30 sg:pub.10.1038/onc.2011.518
31 sg:pub.10.1038/onc.2013.259
32 https://doi.org/10.1006/dbio.2002.0807
33 https://doi.org/10.1016/j.canep.2012.06.005
34 https://doi.org/10.1016/j.ccr.2009.12.047
35 https://doi.org/10.1016/j.ceb.2008.12.010
36 https://doi.org/10.1016/j.cell.2011.02.013
37 https://doi.org/10.1016/j.cub.2011.03.043
38 https://doi.org/10.1016/j.drup.2011.02.004
39 https://doi.org/10.1016/j.jhep.2012.02.019
40 https://doi.org/10.1016/j.semcdb.2014.01.005
41 https://doi.org/10.1016/j.yexcr.2008.10.033
42 https://doi.org/10.1016/s0014-5793(99)00283-5
43 https://doi.org/10.1016/s0083-6729(00)59005-0
44 https://doi.org/10.1021/bi801771g
45 https://doi.org/10.1042/bj20071505
46 https://doi.org/10.1056/nejm198010093031511
47 https://doi.org/10.1073/pnas.0409610102
48 https://doi.org/10.1073/pnas.0611647104
49 https://doi.org/10.1073/pnas.1006218107
50 https://doi.org/10.1074/jbc.m413919200
51 https://doi.org/10.1074/jbc.m606532200
52 https://doi.org/10.1074/jbc.m706287200
53 https://doi.org/10.1080/08977190802312844
54 https://doi.org/10.1083/jcb.201002032
55 https://doi.org/10.1091/mbc.2.8.599
56 https://doi.org/10.1093/annonc/mdt475
57 https://doi.org/10.1093/emboj/17.20.5948
58 https://doi.org/10.1097/pgp.0b013e31815d060d
59 https://doi.org/10.1101/gad.12.23.3663
60 https://doi.org/10.1111/j.1600-0854.2008.00870.x
61 https://doi.org/10.1111/j.1600-0854.2009.00943.x
62 https://doi.org/10.1126/science.2466334
63 https://doi.org/10.1152/physiol.00045.2009
64 https://doi.org/10.1155/2010/568938
65 https://doi.org/10.1158/0008-5472.can-09-1417
66 https://doi.org/10.1158/1078-0432.ccr-08-0957
67 https://doi.org/10.1200/jco.2006.10.5437
68 https://doi.org/10.1242/dev.01966
69 https://doi.org/10.1371/journal.pone.0024071
70 https://doi.org/10.1371/journal.pone.0051964
71 https://doi.org/10.2174/1389450053765879
72 https://doi.org/10.3109/08977194.2011.649918
73 schema:datePublished 2016-01
74 schema:datePublishedReg 2016-01-01
75 schema:description Growth factors of the epidermal growth factor (EGF)/neuregulin family are involved in tumor progression and, accordingly, antibodies that intercept a cognate receptor, epidermal growth factor receptor (EGFR)/ERBB1, or a co-receptor, HER2, have been approved for cancer therapy. Although they might improve safety and delay onset of chemoresistance, no anti-ligand antibodies have been clinically approved. To identify suitable ligands, we surveyed fluids from ovarian and lung cancer patients and found that amphiregulin (AREG) is the most abundant and generalized ligand secreted by advanced tumors. AREG is a low affinity EGFR ligand, which is upregulated following treatment with chemotherapeutic drugs. Because AREG depletion retarded growth of xenografted ovarian tumors in mice, we generated a neutralizing monoclonal anti-AREG antibody. The antibody inhibited growth of ovarian cancer xenografts and strongly enhanced chemotherapy efficacy. Taken together, these results raise the possibility that AREG and other low- or high-affinity binders of EGFR might serve as potential targets for cancer therapy.
76 schema:genre research_article
77 schema:inLanguage en
78 schema:isAccessibleForFree false
79 schema:isPartOf N407de859700144089ae665317d05e0a8
80 N71d3f8f55be14661bf4729be3033fc9d
81 sg:journal.1097543
82 schema:name An antibody to amphiregulin, an abundant growth factor in patients’ fluids, inhibits ovarian tumors
83 schema:pagination 438-447
84 schema:productId N04201ca8c70c45d8b7b3aa65f23c9c7b
85 N0bc1ddd4255643b7b435a713cc691e8b
86 N31536b9bcb804ea3bf291ace0b108157
87 N3b110f84204247dbad77e6d99b6a4624
88 N4b75915baeb245cfb75690c8893cd69c
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017412310
90 https://doi.org/10.1038/onc.2015.93
91 schema:sdDatePublished 2019-04-10T23:11
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Naa3da8f5437444fd902c3cff639bb233
94 schema:url http://www.nature.com/onc/journal/v35/n4/full/onc201593a.html
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N04201ca8c70c45d8b7b3aa65f23c9c7b schema:name nlm_unique_id
99 schema:value 8711562
100 rdf:type schema:PropertyValue
101 N079c624ae53e48cea2fc96a9fed3b63c rdf:first sg:person.01317446441.30
102 rdf:rest Nb4bf832ef3c74567bb363a8959df7132
103 N0bc1ddd4255643b7b435a713cc691e8b schema:name dimensions_id
104 schema:value pub.1017412310
105 rdf:type schema:PropertyValue
106 N14d5ea11cc164429ac2e73d12c49337f rdf:first sg:person.0611244470.74
107 rdf:rest Ncf2569f209104f3ca8ff5455aa739419
108 N15b81a1a6b1a4fc1ada9dfcaa0d971fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Animals
110 rdf:type schema:DefinedTerm
111 N1699855131674c62997629f0f8600fd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Female
113 rdf:type schema:DefinedTerm
114 N1e6a32674778475487beac6ea934c562 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Ubiquitination
116 rdf:type schema:DefinedTerm
117 N225065b6f1bf4c2083beee84ea2937dd rdf:first sg:person.0763552054.93
118 rdf:rest Nca78980866ae4b09abc7e56b572dc8fa
119 N2306344976a54b769eb67c38524cca65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Transforming Growth Factor alpha
121 rdf:type schema:DefinedTerm
122 N314e4870612c4281b9dd8a11c75e55ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Antibodies, Monoclonal
124 rdf:type schema:DefinedTerm
125 N31536b9bcb804ea3bf291ace0b108157 schema:name doi
126 schema:value 10.1038/onc.2015.93
127 rdf:type schema:PropertyValue
128 N3b110f84204247dbad77e6d99b6a4624 schema:name pubmed_id
129 schema:value 25915843
130 rdf:type schema:PropertyValue
131 N403859a9361341c3bc218fde7a1b6025 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Molecular Targeted Therapy
133 rdf:type schema:DefinedTerm
134 N407de859700144089ae665317d05e0a8 schema:issueNumber 4
135 rdf:type schema:PublicationIssue
136 N4b75915baeb245cfb75690c8893cd69c schema:name readcube_id
137 schema:value 52f591201cafc9b8a7f09f983f49d4d88f6d0d8aed247884ac4a4bd78e957565
138 rdf:type schema:PropertyValue
139 N4db98201652e44a3b65441b058593b3d rdf:first sg:person.01063177331.37
140 rdf:rest N91e8655475f44ede832aa5f954003248
141 N5470c00e10ce4492a7712ceec4042449 rdf:first sg:person.01270120714.87
142 rdf:rest N079c624ae53e48cea2fc96a9fed3b63c
143 N5722d0a69a6a45aca66ec4d9e9561a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Culture Media, Conditioned
145 rdf:type schema:DefinedTerm
146 N5f2569a72c6e486f8a3f073528d2599a rdf:first sg:person.01314206071.39
147 rdf:rest N14d5ea11cc164429ac2e73d12c49337f
148 N62ced2dc4b0441f793675248c54ec993 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Receptor, Epidermal Growth Factor
150 rdf:type schema:DefinedTerm
151 N66f101e209774939a97e07ee75b84c80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name EGF Family of Proteins
153 rdf:type schema:DefinedTerm
154 N71d3f8f55be14661bf4729be3033fc9d schema:volumeNumber 35
155 rdf:type schema:PublicationVolume
156 N751a55e0cb8142e58837580731966c15 rdf:first sg:person.01117111100.77
157 rdf:rest N4db98201652e44a3b65441b058593b3d
158 N7a411f9a12234c4b963ac2fceeab8ac8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Amphiregulin
160 rdf:type schema:DefinedTerm
161 N8a3e5f6cc3f64cd49b37a250c3b67c15 schema:name Institute of Pulmonary Oncology, Chaim Sheba Medical Center Ramat Gan, Israel.
162 rdf:type schema:Organization
163 N8b02e3ade49e4d05807356e6344df011 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Xenograft Model Antitumor Assays
165 rdf:type schema:DefinedTerm
166 N8c49564db42f4d0eb1b8b910ac48db4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Tumor Cells, Cultured
168 rdf:type schema:DefinedTerm
169 N91e8655475f44ede832aa5f954003248 rdf:first sg:person.014561627411.61
170 rdf:rest N225065b6f1bf4c2083beee84ea2937dd
171 Na6fe0acfabbe471baa02732a50f69fcf rdf:first sg:person.01263220361.52
172 rdf:rest N5470c00e10ce4492a7712ceec4042449
173 Naa3da8f5437444fd902c3cff639bb233 schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 Nb29ce819ceff42c1836cf8b86c012d66 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
176 schema:familyName Yarden
177 schema:givenName Y
178 rdf:type schema:Person
179 Nb4bf832ef3c74567bb363a8959df7132 rdf:first Ne2273e10fdbf436780728d8bed65d059
180 rdf:rest N5f2569a72c6e486f8a3f073528d2599a
181 Nbe50db0644b04e00ad33d66a57811590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Humans
183 rdf:type schema:DefinedTerm
184 Nc20d23e492a9441ba49e6048d2c0be98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Mice, Nude
186 rdf:type schema:DefinedTerm
187 Nca78980866ae4b09abc7e56b572dc8fa rdf:first sg:person.012742742357.13
188 rdf:rest Nd260346da4194403bf9cabe05bfd971e
189 Ncf2569f209104f3ca8ff5455aa739419 rdf:first sg:person.0647422152.05
190 rdf:rest N751a55e0cb8142e58837580731966c15
191 Ncfc1a3cea81e434986b691526b91e5ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Antineoplastic Agents
193 rdf:type schema:DefinedTerm
194 Nd260346da4194403bf9cabe05bfd971e rdf:first Nb29ce819ceff42c1836cf8b86c012d66
195 rdf:rest rdf:nil
196 Nd60252b423f94f74b4a6d8fe26da7f40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Gene Expression Regulation, Neoplastic
198 rdf:type schema:DefinedTerm
199 Ne2273e10fdbf436780728d8bed65d059 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
200 schema:familyName Shirazi
201 schema:givenName N
202 rdf:type schema:Person
203 Nf3c3314efd3749cc9e297febfa176eaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Ovarian Neoplasms
205 rdf:type schema:DefinedTerm
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
210 schema:name Oncology and Carcinogenesis
211 rdf:type schema:DefinedTerm
212 sg:grant.2440196 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.93
213 rdf:type schema:MonetaryGrant
214 sg:journal.1097543 schema:issn 0950-9232
215 1476-5594
216 schema:name Oncogene
217 rdf:type schema:Periodical
218 sg:person.01063177331.37 schema:affiliation https://www.grid.ac/institutes/grid.413795.d
219 schema:familyName Barshack
220 schema:givenName I
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063177331.37
222 rdf:type schema:Person
223 sg:person.01117111100.77 schema:affiliation https://www.grid.ac/institutes/grid.413795.d
224 schema:familyName Korach
225 schema:givenName J
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117111100.77
227 rdf:type schema:Person
228 sg:person.01263220361.52 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
229 schema:familyName Carvalho
230 schema:givenName S
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263220361.52
232 rdf:type schema:Person
233 sg:person.01270120714.87 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
234 schema:familyName Lindzen
235 schema:givenName M
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270120714.87
237 rdf:type schema:Person
238 sg:person.012742742357.13 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
239 schema:familyName Mills
240 schema:givenName G
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13
242 rdf:type schema:Person
243 sg:person.01314206071.39 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
244 schema:familyName Sinha
245 schema:givenName S
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314206071.39
247 rdf:type schema:Person
248 sg:person.01317446441.30 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
249 schema:familyName Lauriola
250 schema:givenName M
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317446441.30
252 rdf:type schema:Person
253 sg:person.014561627411.61 schema:affiliation https://www.grid.ac/institutes/grid.413795.d
254 schema:familyName Cohen
255 schema:givenName Y
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014561627411.61
257 rdf:type schema:Person
258 sg:person.0611244470.74 schema:affiliation https://www.grid.ac/institutes/grid.415014.5
259 schema:familyName Abdul-Hai
260 schema:givenName A
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611244470.74
262 rdf:type schema:Person
263 sg:person.0647422152.05 schema:affiliation https://www.grid.ac/institutes/grid.413795.d
264 schema:familyName Levanon
265 schema:givenName K
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647422152.05
267 rdf:type schema:Person
268 sg:person.0763552054.93 schema:affiliation N8a3e5f6cc3f64cd49b37a250c3b67c15
269 schema:familyName Onn
270 schema:givenName A
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763552054.93
272 rdf:type schema:Person
273 sg:pub.10.1007/s00109-006-0054-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051605769
274 https://doi.org/10.1007/s00109-006-0054-4
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s10555-008-9123-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050581660
277 https://doi.org/10.1007/s10555-008-9123-1
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/labinvest.2010.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043449389
280 https://doi.org/10.1038/labinvest.2010.100
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nbt1296-1696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017995436
283 https://doi.org/10.1038/nbt1296-1696
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/ng1987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032102166
286 https://doi.org/10.1038/ng1987
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nrc2644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048437103
289 https://doi.org/10.1038/nrc2644
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nrc3309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013979828
292 https://doi.org/10.1038/nrc3309
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nrclinonc.2011.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026352636
295 https://doi.org/10.1038/nrclinonc.2011.177
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/onc.2010.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023984989
298 https://doi.org/10.1038/onc.2010.24
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/onc.2011.518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025407429
301 https://doi.org/10.1038/onc.2011.518
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/onc.2013.259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034620303
304 https://doi.org/10.1038/onc.2013.259
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1006/dbio.2002.0807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031199057
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.canep.2012.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039045607
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.ccr.2009.12.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040149871
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.ceb.2008.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034397580
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.cub.2011.03.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030467690
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.drup.2011.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046508203
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.jhep.2012.02.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011258951
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.semcdb.2014.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019655151
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.yexcr.2008.10.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029731968
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0014-5793(99)00283-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038957543
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s0083-6729(00)59005-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043984153
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1021/bi801771g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055209161
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1042/bj20071505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012943866
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1056/nejm198010093031511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034540108
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1073/pnas.0409610102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040944878
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1073/pnas.0611647104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022070356
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1073/pnas.1006218107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051443947
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1074/jbc.m413919200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015067879
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1074/jbc.m606532200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027369903
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1074/jbc.m706287200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028273374
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1080/08977190802312844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033872167
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1083/jcb.201002032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007247275
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1091/mbc.2.8.599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048909941
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1093/annonc/mdt475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049323916
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1093/emboj/17.20.5948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053680649
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1097/pgp.0b013e31815d060d schema:sameAs https://app.dimensions.ai/details/publication/pub.1010040184
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1101/gad.12.23.3663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052582133
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1111/j.1600-0854.2008.00870.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027661515
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1111/j.1600-0854.2009.00943.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044842102
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1126/science.2466334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062538899
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1152/physiol.00045.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049963202
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1155/2010/568938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044339178
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1158/0008-5472.can-09-1417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048455958
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1158/1078-0432.ccr-08-0957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025684743
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1200/jco.2006.10.5437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024397161
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1242/dev.01966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005560291
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1371/journal.pone.0024071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011372415
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1371/journal.pone.0051964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009634829
383 rdf:type schema:CreativeWork
384 https://doi.org/10.2174/1389450053765879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069180255
385 rdf:type schema:CreativeWork
386 https://doi.org/10.3109/08977194.2011.649918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018809349
387 rdf:type schema:CreativeWork
388 https://www.grid.ac/institutes/grid.13992.30 schema:alternateName Weizmann Institute of Science
389 schema:name Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
392 schema:name Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
393 rdf:type schema:Organization
394 https://www.grid.ac/institutes/grid.413795.d schema:alternateName Sheba Medical Center
395 schema:name Department of Gynecologic Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
396 Department of Pathology, Sheba Medical Center, Ramat Gan, Israel.
397 Institutional Tissue Banks, Sheba Medical Center, Ramat Gan, Israel.
398 The Dr. Pinchas Borenstein Talpiot Medical Leadership Program and Institute of Oncology, The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
399 rdf:type schema:Organization
400 https://www.grid.ac/institutes/grid.415014.5 schema:alternateName Kaplan Medical Center
401 schema:name Kaplan Medical Center, Rehovot, Israel.
402 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...