YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Chunbo He, Xiangmin Lv, Guohua Hua, Subodh M Lele, Steven Remmenga, Jixin Dong, John S Davis, Cheng Wang

ABSTRACT

Mechanisms underlying ovarian cancer initiation and progression are unclear. Herein, we report that the Yes-associated protein (YAP), a major effector of the Hippo tumor suppressor pathway, interacts with ERBB signaling pathways to regulate the initiation and progression of ovarian cancer. Immunohistochemistry studies indicate that YAP expression is associated with poor clinical outcomes in patients. Overexpression or constitutive activation of YAP leads to transformation and tumorigenesis in human ovarian surface epithelial cells, and promotes growth of cancer cells in vivo and in vitro. YAP induces the expression of epidermal growth factor (EGF) receptors (EGFR, ERBB3) and production of EGF-like ligands (HBEGF, NRG1 and NRG2). HBEGF or NRG1, in turn, activates YAP and stimulates cancer cell growth. Knockdown of ERBB3 or HBEGF eliminates YAP effects on cell growth and transformation, whereas knockdown of YAP abrogates NRG1- and HBEGF-stimulated cell proliferation. Collectively, our study demonstrates the existence of HBEGF & NRGs/ERBBs/YAP/HBEGF & NRGs autocrine loop that controls ovarian cell tumorigenesis and cancer progression. More... »

PAGES

6040-6054

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2015.52

DOI

http://dx.doi.org/10.1038/onc.2015.52

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052774966

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25798835


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heparin-binding EGF-like Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "Olson Center for Women\u2019s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA", 
            "College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei province 430070, P.R.China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Chunbo", 
        "id": "sg:person.0760331415.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760331415.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Olson Center for Women\u2019s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lv", 
        "givenName": "Xiangmin", 
        "id": "sg:person.01131556572.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131556572.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "Olson Center for Women\u2019s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA", 
            "College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei province 430070, P.R.China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hua", 
        "givenName": "Guohua", 
        "id": "sg:person.01026444615.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026444615.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha NE 68198, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lele", 
        "givenName": "Subodh M", 
        "id": "sg:person.0722600106.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722600106.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Olson Center for Women\u2019s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA", 
            "Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha NE 68198, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Remmenga", 
        "givenName": "Steven", 
        "id": "sg:person.01354765371.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354765371.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha NE 68198, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Jixin", 
        "id": "sg:person.01000641734.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000641734.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Omaha VA Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413785.c", 
          "name": [
            "Olson Center for Women\u2019s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA", 
            "Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha NE 68198, USA", 
            "Omaha Veterans Affairs Medical Center, Omaha, NE 68105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davis", 
        "givenName": "John S", 
        "id": "sg:person.01304171622.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304171622.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Olson Center for Women\u2019s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA", 
            "Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha NE 68198, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Cheng", 
        "id": "sg:person.0673142073.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673142073.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000074407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1216462110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000887635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1602907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003878122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200703010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004046007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004294782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2008.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004943480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007465969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0091770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010226406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.9.5.534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010420560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2010.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010896030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2010.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011157623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2009-1489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011241744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013461220", 
          "https://doi.org/10.1038/nrc3458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014250067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014847778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014847778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0912203107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015650189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)00317-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015844648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019824543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019824543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.21386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021775446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1212021109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.210773.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026489413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027614855", 
          "https://doi.org/10.1038/onc.2011.8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1478-811x-11-31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032539195", 
          "https://doi.org/10.1186/1478-811x-11-31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-1242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034211766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/erc-13-0339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035400843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(01)00002-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036969280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.09-145367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038688314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.06.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039287087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.12.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040149871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040763048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.192856.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041622523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m305597200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042958454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201210073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044209184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2009.00943.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044842102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2009.00943.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044842102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045054532", 
          "https://doi.org/10.1038/ncb1993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-2243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046423104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2013.01.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047654504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048437103", 
          "https://doi.org/10.1038/nrc2644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048437103", 
          "https://doi.org/10.1038/nrc2644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049655893", 
          "https://doi.org/10.1038/nrc1609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049655893", 
          "https://doi.org/10.1038/nrc1609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2010.01511.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050543129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2010.01511.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050543129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2003.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051448517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2008.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052747736", 
          "https://doi.org/10.1038/cdd.2008.108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.22.2.255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.3.8.1061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074964006", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082489277", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "Mechanisms underlying ovarian cancer initiation and progression are unclear. Herein, we report that the Yes-associated protein (YAP), a major effector of the Hippo tumor suppressor pathway, interacts with ERBB signaling pathways to regulate the initiation and progression of ovarian cancer. Immunohistochemistry studies indicate that YAP expression is associated with poor clinical outcomes in patients. Overexpression or constitutive activation of YAP leads to transformation and tumorigenesis in human ovarian surface epithelial cells, and promotes growth of cancer cells in vivo and in vitro. YAP induces the expression of epidermal growth factor (EGF) receptors (EGFR, ERBB3) and production of EGF-like ligands (HBEGF, NRG1 and NRG2). HBEGF or NRG1, in turn, activates YAP and stimulates cancer cell growth. Knockdown of ERBB3 or HBEGF eliminates YAP effects on cell growth and transformation, whereas knockdown of YAP abrogates NRG1- and HBEGF-stimulated cell proliferation. Collectively, our study demonstrates the existence of HBEGF & NRGs/ERBBs/YAP/HBEGF & NRGs autocrine loop that controls ovarian cell tumorigenesis and cancer progression. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2015.52", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2434798", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2441945", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2401321", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3836035", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "50", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression", 
    "pagination": "6040-6054", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fb624ad3fb25dfbef2577814b34bf50555aad9a28782851bb2e5022e962958b1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25798835"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2015.52"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052774966"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2015.52", 
      "https://app.dimensions.ai/details/publication/pub.1052774966"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/onc/journal/v34/n50/full/onc201552a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.52'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.52'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.52'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.52'


 

This table displays all metadata directly associated to this object as RDF triples.

340 TRIPLES      21 PREDICATES      90 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2015.52 schema:about N18e0c5cbc9024659b704905ea4bc829e
2 N2e6146c6943f4569abef64864a1a626a
3 N3f3398a36ae241b09fb976a1b39efe8e
4 N44540e1bf3cf4971ab0e6b944e4c005c
5 N5829fb843a0543f69002165b3bf3a4ab
6 N5ec51996a40b421b9d2fbe0a6991ca6b
7 N860f04677ea34fe0b2c5355b0c8441c2
8 N956d73ee0f4a4ff49ca28844c0001037
9 N9e16a1809f824b9cb05d3f9d10b4aaf7
10 Na8b26e77926f406c9bdc8db0ca1e6b0c
11 Nb5835a6661fc48f2a60f8df93a9a33e5
12 Nbbd2ac88dd744295bcf8289adefed77a
13 Nbcb2c399c75045ca9d04b9044b776911
14 Neaccf4a0e55b49e8ac135248ff5af9fe
15 Nf8a8c858bc2445bfbcea0ce195719e8b
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N4a6ba259229e4c4d9c1793b57f09084d
19 schema:citation sg:pub.10.1038/cdd.2008.108
20 sg:pub.10.1038/ncb1993
21 sg:pub.10.1038/nrc1609
22 sg:pub.10.1038/nrc2644
23 sg:pub.10.1038/nrc3458
24 sg:pub.10.1038/onc.2011.8
25 sg:pub.10.1186/1478-811x-11-31
26 https://app.dimensions.ai/details/publication/pub.1074964006
27 https://app.dimensions.ai/details/publication/pub.1082489277
28 https://doi.org/10.1002/cncr.24495
29 https://doi.org/10.1016/j.ccr.2009.12.047
30 https://doi.org/10.1016/j.cell.2007.07.019
31 https://doi.org/10.1016/j.cell.2012.06.037
32 https://doi.org/10.1016/j.devcel.2010.09.011
33 https://doi.org/10.1016/j.devcel.2013.01.020
34 https://doi.org/10.1016/j.humpath.2008.04.012
35 https://doi.org/10.1016/j.humpath.2010.08.003
36 https://doi.org/10.1016/j.molcel.2005.04.008
37 https://doi.org/10.1016/j.yexcr.2003.12.002
38 https://doi.org/10.1016/s0022-5347(05)00317-4
39 https://doi.org/10.1016/s1535-6108(01)00002-2
40 https://doi.org/10.1073/pnas.0912203107
41 https://doi.org/10.1073/pnas.1212021109
42 https://doi.org/10.1073/pnas.1216462110
43 https://doi.org/10.1074/jbc.m305597200
44 https://doi.org/10.1083/jcb.200703010
45 https://doi.org/10.1083/jcb.201210073
46 https://doi.org/10.1093/carcin/bgp007
47 https://doi.org/10.1096/fj.09-145367
48 https://doi.org/10.1101/gad.1602907
49 https://doi.org/10.1101/gad.192856.112
50 https://doi.org/10.1101/gad.210773.112
51 https://doi.org/10.1101/gad.9.5.534
52 https://doi.org/10.1111/j.1349-7006.2010.01511.x
53 https://doi.org/10.1111/j.1600-0854.2009.00943.x
54 https://doi.org/10.1158/0008-5472.can-03-3380
55 https://doi.org/10.1158/0008-5472.can-04-0811
56 https://doi.org/10.1158/0008-5472.can-10-1242
57 https://doi.org/10.1158/1078-0432.ccr-12-2243
58 https://doi.org/10.1210/en.2009-1489
59 https://doi.org/10.1210/er.22.2.255
60 https://doi.org/10.1371/journal.pone.0091770
61 https://doi.org/10.1530/erc-13-0339
62 https://doi.org/10.3322/caac.21220
63 https://doi.org/10.4161/cc.21386
64 https://doi.org/10.4161/cc.3.8.1061
65 schema:datePublished 2015-12
66 schema:datePublishedReg 2015-12-01
67 schema:description Mechanisms underlying ovarian cancer initiation and progression are unclear. Herein, we report that the Yes-associated protein (YAP), a major effector of the Hippo tumor suppressor pathway, interacts with ERBB signaling pathways to regulate the initiation and progression of ovarian cancer. Immunohistochemistry studies indicate that YAP expression is associated with poor clinical outcomes in patients. Overexpression or constitutive activation of YAP leads to transformation and tumorigenesis in human ovarian surface epithelial cells, and promotes growth of cancer cells in vivo and in vitro. YAP induces the expression of epidermal growth factor (EGF) receptors (EGFR, ERBB3) and production of EGF-like ligands (HBEGF, NRG1 and NRG2). HBEGF or NRG1, in turn, activates YAP and stimulates cancer cell growth. Knockdown of ERBB3 or HBEGF eliminates YAP effects on cell growth and transformation, whereas knockdown of YAP abrogates NRG1- and HBEGF-stimulated cell proliferation. Collectively, our study demonstrates the existence of HBEGF & NRGs/ERBBs/YAP/HBEGF & NRGs autocrine loop that controls ovarian cell tumorigenesis and cancer progression.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf N96d64a3db76149ae8fa6c8e0beeef742
72 Nabaf22baba61497db12ccbd29175ed16
73 sg:journal.1097543
74 schema:name YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression
75 schema:pagination 6040-6054
76 schema:productId N263ac6c685a94a62b5c1a107805696fa
77 N71e54dd42f1d417ea8ee5632012514cf
78 N794bbceb77f94cbd952c9eb111520f71
79 N8dcc7ed6029542d0b3ffec8dd551d700
80 N954c9d56b42e4707921dc75891a9f729
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052774966
82 https://doi.org/10.1038/onc.2015.52
83 schema:sdDatePublished 2019-04-10T22:19
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N590f7a00036849828acbcbfb1b744fe8
86 schema:url http://www.nature.com/onc/journal/v34/n50/full/onc201552a.html
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N0c9811813b2b496698c534929062365d rdf:first sg:person.01131556572.12
91 rdf:rest Ne55bdab7ab014ed9b6d18eecdd43f48d
92 N18e0c5cbc9024659b704905ea4bc829e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Animals
94 rdf:type schema:DefinedTerm
95 N24b4939da6a94f23b877104374b7787b rdf:first sg:person.01354765371.69
96 rdf:rest Nebf86f0c843b480fac55674b37aff666
97 N263ac6c685a94a62b5c1a107805696fa schema:name nlm_unique_id
98 schema:value 8711562
99 rdf:type schema:PropertyValue
100 N2e6146c6943f4569abef64864a1a626a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Receptor, Epidermal Growth Factor
102 rdf:type schema:DefinedTerm
103 N3f3398a36ae241b09fb976a1b39efe8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Ovarian Neoplasms
105 rdf:type schema:DefinedTerm
106 N44540e1bf3cf4971ab0e6b944e4c005c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Receptor, ErbB-3
108 rdf:type schema:DefinedTerm
109 N4a6ba259229e4c4d9c1793b57f09084d rdf:first sg:person.0760331415.47
110 rdf:rest N0c9811813b2b496698c534929062365d
111 N5829fb843a0543f69002165b3bf3a4ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Mice
113 rdf:type schema:DefinedTerm
114 N590f7a00036849828acbcbfb1b744fe8 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N5ec51996a40b421b9d2fbe0a6991ca6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Prognosis
118 rdf:type schema:DefinedTerm
119 N71e54dd42f1d417ea8ee5632012514cf schema:name pubmed_id
120 schema:value 25798835
121 rdf:type schema:PropertyValue
122 N794bbceb77f94cbd952c9eb111520f71 schema:name dimensions_id
123 schema:value pub.1052774966
124 rdf:type schema:PropertyValue
125 N860f04677ea34fe0b2c5355b0c8441c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Signal Transduction
127 rdf:type schema:DefinedTerm
128 N8dcc7ed6029542d0b3ffec8dd551d700 schema:name doi
129 schema:value 10.1038/onc.2015.52
130 rdf:type schema:PropertyValue
131 N91489568e21547f7a75760856647b0e0 rdf:first sg:person.01304171622.35
132 rdf:rest Nf4290f64674b432ab54c1a77a2ef120a
133 N954c9d56b42e4707921dc75891a9f729 schema:name readcube_id
134 schema:value fb624ad3fb25dfbef2577814b34bf50555aad9a28782851bb2e5022e962958b1
135 rdf:type schema:PropertyValue
136 N956d73ee0f4a4ff49ca28844c0001037 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cell Line, Tumor
138 rdf:type schema:DefinedTerm
139 N96d64a3db76149ae8fa6c8e0beeef742 schema:volumeNumber 34
140 rdf:type schema:PublicationVolume
141 N9e16a1809f824b9cb05d3f9d10b4aaf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Heparin-binding EGF-like Growth Factor
143 rdf:type schema:DefinedTerm
144 Na8b26e77926f406c9bdc8db0ca1e6b0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Cell Proliferation
146 rdf:type schema:DefinedTerm
147 Nabaf22baba61497db12ccbd29175ed16 schema:issueNumber 50
148 rdf:type schema:PublicationIssue
149 Nb5835a6661fc48f2a60f8df93a9a33e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 Nbbd2ac88dd744295bcf8289adefed77a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Adaptor Proteins, Signal Transducing
154 rdf:type schema:DefinedTerm
155 Nbcb2c399c75045ca9d04b9044b776911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 Nd2923ae35683441f8a8bc83abb5dc63c rdf:first sg:person.0722600106.75
159 rdf:rest N24b4939da6a94f23b877104374b7787b
160 Ne55bdab7ab014ed9b6d18eecdd43f48d rdf:first sg:person.01026444615.20
161 rdf:rest Nd2923ae35683441f8a8bc83abb5dc63c
162 Neaccf4a0e55b49e8ac135248ff5af9fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Disease Progression
164 rdf:type schema:DefinedTerm
165 Nebf86f0c843b480fac55674b37aff666 rdf:first sg:person.01000641734.86
166 rdf:rest N91489568e21547f7a75760856647b0e0
167 Nf4290f64674b432ab54c1a77a2ef120a rdf:first sg:person.0673142073.30
168 rdf:rest rdf:nil
169 Nf8a8c858bc2445bfbcea0ce195719e8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Phosphoproteins
171 rdf:type schema:DefinedTerm
172 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
173 schema:name Medical and Health Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
176 schema:name Oncology and Carcinogenesis
177 rdf:type schema:DefinedTerm
178 sg:grant.2401321 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.52
179 rdf:type schema:MonetaryGrant
180 sg:grant.2434798 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.52
181 rdf:type schema:MonetaryGrant
182 sg:grant.2441945 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.52
183 rdf:type schema:MonetaryGrant
184 sg:grant.3836035 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.52
185 rdf:type schema:MonetaryGrant
186 sg:journal.1097543 schema:issn 0950-9232
187 1476-5594
188 schema:name Oncogene
189 rdf:type schema:Periodical
190 sg:person.01000641734.86 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
191 schema:familyName Dong
192 schema:givenName Jixin
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000641734.86
194 rdf:type schema:Person
195 sg:person.01026444615.20 schema:affiliation https://www.grid.ac/institutes/grid.35155.37
196 schema:familyName Hua
197 schema:givenName Guohua
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026444615.20
199 rdf:type schema:Person
200 sg:person.01131556572.12 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
201 schema:familyName Lv
202 schema:givenName Xiangmin
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131556572.12
204 rdf:type schema:Person
205 sg:person.01304171622.35 schema:affiliation https://www.grid.ac/institutes/grid.413785.c
206 schema:familyName Davis
207 schema:givenName John S
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304171622.35
209 rdf:type schema:Person
210 sg:person.01354765371.69 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
211 schema:familyName Remmenga
212 schema:givenName Steven
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354765371.69
214 rdf:type schema:Person
215 sg:person.0673142073.30 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
216 schema:familyName Wang
217 schema:givenName Cheng
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673142073.30
219 rdf:type schema:Person
220 sg:person.0722600106.75 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
221 schema:familyName Lele
222 schema:givenName Subodh M
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722600106.75
224 rdf:type schema:Person
225 sg:person.0760331415.47 schema:affiliation https://www.grid.ac/institutes/grid.35155.37
226 schema:familyName He
227 schema:givenName Chunbo
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760331415.47
229 rdf:type schema:Person
230 sg:pub.10.1038/cdd.2008.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052747736
231 https://doi.org/10.1038/cdd.2008.108
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/ncb1993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045054532
234 https://doi.org/10.1038/ncb1993
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nrc1609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049655893
237 https://doi.org/10.1038/nrc1609
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nrc2644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048437103
240 https://doi.org/10.1038/nrc2644
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nrc3458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013461220
243 https://doi.org/10.1038/nrc3458
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/onc.2011.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027614855
246 https://doi.org/10.1038/onc.2011.8
247 rdf:type schema:CreativeWork
248 sg:pub.10.1186/1478-811x-11-31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032539195
249 https://doi.org/10.1186/1478-811x-11-31
250 rdf:type schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1074964006 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1082489277 schema:CreativeWork
253 https://doi.org/10.1002/cncr.24495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019824543
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.ccr.2009.12.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040149871
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.cell.2007.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040763048
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.cell.2012.06.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039287087
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.devcel.2010.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011157623
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.devcel.2013.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047654504
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.humpath.2008.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004943480
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.humpath.2010.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010896030
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.molcel.2005.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014847778
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.yexcr.2003.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051448517
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0022-5347(05)00317-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015844648
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s1535-6108(01)00002-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036969280
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1073/pnas.0912203107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015650189
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1073/pnas.1212021109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573469
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1073/pnas.1216462110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000887635
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1074/jbc.m305597200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042958454
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1083/jcb.200703010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004046007
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1083/jcb.201210073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044209184
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1093/carcin/bgp007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004294782
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1096/fj.09-145367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038688314
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1101/gad.1602907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003878122
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1101/gad.192856.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041622523
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1101/gad.210773.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026489413
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1101/gad.9.5.534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010420560
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1111/j.1349-7006.2010.01511.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050543129
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1111/j.1600-0854.2009.00943.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044842102
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1158/0008-5472.can-03-3380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000074407
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1158/0008-5472.can-04-0811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007465969
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1158/0008-5472.can-10-1242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034211766
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1158/1078-0432.ccr-12-2243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046423104
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1210/en.2009-1489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011241744
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1210/er.22.2.255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286154
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1371/journal.pone.0091770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010226406
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1530/erc-13-0339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035400843
320 rdf:type schema:CreativeWork
321 https://doi.org/10.3322/caac.21220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014250067
322 rdf:type schema:CreativeWork
323 https://doi.org/10.4161/cc.21386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021775446
324 rdf:type schema:CreativeWork
325 https://doi.org/10.4161/cc.3.8.1061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298021
326 rdf:type schema:CreativeWork
327 https://www.grid.ac/institutes/grid.266813.8 schema:alternateName University of Nebraska Medical Center
328 schema:name Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha NE 68198, USA
329 Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha NE 68198, USA
330 Olson Center for Women’s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.35155.37 schema:alternateName Huazhong Agricultural University
333 schema:name College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei province 430070, P.R.China
334 Olson Center for Women’s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.413785.c schema:alternateName Omaha VA Medical Center
337 schema:name Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha NE 68198, USA
338 Olson Center for Women’s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA
339 Omaha Veterans Affairs Medical Center, Omaha, NE 68105, USA
340 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...