Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSChunbo He, Xiangmin Lv, Guohua Hua, Subodh M Lele, Steven Remmenga, Jixin Dong, John S Davis, Cheng Wang
ABSTRACTMechanisms underlying ovarian cancer initiation and progression are unclear. Herein, we report that the Yes-associated protein (YAP), a major effector of the Hippo tumor suppressor pathway, interacts with ERBB signaling pathways to regulate the initiation and progression of ovarian cancer. Immunohistochemistry studies indicate that YAP expression is associated with poor clinical outcomes in patients. Overexpression or constitutive activation of YAP leads to transformation and tumorigenesis in human ovarian surface epithelial cells, and promotes growth of cancer cells in vivo and in vitro. YAP induces the expression of epidermal growth factor (EGF) receptors (EGFR, ERBB3) and production of EGF-like ligands (HBEGF, NRG1 and NRG2). HBEGF or NRG1, in turn, activates YAP and stimulates cancer cell growth. Knockdown of ERBB3 or HBEGF eliminates YAP effects on cell growth and transformation, whereas knockdown of YAP abrogates NRG1- and HBEGF-stimulated cell proliferation. Collectively, our study demonstrates the existence of HBEGF & NRGs/ERBBs/YAP/HBEGF & NRGs autocrine loop that controls ovarian cell tumorigenesis and cancer progression. More... »
PAGES6040-6054
http://scigraph.springernature.com/pub.10.1038/onc.2015.52
DOIhttp://dx.doi.org/10.1038/onc.2015.52
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25798835
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"https://app.dimensions.ai/details/publication/pub.1052774966"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T22:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000426.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/onc/journal/v34/n50/full/onc201552a.html"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.52'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.52'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.52'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.52'
This table displays all metadata directly associated to this object as RDF triples.
340 TRIPLES
21 PREDICATES
90 URIs
36 LITERALS
24 BLANK NODES