CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11

AUTHORS

David J. Barakat, Jing Zhang, Theresa Barberi, Samuel R. Denmeade, Alan D. Friedman, Ido Paz-Priel

ABSTRACT

The processes associated with transition to castration-resistant prostate cancer (PC) growth are not well understood. Cellular senescence is a stable cell cycle arrest that occurs in response to sublethal stress. It is often overcome in malignant transformation to confer a survival advantage. CCAAT/Enhancer Binding Protein (C/EBP) β function is frequently deregulated in human malignancies and interestingly, androgen-sensitive PC cells express primarily the liver-enriched inhibitory protein isoform. We found that C/EBPβ expression is negatively regulated by androgen receptor (AR) activity and that treatment of androgen-sensitive cell lines with anti-androgens increases C/EBPβ mRNA and protein levels. Accordingly, we also find that C/EBPβ levels are significantly elevated in primary PC samples from castration-resistant compared with therapy-naive patients. Chromatin immunoprecipitation demonstrated enhanced binding of the AR to the proximal promoter of the CEBPB gene in the presence of dihydroxytestosterone. Upon androgen deprivation, induction of C/EBPβ is facilitated by active transcription as evident by increased histone 3 acetylation at the C/EBPβ promoter. Also, the androgen agonist R1881 suppresses the activity of a CEBPB promoter reporter. Loss of C/EBPβ expression prevents growth arrest following androgen deprivation or anti-androgen challenge. Accordingly, suppression of C/EBPβ under low androgen conditions results in reduced expression of senescence-associated secretory genes, significantly decreased number of cells displaying heterochromatin foci and increased numbers of Ki67-positive cells. Ectopic expression of C/EBPβ caused pronounced morphological changes, reduced PC cell growth and increased the number of senescent LNCaP cells. Lastly, we found that senescence contributes to PC cell survival under androgen deprivation, and C/EBPβ-deficient cells were significantly more susceptible to killing by cytotoxic chemotherapy following androgen deprivation. Our data demonstrate that upregulation of C/EBPβ is critical for complete maintenance of androgen deprivation-induced senescence and that targeting C/EBPβ expression may synergize with anti-androgen or chemotherapy in eradicating PC. More... »

PAGES

5912-5922

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2015.41

DOI

http://dx.doi.org/10.1038/onc.2015.41

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016805248

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25772238


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Androgens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CCAAT-Enhancer-Binding Protein-beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Senescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin Immunoprecipitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Antibody Technique", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Divisions of Pediatric and Medical, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barakat", 
        "givenName": "David J.", 
        "id": "sg:person.0612445063.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612445063.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Divisions of Pediatric and Medical, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jing", 
        "id": "sg:person.01320513627.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320513627.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Divisions of Pediatric and Medical, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barberi", 
        "givenName": "Theresa", 
        "id": "sg:person.01366627027.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366627027.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Division of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Denmeade", 
        "givenName": "Samuel R.", 
        "id": "sg:person.013511506637.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013511506637.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Divisions of Pediatric and Medical, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Friedman", 
        "givenName": "Alan D.", 
        "id": "sg:person.016707721442.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016707721442.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Divisions of Pediatric and Medical, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paz-Priel", 
        "givenName": "Ido", 
        "id": "sg:person.01246370566.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246370566.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood-2010-07-294470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000006048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/23.8.1289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000833918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000836922", 
          "https://doi.org/10.1038/modpathol.3800655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000836922", 
          "https://doi.org/10.1038/modpathol.3800655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001076679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001291998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.07112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001776780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0905299106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002073682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002334898", 
          "https://doi.org/10.1038/nature11125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003535198", 
          "https://doi.org/10.1038/nrc2772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003535198", 
          "https://doi.org/10.1038/nrc2772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.15.9.4971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004225385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1054-3589(08)60278-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007390309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-07-0032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009596976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01674-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010822133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.23.1424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011838320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2012.183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013760968", 
          "https://doi.org/10.1038/cddis.2012.183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013815034", 
          "https://doi.org/10.1038/sj.bjc.6604087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.11182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014346995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0068003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015999613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017321743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkr218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018432175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00401-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018706213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgn109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020203555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgi021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020214783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.22.4517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020612123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021191816", 
          "https://doi.org/10.1038/nature11537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023529143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024732272", 
          "https://doi.org/10.1038/onc.2009.373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024732272", 
          "https://doi.org/10.1038/onc.2009.373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.03.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026622054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028886926", 
          "https://doi.org/10.1038/sj.bjc.6690390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028886926", 
          "https://doi.org/10.1038/sj.bjc.6690390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.03.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029924676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030487484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030487484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031451081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra021562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033498441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.22571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034166665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-05-0111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035876657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0507261103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036037001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039759043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0003645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039820881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042227432", 
          "https://doi.org/10.1038/nprot.2009.191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042546155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-4513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042870543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1008322108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044126439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047684246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047684246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00471-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048578883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pathol-121808-102144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048657351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(199604)28:4<251::aid-pros6>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051337521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.37.26591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051956294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.12.11.1749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064326779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.12.11.0191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.14.5.0461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2011.909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071512571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2011.991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071512653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.9.2712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074470261", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074488285", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074678190", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074708302", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03402190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074725880", 
          "https://doi.org/10.1007/bf03402190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074792819", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074797859", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1300895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078762528"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-11", 
    "datePublishedReg": "2015-11-01", 
    "description": "The processes associated with transition to castration-resistant prostate cancer (PC) growth are not well understood. Cellular senescence is a stable cell cycle arrest that occurs in response to sublethal stress. It is often overcome in malignant transformation to confer a survival advantage. CCAAT/Enhancer Binding Protein (C/EBP) \u03b2 function is frequently deregulated in human malignancies and interestingly, androgen-sensitive PC cells express primarily the liver-enriched inhibitory protein isoform. We found that C/EBP\u03b2 expression is negatively regulated by androgen receptor (AR) activity and that treatment of androgen-sensitive cell lines with anti-androgens increases C/EBP\u03b2 mRNA and protein levels. Accordingly, we also find that C/EBP\u03b2 levels are significantly elevated in primary PC samples from castration-resistant compared with therapy-naive patients. Chromatin immunoprecipitation demonstrated enhanced binding of the AR to the proximal promoter of the CEBPB gene in the presence of dihydroxytestosterone. Upon androgen deprivation, induction of C/EBP\u03b2 is facilitated by active transcription as evident by increased histone 3 acetylation at the C/EBP\u03b2 promoter. Also, the androgen agonist R1881 suppresses the activity of a CEBPB promoter reporter. Loss of C/EBP\u03b2 expression prevents growth arrest following androgen deprivation or anti-androgen challenge. Accordingly, suppression of C/EBP\u03b2 under low androgen conditions results in reduced expression of senescence-associated secretory genes, significantly decreased number of cells displaying heterochromatin foci and increased numbers of Ki67-positive cells. Ectopic expression of C/EBP\u03b2 caused pronounced morphological changes, reduced PC cell growth and increased the number of senescent LNCaP cells. Lastly, we found that senescence contributes to PC cell survival under androgen deprivation, and C/EBP\u03b2-deficient cells were significantly more susceptible to killing by cytotoxic chemotherapy following androgen deprivation. Our data demonstrate that upregulation of C/EBP\u03b2 is critical for complete maintenance of androgen deprivation-induced senescence and that targeting C/EBP\u03b2 expression may synergize with anti-androgen or chemotherapy in eradicating PC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2015.41", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438791", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682693", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7144689", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "48", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "CCAAT/Enhancer binding protein \u03b2 controls androgen-deprivation-induced senescence in prostate cancer cells", 
    "pagination": "5912-5922", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "50121c89bcc0ed87b28880d04d494cde1783e17371ca78187585b8557abfd39b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25772238"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2015.41"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016805248"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2015.41", 
      "https://app.dimensions.ai/details/publication/pub.1016805248"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/onc/journal/v34/n48/full/onc201541a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.41'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.41'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.41'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.41'


 

This table displays all metadata directly associated to this object as RDF triples.

378 TRIPLES      21 PREDICATES      110 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2015.41 schema:about N0050046ccf7943fd918082700331e94a
2 N02cae18cf75148fbbbcd96f8e22cd94e
3 N0ae6e02758954ab795cac46cee882603
4 N1862bd39628d48c6991424680ec18cab
5 N50d037dc6b2f4a38936c63443b8bd498
6 N577277ee472741b5ad756937ecdf03dd
7 N6be662ace35e4eb7833334ffdc1026c1
8 N6e984742c36546d7a8fee8a4a81d59b4
9 N7343937ec63046a4a2d76206b234d7d6
10 N83ac6cbcbb034ad7a7386d0d07f2d682
11 N89d91383368149e4a404dcb6422e28c0
12 N919182d973a04f1c862a7c889d459709
13 N92f9743296ab486eaa961c297e125d15
14 N9d79e3c5c5e14c6582a5748d9224fcc2
15 Naf14a65d276f4e2a87c60d4fd1933e3f
16 Nafa6a54c3e6543668bb74f82c91a4eb5
17 Nc303626a8eb24c81be6fffb86ca72a4b
18 Nd151014312fb4fa79db54603f5913521
19 Nde9c63db5c6749c8aeb851f02303ea95
20 Nfa62f2f5cfc8469a87670288385b5bfd
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author Ne18fe3728e7b4c19966e200c3197dec5
24 schema:citation sg:pub.10.1007/bf03402190
25 sg:pub.10.1038/cddis.2012.183
26 sg:pub.10.1038/modpathol.3800655
27 sg:pub.10.1038/nature11125
28 sg:pub.10.1038/nature11537
29 sg:pub.10.1038/nprot.2009.191
30 sg:pub.10.1038/nrc2772
31 sg:pub.10.1038/onc.2009.373
32 sg:pub.10.1038/sj.bjc.6604087
33 sg:pub.10.1038/sj.bjc.6690390
34 https://app.dimensions.ai/details/publication/pub.1074470261
35 https://app.dimensions.ai/details/publication/pub.1074488285
36 https://app.dimensions.ai/details/publication/pub.1074678190
37 https://app.dimensions.ai/details/publication/pub.1074708302
38 https://app.dimensions.ai/details/publication/pub.1074792819
39 https://app.dimensions.ai/details/publication/pub.1074797859
40 https://doi.org/10.1002/(sici)1097-0045(199604)28:4<251::aid-pros6>3.0.co;2-g
41 https://doi.org/10.1002/pros.20595
42 https://doi.org/10.1002/pros.20801
43 https://doi.org/10.1002/pros.20993
44 https://doi.org/10.1002/pros.22571
45 https://doi.org/10.1016/j.ccr.2011.09.001
46 https://doi.org/10.1016/j.ccr.2012.11.010
47 https://doi.org/10.1016/j.cell.2008.03.038
48 https://doi.org/10.1016/j.cell.2008.03.039
49 https://doi.org/10.1016/s0092-8674(03)00401-x
50 https://doi.org/10.1016/s1054-3589(08)60278-1
51 https://doi.org/10.1016/s1097-2765(02)00471-9
52 https://doi.org/10.1038/sj.emboj.7600789
53 https://doi.org/10.1056/nejmra021562
54 https://doi.org/10.1073/pnas.0507261103
55 https://doi.org/10.1073/pnas.0905299106
56 https://doi.org/10.1073/pnas.1008322108
57 https://doi.org/10.1074/jbc.274.37.26591
58 https://doi.org/10.1093/carcin/23.8.1289
59 https://doi.org/10.1093/carcin/bgi021
60 https://doi.org/10.1093/carcin/bgn109
61 https://doi.org/10.1093/nar/27.22.4517
62 https://doi.org/10.1093/nar/gkr218
63 https://doi.org/10.1093/nar/gkt921
64 https://doi.org/10.1128/mcb.01674-12
65 https://doi.org/10.1128/mcb.15.9.4971
66 https://doi.org/10.1146/annurev-pathol-121808-102144
67 https://doi.org/10.1158/0008-5472.can-05-1716
68 https://doi.org/10.1158/0008-5472.can-07-6538
69 https://doi.org/10.1158/0008-5472.can-10-4513
70 https://doi.org/10.1158/1541-7786.mcr-05-0111
71 https://doi.org/10.1158/1541-7786.mcr-07-0032
72 https://doi.org/10.1182/blood-2010-07-294470
73 https://doi.org/10.1210/me.12.11.1749
74 https://doi.org/10.1210/mend.12.11.0191
75 https://doi.org/10.1210/mend.14.5.0461
76 https://doi.org/10.1248/bpb.23.1424
77 https://doi.org/10.1371/journal.pone.0003645
78 https://doi.org/10.1371/journal.pone.0068003
79 https://doi.org/10.1593/neo.07112
80 https://doi.org/10.1593/neo.11182
81 https://doi.org/10.3892/ijo.2011.909
82 https://doi.org/10.3892/ijo.2011.991
83 https://doi.org/10.4049/jimmunol.1300895
84 https://doi.org/10.4161/cc.5.9.2712
85 schema:datePublished 2015-11
86 schema:datePublishedReg 2015-11-01
87 schema:description The processes associated with transition to castration-resistant prostate cancer (PC) growth are not well understood. Cellular senescence is a stable cell cycle arrest that occurs in response to sublethal stress. It is often overcome in malignant transformation to confer a survival advantage. CCAAT/Enhancer Binding Protein (C/EBP) β function is frequently deregulated in human malignancies and interestingly, androgen-sensitive PC cells express primarily the liver-enriched inhibitory protein isoform. We found that C/EBPβ expression is negatively regulated by androgen receptor (AR) activity and that treatment of androgen-sensitive cell lines with anti-androgens increases C/EBPβ mRNA and protein levels. Accordingly, we also find that C/EBPβ levels are significantly elevated in primary PC samples from castration-resistant compared with therapy-naive patients. Chromatin immunoprecipitation demonstrated enhanced binding of the AR to the proximal promoter of the CEBPB gene in the presence of dihydroxytestosterone. Upon androgen deprivation, induction of C/EBPβ is facilitated by active transcription as evident by increased histone 3 acetylation at the C/EBPβ promoter. Also, the androgen agonist R1881 suppresses the activity of a CEBPB promoter reporter. Loss of C/EBPβ expression prevents growth arrest following androgen deprivation or anti-androgen challenge. Accordingly, suppression of C/EBPβ under low androgen conditions results in reduced expression of senescence-associated secretory genes, significantly decreased number of cells displaying heterochromatin foci and increased numbers of Ki67-positive cells. Ectopic expression of C/EBPβ caused pronounced morphological changes, reduced PC cell growth and increased the number of senescent LNCaP cells. Lastly, we found that senescence contributes to PC cell survival under androgen deprivation, and C/EBPβ-deficient cells were significantly more susceptible to killing by cytotoxic chemotherapy following androgen deprivation. Our data demonstrate that upregulation of C/EBPβ is critical for complete maintenance of androgen deprivation-induced senescence and that targeting C/EBPβ expression may synergize with anti-androgen or chemotherapy in eradicating PC.
88 schema:genre research_article
89 schema:inLanguage en
90 schema:isAccessibleForFree true
91 schema:isPartOf Nd64a7bdc884b4700accccb6f5c398de9
92 Nfec9a4b2568345a1bcbcd2245324add7
93 sg:journal.1097543
94 schema:name CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells
95 schema:pagination 5912-5922
96 schema:productId N2737c5e8a3da4963846059c9006e3052
97 Na7a6c32796894245a65c0b9211024e05
98 Nad38883a91f9429dac0a468f06805807
99 Nd7269d6f58db4a338e5cf9466852f391
100 Nddc566fbb93f40bb93a8e2c9a29d4d34
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016805248
102 https://doi.org/10.1038/onc.2015.41
103 schema:sdDatePublished 2019-04-10T22:19
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N25133f82b71a4ef485f767a1182fcb72
106 schema:url http://www.nature.com/onc/journal/v34/n48/full/onc201541a.html
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N0050046ccf7943fd918082700331e94a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Fluorescent Antibody Technique
112 rdf:type schema:DefinedTerm
113 N02cae18cf75148fbbbcd96f8e22cd94e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Tumor Cells, Cultured
115 rdf:type schema:DefinedTerm
116 N0992acab5e7742fcb721b089f444ecbb rdf:first sg:person.01366627027.00
117 rdf:rest N6172998705034e5e88e4048c789da345
118 N0ae6e02758954ab795cac46cee882603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Gene Expression Regulation, Neoplastic
120 rdf:type schema:DefinedTerm
121 N1862bd39628d48c6991424680ec18cab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 N25133f82b71a4ef485f767a1182fcb72 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N2737c5e8a3da4963846059c9006e3052 schema:name pubmed_id
127 schema:value 25772238
128 rdf:type schema:PropertyValue
129 N50d037dc6b2f4a38936c63443b8bd498 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name RNA, Messenger
131 rdf:type schema:DefinedTerm
132 N577277ee472741b5ad756937ecdf03dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Reverse Transcriptase Polymerase Chain Reaction
134 rdf:type schema:DefinedTerm
135 N6172998705034e5e88e4048c789da345 rdf:first sg:person.013511506637.06
136 rdf:rest Na4617514533e45faa95a1ab89a97eab9
137 N62d778f1d2d54ebdbfa7d3a9f757423d rdf:first sg:person.01320513627.41
138 rdf:rest N0992acab5e7742fcb721b089f444ecbb
139 N6be662ace35e4eb7833334ffdc1026c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name CCAAT-Enhancer-Binding Protein-beta
141 rdf:type schema:DefinedTerm
142 N6e984742c36546d7a8fee8a4a81d59b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Chromatin Immunoprecipitation
144 rdf:type schema:DefinedTerm
145 N7343937ec63046a4a2d76206b234d7d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Transcription, Genetic
147 rdf:type schema:DefinedTerm
148 N83ac6cbcbb034ad7a7386d0d07f2d682 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Real-Time Polymerase Chain Reaction
150 rdf:type schema:DefinedTerm
151 N89d91383368149e4a404dcb6422e28c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Cell Proliferation
153 rdf:type schema:DefinedTerm
154 N919182d973a04f1c862a7c889d459709 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Promoter Regions, Genetic
156 rdf:type schema:DefinedTerm
157 N92f9743296ab486eaa961c297e125d15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Male
159 rdf:type schema:DefinedTerm
160 N9d79e3c5c5e14c6582a5748d9224fcc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Flow Cytometry
162 rdf:type schema:DefinedTerm
163 Na4617514533e45faa95a1ab89a97eab9 rdf:first sg:person.016707721442.58
164 rdf:rest Nefa7339d5d58482eb2ffae747ea612f1
165 Na7a6c32796894245a65c0b9211024e05 schema:name nlm_unique_id
166 schema:value 8711562
167 rdf:type schema:PropertyValue
168 Nad38883a91f9429dac0a468f06805807 schema:name dimensions_id
169 schema:value pub.1016805248
170 rdf:type schema:PropertyValue
171 Naf14a65d276f4e2a87c60d4fd1933e3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Androgens
173 rdf:type schema:DefinedTerm
174 Nafa6a54c3e6543668bb74f82c91a4eb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Apoptosis
176 rdf:type schema:DefinedTerm
177 Nc303626a8eb24c81be6fffb86ca72a4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Cellular Senescence
179 rdf:type schema:DefinedTerm
180 Nd151014312fb4fa79db54603f5913521 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Immunoenzyme Techniques
182 rdf:type schema:DefinedTerm
183 Nd64a7bdc884b4700accccb6f5c398de9 schema:issueNumber 48
184 rdf:type schema:PublicationIssue
185 Nd7269d6f58db4a338e5cf9466852f391 schema:name doi
186 schema:value 10.1038/onc.2015.41
187 rdf:type schema:PropertyValue
188 Nddc566fbb93f40bb93a8e2c9a29d4d34 schema:name readcube_id
189 schema:value 50121c89bcc0ed87b28880d04d494cde1783e17371ca78187585b8557abfd39b
190 rdf:type schema:PropertyValue
191 Nde9c63db5c6749c8aeb851f02303ea95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Blotting, Western
193 rdf:type schema:DefinedTerm
194 Ne18fe3728e7b4c19966e200c3197dec5 rdf:first sg:person.0612445063.94
195 rdf:rest N62d778f1d2d54ebdbfa7d3a9f757423d
196 Nefa7339d5d58482eb2ffae747ea612f1 rdf:first sg:person.01246370566.75
197 rdf:rest rdf:nil
198 Nfa62f2f5cfc8469a87670288385b5bfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Prostatic Neoplasms
200 rdf:type schema:DefinedTerm
201 Nfec9a4b2568345a1bcbcd2245324add7 schema:volumeNumber 34
202 rdf:type schema:PublicationVolume
203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
204 schema:name Medical and Health Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
207 schema:name Oncology and Carcinogenesis
208 rdf:type schema:DefinedTerm
209 sg:grant.2438791 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.41
210 rdf:type schema:MonetaryGrant
211 sg:grant.2682693 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.41
212 rdf:type schema:MonetaryGrant
213 sg:grant.7144689 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.41
214 rdf:type schema:MonetaryGrant
215 sg:journal.1097543 schema:issn 0950-9232
216 1476-5594
217 schema:name Oncogene
218 rdf:type schema:Periodical
219 sg:person.01246370566.75 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
220 schema:familyName Paz-Priel
221 schema:givenName Ido
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246370566.75
223 rdf:type schema:Person
224 sg:person.01320513627.41 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
225 schema:familyName Zhang
226 schema:givenName Jing
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320513627.41
228 rdf:type schema:Person
229 sg:person.013511506637.06 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
230 schema:familyName Denmeade
231 schema:givenName Samuel R.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013511506637.06
233 rdf:type schema:Person
234 sg:person.01366627027.00 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
235 schema:familyName Barberi
236 schema:givenName Theresa
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366627027.00
238 rdf:type schema:Person
239 sg:person.016707721442.58 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
240 schema:familyName Friedman
241 schema:givenName Alan D.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016707721442.58
243 rdf:type schema:Person
244 sg:person.0612445063.94 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
245 schema:familyName Barakat
246 schema:givenName David J.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612445063.94
248 rdf:type schema:Person
249 sg:pub.10.1007/bf03402190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074725880
250 https://doi.org/10.1007/bf03402190
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/cddis.2012.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013760968
253 https://doi.org/10.1038/cddis.2012.183
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/modpathol.3800655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000836922
256 https://doi.org/10.1038/modpathol.3800655
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nature11125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002334898
259 https://doi.org/10.1038/nature11125
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nature11537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021191816
262 https://doi.org/10.1038/nature11537
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/nprot.2009.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042227432
265 https://doi.org/10.1038/nprot.2009.191
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/nrc2772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003535198
268 https://doi.org/10.1038/nrc2772
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/onc.2009.373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024732272
271 https://doi.org/10.1038/onc.2009.373
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/sj.bjc.6604087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013815034
274 https://doi.org/10.1038/sj.bjc.6604087
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/sj.bjc.6690390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028886926
277 https://doi.org/10.1038/sj.bjc.6690390
278 rdf:type schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1074470261 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1074488285 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1074678190 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1074708302 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1074792819 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1074797859 schema:CreativeWork
285 https://doi.org/10.1002/(sici)1097-0045(199604)28:4<251::aid-pros6>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1051337521
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1002/pros.20595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042546155
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1002/pros.20801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039759043
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1002/pros.20993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047684246
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1002/pros.22571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034166665
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.ccr.2011.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023529143
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.ccr.2012.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001291998
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.cell.2008.03.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026622054
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.cell.2008.03.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029924676
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s0092-8674(03)00401-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018706213
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/s1054-3589(08)60278-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007390309
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s1097-2765(02)00471-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048578883
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1038/sj.emboj.7600789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030487484
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1056/nejmra021562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033498441
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1073/pnas.0507261103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036037001
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1073/pnas.0905299106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002073682
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1073/pnas.1008322108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044126439
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1074/jbc.274.37.26591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051956294
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/carcin/23.8.1289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000833918
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/carcin/bgi021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020214783
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/carcin/bgn109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020203555
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/nar/27.22.4517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020612123
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/nar/gkr218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018432175
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1093/nar/gkt921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017321743
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1128/mcb.01674-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010822133
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1128/mcb.15.9.4971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004225385
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1146/annurev-pathol-121808-102144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048657351
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1158/0008-5472.can-05-1716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001076679
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1158/0008-5472.can-07-6538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031451081
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1158/0008-5472.can-10-4513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042870543
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1158/1541-7786.mcr-05-0111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035876657
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1158/1541-7786.mcr-07-0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009596976
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1182/blood-2010-07-294470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000006048
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1210/me.12.11.1749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064326779
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1210/mend.12.11.0191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331567
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1210/mend.14.5.0461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331989
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1248/bpb.23.1424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011838320
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.pone.0003645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039820881
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1371/journal.pone.0068003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015999613
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1593/neo.07112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001776780
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1593/neo.11182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014346995
366 rdf:type schema:CreativeWork
367 https://doi.org/10.3892/ijo.2011.909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071512571
368 rdf:type schema:CreativeWork
369 https://doi.org/10.3892/ijo.2011.991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071512653
370 rdf:type schema:CreativeWork
371 https://doi.org/10.4049/jimmunol.1300895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078762528
372 rdf:type schema:CreativeWork
373 https://doi.org/10.4161/cc.5.9.2712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298897
374 rdf:type schema:CreativeWork
375 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
376 schema:name Division of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
377 Divisions of Pediatric and Medical, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
378 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...