N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06

AUTHORS

Yanrong Su, Jifen Li, Chanjuan Shi, Ralph H. Hruban, Glenn L. Radice

ABSTRACT

Cadherin subtype switching from E-cadherin to N-cadherin is associated with the epithelial-to-mesenchymal transition (EMT), a process required for invasion and dissemination of carcinoma cells. We found that N-cadherin is expressed in human and mouse pancreatic intraepithelial neoplasia (PanIN), suggesting that N-cadherin may also have a role in early-stage pancreatic cancer. To investigate the role of N-cadherin in mouse PanIN (mPanIN), we simultaneously activated oncogenic K-ras(G12D) and deleted the N-cadherin (Cdh2) gene in the murine pancreas. Genetic ablation of N-cadherin (N-cad KO) caused hyperproliferation, accelerated mPanIN progression, and early tumor development in K-ras(G12D) mice. Decreased E-cadherin and redistribution of β-catenin accompanied the loss of N-cadherin in pancreatic ductal epithelial cells (PDEC). Nuclear accumulation of β-catenin and its transcription co-activator Tcf4 led to activation of Wnt/β-catenin target genes. Unexpectedly, loss of N-cadherin in the K-ras(G12D) model resulted in increased mPanIN progression and tumor incidence. These in vivo results demonstrate for the first time that N-cadherin functions as a growth suppressor in the context of oncogenic K-ras. More... »

PAGES

3335-3341

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2015.382

DOI

http://dx.doi.org/10.1038/onc.2015.382

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046259400

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26477318


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cadherins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial-Mesenchymal Transition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoblotting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreas", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precancerous Conditions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Signaling Pathway", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Thomas Jefferson University", 
          "id": "https://www.grid.ac/institutes/grid.265008.9", 
          "name": [
            "Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "Yanrong", 
        "id": "sg:person.0722303404.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722303404.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thomas Jefferson University", 
          "id": "https://www.grid.ac/institutes/grid.265008.9", 
          "name": [
            "Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Jifen", 
        "id": "sg:person.01163455150.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163455150.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN", 
            "Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Chanjuan", 
        "id": "sg:person.011122731257.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122731257.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hruban", 
        "givenName": "Ralph H.", 
        "id": "sg:person.07624111077.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624111077.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thomas Jefferson University", 
          "id": "https://www.grid.ac/institutes/grid.265008.9", 
          "name": [
            "Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Radice", 
        "givenName": "Glenn L.", 
        "id": "sg:person.01017472512.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017472512.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000103677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000850931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000850931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000850931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000850931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-2926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004744337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01055-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004885594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1164368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006710792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007477250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1404198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007769668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.140103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009874613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.20628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010303607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.20628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010303607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00309-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012489329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m401705200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014481904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016802144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200202034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018312114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.000455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018416698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.20241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018447035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-0578-03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019061703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.153.5.1049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021347417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-4384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022159132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022310913", 
          "https://doi.org/10.1038/nature09460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022310913", 
          "https://doi.org/10.1038/nature09460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024977054", 
          "https://doi.org/10.1038/onc.2011.574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.304472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025792025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.304472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025792025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.11.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026458823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027349615", 
          "https://doi.org/10.1038/nrc3647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2012.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027566958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032520134", 
          "https://doi.org/10.1038/sj.onc.1202396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032520134", 
          "https://doi.org/10.1038/sj.onc.1202396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1103345108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032717943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034221044", 
          "https://doi.org/10.1038/onc.2013.310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034221044", 
          "https://doi.org/10.1038/onc.2013.310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036835130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2004.03.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041875451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042185129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042185129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-2322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042474145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000156274.72390.2c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046054191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000156274.72390.2c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046054191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047544532"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-06", 
    "datePublishedReg": "2016-06-01", 
    "description": "Cadherin subtype switching from E-cadherin to N-cadherin is associated with the epithelial-to-mesenchymal transition (EMT), a process required for invasion and dissemination of carcinoma cells. We found that N-cadherin is expressed in human and mouse pancreatic intraepithelial neoplasia (PanIN), suggesting that N-cadherin may also have a role in early-stage pancreatic cancer. To investigate the role of N-cadherin in mouse PanIN (mPanIN), we simultaneously activated oncogenic K-ras(G12D) and deleted the N-cadherin (Cdh2) gene in the murine pancreas. Genetic ablation of N-cadherin (N-cad KO) caused hyperproliferation, accelerated mPanIN progression, and early tumor development in K-ras(G12D) mice. Decreased E-cadherin and redistribution of \u03b2-catenin accompanied the loss of N-cadherin in pancreatic ductal epithelial cells (PDEC). Nuclear accumulation of \u03b2-catenin and its transcription co-activator Tcf4 led to activation of Wnt/\u03b2-catenin target genes. Unexpectedly, loss of N-cadherin in the K-ras(G12D) model resulted in increased mPanIN progression and tumor incidence. These in vivo results demonstrate for the first time that N-cadherin functions as a growth suppressor in the context of oncogenic K-ras.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2015.382", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440141", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438860", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2606247", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "25", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "name": "N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN", 
    "pagination": "3335-3341", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dc5b85a25057b4f5c5e086181950d243735f93d8d3edbd99f6a1f9b59d1572be"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26477318"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2015.382"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046259400"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2015.382", 
      "https://app.dimensions.ai/details/publication/pub.1046259400"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/onc/journal/v35/n25/full/onc2015382a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.382'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.382'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.382'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.382'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      21 PREDICATES      80 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2015.382 schema:about N044d23776cb14b28857df3c0b71344fb
2 N0b4cae96b4d5451cbd20d02c2eea6cc9
3 N16d6769f23a44374bfba9d4d18762eee
4 N184348d712f54f27b6eec178dd9e2b09
5 N217f10c4cb06415686c0d012878a172f
6 N2a04fde42e534703badcf7c7ce451b5f
7 N3237fed5601f41a59516ff2f088fa57f
8 N392783028a3d4a879fb69941191bbf91
9 N5742b6878fc44969a882d652fe39546b
10 N7200665a11634efab424532acbbc56b0
11 N79e69b5341544402899b05c26ffce0f0
12 N7de8295b40d54c9eaec7d1b3254eba95
13 Nabd9dfccd89b49b993f16b328e327a35
14 Nb39cf035d0d143fc9006e7d3c2aa3588
15 Nb9c187f68e794eb998cdbb4590d44666
16 Nc940475d0e3a44b6848d21385965b22c
17 Nd726fd5169ba4e81b30278791a86d1ec
18 Nffd732c5826f42ac98e272b4405a8e60
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Nb6f7f9f014594f728243b63d871a9731
22 schema:citation sg:pub.10.1038/nature09460
23 sg:pub.10.1038/nrc3647
24 sg:pub.10.1038/onc.2011.574
25 sg:pub.10.1038/onc.2013.310
26 sg:pub.10.1038/sj.onc.1202396
27 https://doi.org/10.1002/dvdy.20241
28 https://doi.org/10.1002/dvg.20628
29 https://doi.org/10.1016/j.ccr.2005.04.023
30 https://doi.org/10.1016/j.ceb.2012.06.009
31 https://doi.org/10.1016/j.cell.2012.11.026
32 https://doi.org/10.1016/j.celrep.2015.02.023
33 https://doi.org/10.1016/s1535-6108(03)00309-x
34 https://doi.org/10.1053/j.gastro.2004.03.058
35 https://doi.org/10.1056/nejmra1404198
36 https://doi.org/10.1073/pnas.1103345108
37 https://doi.org/10.1074/jbc.m401705200
38 https://doi.org/10.1083/jcb.153.5.1049
39 https://doi.org/10.1083/jcb.200202034
40 https://doi.org/10.1126/science.1164368
41 https://doi.org/10.1128/mcb.01055-05
42 https://doi.org/10.1158/0008-5472.can-04-0807
43 https://doi.org/10.1158/0008-5472.can-05-2168
44 https://doi.org/10.1158/0008-5472.can-06-2322
45 https://doi.org/10.1158/0008-5472.can-12-4384
46 https://doi.org/10.1158/1078-0432.ccr-03-0087
47 https://doi.org/10.1158/1078-0432.ccr-0578-03
48 https://doi.org/10.1158/1078-0432.ccr-06-2926
49 https://doi.org/10.1161/01.res.0000156274.72390.2c
50 https://doi.org/10.1161/circresaha.116.304472
51 https://doi.org/10.1242/jcs.000455
52 https://doi.org/10.1242/jcs.01634
53 https://doi.org/10.1242/jcs.140103
54 https://doi.org/10.1371/journal.pone.0001155
55 schema:datePublished 2016-06
56 schema:datePublishedReg 2016-06-01
57 schema:description Cadherin subtype switching from E-cadherin to N-cadherin is associated with the epithelial-to-mesenchymal transition (EMT), a process required for invasion and dissemination of carcinoma cells. We found that N-cadherin is expressed in human and mouse pancreatic intraepithelial neoplasia (PanIN), suggesting that N-cadherin may also have a role in early-stage pancreatic cancer. To investigate the role of N-cadherin in mouse PanIN (mPanIN), we simultaneously activated oncogenic K-ras(G12D) and deleted the N-cadherin (Cdh2) gene in the murine pancreas. Genetic ablation of N-cadherin (N-cad KO) caused hyperproliferation, accelerated mPanIN progression, and early tumor development in K-ras(G12D) mice. Decreased E-cadherin and redistribution of β-catenin accompanied the loss of N-cadherin in pancreatic ductal epithelial cells (PDEC). Nuclear accumulation of β-catenin and its transcription co-activator Tcf4 led to activation of Wnt/β-catenin target genes. Unexpectedly, loss of N-cadherin in the K-ras(G12D) model resulted in increased mPanIN progression and tumor incidence. These in vivo results demonstrate for the first time that N-cadherin functions as a growth suppressor in the context of oncogenic K-ras.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N03d05eda27de4edb80c32b7edb2977b3
62 Nba7d2182c08e41cc8b3250a8f5856e84
63 sg:journal.1097543
64 schema:name N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN
65 schema:pagination 3335-3341
66 schema:productId N0b9d3e785ff74a0bb87351facd7d73dc
67 N0e366c82a0514586b9fe577d3c26a571
68 N49b46b34bf624f69a4ddae87e8748124
69 N6f1fa86b0f1f4683823494b79ac1534a
70 N9ed002cbb1b5476f856cee7a27d7f5da
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046259400
72 https://doi.org/10.1038/onc.2015.382
73 schema:sdDatePublished 2019-04-10T22:39
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nb3ace34f23f84004bbf093f3e8e08fea
76 schema:url http://www.nature.com/onc/journal/v35/n25/full/onc2015382a.html
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N03d05eda27de4edb80c32b7edb2977b3 schema:volumeNumber 35
81 rdf:type schema:PublicationVolume
82 N044d23776cb14b28857df3c0b71344fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Pancreatic Neoplasms
84 rdf:type schema:DefinedTerm
85 N0b4cae96b4d5451cbd20d02c2eea6cc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Precancerous Conditions
87 rdf:type schema:DefinedTerm
88 N0b9d3e785ff74a0bb87351facd7d73dc schema:name readcube_id
89 schema:value dc5b85a25057b4f5c5e086181950d243735f93d8d3edbd99f6a1f9b59d1572be
90 rdf:type schema:PropertyValue
91 N0e366c82a0514586b9fe577d3c26a571 schema:name nlm_unique_id
92 schema:value 8711562
93 rdf:type schema:PropertyValue
94 N16d6769f23a44374bfba9d4d18762eee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Immunoblotting
96 rdf:type schema:DefinedTerm
97 N184348d712f54f27b6eec178dd9e2b09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Epithelial-Mesenchymal Transition
99 rdf:type schema:DefinedTerm
100 N1a61843a7ddd4f58967406ffbc001ce7 rdf:first sg:person.01163455150.64
101 rdf:rest N7716f55f57544df386741a40f671323f
102 N217f10c4cb06415686c0d012878a172f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Immunohistochemistry
104 rdf:type schema:DefinedTerm
105 N2a04fde42e534703badcf7c7ce451b5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Cell Proliferation
107 rdf:type schema:DefinedTerm
108 N3237fed5601f41a59516ff2f088fa57f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name beta Catenin
110 rdf:type schema:DefinedTerm
111 N392783028a3d4a879fb69941191bbf91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cell Line
113 rdf:type schema:DefinedTerm
114 N49b46b34bf624f69a4ddae87e8748124 schema:name doi
115 schema:value 10.1038/onc.2015.382
116 rdf:type schema:PropertyValue
117 N5742b6878fc44969a882d652fe39546b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Mice, Knockout
119 rdf:type schema:DefinedTerm
120 N6f1fa86b0f1f4683823494b79ac1534a schema:name dimensions_id
121 schema:value pub.1046259400
122 rdf:type schema:PropertyValue
123 N7200665a11634efab424532acbbc56b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Pancreas
125 rdf:type schema:DefinedTerm
126 N7716f55f57544df386741a40f671323f rdf:first sg:person.011122731257.67
127 rdf:rest N858feab3de0247afba0d68b6d7a0c8a9
128 N79e69b5341544402899b05c26ffce0f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Disease Models, Animal
130 rdf:type schema:DefinedTerm
131 N7de8295b40d54c9eaec7d1b3254eba95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Wnt Signaling Pathway
133 rdf:type schema:DefinedTerm
134 N858feab3de0247afba0d68b6d7a0c8a9 rdf:first sg:person.07624111077.08
135 rdf:rest Nf3c3b268384741dfaafa46408d2d8b24
136 N9ed002cbb1b5476f856cee7a27d7f5da schema:name pubmed_id
137 schema:value 26477318
138 rdf:type schema:PropertyValue
139 Nabd9dfccd89b49b993f16b328e327a35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Mice, Transgenic
141 rdf:type schema:DefinedTerm
142 Nb39cf035d0d143fc9006e7d3c2aa3588 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Animals
144 rdf:type schema:DefinedTerm
145 Nb3ace34f23f84004bbf093f3e8e08fea schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Nb6f7f9f014594f728243b63d871a9731 rdf:first sg:person.0722303404.66
148 rdf:rest N1a61843a7ddd4f58967406ffbc001ce7
149 Nb9c187f68e794eb998cdbb4590d44666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cadherins
151 rdf:type schema:DefinedTerm
152 Nba7d2182c08e41cc8b3250a8f5856e84 schema:issueNumber 25
153 rdf:type schema:PublicationIssue
154 Nc940475d0e3a44b6848d21385965b22c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Proto-Oncogene Proteins p21(ras)
156 rdf:type schema:DefinedTerm
157 Nd726fd5169ba4e81b30278791a86d1ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Nf3c3b268384741dfaafa46408d2d8b24 rdf:first sg:person.01017472512.08
161 rdf:rest rdf:nil
162 Nffd732c5826f42ac98e272b4405a8e60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Disease Progression
164 rdf:type schema:DefinedTerm
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
169 schema:name Oncology and Carcinogenesis
170 rdf:type schema:DefinedTerm
171 sg:grant.2438860 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.382
172 rdf:type schema:MonetaryGrant
173 sg:grant.2440141 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.382
174 rdf:type schema:MonetaryGrant
175 sg:grant.2606247 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.382
176 rdf:type schema:MonetaryGrant
177 sg:journal.1097543 schema:issn 0950-9232
178 1476-5594
179 schema:name Oncogene
180 rdf:type schema:Periodical
181 sg:person.01017472512.08 schema:affiliation https://www.grid.ac/institutes/grid.265008.9
182 schema:familyName Radice
183 schema:givenName Glenn L.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017472512.08
185 rdf:type schema:Person
186 sg:person.011122731257.67 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
187 schema:familyName Shi
188 schema:givenName Chanjuan
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122731257.67
190 rdf:type schema:Person
191 sg:person.01163455150.64 schema:affiliation https://www.grid.ac/institutes/grid.265008.9
192 schema:familyName Li
193 schema:givenName Jifen
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163455150.64
195 rdf:type schema:Person
196 sg:person.0722303404.66 schema:affiliation https://www.grid.ac/institutes/grid.265008.9
197 schema:familyName Su
198 schema:givenName Yanrong
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722303404.66
200 rdf:type schema:Person
201 sg:person.07624111077.08 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
202 schema:familyName Hruban
203 schema:givenName Ralph H.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624111077.08
205 rdf:type schema:Person
206 sg:pub.10.1038/nature09460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022310913
207 https://doi.org/10.1038/nature09460
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/nrc3647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027349615
210 https://doi.org/10.1038/nrc3647
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/onc.2011.574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024977054
213 https://doi.org/10.1038/onc.2011.574
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/onc.2013.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034221044
216 https://doi.org/10.1038/onc.2013.310
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/sj.onc.1202396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032520134
219 https://doi.org/10.1038/sj.onc.1202396
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/dvdy.20241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018447035
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/dvg.20628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010303607
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.ccr.2005.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042185129
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.ceb.2012.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027566958
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.cell.2012.11.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026458823
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.celrep.2015.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000850931
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s1535-6108(03)00309-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012489329
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1053/j.gastro.2004.03.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041875451
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1056/nejmra1404198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007769668
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.1103345108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032717943
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.m401705200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014481904
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1083/jcb.153.5.1049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021347417
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1083/jcb.200202034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018312114
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1126/science.1164368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006710792
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1128/mcb.01055-05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004885594
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1158/0008-5472.can-04-0807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016802144
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1158/0008-5472.can-05-2168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000103677
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1158/0008-5472.can-06-2322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042474145
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1158/0008-5472.can-12-4384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022159132
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1158/1078-0432.ccr-03-0087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036835130
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1158/1078-0432.ccr-0578-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061703
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1158/1078-0432.ccr-06-2926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004744337
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1161/01.res.0000156274.72390.2c schema:sameAs https://app.dimensions.ai/details/publication/pub.1046054191
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1161/circresaha.116.304472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025792025
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1242/jcs.000455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018416698
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1242/jcs.01634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047544532
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1242/jcs.140103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009874613
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1371/journal.pone.0001155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007477250
276 rdf:type schema:CreativeWork
277 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
278 schema:name Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN
279 Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.265008.9 schema:alternateName Thomas Jefferson University
282 schema:name Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA
283 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...