YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04

AUTHORS

Guohua Hua, Xiangmin Lv, Chunbo He, Steven W. Remmenga, Kerry J. Rodabough, Jixin Dong, Liguo Yang, Subodh M. Lele, Peixin Yang, Jin Zhou, Alison Karst, Ronny I. Drapkin, John S. Davis, Cheng Wang

ABSTRACT

Accumulating evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from fallopian tube secretory epithelial cells (FTSECs). However, the molecular mechanisms underlying the initiation and progression of HGSC derived from FTSECs remains unclear. In this study, we found that the Hippo/Yes-associated protein (YAP) signaling pathway has a critical role in the initiation and progression of fallopian tube and ovarian HGSC. Importantly, YAP was overexpressed in inflammatory and cancerous fallopian tube tissues. Further, overexpression of wild-type YAP, or constitutively active YAP in immortalized FTSECs, induced cell proliferation, migration, colony formation and tumorigenesis. Moreover, the Hippo/YAP and the fibroblast growth factor (FGF) signaling pathways formed an autocrine/paracrine-positive feedback loop to drive the progression of the FTSEC-derived HGSC. Evidence in this study strongly suggests that combined therapy with inhibitors of YAP (such as verteporfin) and FGF receptors (such as BGJ398) can provide a novel therapeutic strategy to treat fallopian tube and ovarian HGSC. More... »

PAGES

2247-2265

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2015.288

    DOI

    http://dx.doi.org/10.1038/onc.2015.288

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013308148

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26364602


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