Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-01

AUTHORS

Brian T. Gaudette, Bhakti Dwivedi, Kasyapa S. Chitta, Stéphanie Poulain, Doris Powell, Paula Vertino, Xavier Leleu, Sagar Lonial, Asher A. Chanan-Khan, Jeanne Kowalski, Lawrence H. Boise

ABSTRACT

Waldenström macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The disease carries a high prevalence of activating mutations in MyD88 (91%) and CXCR4 (28%). Because signaling through these pathways leads to Bcl-xL induction, we examined Bcl-2 family expression in WM patients and cell lines. Unlike other B-lymphocyte-derived malignancies, which become dependent on expression of anti-apoptotic proteins to counter expression of pro-apoptotic proteins, WM samples expressed both pro- and anti-apoptotic Bcl-2 proteins at low levels similar to their normal B-cell and plasma cell counterparts. Three WM cell lines expressed pro-apoptotic Bcl-2 family members Bim or Bax and Bak at low levels, which determined their sensitivity to inducers of intrinsic apoptosis. In two cell lines, miR-155 upregulation, which is common in WM, was responsible for the inhibition of FOXO3a and Bim expression. Both antagonizing miR-155 to induce Bim and proteasome inhibition increased the sensitivity to ABT-737 in these lines indicating a lowering of the apoptotic threshold. In this manner, treatments that increase pro-apoptotic protein expression increase the efficacy of agents treated in combination in addition to direct killing. More... »

PAGES

479

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2015.103

DOI

http://dx.doi.org/10.1038/onc.2015.103

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028882119

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25893290


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bcl-2-Like Protein 11", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biphenyl Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bortezomib", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Forkhead Box Protein O3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Forkhead Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Myeloma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitrophenols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfonamides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Waldenstrom Macroglobulinemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-2 Homologous Antagonist-Killer Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-2-Associated X Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322", 
            "Winship Cancer Institute, Emory University, Atlanta, GA 30322", 
            "Graduate Program in Immunology and Molecular Pathogenesis, Emory University, Atlanta, GA 30322"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaudette", 
        "givenName": "Brian T.", 
        "id": "sg:person.01332464704.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332464704.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Winship Cancer Institute, Emory University, Atlanta, GA 30322"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dwivedi", 
        "givenName": "Bhakti", 
        "id": "sg:person.01072730031.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072730031.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.417467.7", 
          "name": [
            "Cancer Biology, Mayo Clinic, Jacksonville, FL"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chitta", 
        "givenName": "Kasyapa S.", 
        "id": "sg:person.01016453312.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016453312.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Service d\u2019H\u00e9matologie Immunologie Cytog\u00e9n\u00e9tique, Hopital de Valenciennes, Valenciennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poulain", 
        "givenName": "St\u00e9phanie", 
        "id": "sg:person.0642052023.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642052023.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Winship Cancer Institute, Emory University, Atlanta, GA 30322", 
            "Department of Radiation Oncology, Emory University, Atlanta, GA 30322"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Powell", 
        "givenName": "Doris", 
        "id": "sg:person.01103540363.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103540363.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Winship Cancer Institute, Emory University, Atlanta, GA 30322", 
            "Department of Radiation Oncology, Emory University, Atlanta, GA 30322"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vertino", 
        "givenName": "Paula", 
        "id": "sg:person.01151653563.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151653563.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Claude Huriez", 
          "id": "https://www.grid.ac/institutes/grid.413875.c", 
          "name": [
            "Service des Maladies du Sang, Hopital Claude Huriez, CHRU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leleu", 
        "givenName": "Xavier", 
        "id": "sg:person.01054405141.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054405141.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322", 
            "Winship Cancer Institute, Emory University, Atlanta, GA 30322"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lonial", 
        "givenName": "Sagar", 
        "id": "sg:person.0741465672.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741465672.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.417467.7", 
          "name": [
            "Hematology and Oncology, Mayo Clinic, Jacksonville, FL"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chanan-Khan", 
        "givenName": "Asher A.", 
        "id": "sg:person.01272431477.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272431477.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Winship Cancer Institute, Emory University, Atlanta, GA 30322"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kowalski", 
        "givenName": "Jeanne", 
        "id": "sg:person.0631766734.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631766734.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322", 
            "Winship Cancer Institute, Emory University, Atlanta, GA 30322", 
            "Graduate Program in Immunology and Molecular Pathogenesis, Emory University, Atlanta, GA 30322", 
            "Department of Cell Biology, Emory University, Atlanta, GA 30322"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boise", 
        "givenName": "Lawrence H.", 
        "id": "sg:person.0754632057.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754632057.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ajh.23472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001252747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1200710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002118080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-06-436329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006462397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-09-243402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008985683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00046-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009019174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1206727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009224925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.01.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009787457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2006.03.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010388310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90161-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010596773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-03-566273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012220791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/348331a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019679922", 
          "https://doi.org/10.1038/348331a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.12.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020132624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-10-116889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020506040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-09-178228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023025087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-12-326868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023213166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025520673", 
          "https://doi.org/10.1038/nature03579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025520673", 
          "https://doi.org/10.1038/nature03579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.101055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025781556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025909668", 
          "https://doi.org/10.1038/sj.leu.2404520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1059108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027799699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029425852", 
          "https://doi.org/10.1038/onc.2008.466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(03)01246-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031038321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.112.191536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031388682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-01-327197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033107978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m114.569376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045117490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428194.2012.713481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045268517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-02-270231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046226069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2007.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048228396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-06-222794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050826413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-02-410647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051700765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1190217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062462434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082707193", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-01", 
    "datePublishedReg": "2016-01-01", 
    "description": "Waldenstr\u00f6m macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The disease carries a high prevalence of activating mutations in MyD88 (91%) and CXCR4 (28%). Because signaling through these pathways leads to Bcl-xL induction, we examined Bcl-2 family expression in WM patients and cell lines. Unlike other B-lymphocyte-derived malignancies, which become dependent on expression of anti-apoptotic proteins to counter expression of pro-apoptotic proteins, WM samples expressed both pro- and anti-apoptotic Bcl-2 proteins at low levels similar to their normal B-cell and plasma cell counterparts. Three WM cell lines expressed pro-apoptotic Bcl-2 family members Bim or Bax and Bak at low levels, which determined their sensitivity to inducers of intrinsic apoptosis. In two cell lines, miR-155 upregulation, which is common in WM, was responsible for the inhibition of FOXO3a and Bim expression. Both antagonizing miR-155 to induce Bim and proteasome inhibition increased the sensitivity to ABT-737 in these lines indicating a lowering of the apoptotic threshold. In this manner, treatments that increase pro-apoptotic protein expression increase the efficacy of agents treated in combination in addition to direct killing. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2015.103", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438879", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479347", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479566", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "name": "Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenstr\u00f6m macroglobulinemia", 
    "pagination": "479", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "899687ddaadfffbace9e696c7f11b532fa9e9e4719dbc3bbfac85ac38cdb8c60"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25893290"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2015.103"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028882119"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2015.103", 
      "https://app.dimensions.ai/details/publication/pub.1028882119"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc2015103"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.103'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.103'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.103'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2015.103'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      81 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2015.103 schema:about N0dc711cf54244780b0d09d6dd2d28686
2 N15444da76e3b48dc89be4bc43e8a24f8
3 N1da31455c07444d189f3c8feeb5aecb9
4 N247df229f6824355949e5766fd3c4450
5 N28768239a5e8477fbb5daf9ea79c8bea
6 N3ff04816729447b2a5ead414b41f1cba
7 N4ffc6dfaff114194ad9baf63d0affde1
8 N57c1a8bbb76e4d8eb444036dc773df02
9 N5b7299e28a2543ed8dff0ea3767288c6
10 N6542af42fcc343ff8eef46a8b91dda20
11 N99f79e39ef00474c94af1f32bfd28ea8
12 N9c7a7503972a41d493cee525022768a8
13 Na5f9d65b86294e63af7adb2c5b876b1b
14 Na64fbad8ab714704a56e0f17fd83f1bf
15 Nc349492fcfb54dce826cb13d56cbdfcd
16 Nc39c7c6fa1a24a8aa23cd2208a94553e
17 Nca9ac3a46e2a4914a932b38e3cf48b88
18 Nd4b12e6b393144b88561bf731a2c3749
19 Nd927173b982d4c62a70c2c0ca3ceeb8b
20 Ne439d21c823d47ba8f2ad083a508cfb4
21 Ne5d2b15d8cf345c79d68770fade828ed
22 anzsrc-for:06
23 anzsrc-for:0601
24 schema:author N0d37ea999beb4034ae19a02e4815f1a3
25 schema:citation sg:pub.10.1038/348331a0
26 sg:pub.10.1038/nature03579
27 sg:pub.10.1038/onc.2008.466
28 sg:pub.10.1038/sj.leu.2404520
29 https://app.dimensions.ai/details/publication/pub.1082707193
30 https://doi.org/10.1002/ajh.23472
31 https://doi.org/10.1016/1074-7613(95)90161-2
32 https://doi.org/10.1016/j.ccr.2006.03.027
33 https://doi.org/10.1016/j.cell.2004.12.035
34 https://doi.org/10.1016/j.exphem.2007.05.022
35 https://doi.org/10.1016/j.molcel.2010.01.025
36 https://doi.org/10.1016/s0092-8674(04)00046-7
37 https://doi.org/10.1016/s1470-2045(03)01246-4
38 https://doi.org/10.1056/nejmoa1200710
39 https://doi.org/10.1074/jbc.m110.101055
40 https://doi.org/10.1074/jbc.m114.569376
41 https://doi.org/10.1124/jpet.112.191536
42 https://doi.org/10.1126/science.1059108
43 https://doi.org/10.1126/science.1190217
44 https://doi.org/10.1126/science.1206727
45 https://doi.org/10.1182/blood-2007-10-116889
46 https://doi.org/10.1182/blood-2008-09-178228
47 https://doi.org/10.1182/blood-2009-06-222794
48 https://doi.org/10.1182/blood-2009-09-243402
49 https://doi.org/10.1182/blood-2010-02-270231
50 https://doi.org/10.1182/blood-2010-12-326868
51 https://doi.org/10.1182/blood-2011-01-327197
52 https://doi.org/10.1182/blood-2012-02-410647
53 https://doi.org/10.1182/blood-2012-06-436329
54 https://doi.org/10.1182/blood-2014-03-566273
55 https://doi.org/10.3109/10428194.2012.713481
56 schema:datePublished 2016-01
57 schema:datePublishedReg 2016-01-01
58 schema:description Waldenström macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The disease carries a high prevalence of activating mutations in MyD88 (91%) and CXCR4 (28%). Because signaling through these pathways leads to Bcl-xL induction, we examined Bcl-2 family expression in WM patients and cell lines. Unlike other B-lymphocyte-derived malignancies, which become dependent on expression of anti-apoptotic proteins to counter expression of pro-apoptotic proteins, WM samples expressed both pro- and anti-apoptotic Bcl-2 proteins at low levels similar to their normal B-cell and plasma cell counterparts. Three WM cell lines expressed pro-apoptotic Bcl-2 family members Bim or Bax and Bak at low levels, which determined their sensitivity to inducers of intrinsic apoptosis. In two cell lines, miR-155 upregulation, which is common in WM, was responsible for the inhibition of FOXO3a and Bim expression. Both antagonizing miR-155 to induce Bim and proteasome inhibition increased the sensitivity to ABT-737 in these lines indicating a lowering of the apoptotic threshold. In this manner, treatments that increase pro-apoptotic protein expression increase the efficacy of agents treated in combination in addition to direct killing.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf Nc7648a240845481d8666856f1e00e0c5
63 Nd4d099f5296c4aac9f25c3eb090dc839
64 sg:journal.1097543
65 schema:name Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia
66 schema:pagination 479
67 schema:productId N15ab0c92ce134b9c9bd04c0e0ff057e9
68 N394123be528e4f118a8e52c979d8f6a2
69 N3b397b7c5cb24e8b852fa088fa4f8d82
70 N3ebeaf31ca014f2eb3087b5122b2948e
71 Nef9bdd2160ba48bb9c56d25aa87755ca
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028882119
73 https://doi.org/10.1038/onc.2015.103
74 schema:sdDatePublished 2019-04-10T20:04
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher Nff0161f93a334740a411f183d607230c
77 schema:url https://www.nature.com/articles/onc2015103
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N0d37ea999beb4034ae19a02e4815f1a3 rdf:first sg:person.01332464704.05
82 rdf:rest Ne3c3fda7843a41c891bab5e576198cb6
83 N0dc711cf54244780b0d09d6dd2d28686 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Membrane Proteins
85 rdf:type schema:DefinedTerm
86 N15444da76e3b48dc89be4bc43e8a24f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Biphenyl Compounds
88 rdf:type schema:DefinedTerm
89 N159451acc6f24ac5892b1aaa32888898 rdf:first sg:person.01054405141.54
90 rdf:rest N1e79caf615c546f7899df79df97a9f24
91 N15ab0c92ce134b9c9bd04c0e0ff057e9 schema:name readcube_id
92 schema:value 899687ddaadfffbace9e696c7f11b532fa9e9e4719dbc3bbfac85ac38cdb8c60
93 rdf:type schema:PropertyValue
94 N1da31455c07444d189f3c8feeb5aecb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Multiple Myeloma
96 rdf:type schema:DefinedTerm
97 N1e79caf615c546f7899df79df97a9f24 rdf:first sg:person.0741465672.45
98 rdf:rest N6d31849a489945d89b7345dee00731c5
99 N247df229f6824355949e5766fd3c4450 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Proto-Oncogene Proteins
101 rdf:type schema:DefinedTerm
102 N28768239a5e8477fbb5daf9ea79c8bea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name bcl-2-Associated X Protein
104 rdf:type schema:DefinedTerm
105 N33268052358f4a119dc5133fade4d8b2 rdf:first sg:person.0754632057.22
106 rdf:rest rdf:nil
107 N394123be528e4f118a8e52c979d8f6a2 schema:name dimensions_id
108 schema:value pub.1028882119
109 rdf:type schema:PropertyValue
110 N3b397b7c5cb24e8b852fa088fa4f8d82 schema:name doi
111 schema:value 10.1038/onc.2015.103
112 rdf:type schema:PropertyValue
113 N3e4e8459aca64b72ab18a781c7e37a32 rdf:first sg:person.01151653563.29
114 rdf:rest N159451acc6f24ac5892b1aaa32888898
115 N3ebeaf31ca014f2eb3087b5122b2948e schema:name nlm_unique_id
116 schema:value 8711562
117 rdf:type schema:PropertyValue
118 N3ff04816729447b2a5ead414b41f1cba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Forkhead Box Protein O3
120 rdf:type schema:DefinedTerm
121 N4ffc6dfaff114194ad9baf63d0affde1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Apoptosis
123 rdf:type schema:DefinedTerm
124 N57c1a8bbb76e4d8eb444036dc773df02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Bcl-2-Like Protein 11
126 rdf:type schema:DefinedTerm
127 N5b7299e28a2543ed8dff0ea3767288c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Nitrophenols
129 rdf:type schema:DefinedTerm
130 N6542af42fcc343ff8eef46a8b91dda20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name bcl-2 Homologous Antagonist-Killer Protein
132 rdf:type schema:DefinedTerm
133 N6d31849a489945d89b7345dee00731c5 rdf:first sg:person.01272431477.10
134 rdf:rest Nbcd8af34160940c08f06b74f25535268
135 N99c01ac64789481a8a88ef36f1c90926 rdf:first sg:person.01103540363.03
136 rdf:rest N3e4e8459aca64b72ab18a781c7e37a32
137 N99f79e39ef00474c94af1f32bfd28ea8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Line, Tumor
139 rdf:type schema:DefinedTerm
140 N9c7a7503972a41d493cee525022768a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Forkhead Transcription Factors
142 rdf:type schema:DefinedTerm
143 Na5f9d65b86294e63af7adb2c5b876b1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Sulfonamides
145 rdf:type schema:DefinedTerm
146 Na64fbad8ab714704a56e0f17fd83f1bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name MicroRNAs
148 rdf:type schema:DefinedTerm
149 Nbcd8af34160940c08f06b74f25535268 rdf:first sg:person.0631766734.79
150 rdf:rest N33268052358f4a119dc5133fade4d8b2
151 Nc349492fcfb54dce826cb13d56cbdfcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Proto-Oncogene Proteins c-bcl-2
153 rdf:type schema:DefinedTerm
154 Nc39c7c6fa1a24a8aa23cd2208a94553e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Nc7648a240845481d8666856f1e00e0c5 schema:issueNumber 4
158 rdf:type schema:PublicationIssue
159 Nca9ac3a46e2a4914a932b38e3cf48b88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Gene Expression Regulation, Neoplastic
161 rdf:type schema:DefinedTerm
162 Nd3d95606964549c09c98381e49dafd0a rdf:first sg:person.01016453312.13
163 rdf:rest Nf9ef3d66dd10494d8f65fa13aef6cd49
164 Nd4b12e6b393144b88561bf731a2c3749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Apoptosis Regulatory Proteins
166 rdf:type schema:DefinedTerm
167 Nd4d099f5296c4aac9f25c3eb090dc839 schema:volumeNumber 35
168 rdf:type schema:PublicationVolume
169 Nd927173b982d4c62a70c2c0ca3ceeb8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Piperazines
171 rdf:type schema:DefinedTerm
172 Ne1a8d346ddda4b9eb76896189c1b0f4e schema:name Service d’Hématologie Immunologie Cytogénétique, Hopital de Valenciennes, Valenciennes, France
173 rdf:type schema:Organization
174 Ne3c3fda7843a41c891bab5e576198cb6 rdf:first sg:person.01072730031.43
175 rdf:rest Nd3d95606964549c09c98381e49dafd0a
176 Ne439d21c823d47ba8f2ad083a508cfb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Bortezomib
178 rdf:type schema:DefinedTerm
179 Ne5d2b15d8cf345c79d68770fade828ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Waldenstrom Macroglobulinemia
181 rdf:type schema:DefinedTerm
182 Nef9bdd2160ba48bb9c56d25aa87755ca schema:name pubmed_id
183 schema:value 25893290
184 rdf:type schema:PropertyValue
185 Nf9ef3d66dd10494d8f65fa13aef6cd49 rdf:first sg:person.0642052023.24
186 rdf:rest N99c01ac64789481a8a88ef36f1c90926
187 Nff0161f93a334740a411f183d607230c schema:name Springer Nature - SN SciGraph project
188 rdf:type schema:Organization
189 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
190 schema:name Biological Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
193 schema:name Biochemistry and Cell Biology
194 rdf:type schema:DefinedTerm
195 sg:grant.2438879 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.103
196 rdf:type schema:MonetaryGrant
197 sg:grant.2479347 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.103
198 rdf:type schema:MonetaryGrant
199 sg:grant.2479566 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2015.103
200 rdf:type schema:MonetaryGrant
201 sg:journal.1097543 schema:issn 0950-9232
202 1476-5594
203 schema:name Oncogene
204 rdf:type schema:Periodical
205 sg:person.01016453312.13 schema:affiliation https://www.grid.ac/institutes/grid.417467.7
206 schema:familyName Chitta
207 schema:givenName Kasyapa S.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016453312.13
209 rdf:type schema:Person
210 sg:person.01054405141.54 schema:affiliation https://www.grid.ac/institutes/grid.413875.c
211 schema:familyName Leleu
212 schema:givenName Xavier
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054405141.54
214 rdf:type schema:Person
215 sg:person.01072730031.43 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
216 schema:familyName Dwivedi
217 schema:givenName Bhakti
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072730031.43
219 rdf:type schema:Person
220 sg:person.01103540363.03 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
221 schema:familyName Powell
222 schema:givenName Doris
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103540363.03
224 rdf:type schema:Person
225 sg:person.01151653563.29 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
226 schema:familyName Vertino
227 schema:givenName Paula
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151653563.29
229 rdf:type schema:Person
230 sg:person.01272431477.10 schema:affiliation https://www.grid.ac/institutes/grid.417467.7
231 schema:familyName Chanan-Khan
232 schema:givenName Asher A.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272431477.10
234 rdf:type schema:Person
235 sg:person.01332464704.05 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
236 schema:familyName Gaudette
237 schema:givenName Brian T.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332464704.05
239 rdf:type schema:Person
240 sg:person.0631766734.79 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
241 schema:familyName Kowalski
242 schema:givenName Jeanne
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631766734.79
244 rdf:type schema:Person
245 sg:person.0642052023.24 schema:affiliation Ne1a8d346ddda4b9eb76896189c1b0f4e
246 schema:familyName Poulain
247 schema:givenName Stéphanie
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642052023.24
249 rdf:type schema:Person
250 sg:person.0741465672.45 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
251 schema:familyName Lonial
252 schema:givenName Sagar
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741465672.45
254 rdf:type schema:Person
255 sg:person.0754632057.22 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
256 schema:familyName Boise
257 schema:givenName Lawrence H.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754632057.22
259 rdf:type schema:Person
260 sg:pub.10.1038/348331a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019679922
261 https://doi.org/10.1038/348331a0
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/nature03579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025520673
264 https://doi.org/10.1038/nature03579
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/onc.2008.466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029425852
267 https://doi.org/10.1038/onc.2008.466
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/sj.leu.2404520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025909668
270 https://doi.org/10.1038/sj.leu.2404520
271 rdf:type schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1082707193 schema:CreativeWork
273 https://doi.org/10.1002/ajh.23472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001252747
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/1074-7613(95)90161-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010596773
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.ccr.2006.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010388310
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.cell.2004.12.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020132624
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.exphem.2007.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048228396
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.molcel.2010.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009787457
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0092-8674(04)00046-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009019174
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s1470-2045(03)01246-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031038321
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1056/nejmoa1200710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002118080
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1074/jbc.m110.101055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025781556
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1074/jbc.m114.569376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045117490
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1124/jpet.112.191536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031388682
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1126/science.1059108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027799699
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1126/science.1190217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062462434
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.1206727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009224925
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1182/blood-2007-10-116889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020506040
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1182/blood-2008-09-178228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023025087
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1182/blood-2009-06-222794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050826413
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1182/blood-2009-09-243402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008985683
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1182/blood-2010-02-270231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046226069
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1182/blood-2010-12-326868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023213166
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1182/blood-2011-01-327197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033107978
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1182/blood-2012-02-410647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051700765
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1182/blood-2012-06-436329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006462397
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1182/blood-2014-03-566273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012220791
322 rdf:type schema:CreativeWork
323 https://doi.org/10.3109/10428194.2012.713481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045268517
324 rdf:type schema:CreativeWork
325 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
326 schema:name Department of Cell Biology, Emory University, Atlanta, GA 30322
327 Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322
328 Department of Radiation Oncology, Emory University, Atlanta, GA 30322
329 Graduate Program in Immunology and Molecular Pathogenesis, Emory University, Atlanta, GA 30322
330 Winship Cancer Institute, Emory University, Atlanta, GA 30322
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.413875.c schema:alternateName Hôpital Claude Huriez
333 schema:name Service des Maladies du Sang, Hopital Claude Huriez, CHRU Lille, Lille, France
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.417467.7 schema:alternateName Mayo Clinic
336 schema:name Cancer Biology, Mayo Clinic, Jacksonville, FL
337 Hematology and Oncology, Mayo Clinic, Jacksonville, FL
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...