Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04-21

AUTHORS

Xia Li, Yuexin Liu, Kirsi J. Granberg, Qinhao Wang, Lynette M. Moore, Ping Ji, Joy Gumin, Erik P. Sulman, George A. Calin, Hannu Haapasalo, Matti Nykter, Ilya Shmulevich, Gregory N. Fuller, Frederick F. Lang, Wei Zhang

ABSTRACT

MIR-491 is commonly co-deleted with its adjacent CDKN2A on chromosome 9p21.3 in glioblastoma multiforme (GBM). However, it is not known whether deletion of MIR-491 is only a passenger event or has an important role. Small-RNA sequencing of samples from GBM patients demonstrated that both mature products of MIR-491 (miR-491-5p and -3p) are downregulated in tumors compared with the normal brain. The integration of GBM data from The Cancer Genome Atlas (TCGA), miRNA target prediction and reporter assays showed that miR-491-5p directly targets EGFR, CDK6 and Bcl-xL, whereas miR-491-3p targets IGFBP2 and CDK6. Functionally, miR-491-3p inhibited glioma cell invasion; overexpression of both miR-491-5p and -3p inhibited proliferation of glioma cell lines and impaired the propagation of glioma stem cells (GSCs), thereby prolonging survival of xenograft mice. Moreover, knockdown of miR-491-5p in primary Ink4a-Arf-null mouse glial progenitor cells exacerbated cell proliferation and invasion. Therefore, MIR-491 is a tumor suppressor gene that, by utilizing both mature forms, coordinately controls the key cancer hallmarks: proliferation, invasion and stem cell propagation. More... »

PAGES

1619-1628

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2014.98

DOI

http://dx.doi.org/10.1038/onc.2014.98

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036831360

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24747968


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase 6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Like Growth Factor Binding Protein 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-X Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China", 
          "id": "http://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
            "Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xia", 
        "id": "sg:person.0630461205.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630461205.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Yuexin", 
        "id": "sg:person.013206747504.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013206747504.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Fimlab Laboratories and University of Tampere, Tampere, Finland", 
          "id": "http://www.grid.ac/institutes/grid.502801.e", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
            "Department of Signal Processing, Tampere University of Technology, Tampere, Finland", 
            "Department of Pathology, Fimlab Laboratories and University of Tampere, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Granberg", 
        "givenName": "Kirsi J.", 
        "id": "sg:person.01050511522.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050511522.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China", 
          "id": "http://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Qinhao", 
        "id": "sg:person.013423516137.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013423516137.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moore", 
        "givenName": "Lynette M.", 
        "id": "sg:person.0664762717.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664762717.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "Ping", 
        "id": "sg:person.01024130752.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024130752.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gumin", 
        "givenName": "Joy", 
        "id": "sg:person.0623204224.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623204224.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sulman", 
        "givenName": "Erik P.", 
        "id": "sg:person.012363700077.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012363700077.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Non-coding RNA center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
            "Department of Non-coding RNA center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calin", 
        "givenName": "George A.", 
        "id": "sg:person.01176437025.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176437025.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Fimlab Laboratories and University of Tampere, Tampere, Finland", 
          "id": "http://www.grid.ac/institutes/grid.502801.e", 
          "name": [
            "Department of Pathology, Fimlab Laboratories and University of Tampere, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haapasalo", 
        "givenName": "Hannu", 
        "id": "sg:person.01164074454.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164074454.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Technology, University of Tampere, Tampere, Finland", 
          "id": "http://www.grid.ac/institutes/grid.502801.e", 
          "name": [
            "Department of Signal Processing, Tampere University of Technology, Tampere, Finland", 
            "Institute of Biomedical Technology, University of Tampere, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nykter", 
        "givenName": "Matti", 
        "id": "sg:person.01332506074.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332506074.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Systems Biology, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.64212.33", 
          "name": [
            "Institute for Systems Biology, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shmulevich", 
        "givenName": "Ilya", 
        "id": "sg:person.01354314446.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354314446.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fuller", 
        "givenName": "Gregory N.", 
        "id": "sg:person.013732343337.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732343337.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lang", 
        "givenName": "Frederick F.", 
        "id": "sg:person.012270527477.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012270527477.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Non-coding RNA center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA", 
            "Department of Non-coding RNA center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Wei", 
        "id": "sg:person.016617025407.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016617025407.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature03128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027226854", 
          "https://doi.org/10.1038/nature03128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010208236", 
          "https://doi.org/10.1038/nature10661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015575125780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008118949", 
          "https://doi.org/10.1023/a:1015575125780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpneuro0862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001343349", 
          "https://doi.org/10.1038/ncpneuro0862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017178358", 
          "https://doi.org/10.1038/sj.onc.1206589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044012298", 
          "https://doi.org/10.1038/nrc1997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015793721", 
          "https://doi.org/10.1038/onc.2011.380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1741-7015-6-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037637739", 
          "https://doi.org/10.1186/1741-7015-6-14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-4-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029582210", 
          "https://doi.org/10.1186/1476-4598-4-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039570773", 
          "https://doi.org/10.1038/nature07385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-009-0035-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003962804", 
          "https://doi.org/10.1007/s11060-009-0035-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-04-21", 
    "datePublishedReg": "2014-04-21", 
    "description": "MIR-491 is commonly co-deleted with its adjacent CDKN2A on chromosome 9p21.3 in glioblastoma\u00a0multiforme (GBM). However, it is not known whether deletion of MIR-491 is only a passenger event or has an important role. Small-RNA sequencing of samples from GBM patients demonstrated that both mature products of MIR-491 (miR-491-5p and -3p) are downregulated in tumors compared with the normal brain. The integration of GBM data from The Cancer Genome Atlas (TCGA), miRNA target prediction and reporter assays showed that miR-491-5p directly targets EGFR, CDK6 and Bcl-xL, whereas miR-491-3p targets IGFBP2 and CDK6. Functionally, miR-491-3p inhibited glioma cell invasion; overexpression of both miR-491-5p and -3p inhibited proliferation of glioma cell lines and impaired the propagation of glioma stem cells (GSCs), thereby prolonging survival of xenograft mice. Moreover, knockdown of miR-491-5p in primary Ink4a-Arf-null mouse glial progenitor cells exacerbated cell proliferation and invasion. Therefore, MIR-491 is a tumor suppressor gene that, by utilizing both mature forms, coordinately controls the key cancer hallmarks: proliferation, invasion and stem cell propagation. ", 
    "genre": "article", 
    "id": "sg:pub.10.1038/onc.2014.98", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2476444", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4248003", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440223", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2480621", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2478242", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2666946", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696331", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "13", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "keywords": [
      "key cancer hallmarks", 
      "miR-491", 
      "cancer hallmarks", 
      "glioma stem cells", 
      "miRNA target prediction", 
      "mature products", 
      "tumor suppressor gene", 
      "stem cell propagation", 
      "Cancer Genome Atlas", 
      "RNA sequencing", 
      "glial progenitor cells", 
      "passenger events", 
      "reporter assays", 
      "mature form", 
      "target prediction", 
      "Bcl-xL", 
      "glioma cell invasion", 
      "suppressor gene", 
      "cell invasion", 
      "glioma cell lines", 
      "Genome Atlas", 
      "stem cells", 
      "INK4a-ARF", 
      "progenitor cells", 
      "cell propagation", 
      "cell proliferation", 
      "cell lines", 
      "chromosome 9p21.3", 
      "GBM data", 
      "inhibited proliferation", 
      "CDK6", 
      "invasion", 
      "proliferation", 
      "hallmark", 
      "important role", 
      "cells", 
      "xenograft mice", 
      "genes", 
      "knockdown", 
      "sequencing", 
      "overexpression", 
      "glioblastoma", 
      "deletion", 
      "GBM patients", 
      "CDKN2A", 
      "IGFBP2", 
      "assays", 
      "atlas", 
      "normal brain", 
      "role", 
      "mice", 
      "EGFR", 
      "lines", 
      "survival", 
      "products", 
      "multiforme", 
      "events", 
      "brain", 
      "form", 
      "patients", 
      "tumors", 
      "data", 
      "prediction", 
      "propagation", 
      "integration", 
      "samples", 
      "adjacent CDKN2A", 
      "miR-491-3p targets IGFBP2", 
      "targets IGFBP2", 
      "null mouse glial progenitor cells", 
      "mouse glial progenitor cells"
    ], 
    "name": "Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma", 
    "pagination": "1619-1628", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036831360"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2014.98"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24747968"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2014.98", 
      "https://app.dimensions.ai/details/publication/pub.1036831360"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_629.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/onc.2014.98"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.98'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.98'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.98'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.98'


 

This table displays all metadata directly associated to this object as RDF triples.

372 TRIPLES      22 PREDICATES      123 URIs      104 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2014.98 schema:about N0da98b205fc5476dbe804d16cc381f25
2 N27d2d3e326d54502a8c720c76d34f5ca
3 N30ad116597a74dab8e3cc6480e07b0bb
4 N4cc044aeded64896906e0801d6c0604f
5 N63b096932bb64ffa9b761cf0af82c5cd
6 N6c3962d287384e50bfc536de76efed95
7 N717a88c0a7d94fc7b6a18efc1cca3c9b
8 N77e96bf9b6b34b1ca9651c8ef6483abd
9 N806f5ff037cb4abeaf37cd9623a69409
10 N8f755b0253134d1f9449610b2f6df29d
11 Na57bd7df1fa347528968705bc234f8c9
12 Nbb8361799f1c48e5bc719066096ecd4e
13 Ned08d787f70c46f09875708478e61b4f
14 Nf84da4e492e844a48e07f20853b5d2dc
15 Nff8173a8e48743aa9829b3dbc6c2df2e
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N2cba77cc57c4481f8ae9685dc459699a
19 schema:citation sg:pub.10.1007/s11060-009-0035-x
20 sg:pub.10.1023/a:1015575125780
21 sg:pub.10.1038/nature03128
22 sg:pub.10.1038/nature07385
23 sg:pub.10.1038/nature10661
24 sg:pub.10.1038/ncpneuro0862
25 sg:pub.10.1038/nrc1997
26 sg:pub.10.1038/onc.2011.380
27 sg:pub.10.1038/sj.onc.1206589
28 sg:pub.10.1186/1476-4598-4-7
29 sg:pub.10.1186/1741-7015-6-14
30 schema:datePublished 2014-04-21
31 schema:datePublishedReg 2014-04-21
32 schema:description MIR-491 is commonly co-deleted with its adjacent CDKN2A on chromosome 9p21.3 in glioblastoma multiforme (GBM). However, it is not known whether deletion of MIR-491 is only a passenger event or has an important role. Small-RNA sequencing of samples from GBM patients demonstrated that both mature products of MIR-491 (miR-491-5p and -3p) are downregulated in tumors compared with the normal brain. The integration of GBM data from The Cancer Genome Atlas (TCGA), miRNA target prediction and reporter assays showed that miR-491-5p directly targets EGFR, CDK6 and Bcl-xL, whereas miR-491-3p targets IGFBP2 and CDK6. Functionally, miR-491-3p inhibited glioma cell invasion; overexpression of both miR-491-5p and -3p inhibited proliferation of glioma cell lines and impaired the propagation of glioma stem cells (GSCs), thereby prolonging survival of xenograft mice. Moreover, knockdown of miR-491-5p in primary Ink4a-Arf-null mouse glial progenitor cells exacerbated cell proliferation and invasion. Therefore, MIR-491 is a tumor suppressor gene that, by utilizing both mature forms, coordinately controls the key cancer hallmarks: proliferation, invasion and stem cell propagation.
33 schema:genre article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N4d1bf6a0642b404b8561ba6884363cf5
37 Nbc94a77273844fe6a64b3f0072ac01f5
38 sg:journal.1097543
39 schema:keywords Bcl-xL
40 CDK6
41 CDKN2A
42 Cancer Genome Atlas
43 EGFR
44 GBM data
45 GBM patients
46 Genome Atlas
47 IGFBP2
48 INK4a-ARF
49 RNA sequencing
50 adjacent CDKN2A
51 assays
52 atlas
53 brain
54 cancer hallmarks
55 cell invasion
56 cell lines
57 cell proliferation
58 cell propagation
59 cells
60 chromosome 9p21.3
61 data
62 deletion
63 events
64 form
65 genes
66 glial progenitor cells
67 glioblastoma
68 glioma cell invasion
69 glioma cell lines
70 glioma stem cells
71 hallmark
72 important role
73 inhibited proliferation
74 integration
75 invasion
76 key cancer hallmarks
77 knockdown
78 lines
79 mature form
80 mature products
81 miR-491
82 miR-491-3p targets IGFBP2
83 miRNA target prediction
84 mice
85 mouse glial progenitor cells
86 multiforme
87 normal brain
88 null mouse glial progenitor cells
89 overexpression
90 passenger events
91 patients
92 prediction
93 products
94 progenitor cells
95 proliferation
96 propagation
97 reporter assays
98 role
99 samples
100 sequencing
101 stem cell propagation
102 stem cells
103 suppressor gene
104 survival
105 target prediction
106 targets IGFBP2
107 tumor suppressor gene
108 tumors
109 xenograft mice
110 schema:name Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma
111 schema:pagination 1619-1628
112 schema:productId N24f86fd8b3af4a0eb76d1859b3c43088
113 N3862642cba254e6ab754a547cf162c1a
114 N3e275960ae654ec9bbf007664fd67281
115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036831360
116 https://doi.org/10.1038/onc.2014.98
117 schema:sdDatePublished 2021-12-01T19:31
118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
119 schema:sdPublisher Nd15ed1f9ee764ae0b3e9a71bfca66f7e
120 schema:url https://doi.org/10.1038/onc.2014.98
121 sgo:license sg:explorer/license/
122 sgo:sdDataset articles
123 rdf:type schema:ScholarlyArticle
124 N0da98b205fc5476dbe804d16cc381f25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name bcl-X Protein
126 rdf:type schema:DefinedTerm
127 N129278b8064c49caa4b03617af94cdc8 rdf:first sg:person.012363700077.87
128 rdf:rest N8db62615d8a644469cf785bf468f4238
129 N186aab936d634a6c8068b1f4e0b466d5 rdf:first sg:person.01332506074.18
130 rdf:rest N7f524ea9deb04f34b99ec49e2b57dbaa
131 N24f86fd8b3af4a0eb76d1859b3c43088 schema:name dimensions_id
132 schema:value pub.1036831360
133 rdf:type schema:PropertyValue
134 N27d2d3e326d54502a8c720c76d34f5ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Animals
136 rdf:type schema:DefinedTerm
137 N2cba77cc57c4481f8ae9685dc459699a rdf:first sg:person.0630461205.19
138 rdf:rest Nc50e55cf2a224b32ad772834ecca601a
139 N30ad116597a74dab8e3cc6480e07b0bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Mice
141 rdf:type schema:DefinedTerm
142 N3862642cba254e6ab754a547cf162c1a schema:name pubmed_id
143 schema:value 24747968
144 rdf:type schema:PropertyValue
145 N3e275960ae654ec9bbf007664fd67281 schema:name doi
146 schema:value 10.1038/onc.2014.98
147 rdf:type schema:PropertyValue
148 N43b6a55262f04e33aec29a004412b969 rdf:first sg:person.016617025407.36
149 rdf:rest rdf:nil
150 N4cc044aeded64896906e0801d6c0604f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cyclin-Dependent Kinase 6
152 rdf:type schema:DefinedTerm
153 N4cfad642234e4e0b8184ef6963730f60 rdf:first sg:person.0664762717.85
154 rdf:rest Nc0d23e3ffdcf4b8e9b601a8ac8d9923d
155 N4d1bf6a0642b404b8561ba6884363cf5 schema:issueNumber 13
156 rdf:type schema:PublicationIssue
157 N63b096932bb64ffa9b761cf0af82c5cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Gene Expression Regulation, Neoplastic
159 rdf:type schema:DefinedTerm
160 N6c3962d287384e50bfc536de76efed95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name MicroRNAs
162 rdf:type schema:DefinedTerm
163 N717a88c0a7d94fc7b6a18efc1cca3c9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Neoplasm Invasiveness
165 rdf:type schema:DefinedTerm
166 N77e96bf9b6b34b1ca9651c8ef6483abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Male
168 rdf:type schema:DefinedTerm
169 N7abe1a07dac34522b3247fdb118a79eb rdf:first sg:person.01164074454.10
170 rdf:rest N186aab936d634a6c8068b1f4e0b466d5
171 N7f524ea9deb04f34b99ec49e2b57dbaa rdf:first sg:person.01354314446.15
172 rdf:rest Nd1d2a8d384854540b5b64496ec059b02
173 N806f5ff037cb4abeaf37cd9623a69409 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Insulin-Like Growth Factor Binding Protein 2
175 rdf:type schema:DefinedTerm
176 N80e58c75d0e9447c92326ac93292bb81 rdf:first sg:person.013423516137.85
177 rdf:rest N4cfad642234e4e0b8184ef6963730f60
178 N85d71c2bad404cd797cf23517c0a7eed rdf:first sg:person.01050511522.10
179 rdf:rest N80e58c75d0e9447c92326ac93292bb81
180 N8db62615d8a644469cf785bf468f4238 rdf:first sg:person.01176437025.21
181 rdf:rest N7abe1a07dac34522b3247fdb118a79eb
182 N8f755b0253134d1f9449610b2f6df29d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Genes, Tumor Suppressor
184 rdf:type schema:DefinedTerm
185 N947443dfa9a44706963ace6983af4719 rdf:first sg:person.012270527477.93
186 rdf:rest N43b6a55262f04e33aec29a004412b969
187 Na57bd7df1fa347528968705bc234f8c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Cell Line, Tumor
189 rdf:type schema:DefinedTerm
190 Nbb8361799f1c48e5bc719066096ecd4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Glioblastoma
192 rdf:type schema:DefinedTerm
193 Nbc94a77273844fe6a64b3f0072ac01f5 schema:volumeNumber 34
194 rdf:type schema:PublicationVolume
195 Nc0d23e3ffdcf4b8e9b601a8ac8d9923d rdf:first sg:person.01024130752.67
196 rdf:rest Nc905e6f95d0143188f7007d0931a4657
197 Nc50e55cf2a224b32ad772834ecca601a rdf:first sg:person.013206747504.23
198 rdf:rest N85d71c2bad404cd797cf23517c0a7eed
199 Nc905e6f95d0143188f7007d0931a4657 rdf:first sg:person.0623204224.95
200 rdf:rest N129278b8064c49caa4b03617af94cdc8
201 Nd15ed1f9ee764ae0b3e9a71bfca66f7e schema:name Springer Nature - SN SciGraph project
202 rdf:type schema:Organization
203 Nd1d2a8d384854540b5b64496ec059b02 rdf:first sg:person.013732343337.08
204 rdf:rest N947443dfa9a44706963ace6983af4719
205 Ned08d787f70c46f09875708478e61b4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Brain Neoplasms
207 rdf:type schema:DefinedTerm
208 Nf84da4e492e844a48e07f20853b5d2dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Humans
210 rdf:type schema:DefinedTerm
211 Nff8173a8e48743aa9829b3dbc6c2df2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name ErbB Receptors
213 rdf:type schema:DefinedTerm
214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
215 schema:name Medical and Health Sciences
216 rdf:type schema:DefinedTerm
217 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
218 schema:name Oncology and Carcinogenesis
219 rdf:type schema:DefinedTerm
220 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.98
221 rdf:type schema:MonetaryGrant
222 sg:grant.2440223 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.98
223 rdf:type schema:MonetaryGrant
224 sg:grant.2476444 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.98
225 rdf:type schema:MonetaryGrant
226 sg:grant.2478242 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.98
227 rdf:type schema:MonetaryGrant
228 sg:grant.2480621 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.98
229 rdf:type schema:MonetaryGrant
230 sg:grant.2666946 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.98
231 rdf:type schema:MonetaryGrant
232 sg:grant.2696331 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.98
233 rdf:type schema:MonetaryGrant
234 sg:grant.4248003 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.98
235 rdf:type schema:MonetaryGrant
236 sg:journal.1097543 schema:issn 0950-9232
237 1476-5594
238 schema:name Oncogene
239 schema:publisher Springer Nature
240 rdf:type schema:Periodical
241 sg:person.01024130752.67 schema:affiliation grid-institutes:grid.240145.6
242 schema:familyName Ji
243 schema:givenName Ping
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024130752.67
245 rdf:type schema:Person
246 sg:person.01050511522.10 schema:affiliation grid-institutes:grid.502801.e
247 schema:familyName Granberg
248 schema:givenName Kirsi J.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050511522.10
250 rdf:type schema:Person
251 sg:person.01164074454.10 schema:affiliation grid-institutes:grid.502801.e
252 schema:familyName Haapasalo
253 schema:givenName Hannu
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164074454.10
255 rdf:type schema:Person
256 sg:person.01176437025.21 schema:affiliation grid-institutes:grid.240145.6
257 schema:familyName Calin
258 schema:givenName George A.
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176437025.21
260 rdf:type schema:Person
261 sg:person.012270527477.93 schema:affiliation grid-institutes:grid.240145.6
262 schema:familyName Lang
263 schema:givenName Frederick F.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012270527477.93
265 rdf:type schema:Person
266 sg:person.012363700077.87 schema:affiliation grid-institutes:grid.240145.6
267 schema:familyName Sulman
268 schema:givenName Erik P.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012363700077.87
270 rdf:type schema:Person
271 sg:person.013206747504.23 schema:affiliation grid-institutes:grid.240145.6
272 schema:familyName Liu
273 schema:givenName Yuexin
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013206747504.23
275 rdf:type schema:Person
276 sg:person.01332506074.18 schema:affiliation grid-institutes:grid.502801.e
277 schema:familyName Nykter
278 schema:givenName Matti
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332506074.18
280 rdf:type schema:Person
281 sg:person.013423516137.85 schema:affiliation grid-institutes:grid.233520.5
282 schema:familyName Wang
283 schema:givenName Qinhao
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013423516137.85
285 rdf:type schema:Person
286 sg:person.01354314446.15 schema:affiliation grid-institutes:grid.64212.33
287 schema:familyName Shmulevich
288 schema:givenName Ilya
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354314446.15
290 rdf:type schema:Person
291 sg:person.013732343337.08 schema:affiliation grid-institutes:grid.240145.6
292 schema:familyName Fuller
293 schema:givenName Gregory N.
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732343337.08
295 rdf:type schema:Person
296 sg:person.016617025407.36 schema:affiliation grid-institutes:grid.240145.6
297 schema:familyName Zhang
298 schema:givenName Wei
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016617025407.36
300 rdf:type schema:Person
301 sg:person.0623204224.95 schema:affiliation grid-institutes:grid.240145.6
302 schema:familyName Gumin
303 schema:givenName Joy
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623204224.95
305 rdf:type schema:Person
306 sg:person.0630461205.19 schema:affiliation grid-institutes:grid.233520.5
307 schema:familyName Li
308 schema:givenName Xia
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630461205.19
310 rdf:type schema:Person
311 sg:person.0664762717.85 schema:affiliation grid-institutes:grid.240145.6
312 schema:familyName Moore
313 schema:givenName Lynette M.
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664762717.85
315 rdf:type schema:Person
316 sg:pub.10.1007/s11060-009-0035-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003962804
317 https://doi.org/10.1007/s11060-009-0035-x
318 rdf:type schema:CreativeWork
319 sg:pub.10.1023/a:1015575125780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008118949
320 https://doi.org/10.1023/a:1015575125780
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/nature03128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027226854
323 https://doi.org/10.1038/nature03128
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/nature07385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039570773
326 https://doi.org/10.1038/nature07385
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/nature10661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010208236
329 https://doi.org/10.1038/nature10661
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/ncpneuro0862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001343349
332 https://doi.org/10.1038/ncpneuro0862
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/nrc1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044012298
335 https://doi.org/10.1038/nrc1997
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/onc.2011.380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015793721
338 https://doi.org/10.1038/onc.2011.380
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/sj.onc.1206589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017178358
341 https://doi.org/10.1038/sj.onc.1206589
342 rdf:type schema:CreativeWork
343 sg:pub.10.1186/1476-4598-4-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029582210
344 https://doi.org/10.1186/1476-4598-4-7
345 rdf:type schema:CreativeWork
346 sg:pub.10.1186/1741-7015-6-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037637739
347 https://doi.org/10.1186/1741-7015-6-14
348 rdf:type schema:CreativeWork
349 grid-institutes:grid.233520.5 schema:alternateName Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China
350 schema:name Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China
351 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
352 rdf:type schema:Organization
353 grid-institutes:grid.240145.6 schema:alternateName Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
354 Department of Non-coding RNA center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
355 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
356 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
357 schema:name Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
358 Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
359 Department of Non-coding RNA center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
360 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
361 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
362 rdf:type schema:Organization
363 grid-institutes:grid.502801.e schema:alternateName Department of Pathology, Fimlab Laboratories and University of Tampere, Tampere, Finland
364 Institute of Biomedical Technology, University of Tampere, Tampere, Finland
365 schema:name Department of Pathology, Fimlab Laboratories and University of Tampere, Tampere, Finland
366 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
367 Department of Signal Processing, Tampere University of Technology, Tampere, Finland
368 Institute of Biomedical Technology, University of Tampere, Tampere, Finland
369 rdf:type schema:Organization
370 grid-institutes:grid.64212.33 schema:alternateName Institute for Systems Biology, Seattle, Washington, USA
371 schema:name Institute for Systems Biology, Seattle, Washington, USA
372 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...