Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

D Zhao, A H Besser, S A Wander, J Sun, W Zhou, B Wang, T Ince, M A Durante, W Guo, G Mills, D Theodorescu, J Slingerland

ABSTRACT

p27 restrains normal cell growth, but PI3K-dependent C-terminal phosphorylation of p27 at threonine 157 (T157) and T198 promotes cancer cell invasion. Here, we describe an oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator of transcription 3) recruitment and activation. STAT3 induces TWIST1 to drive a p27-dependent epithelial-mesenchymal transition (EMT) and further activates AKT contributing to acquisition and maintenance of metastatic potential. p27 knockdown in highly metastatic PI3K-activated cells reduces STAT3 binding to the TWIST1 promoter, TWIST1 promoter activity and TWIST1 expression, reverts EMT and impairs metastasis, whereas activated STAT3 rescues p27 knockdown. Cell cycle-defective phosphomimetic p27T157DT198D (p27CK-DD) activates STAT3 to induce a TWIST1-dependent EMT in human mammary epithelial cells and increases breast and bladder cancer invasion and metastasis. Data support a mechanism in which PI3K-deregulated p27 binds JAK2, to drive STAT3 activation and EMT through STAT3-mediated TWIST1 induction. Furthermore, STAT3, once activated, feeds forward to further activate AKT. More... »

PAGES

5447-5459

References to SciGraph publications

  • 2008-04. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy in NATURE REVIEWS CANCER
  • 2011-08. Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control in ONCOGENE
  • 2010-12. A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers in CLINICAL PROTEOMICS
  • 2013-04. PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy in BREAST CANCER RESEARCH AND TREATMENT
  • 2002-10. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest in NATURE MEDICINE
  • 2012-09. p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes in ONCOGENE
  • 2002-10. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer in NATURE MEDICINE
  • 2010-06. TWISTing an embryonic transcription factor into an oncoprotein in ONCOGENE
  • 2008-12. STAT3 can be activated through paracrine signaling in breast epithelial cells in BMC CANCER
  • 2010-06. Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2011-10. Unravelling the complexity of metastasis — molecular understanding and targeted therapies in NATURE REVIEWS CANCER
  • 2007-02. The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis in NATURE CELL BIOLOGY
  • 1998-12. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration in NATURE MEDICINE
  • 2002-10. PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization in NATURE MEDICINE
  • 2005-07. Genes that mediate breast cancer metastasis to lung in NATURE
  • 2014-06. Oncogenic roles of EMT-inducing transcription factors in NATURE CELL BIOLOGY
  • 2011-06. Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro in ONCOGENE
  • 1998-11. The murine gene p27Kip1 is haplo-insufficient for tumour suppression in NATURE
  • 2004-12. Regulation of the cytoskeleton: an oncogenic function for cdk inhibitors? in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2014.473

    DOI

    http://dx.doi.org/10.1038/onc.2014.473

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046963596

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25684140


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