BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08

AUTHORS

E Kumaraswamy, K L Wendt, L A Augustine, S R Stecklein, E C Sibala, D Li, S Gunewardena, R A Jensen

ABSTRACT

Breast cancer 1 (BRCA1)-associated breast cancers are mostly basal-like high-grade ductal carcinomas that frequently overexpress epidermal growth factor receptor (EGFR). Aberrant EGFR expression is correlated with disease progression, resistance to radiation and chemotherapy, and poor clinical prognosis. Although BRCA1 is involved in multiple cellular processes, its functional role in EGFR regulation remains enigmatic. Here, we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a. We demonstrate that EGFR expression correlates negatively with BRCA1, whereas miR-146a levels increase with BRCA1. We show that BRCA1 binds to MIR146A promoter and activates transcription, which in turn attenuates EGFR expression. Knockdown of miR-146a in BRCA1-overexpressing cells negated this effect and suppressed its ability to inhibit proliferation and transformation. In archived triple-negative breast cancer samples, we show a strong positive correlation between BRCA1 and miR-146a expression. We also show that low expression of miR-146a strongly predicts positive lymph node status and is associated with distinctively poor overall survival of patients. Together, these observations provide an insight into a novel BRCA1miR-146aEGFR paradigm by which BRCA1 carries out an aspect of tumor suppressor function that is potentially amenable to therapeutic intervention. More... »

PAGES

4333

References to SciGraph publications

  • 2011-10. Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155 in NATURE MEDICINE
  • 2012-11. BRCA1 and MicroRNAs: Emerging networks and potential therapeutic targets in MOLECULES AND CELLS
  • 2005-08. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing in NATURE
  • 2000-08. Molecular portraits of human breast tumours in NATURE
  • 2010-02. BRCA1 and its toolbox for the maintenance of genome integrity in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2011-04. Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice in BREAST CANCER RESEARCH
  • 2004-10. Hallmarks of 'BRCAness' in sporadic cancers in NATURE REVIEWS CANCER
  • 2012-07. Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway in BREAST CANCER RESEARCH AND TREATMENT
  • 2012-09. BRCA1 – Conductor of the Breast Stem Cell Orchestra: The Role of BRCA1 in Mammary Gland Development and Identification of Cell of Origin of BRCA1 Mutant Breast Cancer in STEM CELL REVIEWS AND REPORTS
  • 2009-07. Invasive ductal carcinoma of the breast with the “triple-negative” phenotype: prognostic implications of EGFR immunoreactivity in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-08. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers in NATURE MEDICINE
  • 2011-09. Vascular anastomosis using controlled phase transitions in poloxamer gels in NATURE MEDICINE
  • 1995-04. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression in NATURE GENETICS
  • 2008-09. Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells in ONCOGENE
  • 2008-12. Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers in BMC CANCER
  • 1996-03. Growth retardation and tumour inhibition by BRCA1 in NATURE GENETICS
  • 2010-08. BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2007-12. EGFR associated expression profiles vary with breast tumor subtype in BMC GENOMICS
  • 2011-04. Inherited Mutations in Breast Cancer Genes—Risk and Response in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2014.363

    DOI

    http://dx.doi.org/10.1038/onc.2014.363

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032901436

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25417703


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "BRCA1 Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymph Nodes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Promoter Regions, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Processing, Post-Transcriptional", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, Epidermal Growth Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptional Activation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Triple Negative Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Kansas Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468219.0", 
              "name": [
                "Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA", 
                "The University of Kansas Cancer Center, Kansas City, KS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kumaraswamy", 
            "givenName": "E", 
            "id": "sg:person.01326566537.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326566537.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kansas Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468219.0", 
              "name": [
                "The University of Kansas Cancer Center, Kansas City, KS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wendt", 
            "givenName": "K L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kansas Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468219.0", 
              "name": [
                "The University of Kansas Cancer Center, Kansas City, KS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Augustine", 
            "givenName": "L A", 
            "id": "sg:person.01156365347.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156365347.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kansas Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412016.0", 
              "name": [
                "Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stecklein", 
            "givenName": "S R", 
            "id": "sg:person.0740260107.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740260107.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kansas Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468219.0", 
              "name": [
                "The University of Kansas Cancer Center, Kansas City, KS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sibala", 
            "givenName": "E C", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kansas Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468219.0", 
              "name": [
                "The University of Kansas Cancer Center, Kansas City, KS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "D", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kansas Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412016.0", 
              "name": [
                "Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA", 
                "Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gunewardena", 
            "givenName": "S", 
            "id": "sg:person.01020412776.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020412776.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kansas", 
              "id": "https://www.grid.ac/institutes/grid.266515.3", 
              "name": [
                "Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA", 
                "The University of Kansas Cancer Center, Kansas City, KS, USA", 
                "Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA", 
                "Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA", 
                "Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jensen", 
            "givenName": "R A", 
            "id": "sg:person.016236702557.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016236702557.70"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1101/gad.1061803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004107821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pros.22466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005846835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-8-309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006580732", 
              "https://doi.org/10.1186/1471-2407-8-309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.24816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007419838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.24816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007419838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbcan.2006.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008590871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00961-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009876297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.201100136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011192499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(01)00231-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011723495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00114-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011791924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0565-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012090504", 
              "https://doi.org/10.1007/s10549-009-0565-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0565-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012090504", 
              "https://doi.org/10.1007/s10549-009-0565-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0565-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012090504", 
              "https://doi.org/10.1007/s10549-009-0565-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.05821-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014384154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016970769", 
              "https://doi.org/10.1038/nrm2831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016970769", 
              "https://doi.org/10.1038/nrm2831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0396-298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017220089", 
              "https://doi.org/10.1038/ng0396-298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0495-444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018646090", 
              "https://doi.org/10.1038/ng0495-444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10059-012-0118-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019606369", 
              "https://doi.org/10.1007/s10059-012-0118-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20101823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019895028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-8-258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019972796", 
              "https://doi.org/10.1186/1471-2164-8-258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020869588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021513783", 
              "https://doi.org/10.1038/nm.2459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10911-011-9213-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021641754", 
              "https://doi.org/10.1007/s10911-011-9213-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.201100209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022068361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-008-0206-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023166547", 
              "https://doi.org/10.1007/s10549-008-0206-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-008-0206-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023166547", 
              "https://doi.org/10.1007/s10549-008-0206-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023682432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024464845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2009.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024485037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb.2011.100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025546294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb.2011.100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025546294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr2850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028771137", 
              "https://doi.org/10.1186/bcr2850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201110008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029914131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031148109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(01)00230-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033094712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35021093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033846543", 
              "https://doi.org/10.1038/35021093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2008.12.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034397580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-011-1905-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035530194", 
              "https://doi.org/10.1007/s10549-011-1905-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1105398108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036726677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12015-012-9354-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042078720", 
              "https://doi.org/10.1007/s12015-012-9354-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042196381", 
              "https://doi.org/10.1038/nature03868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042196381", 
              "https://doi.org/10.1038/nature03868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042257134", 
              "https://doi.org/10.1038/nrc1457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042257134", 
              "https://doi.org/10.1038/nrc1457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.11.5605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043314283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045151043", 
              "https://doi.org/10.1038/nm.2000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045151043", 
              "https://doi.org/10.1038/nm.2000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046286456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(87)90593-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046668239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(87)90593-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046668239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djk133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046683146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046872253", 
              "https://doi.org/10.1038/nm.2424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046998641", 
              "https://doi.org/10.1038/onc.2008.171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0605298103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049075000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0031615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052544054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djg050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053228023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.2008.056291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053600762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-3559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053604126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7939630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062650649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075097640", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-08", 
        "datePublishedReg": "2015-08-01", 
        "description": "Breast cancer 1 (BRCA1)-associated breast cancers are mostly basal-like high-grade ductal carcinomas that frequently overexpress epidermal growth factor receptor (EGFR). Aberrant EGFR expression is correlated with disease progression, resistance to radiation and chemotherapy, and poor clinical prognosis. Although BRCA1 is involved in multiple cellular processes, its functional role in EGFR regulation remains enigmatic. Here, we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a. We demonstrate that EGFR expression correlates negatively with BRCA1, whereas miR-146a levels increase with BRCA1. We show that BRCA1 binds to MIR146A promoter and activates transcription, which in turn attenuates EGFR expression. Knockdown of miR-146a in BRCA1-overexpressing cells negated this effect and suppressed its ability to inhibit proliferation and transformation. In archived triple-negative breast cancer samples, we show a strong positive correlation between BRCA1 and miR-146a expression. We also show that low expression of miR-146a strongly predicts positive lymph node status and is associated with distinctively poor overall survival of patients. Together, these observations provide an insight into a novel BRCA1\ue232miR-146a\ue232EGFR paradigm by which BRCA1 carries out an aspect of tumor suppressor function that is potentially amenable to therapeutic intervention. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/onc.2014.363", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438407", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438895", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "33", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "34"
          }
        ], 
        "name": "BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor function", 
        "pagination": "4333", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "9cbd2f4c4a8489f707b3aa3e764789e9783d02bdc92e57ddbccc85fa2361d0f4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25417703"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2014.363"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1032901436"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2014.363", 
          "https://app.dimensions.ai/details/publication/pub.1032901436"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T12:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/onc2014363"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.363'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.363'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.363'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.363'


     

    This table displays all metadata directly associated to this object as RDF triples.

    359 TRIPLES      21 PREDICATES      94 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2014.363 schema:about N08ade8a6b07f407281aaae0ab1ea2681
    2 N101c3231318e47d5a3998e7b7d3c1cf0
    3 N1b602c7747784460834360a453a4f6c2
    4 N259dd731e917432facd745e1b025291c
    5 N2c0281d6a7c04fa6ba9b6ede11935258
    6 N44c638b49fca45cfbcf23e8cc1fe5715
    7 N5eb767d236f6444c9242b9b2e4a96600
    8 N86468f9215da40e5821f5a56fadf00df
    9 N8e68fed0359e4c8fa186d16ed4161156
    10 Ncbdf96f9e59c45bb97fd598d0b7e8ebb
    11 Nd67a5c104599442dafe364b6ca5a8af9
    12 Ndd3cea621a35492a82889d0f89cdbe8a
    13 Ned82562830e846daaf8e73344f3067c3
    14 Nf515e20e25604334bf19179fc90600bd
    15 anzsrc-for:11
    16 anzsrc-for:1112
    17 schema:author Ndd6d42a3fa774890bcae2e42b6916c87
    18 schema:citation sg:pub.10.1007/s10059-012-0118-y
    19 sg:pub.10.1007/s10549-008-0206-z
    20 sg:pub.10.1007/s10549-009-0565-0
    21 sg:pub.10.1007/s10549-011-1905-4
    22 sg:pub.10.1007/s10911-011-9213-5
    23 sg:pub.10.1007/s12015-012-9354-y
    24 sg:pub.10.1038/35021093
    25 sg:pub.10.1038/nature03868
    26 sg:pub.10.1038/ng0396-298
    27 sg:pub.10.1038/ng0495-444
    28 sg:pub.10.1038/nm.2000
    29 sg:pub.10.1038/nm.2424
    30 sg:pub.10.1038/nm.2459
    31 sg:pub.10.1038/nrc1457
    32 sg:pub.10.1038/nrm2831
    33 sg:pub.10.1038/onc.2008.171
    34 sg:pub.10.1186/1471-2164-8-258
    35 sg:pub.10.1186/1471-2407-8-309
    36 sg:pub.10.1186/bcr2850
    37 https://app.dimensions.ai/details/publication/pub.1075097640
    38 https://doi.org/10.1002/cncr.24816
    39 https://doi.org/10.1002/emmm.201100136
    40 https://doi.org/10.1002/emmm.201100209
    41 https://doi.org/10.1002/pros.22466
    42 https://doi.org/10.1016/j.bbcan.2006.06.001
    43 https://doi.org/10.1016/j.ceb.2008.12.010
    44 https://doi.org/10.1016/j.cell.2009.01.002
    45 https://doi.org/10.1016/j.stem.2010.07.010
    46 https://doi.org/10.1016/j.yexcr.2009.11.006
    47 https://doi.org/10.1016/s0092-8674(00)00114-8
    48 https://doi.org/10.1016/s0140-6736(87)90593-9
    49 https://doi.org/10.1016/s0959-8049(01)00230-1
    50 https://doi.org/10.1016/s0959-8049(01)00231-3
    51 https://doi.org/10.1038/msb.2011.100
    52 https://doi.org/10.1073/pnas.0605298103
    53 https://doi.org/10.1073/pnas.1105398108
    54 https://doi.org/10.1073/pnas.94.11.5605
    55 https://doi.org/10.1083/jcb.201110008
    56 https://doi.org/10.1084/jem.20101823
    57 https://doi.org/10.1093/jnci/djg050
    58 https://doi.org/10.1093/jnci/djk133
    59 https://doi.org/10.1093/nar/gkh012
    60 https://doi.org/10.1101/gad.1061803
    61 https://doi.org/10.1126/science.7939630
    62 https://doi.org/10.1128/mcb.00961-07
    63 https://doi.org/10.1128/mcb.05821-11
    64 https://doi.org/10.1136/jcp.2008.056291
    65 https://doi.org/10.1158/0008-5472.can-08-3559
    66 https://doi.org/10.1158/0008-5472.can-09-2792
    67 https://doi.org/10.1158/2159-8290.cd-12-0221
    68 https://doi.org/10.1371/journal.pone.0031615
    69 schema:datePublished 2015-08
    70 schema:datePublishedReg 2015-08-01
    71 schema:description Breast cancer 1 (BRCA1)-associated breast cancers are mostly basal-like high-grade ductal carcinomas that frequently overexpress epidermal growth factor receptor (EGFR). Aberrant EGFR expression is correlated with disease progression, resistance to radiation and chemotherapy, and poor clinical prognosis. Although BRCA1 is involved in multiple cellular processes, its functional role in EGFR regulation remains enigmatic. Here, we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a. We demonstrate that EGFR expression correlates negatively with BRCA1, whereas miR-146a levels increase with BRCA1. We show that BRCA1 binds to MIR146A promoter and activates transcription, which in turn attenuates EGFR expression. Knockdown of miR-146a in BRCA1-overexpressing cells negated this effect and suppressed its ability to inhibit proliferation and transformation. In archived triple-negative breast cancer samples, we show a strong positive correlation between BRCA1 and miR-146a expression. We also show that low expression of miR-146a strongly predicts positive lymph node status and is associated with distinctively poor overall survival of patients. Together, these observations provide an insight into a novel BRCA1miR-146aEGFR paradigm by which BRCA1 carries out an aspect of tumor suppressor function that is potentially amenable to therapeutic intervention.
    72 schema:genre research_article
    73 schema:inLanguage en
    74 schema:isAccessibleForFree true
    75 schema:isPartOf Nd65c79decd7440b286f352296fbeb53e
    76 Nf2178751c949422f8e8844dda7b3085d
    77 sg:journal.1097543
    78 schema:name BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor function
    79 schema:pagination 4333
    80 schema:productId N7841e9945858425dbe171bf8aa76d8cd
    81 N907ab7ed27fb4112bda1d4e4961bb743
    82 Nc3d7a5bc8ecd49ef8db45a37c91a62d2
    83 Ndd461395633d4ce5bb4f14d3a86988ef
    84 Ne12fbc65945f4221b8aea8c785be2a03
    85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032901436
    86 https://doi.org/10.1038/onc.2014.363
    87 schema:sdDatePublished 2019-04-10T12:59
    88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    89 schema:sdPublisher Na61fdc136be34efaa0ed92c115ab23f6
    90 schema:url https://www.nature.com/articles/onc2014363
    91 sgo:license sg:explorer/license/
    92 sgo:sdDataset articles
    93 rdf:type schema:ScholarlyArticle
    94 N04ce6ae2de334dd3873f7749fb1d06f0 schema:affiliation https://www.grid.ac/institutes/grid.468219.0
    95 schema:familyName Sibala
    96 schema:givenName E C
    97 rdf:type schema:Person
    98 N08ade8a6b07f407281aaae0ab1ea2681 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Cell Line, Tumor
    100 rdf:type schema:DefinedTerm
    101 N101c3231318e47d5a3998e7b7d3c1cf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Triple Negative Breast Neoplasms
    103 rdf:type schema:DefinedTerm
    104 N10a432d1b91548239d5f1051bc220b31 rdf:first N04ce6ae2de334dd3873f7749fb1d06f0
    105 rdf:rest N81049aabf9fa4601bf07cd2001378e49
    106 N1b602c7747784460834360a453a4f6c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Humans
    108 rdf:type schema:DefinedTerm
    109 N259dd731e917432facd745e1b025291c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Cell Proliferation
    111 rdf:type schema:DefinedTerm
    112 N2c0281d6a7c04fa6ba9b6ede11935258 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name RNA Processing, Post-Transcriptional
    114 rdf:type schema:DefinedTerm
    115 N2ecef9d491fa4ff3a6bd9f5eaa396a93 rdf:first sg:person.016236702557.70
    116 rdf:rest rdf:nil
    117 N36178a7d7d5542488e29975eace072fa schema:affiliation https://www.grid.ac/institutes/grid.468219.0
    118 schema:familyName Wendt
    119 schema:givenName K L
    120 rdf:type schema:Person
    121 N44c638b49fca45cfbcf23e8cc1fe5715 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Promoter Regions, Genetic
    123 rdf:type schema:DefinedTerm
    124 N58076d8648f54c49b43aa1c4bbc5d1ee rdf:first sg:person.01020412776.84
    125 rdf:rest N2ecef9d491fa4ff3a6bd9f5eaa396a93
    126 N5eb767d236f6444c9242b9b2e4a96600 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Lymph Nodes
    128 rdf:type schema:DefinedTerm
    129 N7841e9945858425dbe171bf8aa76d8cd schema:name pubmed_id
    130 schema:value 25417703
    131 rdf:type schema:PropertyValue
    132 N792ad86777ca414da013376081a3386a schema:affiliation https://www.grid.ac/institutes/grid.468219.0
    133 schema:familyName Li
    134 schema:givenName D
    135 rdf:type schema:Person
    136 N81049aabf9fa4601bf07cd2001378e49 rdf:first N792ad86777ca414da013376081a3386a
    137 rdf:rest N58076d8648f54c49b43aa1c4bbc5d1ee
    138 N86468f9215da40e5821f5a56fadf00df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Transcriptional Activation
    140 rdf:type schema:DefinedTerm
    141 N8e68fed0359e4c8fa186d16ed4161156 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Cell Transformation, Neoplastic
    143 rdf:type schema:DefinedTerm
    144 N907ab7ed27fb4112bda1d4e4961bb743 schema:name doi
    145 schema:value 10.1038/onc.2014.363
    146 rdf:type schema:PropertyValue
    147 N9c74a86a58364e6fb508daf0067f73e3 rdf:first sg:person.01156365347.27
    148 rdf:rest Nd5a7da3cb3dd41da9940da664e1e1d7f
    149 Na61fdc136be34efaa0ed92c115ab23f6 schema:name Springer Nature - SN SciGraph project
    150 rdf:type schema:Organization
    151 Nc007a509165f4ea0b925f894494029f0 rdf:first N36178a7d7d5542488e29975eace072fa
    152 rdf:rest N9c74a86a58364e6fb508daf0067f73e3
    153 Nc3d7a5bc8ecd49ef8db45a37c91a62d2 schema:name nlm_unique_id
    154 schema:value 8711562
    155 rdf:type schema:PropertyValue
    156 Ncbdf96f9e59c45bb97fd598d0b7e8ebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Tumor Suppressor Proteins
    158 rdf:type schema:DefinedTerm
    159 Nd5a7da3cb3dd41da9940da664e1e1d7f rdf:first sg:person.0740260107.58
    160 rdf:rest N10a432d1b91548239d5f1051bc220b31
    161 Nd65c79decd7440b286f352296fbeb53e schema:issueNumber 33
    162 rdf:type schema:PublicationIssue
    163 Nd67a5c104599442dafe364b6ca5a8af9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Receptor, Epidermal Growth Factor
    165 rdf:type schema:DefinedTerm
    166 Ndd3cea621a35492a82889d0f89cdbe8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name MicroRNAs
    168 rdf:type schema:DefinedTerm
    169 Ndd461395633d4ce5bb4f14d3a86988ef schema:name readcube_id
    170 schema:value 9cbd2f4c4a8489f707b3aa3e764789e9783d02bdc92e57ddbccc85fa2361d0f4
    171 rdf:type schema:PropertyValue
    172 Ndd6d42a3fa774890bcae2e42b6916c87 rdf:first sg:person.01326566537.04
    173 rdf:rest Nc007a509165f4ea0b925f894494029f0
    174 Ne12fbc65945f4221b8aea8c785be2a03 schema:name dimensions_id
    175 schema:value pub.1032901436
    176 rdf:type schema:PropertyValue
    177 Ned82562830e846daaf8e73344f3067c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name BRCA1 Protein
    179 rdf:type schema:DefinedTerm
    180 Nf2178751c949422f8e8844dda7b3085d schema:volumeNumber 34
    181 rdf:type schema:PublicationVolume
    182 Nf515e20e25604334bf19179fc90600bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Female
    184 rdf:type schema:DefinedTerm
    185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    186 schema:name Medical and Health Sciences
    187 rdf:type schema:DefinedTerm
    188 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    189 schema:name Oncology and Carcinogenesis
    190 rdf:type schema:DefinedTerm
    191 sg:grant.2438407 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.363
    192 rdf:type schema:MonetaryGrant
    193 sg:grant.2438895 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.363
    194 rdf:type schema:MonetaryGrant
    195 sg:journal.1097543 schema:issn 0950-9232
    196 1476-5594
    197 schema:name Oncogene
    198 rdf:type schema:Periodical
    199 sg:person.01020412776.84 schema:affiliation https://www.grid.ac/institutes/grid.412016.0
    200 schema:familyName Gunewardena
    201 schema:givenName S
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020412776.84
    203 rdf:type schema:Person
    204 sg:person.01156365347.27 schema:affiliation https://www.grid.ac/institutes/grid.468219.0
    205 schema:familyName Augustine
    206 schema:givenName L A
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156365347.27
    208 rdf:type schema:Person
    209 sg:person.01326566537.04 schema:affiliation https://www.grid.ac/institutes/grid.468219.0
    210 schema:familyName Kumaraswamy
    211 schema:givenName E
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326566537.04
    213 rdf:type schema:Person
    214 sg:person.016236702557.70 schema:affiliation https://www.grid.ac/institutes/grid.266515.3
    215 schema:familyName Jensen
    216 schema:givenName R A
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016236702557.70
    218 rdf:type schema:Person
    219 sg:person.0740260107.58 schema:affiliation https://www.grid.ac/institutes/grid.412016.0
    220 schema:familyName Stecklein
    221 schema:givenName S R
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740260107.58
    223 rdf:type schema:Person
    224 sg:pub.10.1007/s10059-012-0118-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1019606369
    225 https://doi.org/10.1007/s10059-012-0118-y
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s10549-008-0206-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1023166547
    228 https://doi.org/10.1007/s10549-008-0206-z
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s10549-009-0565-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012090504
    231 https://doi.org/10.1007/s10549-009-0565-0
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s10549-011-1905-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035530194
    234 https://doi.org/10.1007/s10549-011-1905-4
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s10911-011-9213-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021641754
    237 https://doi.org/10.1007/s10911-011-9213-5
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s12015-012-9354-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1042078720
    240 https://doi.org/10.1007/s12015-012-9354-y
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/35021093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846543
    243 https://doi.org/10.1038/35021093
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature03868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042196381
    246 https://doi.org/10.1038/nature03868
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/ng0396-298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017220089
    249 https://doi.org/10.1038/ng0396-298
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/ng0495-444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018646090
    252 https://doi.org/10.1038/ng0495-444
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nm.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045151043
    255 https://doi.org/10.1038/nm.2000
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nm.2424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046872253
    258 https://doi.org/10.1038/nm.2424
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nm.2459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021513783
    261 https://doi.org/10.1038/nm.2459
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nrc1457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042257134
    264 https://doi.org/10.1038/nrc1457
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/nrm2831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016970769
    267 https://doi.org/10.1038/nrm2831
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/onc.2008.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046998641
    270 https://doi.org/10.1038/onc.2008.171
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1186/1471-2164-8-258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019972796
    273 https://doi.org/10.1186/1471-2164-8-258
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1186/1471-2407-8-309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006580732
    276 https://doi.org/10.1186/1471-2407-8-309
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1186/bcr2850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028771137
    279 https://doi.org/10.1186/bcr2850
    280 rdf:type schema:CreativeWork
    281 https://app.dimensions.ai/details/publication/pub.1075097640 schema:CreativeWork
    282 https://doi.org/10.1002/cncr.24816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007419838
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1002/emmm.201100136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011192499
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1002/emmm.201100209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022068361
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1002/pros.22466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005846835
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.bbcan.2006.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008590871
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.ceb.2008.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034397580
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.cell.2009.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023682432
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.stem.2010.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024464845
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.yexcr.2009.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024485037
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/s0092-8674(00)00114-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011791924
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/s0140-6736(87)90593-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046668239
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/s0959-8049(01)00230-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033094712
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/s0959-8049(01)00231-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011723495
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1038/msb.2011.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025546294
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1073/pnas.0605298103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049075000
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1073/pnas.1105398108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036726677
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1073/pnas.94.11.5605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043314283
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1083/jcb.201110008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029914131
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1084/jem.20101823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019895028
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1093/jnci/djg050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053228023
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1093/jnci/djk133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046683146
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1093/nar/gkh012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031148109
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1101/gad.1061803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004107821
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1126/science.7939630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650649
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1128/mcb.00961-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009876297
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1128/mcb.05821-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014384154
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1136/jcp.2008.056291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053600762
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1158/0008-5472.can-08-3559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053604126
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1158/0008-5472.can-09-2792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046286456
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1158/2159-8290.cd-12-0221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020869588
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1371/journal.pone.0031615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052544054
    343 rdf:type schema:CreativeWork
    344 https://www.grid.ac/institutes/grid.266515.3 schema:alternateName University of Kansas
    345 schema:name Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA
    346 Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA
    347 Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
    348 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA
    349 The University of Kansas Cancer Center, Kansas City, KS, USA
    350 rdf:type schema:Organization
    351 https://www.grid.ac/institutes/grid.412016.0 schema:alternateName University of Kansas Medical Center
    352 schema:name Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA
    353 Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    354 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA
    355 rdf:type schema:Organization
    356 https://www.grid.ac/institutes/grid.468219.0 schema:alternateName University of Kansas Cancer Center
    357 schema:name Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA
    358 The University of Kansas Cancer Center, Kansas City, KS, USA
    359 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...